14 3 3 protein epsilon


Gene Symbol: 14 3 3 protein epsilon
Description: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
Alias: 14-3-3E, HEL2, KCIP-1, MDCR, MDS, 14-3-3 protein epsilon, 14-3-3 epsilon, epididymis luminal protein 2, mitochondrial import stimulation factor L subunit, protein kinase C inhibitor protein-1, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide, tyrosine 3/tryptophan 5 -monooxygenase activation protein, epsilon polypeptide
Species: human
Products:     14 3 3 protein epsilon

Top Publications

  1. Yahyaoui W, Callejo M, Price G, Zannis Hadjopoulos M. Deletion of the cruciform binding domain in CBP/14-3-3 displays reduced origin binding and initiation of DNA replication in budding yeast. BMC Mol Biol. 2007;8:27 pubmed
    ..14-3-3, a cruciform DNA binding protein, associates with yeast origins of replication and functions as an initiator of DNA replication, presumably through binding to cruciform DNA forming at yeast replicators. ..
  2. Jones D, Ley S, Aitken A. Isoforms of 14-3-3 protein can form homo- and heterodimers in vivo and in vitro: implications for function as adapter proteins. FEBS Lett. 1995;368:55-8 pubmed
    ..The composition of 14-3-3 dimers within a cell may play a key part in the role of this family of proteins as modulators or adapters which facilitate the interaction of distinct components of signalling pathways. ..
  3. MacDonald N, Welburn J, Noble M, Nguyen A, Yaffe M, Clynes D, et al. Molecular basis for the recognition of phosphorylated and phosphoacetylated histone h3 by 14-3-3. Mol Cell. 2005;20:199-211 pubmed
    ..14-3-3 isoforms thus represent a class of proteins that mediate the effect of histone phosphorylation at inducible genes. ..
  4. Mizuno E, Kitamura N, Komada M. 14-3-3-dependent inhibition of the deubiquitinating activity of UBPY and its cancellation in the M phase. Exp Cell Res. 2007;313:3624-34 pubmed
    ..We conclude that UBPY is catalytically inhibited in a phosphorylation-dependent manner by 14-3-3s during the interphase, and this regulation is cancelled in the M phase. ..
  5. Nagamani S, Zhang F, Shchelochkov O, Bi W, Ou Z, Scaglia F, et al. Microdeletions including YWHAE in the Miller-Dieker syndrome region on chromosome 17p13.3 result in facial dysmorphisms, growth restriction, and cognitive impairment. J Med Genet. 2009;46:825-33 pubmed publisher
    ..3 involving YWHAE present with growth restriction, craniofacial dysmorphisms, structural abnormalities of brain and cognitive impairment. The interstitial deletions are mediated by diverse molecular mechanisms. ..
  6. Tzivion G, Luo Z, Avruch J. Calyculin A-induced vimentin phosphorylation sequesters 14-3-3 and displaces other 14-3-3 partners in vivo. J Biol Chem. 2000;275:29772-8 pubmed
    ..Thus, phosphovimentin, by sequestering 14-3-3 and limiting its availability to other target proteins can affect intracellular signaling processes that require 14-3-3. ..
  7. Zuo S, Xue Y, Tang S, Yao J, Du R, Yang P, et al. 14-3-3 epsilon dynamically interacts with key components of mitogen-activated protein kinase signal module for selective modulation of the TNF-alpha-induced time course-dependent NF-kappaB activity. J Proteome Res. 2010;9:3465-78 pubmed publisher
  8. Che X, Chen H, Xu Z, Shang C, Sun K, Fu W. 14-3-3epsilon contributes to tumour suppression in laryngeal carcinoma by affecting apoptosis and invasion. BMC Cancer. 2010;10:306 pubmed publisher
    ..Decreased expression of 14-3-3epsilon in LSCC tissues contributes to the initiation and progression of LSCC. 14-3-3epsilon can promote apoptosis and inhibit the invasiveness of LSCC. ..
  9. Reincke M, Sbiera S, Hayakawa A, Theodoropoulou M, Osswald A, Beuschlein F, et al. Mutations in the deubiquitinase gene USP8 cause Cushing's disease. Nat Genet. 2015;47:31-8 pubmed publisher
    ..USP8 mutants enhanced promoter activity of the gene encoding proopiomelanocortin. In summary, our data show that dominant mutations in USP8 cause Cushing's disease via activation of EGF receptor signaling. ..

More Information


  1. Liu Y, Tian R, Li Y, Liu W, Cao L, Yang X, et al. The expression of seven 14-3-3 isoforms in human meningioma. Brain Res. 2010;1336:98-102 pubmed publisher
    ..In conclusion, The 14-3-3 epsilon, zeta and theta may be involved in tumorigenesis of meningioma and be efficient markers for predicting the degree of malignancy in meningioma. ..
  2. Nichols R, Dzamko N, Morrice N, Campbell D, Deak M, Ordureau A, et al. 14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization. Biochem J. 2010;430:393-404 pubmed publisher
    ..These results provide the first evidence suggesting that 14-3-3 regulates LRRK2 and that disruption of the interaction of LRRK2 with 14-3-3 may be linked to Parkinson's disease...
  3. Wang Z, Nesland J, Suo Z, Trope C, Holm R. The prognostic value of 14-3-3 isoforms in vulvar squamous cell carcinoma cases: 14-3-3? and ? are independent prognostic factors for these tumors. PLoS ONE. 2011;6:e24843 pubmed publisher
    ..In our current study, we examined the expression of 14-3-3?, ?, ?, ?, ? and ? in a large series of vulvar squamous cell carcinomas to evaluate any clinical significance...
  4. Ikeda M, Hikita T, Taya S, Uraguchi Asaki J, Toyo oka K, Wynshaw Boris A, et al. Identification of YWHAE, a gene encoding 14-3-3epsilon, as a possible susceptibility gene for schizophrenia. Hum Mol Genet. 2008;17:3212-22 pubmed publisher
    ..Our results suggest that YWHAE is a possible susceptibility gene that functions protectively in schizophrenia. ..
  5. LeBron C, Chen L, Gilkes D, Chen J. Regulation of MDMX nuclear import and degradation by Chk2 and 14-3-3. EMBO J. 2006;25:1196-206 pubmed
    ..These results suggest that MDMX-14-3-3 interaction plays a role in p53 response to DNA damage by regulating MDMX localization and stability. ..
  6. Chong S, Tanigami A, Roschke A, Ledbetter D. 14-3-3 epsilon has no homology to LIS1 and lies telomeric to it on chromosome 17p13.3 outside the Miller-Dieker syndrome chromosome region. Genome Res. 1996;6:735-41 pubmed
    ..3). However, 14-3-3 epsilon lies telomeric to LIS1 and outside the Miller-Dieker syndrome chromosome region but in a region frequently deleted in several types of cancer, and is a reasonable candidate tumor suppressor gene. ..
  7. Diviani D, Abuin L, Cotecchia S, Pansier L. Anchoring of both PKA and 14-3-3 inhibits the Rho-GEF activity of the AKAP-Lbc signaling complex. EMBO J. 2004;23:2811-20 pubmed
    ..Therefore, while it is known that AKAP-Lbc activity can be stimulated by Galpha12, in this study we demonstrated that it is inhibited by the anchoring of both PKA and 14-3-3. ..
  8. Uchida S, Kuma A, Ohtsubo M, Shimura M, Hirata M, Nakagama H, et al. Binding of 14-3-3beta but not 14-3-3sigma controls the cytoplasmic localization of CDC25B: binding site preferences of 14-3-3 subtypes and the subcellular localization of CDC25B. J Cell Sci. 2004;117:3011-20 pubmed
  9. Sekimoto T, Fukumoto M, Yoneda Y. 14-3-3 suppresses the nuclear localization of threonine 157-phosphorylated p27(Kip1). EMBO J. 2004;23:1934-42 pubmed
    ..These findings indicate that 14-3-3 suppresses importin alpha/beta-dependent nuclear localization of Thr157-phosphorylated p27, suggesting implications for cell cycle disorder in Akt-activated cancer cells. ..
  10. Wang X, Grammatikakis N, Siganou A, Calderwood S. Regulation of molecular chaperone gene transcription involves the serine phosphorylation, 14-3-3 epsilon binding, and cytoplasmic sequestration of heat shock factor 1. Mol Cell Biol. 2003;23:6013-26 pubmed
    ..Our experiments indicate a novel pathway for HSF1 regulation and suggest a mechanism for suppression of its activity during cellular proliferation. ..
  11. Chen H, Fernandez Funez P, Acevedo S, Lam Y, Kaytor M, Fernandez M, et al. Interaction of Akt-phosphorylated ataxin-1 with 14-3-3 mediates neurodegeneration in spinocerebellar ataxia type 1. Cell. 2003;113:457-68 pubmed
    ..Our finding that phosphatidylinositol 3-kinase/Akt signaling and 14-3-3 cooperate to modulate the neurotoxicity of ataxin-1 provides insight into SCA1 pathogenesis and identifies potential targets for therapeutic intervention. ..
  12. Luk S, Ngai S, Tsui S, Fung K, Lee C, Waye M. In vivo and in vitro association of 14-3-3 epsilon isoform with calmodulin: implication for signal transduction and cell proliferation. J Cell Biochem. 1999;73:31-5 pubmed
    ..Our results, along with the association of the 14-3-3 epsilon protein with other signaling proteins, suggest that the 14-3-3 protein could provide a link between signal transduction and cell proliferation. ..
  13. Dalal S, Schweitzer C, Gan J, DeCaprio J. Cytoplasmic localization of human cdc25C during interphase requires an intact 14-3-3 binding site. Mol Cell Biol. 1999;19:4465-79 pubmed
    ..These results suggest that 14-3-3 proteins may negatively regulate cdc25C function by sequestering cdc25C in the cytoplasm. ..
  14. Brunet A, Kanai F, Stehn J, Xu J, Sarbassova D, Frangioni J, et al. 14-3-3 transits to the nucleus and participates in dynamic nucleocytoplasmic transport. J Cell Biol. 2002;156:817-28 pubmed
    ..These results indicate that 14-3-3 can mediate the relocalization of nuclear ligands by several mechanisms that ensure complete sequestration of the bound 14-3-3 complex in the cytoplasm. ..
  15. Konishi H, Nakagawa T, Harano T, Mizuno K, Saito H, Masuda A, et al. Identification of frequent G(2) checkpoint impairment and a homozygous deletion of 14-3-3epsilon at 17p13.3 in small cell lung cancers. Cancer Res. 2002;62:271-6 pubmed
    ..These findings suggest the possible involvement of the perturbed G(2) checkpoint in the pathogenesis of this aggressive form of human lung cancers. ..
  16. Craparo A, Freund R, Gustafson T. 14-3-3 (epsilon) interacts with the insulin-like growth factor I receptor and insulin receptor substrate I in a phosphoserine-dependent manner. J Biol Chem. 1997;272:11663-9 pubmed
    ..The potential functional roles which 14-3-3 may play in IGFIR and IRS-1-mediated signaling remain to be elucidated. ..
  17. Zhai J, Lin H, Shamim M, Schlaepfer W, Canete Soler R. Identification of a novel interaction of 14-3-3 with p190RhoGEF. J Biol Chem. 2001;276:41318-24 pubmed
    ..The findings suggest a potential role for 14-3-3 in modulating p190RhoGEF activity or in linking p190RhoGEF to the activities of other pathways in the neuron. ..
  18. Hsu S, Kaipia A, Zhu L, Hsueh A. Interference of BAD (Bcl-xL/Bcl-2-associated death promoter)-induced apoptosis in mammalian cells by 14-3-3 isoforms and P11. Mol Endocrinol. 1997;11:1858-67 pubmed
  19. Ostrerova N, Petrucelli L, Farrer M, Mehta N, Choi P, Hardy J, et al. alpha-Synuclein shares physical and functional homology with 14-3-3 proteins. J Neurosci. 1999;19:5782-91 pubmed
    ..The activity and binding profile of alpha-synuclein suggests that it might act as a protein chaperone and that accumulation of alpha-synuclein could contribute to cell death in neurodegenerative diseases. ..
  20. Bruno D, Anderlid B, Lindstrand A, van Ravenswaaij Arts C, Ganesamoorthy D, Lundin J, et al. Further molecular and clinical delineation of co-locating 17p13.3 microdeletions and microduplications that show distinctive phenotypes. J Med Genet. 2010;47:299-311 pubmed publisher
  21. Grozinger C, Schreiber S. Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent cellular localization. Proc Natl Acad Sci U S A. 2000;97:7835-40 pubmed
    ..Regulation of the cellular localization of HDAC4 and HDAC5 by 14-3-3 represents a mechanism for controlling the transcriptional activity of these class II HDAC proteins. ..
  22. Mignon Ravix C, Cacciagli P, El Waly B, Moncla A, Milh M, Girard N, et al. Deletion of YWHAE in a patient with periventricular heterotopias and pronounced corpus callosum hypoplasia. J Med Genet. 2010;47:132-6 pubmed publisher
    ..The case described here represents the smallest reported deletion involving the YWHAE gene and could represent the human counterpart of the abnormal cortical organisation phenotype presented by the Ywhae heterozygous knockout mouse. ..
  23. Kanai F, Marignani P, Sarbassova D, Yagi R, Hall R, Donowitz M, et al. TAZ: a novel transcriptional co-activator regulated by interactions with 14-3-3 and PDZ domain proteins. EMBO J. 2000;19:6778-91 pubmed
    ..TAZ may link events at the plasma membrane and cytoskeleton to nuclear transcription in a manner that can be regulated by 14-3-3. ..
  24. Linde C, Di Leva F, Domi T, Tosatto S, Brini M, Carafoli E. Inhibitory interaction of the 14-3-3 proteins with ubiquitous (PMCA1) and tissue-specific (PMCA3) isoforms of the plasma membrane Ca2+ pump. Cell Calcium. 2008;43:550-61 pubmed
  25. Tak H, Jang E, Kim S, Park J, Suk J, Yoon Y, et al. 14-3-3epsilon inhibits MK5-mediated cell migration by disrupting F-actin polymerization. Cell Signal. 2007;19:2379-87 pubmed
  26. Yang X, Lee W, Sobott F, Papagrigoriou E, Robinson C, Grossmann J, et al. Structural basis for protein-protein interactions in the 14-3-3 protein family. Proc Natl Acad Sci U S A. 2006;103:17237-42 pubmed
    ..These results show that the 14-3-3 proteins are adaptable structures in which internal flexibility is likely to facilitate recognition and binding of their interaction partners. ..
  27. Göransson O, Deak M, Wullschleger S, Morrice N, Prescott A, Alessi D. Regulation of the polarity kinases PAR-1/MARK by 14-3-3 interaction and phosphorylation. J Cell Sci. 2006;119:4059-70 pubmed
    ..Collectively, these results indicate that 14-3-3 binding to MARK isoforms is mediated by multiple phosphorylation sites, and serves to anchor MARK isoforms in the cytoplasm. ..
  28. Satoh J, Nanri Y, Yamamura T. Rapid identification of 14-3-3-binding proteins by protein microarray analysis. J Neurosci Methods. 2006;152:278-88 pubmed
    ..These results suggest that protein microarray is a powerful tool for rapid and comprehensive profiling of 14-3-3-binding proteins. ..
  29. Toyo oka K, Shionoya A, Gambello M, Cardoso C, Leventer R, Ward H, et al. 14-3-3epsilon is important for neuronal migration by binding to NUDEL: a molecular explanation for Miller-Dieker syndrome. Nat Genet. 2003;34:274-85 pubmed
    ..neuronal migration disorders isolated lissencephaly sequence (ILS) and the more severe Miller-Dieker syndrome (MDS)...
  30. Nguyen T, Takemoto L, Takemoto D. Inhibition of gap junction activity through the release of the C1B domain of protein kinase Cgamma (PKCgamma) from 14-3-3: identification of PKCgamma-binding sites. J Biol Chem. 2004;279:52714-25 pubmed
    ..This demonstrates that synthetic peptides can be used to exogenously regulate gap junctions. ..
  31. Fujita N, Sato S, Katayama K, Tsuruo T. Akt-dependent phosphorylation of p27Kip1 promotes binding to 14-3-3 and cytoplasmic localization. J Biol Chem. 2002;277:28706-13 pubmed
    ..p27(Kip1) phosphorylated at Thr(198) exists only in the cytoplasm. Therefore, Akt promotes cell-cycle progression through the mechanisms of phosphorylation-dependent 14-3-3 binding to p27(Kip1) and cytoplasmic localization. ..
  32. Chaudhri M, Scarabel M, Aitken A. Mammalian and yeast 14-3-3 isoforms form distinct patterns of dimers in vivo. Biochem Biophys Res Commun. 2003;300:679-85 pubmed
    ..The epsilon isoform formed heterodimers with 14-3-3 beta, gamma, zeta, and eta, but no homodimers were detected. The two 14-3-3 homologues, BMH1 and BMH2 from Saccharomyces cerevisiae, were mainly heterodimers. ..
  33. Won J, Kim D, La M, Kim D, Meadows G, Joe C. Cleavage of 14-3-3 protein by caspase-3 facilitates bad interaction with Bcl-x(L) during apoptosis. J Biol Chem. 2003;278:19347-51 pubmed
  34. Chen M, Ryan C, Piwnica Worms H. Chk1 kinase negatively regulates mitotic function of Cdc25A phosphatase through 14-3-3 binding. Mol Cell Biol. 2003;23:7488-97 pubmed
    ..We propose that the Chk1/Cdc25A/14-3-3 pathway functions to prevent cells from entering into mitosis prior to replicating their genomes to ensure the fidelity of the cell division process. ..
  35. Ko B, Chang T, Hsu C, Chen Y, Shen T, Chen S, et al. Overexpression of 14-3-3? predicts tumour metastasis and poor survival in hepatocellular carcinoma. Histopathology. 2011;58:705-11 pubmed publisher
    ..Furthermore, 14-3-3? overexpression increased the risk of metastasis 4.6-fold. Overexpression of 14-3-3? in primary HCC tissues predicts a high risk of extrahepatic metastasis and worse survival, and is a potential therapeutic target. ..
  36. Foebel A, Ballokova A, Wellens N, Fialova D, Milisen K, Liperoti R, et al. A retrospective, longitudinal study of factors associated with new antipsychotic medication use among recently admitted long-term care residents. BMC Geriatr. 2015;15:128 pubmed publisher
    ..This longitudinal, retrospective study used data from the interRAI - Nursing Home Minimum Data Set version 2.0 (MDS 2.0) instrument...
  37. Hashemian Z, Khayamian T, Saraji M, Shirani M. Aptasensor based on fluorescence resonance energy transfer for the analysis of adenosine in urine samples of lung cancer patients. Biosens Bioelectron. 2016;79:334-40 pubmed publisher
    ..interactions of adenosine molecules with the aptamer were investigated using molecular modeling, including molecular dynamic simulations (MDS). The results demonstrated that each G-quadruplex aptamer can capture two adenosine molecules.
  38. Temmingh H, Williams T, Siegfried N, Stein D. Risperidone versus other antipsychotics for people with severe mental illness and co-occurring substance misuse. Cochrane Database Syst Rev. 2018;1:CD011057 pubmed publisher
    ..For continuous outcomes we calculated the mean differences (MDs) and their 95% confidence intervals...
  39. Sakellari I, Mallouri D, Gavriilaki E, Batsis I, Kaliou M, Constantinou V, et al. Survival Advantage and Comparable Toxicity in Reduced-Toxicity Treosulfan-Based versus Reduced-Intensity Busulfan-Based Conditioning Regimen in Myelodysplastic Syndrome and Acute Myeloid Leukemia Patients after Allogeneic Hematopoietic Cell Transplan. Biol Blood Marrow Transplant. 2017;23:445-451 pubmed publisher
    ..Thirty-one consecutive patients with acute myeloid leukemia (AML; n = 21), myelodysplastic syndrome (MDS; n = 6), or treatment-related AML (n = 4) received FluTreo conditioning...
  40. Ali A, Weisel D, Gao F, Uy G, Cashen A, Jacoby M, et al. Patterns of infectious complications in acute myeloid leukemia and myelodysplastic syndromes patients treated with 10-day decitabine regimen. Cancer Med. 2017;: pubmed publisher
    ..results from each infection-related serious adverse event that occurred among 85 AML and myelodysplastic syndromes (MDS) patients treated in a prospective clinical study using 10-day cycles of decitabine at Washington University School ..
  41. Gueron Sela N, Camerota M, Willoughby M, Vernon Feagans L, Cox M. Maternal Depressive Symptoms, Mother-Child Interactions, and Children's Executive Function. Dev Psychol. 2017;: pubmed publisher
    This study examined the independent and mediated associations between maternal depression symptoms (MDS), mother-child interaction, and child executive function (EF) in a prospective longitudinal sample of 1,037 children (50% boys) from ..
  42. Roberts T, Gilmore Bykovskyi A, Lor M, Liebzeit D, Crnich C, Saliba D. Important Care and Activity Preferences in a Nationally Representative Sample of Nursing Home Residents. J Am Med Dir Assoc. 2018;19:25-32 pubmed publisher
    ..Delivery of PCC fundamentally relies on knowledge of resident preferences. The Minimum Data Set (MDS) 3...
  43. Sekigawa Hosozawa M, Tanaka K, Shimizu T, Nakano T, Kitazawa S. A group of very preterm children characterized by atypical gaze patterns. Brain Dev. 2017;39:218-224 pubmed publisher
    ..The temporo-spatial gaze patterns were summarized on a two-dimensional plane using multidimensional scaling (MDS) and the median of the TD children was used to characterize the gazes of the VP children...
  44. Bernstein C, Ellard D, Davies G, Hertenstein E, Tang N, Underwood M, et al. Behavioural interventions for people living with adult-onset primary dystonia: a systematic review. BMC Neurol. 2016;16:40 pubmed publisher
    ..Only two were Randomised Controlled Trials (RCTs). Using the Movement Disorders Society (MDS) dystonia classification, that was published after this work started, all of the included studies were of ..
  45. Son M, Deng C, Hoeijmarkers J, Rebel V, Hasty P. A mechanism for 1,4-Benzoquinone-induced genotoxicity. Oncotarget. 2016;7:46433-46447 pubmed publisher
    ..toxin and its metabolite, 1-4-Benzoquinone (BQ) causes hematopoietic cancers like myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML)...
  46. Kim Y, Abdel Wahab O. Therapeutic targeting of RNA splicing in myelodysplasia. Semin Hematol. 2017;54:167-173 pubmed publisher
    Genomic analysis of patients with myelodysplastic syndromes (MDS) has identified that mutations within genes encoding RNA splicing factors represent the most common class of genetic alterations in MDS...
  47. Komrokji R, List A. Short- and long-term benefits of lenalidomide treatment in patients with lower-risk del(5q) myelodysplastic syndromes. Ann Oncol. 2016;27:62-8 pubmed publisher
    The treatment of patients with myelodysplastic syndromes (MDS) begins with assessment of karyotype and risk...
  48. Cheah J, Hahn C, Hiwase D, Scott H, Brown A. Myeloid neoplasms with germline DDX41 mutation. Int J Hematol. 2017;106:163-174 pubmed publisher
    ..as germline and acquired somatic mutations in families with multiple cases of late-onset myelodysplastic syndrome (MDS) and/or acute myeloid leukemia...
  49. Bergsma H, van Lom K, Raaijmakers M, Konijnenberg M, Kam B, Teunissen J, et al. Persistent Hematologic Dysfunction after Peptide Receptor Radionuclide Therapy with 177Lu-DOTATATE: Incidence, Course, and Predicting Factors in Patients with Gastroenteropancreatic Neuroendocrine Tumors. J Nucl Med. 2018;59:452-458 pubmed publisher
    ..PHD was defined as diagnosis of myelodysplastic syndrome (MDS), acute myeloid leukemia (AML), myeloproliferative neoplasm (MPN), MDS/MPN, or otherwise unexplained cytopenia (for ..
  50. Shen X, Wang Z, Huang X, Hu H, Wang W, Zhang X. Developing genome-reduced Pseudomonas chlororaphis strains for the production of secondary metabolites. BMC Genomics. 2017;18:715 pubmed publisher
    ..Then we characterized the 22 multiple-deletion series (MDS) strains...
  51. Cimarolli V, Jung S. Intensity of Occupational Therapy Utilization in Nursing Home Residents: The Role of Sensory Impairments. J Am Med Dir Assoc. 2016;17:939-42 pubmed publisher
    ..extent of sensory difficulties (hearing and vision) as well as pain presence based on Minimum Data Set (MDS 3.0) assessments in EMRs. MDS 3...
  52. Normansell R, Kew K, Bridgman A. Sublingual immunotherapy for asthma. Cochrane Database Syst Rev. 2015;:CD011293 pubmed publisher
    ..RDs) using study participants as the unit of analysis; we analysed continuous data as mean differences (MDs) or standardised mean differences (SMDs) using random-effects models...
  53. Ohanian M, Bueso Ramos C, Ok C, Lin P, Patel K, Alattar M, et al. Acute myeloid leukemia with MYC rearrangement and JAK2 V617F mutation. Cancer Genet. 2015;208:571-4 pubmed publisher
    ..to find published studies that evaluated MYC protein expression in primary cases of myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML)...
  54. Kim D, Lee H, Moon J, Sohn S, Kim H, Cheong J, et al. Can we consider discontinuation of hypomethylating agents in patients with myelodysplastic syndrome : a retrospective study from The Korean Society of Hematology AML/MDS Working Party. Oncotarget. 2017;8:79414-79424 pubmed publisher
    ..Especially, a lower risk by WPSS and longer duration of HMA treatment may be predictive factors for a longer PFS and OS in patients who discontinued HMA...
  55. Wang M, Yi S, Han J, Park S, Jang J, Chun I, et al. Oligomeric forms of amyloid-? protein in plasma as a potential blood-based biomarker for Alzheimer's disease. Alzheimers Res Ther. 2017;9:98 pubmed publisher
    ..In the present study, the recently developed Multimer Detection System (MDS) for AD, a new enzyme-linked immunosorbent assay for measuring A? oligomers selectively, was used to detect A? ..
  56. Zhang X, Zeng B, Wen C, Zheng S, Chen H, She F. YWHAE is a novel interaction partner of Helicobacter pylori CagA. FEMS Microbiol Lett. 2017;: pubmed publisher
    ..These results indicate that CagA enhances the YWHAE-mediated transactivation of NF-?B, providing a new clue to the molecular mechanisms of H. pylori-associated tumorigenesis mediated by CagA...
  57. Portinari M, Carcoforo P. The application of drains in thyroid surgery. Gland Surg. 2017;6:563-573 pubmed publisher
    ..Risk ratios (RRs) and 95% confident intervals (95% CI) were used for dichotomous variables; mean differences (MDs) and 95% CI for continuous variables...
  58. Courchet J, Buchet Poyau K, Potemski A, Brès A, Jariel Encontre I, Billaud M. Interaction with 14-3-3 adaptors regulates the sorting of hMex-3B RNA-binding protein to distinct classes of RNA granules. J Biol Chem. 2008;283:32131-42 pubmed publisher
    ..Thus, 14-3-3 exerts combined effects on hMex-3B and acts as a major regulator of the sorting between distinct classes of RNA granules. ..
  59. Garderet L, Ziagkos D, van Biezen A, Iacobelli S, Finke J, Maertens J, et al. Allogeneic Stem Cell Transplantation for Myelodysplastic Syndrome Patients with a 5q Deletion. Biol Blood Marrow Transplant. 2018;24:507-513 pubmed publisher
    The deletion (5q) karyotype (del [5q]) in patients with myelodysplastic syndrome (MDS) is the most common karyotypic abnormality in de novo MDS...
  60. Zhou Y, Shao C, Li L, Zhang Y, Liu B, Yang Q, et al. Genetic analysis of 29 Y-STR loci in the Chinese Han population from Shanghai. Forensic Sci Int Genet. 2018;32:e1-e4 pubmed publisher
    ..Visualization of pairwise genetic distances between 17 worldwide populations using multidimensional scaling (MDS) demonstrates the distribution of populations according to their ethno-geographic patterns...
  61. Poli A, Ratti S, Finelli C, Mongiorgi S, Clissa C, Lonetti A, et al. Nuclear translocation of PKC-? is associated with cell cycle arrest and erythroid differentiation in myelodysplastic syndromes (MDSs). FASEB J. 2017;: pubmed publisher
    PI-PLC?1 is involved in cell proliferation, differentiation, and myelodysplastic syndrome (MDS) pathogenesis...
  62. Hemming M, Wagner A, Nucci M, Chiang S, Wang L, Hensley M, et al. YWHAE-rearranged high-grade endometrial stromal sarcoma: Two-center case series and response to chemotherapy. Gynecol Oncol. 2017;145:531-535 pubmed publisher
    ..This emphasizes the need for appropriate molecular testing of uterine mesenchymal malignancies and suggests that chemotherapy is an effective treatment option for metastatic YWHAE-rearranged HG-ESS. ..
  63. Sirili N, Kiwara A, Gasto F, Goicolea I, Hurtig A. Training and deployment of medical doctors in Tanzania post-1990s health sector reforms: assessing the achievements. Hum Resour Health. 2017;15:27 pubmed publisher
    ..Little is documented on how the post-reform training and deployment of medical doctors (MDs) have contributed to resolving Tanzania's shortage of doctors...
  64. Pulina M, Rizzuto R, Brini M, Carafoli E. Inhibitory interaction of the plasma membrane Na+/Ca2+ exchangers with the 14-3-3 proteins. J Biol Chem. 2006;281:19645-54 pubmed
    ..In vitro binding experiments revealed that all three NCX isoforms interacted with multiple 14-3-3 isoforms. 14-3-3 was bound by both phosphorylated and nonphosphorylated NCX, but the phosphorylated form had much higher binding affinity. ..
  65. Miska E, Langley E, Wolf D, Karlsson C, Pines J, Kouzarides T. Differential localization of HDAC4 orchestrates muscle differentiation. Nucleic Acids Res. 2001;29:3439-47 pubmed
    ..However, despite the functional similarities of HDAC4 and HDAC5, their intracellular localisations are opposed, suggesting a distinct role for these enzymes during muscle differentiation. ..
  66. Selbmann L, Onofri S, Coleine C, Buzzini P, Canini F, Zucconi L. Effect of environmental parameters on biodiversity of the fungal component in lithic Antarctic communities. Extremophiles. 2017;21:1069-1080 pubmed publisher
    ..The n-MDS analysis showed that altitude and sea distance affect fungal biodiversity, while sandstone allows the communities ..
  67. Chen C, Liu C, Chen R, Wang W, Li W, Kan H, et al. Ambient air pollution and daily hospital admissions for mental disorders in Shanghai, China. Sci Total Environ. 2018;613-614:324-330 pubmed publisher
    Few studies have investigated the associations between ambient air pollution and mental disorders (MDs), especially in developing countries...
  68. Prebet T, Cluzeau T, Park S, Sekeres M, Germing U, Ades L, et al. Outcome of patients treated for myelodysplastic syndromes with 5q deletion after failure of lenalidomide therapy. Oncotarget. 2017;8:81926-81935 pubmed publisher
    While lenalidomide (LEN) is the standard of care for the lower-risk myelodysplastic syndromes (MDS) patients with deletion 5q, 35% will not respond to or do not tolerate the drug...
  69. Rosato V, Temple N, La Vecchia C, Castellan G, Tavani A, Guercio V. Mediterranean diet and cardiovascular disease: a systematic review and meta-analysis of observational studies. Eur J Nutr. 2019;58:173-191 pubmed publisher
    ..infarction (AMI) and stroke (ischemic/hemorrhagic) by sex, geographic region, study design and type of MD score (MDS). We performed a systematic review and meta-analysis of observational studies...
  70. Takahashi T, Nakamura Y, Nakamura Y, Aleksic B, Takayanagi Y, Furuichi A, et al. The polymorphism of YWHAE, a gene encoding 14-3-3epsilon, and orbitofrontal sulcogyral pattern in patients with schizophrenia and healthy subjects. Prog Neuropsychopharmacol Biol Psychiatry. 2014;51:166-71 pubmed publisher
    ..These results suggest a possible role for the YWHAE genotype in the early development of the OFC sulcogyral pattern, but its effect alone is not likely to explain the altered sulcogyral pattern in schizophrenia. ..
  71. Kino T, Gragerov A, Valentin A, Tsopanomihalou M, Ilyina Gragerova G, Erwin Cohen R, et al. Vpr protein of human immunodeficiency virus type 1 binds to 14-3-3 proteins and facilitates complex formation with Cdc25C: implications for cell cycle arrest. J Virol. 2005;79:2780-7 pubmed
    ..These results indicate that Vpr promotes cell cycle arrest at the G(2)/M phase by facilitating association of 14-3-3 and Cdc25C independently of the latter's phosphorylation status. ..