14 3 3 protein beta alpha


Gene Symbol: 14 3 3 protein beta alpha
Description: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
Alias: GW128, HEL-S-1, HS1, KCIP-1, YWHAA, 14-3-3 protein beta/alpha, 14-3-3 alpha, brain protein 14-3-3, beta isoform, epididymis secretory protein Li 1, protein 1054, protein kinase C inhibitor protein-1, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, alpha polypeptide, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide
Species: human
Products:     14 3 3 protein beta alpha

Top Publications

  1. Zhang S, Kobayashi R, Graves P, Piwnica Worms H, Tonks N. Serine phosphorylation-dependent association of the band 4.1-related protein-tyrosine phosphatase PTPH1 with 14-3-3beta protein. J Biol Chem. 1997;272:27281-7 pubmed
    ..These results raise the possibility that 14-3-3beta may function as an adaptor molecule in the regulation of PTPH1 and may provide a link between serine/threonine and tyrosine phosphorylation-dependent signaling pathways. ..
  2. Kosaki A, Yamada K, Suga J, Otaka A, Kuzuya H. 14-3-3beta protein associates with insulin receptor substrate 1 and decreases insulin-stimulated phosphatidylinositol 3'-kinase activity in 3T3L1 adipocytes. J Biol Chem. 1998;273:940-4 pubmed
    ..The specific activity of the PI3K in the former was approximately half of that in the latter, suggesting that 14-3-3beta protein bound to IRS-1 inhibits insulin-stimulated lipid kinase activity of PI3K in 3T3L1 adipocytes. ..
  3. Wang Y, Jacobs C, Hook K, Duan H, Booher R, Sun Y. Binding of 14-3-3beta to the carboxyl terminus of Wee1 increases Wee1 stability, kinase activity, and G2-M cell population. Cell Growth Differ. 2000;11:211-9 pubmed
    ..The finding reveals a novel mechanism by which 14-3-3 regulates G2-M arrest and suggests that the NH2-terminal domain of Wee1 contains a negative regulatory sequence that determines Wee1 stability. ..
  4. Liu Y, Tian R, Li Y, Liu W, Cao L, Yang X, et al. The expression of seven 14-3-3 isoforms in human meningioma. Brain Res. 2010;1336:98-102 pubmed publisher
    ..In conclusion, The 14-3-3 epsilon, zeta and theta may be involved in tumorigenesis of meningioma and be efficient markers for predicting the degree of malignancy in meningioma. ..
  5. Yaffe M, Rittinger K, Volinia S, Caron P, Aitken A, Leffers H, et al. The structural basis for 14-3-3:phosphopeptide binding specificity. Cell. 1997;91:961-71 pubmed
    ..Finally, we show that the 14-3-3 dimer binds tightly to single molecules containing tandem repeats of phosphoserine motifs, implicating bidentate association as a signaling mechanism with molecules such as Raf, BAD, and Cbl. ..
  6. Wang A, Kruhlak M, Wu J, Bertos N, Vezmar M, Posner B, et al. Regulation of histone deacetylase 4 by binding of 14-3-3 proteins. Mol Cell Biol. 2000;20:6904-12 pubmed
    ..These results indicate that 14-3-3 proteins negatively regulate HDAC4 by preventing its nuclear localization and thereby uncover a novel regulatory mechanism for HDACs. ..
  7. Rajan S, Preisig Müller R, Wischmeyer E, Nehring R, Hanley P, Renigunta V, et al. Interaction with 14-3-3 proteins promotes functional expression of the potassium channels TASK-1 and TASK-3. J Physiol. 2002;545:13-26 pubmed
    ..Our findings suggest that interaction of 14-3-3 with TASK-1 or TASK-3 may promote the trafficking of the channels to the surface membrane. ..
  8. Li Y, Inoki K, Vacratsis P, Guan K. The p38 and MK2 kinase cascade phosphorylates tuberin, the tuberous sclerosis 2 gene product, and enhances its interaction with 14-3-3. J Biol Chem. 2003;278:13663-71 pubmed
    ..Phosphorylation of TSC2 by MK2 creates a 14-3-3 binding site and thus regulates the cellular function of the TSC2 tumor suppressor protein. ..
  9. Komiya Y, Kurabe N, Katagiri K, Ogawa M, Sugiyama A, Kawasaki Y, et al. A novel binding factor of 14-3-3beta functions as a transcriptional repressor and promotes anchorage-independent growth, tumorigenicity, and metastasis. J Biol Chem. 2008;283:18753-64 pubmed publisher
    ..These results indicate that FBI1 promotes sustained ERK1/2 activation through repression of MKP-1 transcription, resulting in promotion of tumorigenicity and metastasis. ..

More Information

Publications238 found, 100 shown here

  1. Ostrerova N, Petrucelli L, Farrer M, Mehta N, Choi P, Hardy J, et al. alpha-Synuclein shares physical and functional homology with 14-3-3 proteins. J Neurosci. 1999;19:5782-91 pubmed
    ..The activity and binding profile of alpha-synuclein suggests that it might act as a protein chaperone and that accumulation of alpha-synuclein could contribute to cell death in neurodegenerative diseases. ..
  2. Grozinger C, Schreiber S. Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent cellular localization. Proc Natl Acad Sci U S A. 2000;97:7835-40 pubmed
    ..Regulation of the cellular localization of HDAC4 and HDAC5 by 14-3-3 represents a mechanism for controlling the transcriptional activity of these class II HDAC proteins. ..
  3. Toshima J, Toshima J, Watanabe T, Mizuno K. Binding of 14-3-3beta regulates the kinase activity and subcellular localization of testicular protein kinase 1. J Biol Chem. 2001;276:43471-81 pubmed
    ..We propose that 14-3-3beta plays important roles in regulating the kinase activity of TESK1 and localizing TESK1 to cell adhesion sites following integrin stimulation. ..
  4. Johnson B, Stehn J, Yaffe M, Blackwell T. Cytoplasmic localization of tristetraprolin involves 14-3-3-dependent and -independent mechanisms. J Biol Chem. 2002;277:18029-36 pubmed
    ..They also suggest that 14-3-3 binding is part of a complex network of stimuli and interactions that regulate TTP function. ..
  5. Li Y, Inoki K, Yeung R, Guan K. Regulation of TSC2 by 14-3-3 binding. J Biol Chem. 2002;277:44593-6 pubmed
    ..Phosphorylation of Ser(1210) in TSC2 is required for its association with 14-3-3. Our data indicate that 14-3-3 association may inhibit the function of TSC2 and represents a possible mechanism of TSC2 regulation. ..
  6. O Kelly I, Butler M, Zilberberg N, Goldstein S. Forward transport. 14-3-3 binding overcomes retention in endoplasmic reticulum by dibasic signals. Cell. 2002;111:577-88 pubmed
    ..Other retained proteins are demonstrated to carry functional 14-3-3beta release motifs. ..
  7. Liu M, Cai S, Espejo A, Bedford M, Walker C. 14-3-3 interacts with the tumor suppressor tuberin at Akt phosphorylation site(s). Cancer Res. 2002;62:6475-80 pubmed
    ..Tuberin also coimmunoprecipitated with 14-3-3, confirming the interaction between endogenous 14-3-3 and tuberin. These data establish the presence of functional and overlapping 14-3-3 and Akt recognition site(s) in tuberin. ..
  8. Chaudhri M, Scarabel M, Aitken A. Mammalian and yeast 14-3-3 isoforms form distinct patterns of dimers in vivo. Biochem Biophys Res Commun. 2003;300:679-85 pubmed
    ..The epsilon isoform formed heterodimers with 14-3-3 beta, gamma, zeta, and eta, but no homodimers were detected. The two 14-3-3 homologues, BMH1 and BMH2 from Saccharomyces cerevisiae, were mainly heterodimers. ..
  9. Chrestensen C, Schroeder M, Shabanowitz J, Hunt D, Pelo J, Worthington M, et al. MAPKAP kinase 2 phosphorylates tristetraprolin on in vivo sites including Ser178, a site required for 14-3-3 binding. J Biol Chem. 2004;279:10176-84 pubmed
    ..Thus, Ser(52) and Ser(178) are putative MK2 sites in vivo. Identified phosphosite(s) may be biologic switches controlling mRNA stability and translation. ..
  10. Nagata Ohashi K, Ohta Y, Goto K, Chiba S, Mori R, Nishita M, et al. A pathway of neuregulin-induced activation of cofilin-phosphatase Slingshot and cofilin in lamellipodia. J Cell Biol. 2004;165:465-71 pubmed
  11. Cai S, Tee A, Short J, Bergeron J, Kim J, Shen J, et al. Activity of TSC2 is inhibited by AKT-mediated phosphorylation and membrane partitioning. J Cell Biol. 2006;173:279-89 pubmed
    ..Thus, tuberin bound by 14-3-3 in response to AKT phosphorylation is sequestered away from its membrane-bound activation partner (hamartin) and its target GTPase (Rheb) to relieve the growth inhibitory effects of this tumor suppressor. ..
  12. Yang X, Lee W, Sobott F, Papagrigoriou E, Robinson C, Grossmann J, et al. Structural basis for protein-protein interactions in the 14-3-3 protein family. Proc Natl Acad Sci U S A. 2006;103:17237-42 pubmed
    ..These results show that the 14-3-3 proteins are adaptable structures in which internal flexibility is likely to facilitate recognition and binding of their interaction partners. ..
  13. Henshall D, Araki T, Schindler C, Shinoda S, Lan J, Simon R. Expression of death-associated protein kinase and recruitment to the tumor necrosis factor signaling pathway following brief seizures. J Neurochem. 2003;86:1260-70 pubmed
    ..In contrast, within surviving fields of the hippocampus, DAP kinase interacted with the molecular chaperone 14-3-3. These data suggest DAP kinase is involved in the molecular pathways activated during seizure-induced neuronal death. ..
  14. Ward Y, Spinelli B, Quon M, Chen H, Ikeda S, Kelly K. Phosphorylation of critical serine residues in Gem separates cytoskeletal reorganization from down-regulation of calcium channel activity. Mol Cell Biol. 2004;24:651-61 pubmed
    ..These data demonstrate that phosphorylation of serines 261 and 289, outside the GTP-binding region of Gem, controls its inhibition of Rho kinase beta and associated changes in the cytoskeleton. ..
  15. Liang X, da Paula A, Bozoky Z, Zhang H, Bertrand C, Peters K, et al. Phosphorylation-dependent 14-3-3 protein interactions regulate CFTR biogenesis. Mol Biol Cell. 2012;23:996-1009 pubmed publisher
    ..Thus 14-3-3 binding to phosphorylated CFTR augments its biogenesis by reducing retrograde retrieval of CFTR to the endoplasmic reticulum. This mechanism permits cAMP/PKA stimulation to make more CFTR available for anion secretion. ..
  16. You Y, Yao H, You B, Li X, Ni H, Shi S, et al. Clinical significance of HAX-1 expression in laryngeal carcinoma. Auris Nasus Larynx. 2015;42:299-304 pubmed publisher
    b>HS1-associated protein X-1 (HAX-1) is a multifunctional protein that has been highlighted as an important marker in many types of cancers. However, little is known about the role of HAX-1 in laryngeal carcinoma...
  17. Wu J, Li M, Cao L, Sun M, Chen D, Ren H, et al. Protease Omi cleaving Hax-1 protein contributes to OGD/R-induced mitochondrial damage in neuroblastoma N2a cells and cerebral injury in MCAO mice. Acta Pharmacol Sin. 2015;36:1043-52 pubmed publisher
    In the penumbra after focal cerebral ischemia, an increase of protease Omi is linked to a decrease of Hs1-associated protein X-1 (Hax-1), a protein belonging to the Bcl-2 family...
  18. Hassan H, Dawah S, El Sheekh M. Monitoring the degradation capability of novel haloalkaliphilic tributyltin chloride (TBTCl) resistant bacteria from butyltin-polluted site. Rev Argent Microbiol. 2019;51:39-46 pubmed publisher
    ..After analysis of the 16S rRNA gene sequences the isolates were identified as Sphingobium sp. HS1, Stenotrophomonas chelatiphaga HS2 and Rhizobium borbori HS5...
  19. Vincenz C, Dixit V. 14-3-3 proteins associate with A20 in an isoform-specific manner and function both as chaperone and adapter molecules. J Biol Chem. 1996;271:20029-34 pubmed
    ..Furthermore, c-Raf and A20 co-immunoprecipitated in a 14-3-3-dependent manner, suggesting that 14-3-3 can function as a bridging or adapter molecule. ..
  20. Robertson H, Langdon W, Thien C, Bowtell D. A c-Cbl yeast two hybrid screen reveals interactions with 14-3-3 isoforms and cytoskeletal components. Biochem Biophys Res Commun. 1997;240:46-50 pubmed
    ..We have used the yeast two hybrid assay to localise regions of c-Cbl required for its interaction with each of the proteins. Interaction with 14-3-3 is demonstrated in mammalian cell extracts. ..
  21. Gringhuis S, García Vallejo J, Van het Hof B, van Dijk W. Convergent actions of I kappa B kinase beta and protein kinase C delta modulate mRNA stability through phosphorylation of 14-3-3 beta complexed with tristetraprolin. Mol Cell Biol. 2005;25:6454-63 pubmed
    ..Thus, a key mechanism regulating mRNA binding and function of the destabilizing AUBP TTP involves the phosphorylation status of 14-3-3beta. ..
  22. Yoshimura Y, Terabayashi T, Miki H. Par1b/MARK2 phosphorylates kinesin-like motor protein GAKIN/KIF13B to regulate axon formation. Mol Cell Biol. 2010;30:2206-19 pubmed publisher
    ..These results reveal that GAKIN/KIF13B is a key intermediate linking Par1b to the regulation of axon formation. ..
  23. Huang Y, Biswas C, Klos Dehring D, Sriram U, Williamson E, Li S, et al. The actin regulatory protein HS1 is required for antigen uptake and presentation by dendritic cells. J Immunol. 2011;187:5952-63 pubmed publisher
    The hematopoietic actin regulatory protein hematopoietic lineage cell-specific protein 1 (HS1) is required for cell spreading and signaling in lymphocytes, but the scope of HS1 function in Ag presentation has not been addressed...
  24. Matitau A, Scheid M. Phosphorylation of MEKK3 at threonine 294 promotes 14-3-3 association to inhibit nuclear factor kappaB activation. J Biol Chem. 2008;283:13261-8 pubmed publisher
    ..Thus, this study identifies a potentially important regulatory step in MEKK3 signaling via dephosphorylation of Thr(294), which reduces 14-3-3 binding correlating with MEKK3 pathway activation. ..
  25. Clapp C, Portt L, Khoury C, Sheibani S, Norman G, Ebner P, et al. 14-3-3 protects against stress-induced apoptosis. Cell Death Dis. 2012;3:e348 pubmed publisher
    ..Finally, we demonstrate functional conservation of these phenotypes using the yeast homolog of 14-3-3: Bmh1. In sum, cell death in response to multiple stresses can be counteracted by 14-3-3 proteins. ..
  26. Jasinski Bergner S, Stehle F, Gonschorek E, Kalich J, Schulz K, Huettelmaier S, et al. Identification of 14-3-3β gene as a novel miR-152 target using a proteome-based approach. J Biol Chem. 2014;289:31121-35 pubmed publisher
    ..Because miR-152 controls both the expression of 14-3-3β and HLA-G, it exerts a dual role in tumor cells by both altering the immunogenicity and the tumorigenicity. ..
  27. Asner S, Giulieri S, Diezi M, Marchetti O, Sanglard D. Acquired Multidrug Antifungal Resistance in Candida lusitaniae during Therapy. Antimicrob Agents Chemother. 2015;59:7715-22 pubmed publisher
    ..A few missense mutations in the C. lusitaniae FKS1 hot spot 1 (HS1) have been reported. We report here the rapid emergence of antifungal resistance in C...
  28. Lallitto F, Prigitano A, Mangione F, Piralla A, Tamarozzi F, Marone P, et al. Presence of L701 M mutation in the FKS1 gene of echinocandin-susceptible Candida krusei isolates. Diagn Microbiol Infect Dis. 2018;92:311-314 pubmed publisher
    ..been associated with mutations in hot spot (HS) regions of the FKS1 gene or L701 M mutation in a region between HS1 and HS3 of FKS1...
  29. Fantl W, Muslin A, Kikuchi A, Martin J, MacNicol A, Gross R, et al. Activation of Raf-1 by 14-3-3 proteins. Nature. 1994;371:612-4 pubmed
    ..These proteins, 14-3-3 zeta (PLA2) and 14-3-3 beta (HS1), are members of the 14-3-3 family of proteins...
  30. Clokie S, Cheung K, Mackie S, Marquez R, Peden A, Aitken A. BCR kinase phosphorylates 14-3-3 Tau on residue 233. FEBS J. 2005;272:3767-76 pubmed
    ..We have previously shown that these two isoforms are also phosphorylated at this site by casein kinase 1, which, in contrast to BCR, preferentially phosphorylates 14-3-3zeta. ..
  31. Nord H, Segersten U, Sandgren J, Wester K, Busch C, Menzel U, et al. Focal amplifications are associated with high grade and recurrences in stage Ta bladder carcinoma. Int J Cancer. 2010;126:1390-402 pubmed publisher
    ..The observed overrepresentation of amplicons within high-grade and recurrent cases may be clinically useful for the identification of patients who will benefit from a more aggressive therapy. ..
  32. Wang W, Huang J, Wang X, Yuan J, Li X, Feng L, et al. PTPN14 is required for the density-dependent control of YAP1. Genes Dev. 2012;26:1959-71 pubmed publisher
    ..Collectively, these data suggest that PTPN14 acts to suppress cell proliferation by promoting cell density-dependent cytoplasmic translocation of YAP1. ..
  33. Zhao Y, Nagasaki Y, Kordalewska M, Press E, Shields R, Nguyen M, et al. Rapid Detection of FKS-Associated Echinocandin Resistance in Candida glabrata. Antimicrob Agents Chemother. 2016;60:6573-6577 pubmed publisher
    ..to identify within 3 h the most common and clinically relevant resistance-associated mutations, including 8 FKS1 HS1 (wild type [WT], S629P, F625S, D632Y, D632E [T1896G], D632E [T1896A], I634V, and F625F) and 7 FKS2 HS1 (WT, F659del,..
  34. Cianci R, Lolli S, Pagliari D, Gambassi G, Frosali S, Marmo R, et al. The involvement of IgH enhancer HS1.2 in the pathogenesis of Crohn's disease: how the immune system can influence a multifactorial disease. Eur Rev Med Pharmacol Sci. 2016;20:3618-27 pubmed
    ..We conducted a selective PCR, which amplified the hs1.2-A region. The nested second PCR to amplify the polymorphic core of the enhancer was performed...
  35. Choi M, Widhopf G, Ghia E, Kidwell R, Hasan M, Yu J, et al. Phase I Trial: Cirmtuzumab Inhibits ROR1 Signaling and Stemness Signatures in Patients with Chronic Lymphocytic Leukemia. Cell Stem Cell. 2018;22:951-959.e3 pubmed publisher
    ..Inhibition of ROR1 signaling was observed, including decreased activation of RhoA and HS1. Transcriptome analyses showed that therapy inhibited CLL stemness gene expression signatures in vivo...
  36. Heikema A, Islam Z, Horst Kreft D, Huizinga R, Jacobs B, Wagenaar J, et al. Campylobacter jejuni capsular genotypes are related to Guillain-Barré syndrome. Clin Microbiol Infect. 2015;21:852.e1-9 pubmed publisher
    ..Capsular genotyping of C. jejuni strains from the Netherlands revealed that three capsular genotypes, HS1/44c, HS2 and HS4c, were dominant in GBS-associated strains and capsular types HS1/44c and HS4c were significantly ..
  37. Sarfraz R, Ahmad M, Mahmood A, Akram M, Abrar A. Development of ?-cyclodextrin-based hydrogel microparticles for solubility enhancement of rosuvastatin: an in vitro and in vivo evaluation. Drug Des Devel Ther. 2017;11:3083-3096 pubmed publisher
    ..Formulations (HS1-HS9) have shown entrapment efficiency between 83.50%±0.30% and 88.50%±0...
  38. Faul C, Dhume A, Schecter A, Mundel P. Protein kinase A, Ca2+/calmodulin-dependent kinase II, and calcineurin regulate the intracellular trafficking of myopodin between the Z-disc and the nucleus of cardiac myocytes. Mol Cell Biol. 2007;27:8215-27 pubmed
    ..The identification of myopodin as a direct target of PKA, CaMKII, and calcineurin defines a novel intracellular signaling pathway whereby changes in Z-disc dynamics may translate into compartmentalized signal transduction in the heart. ..
  39. Scielzo C, ten Hacken E, Bertilaccio M, Muzio M, Calissano C, Ghia P, et al. How the microenvironment shapes chronic lymphocytic leukemia: the cytoskeleton connection. Leuk Lymphoma. 2010;51:1371-4 pubmed publisher
    ..We hypothesize that hematopoietic cell-specific Lyn substrate 1 (HS1), a putative prognostic marker in CLL that interacts with distinct cytoskeleton adapters in leukemic B-lymphocytes, ..
  40. Wang Z, Nesland J, Suo Z, Trope C, Holm R. The prognostic value of 14-3-3 isoforms in vulvar squamous cell carcinoma cases: 14-3-3? and ? are independent prognostic factors for these tumors. PLoS ONE. 2011;6:e24843 pubmed publisher
    ..In our current study, we examined the expression of 14-3-3?, ?, ?, ?, ? and ? in a large series of vulvar squamous cell carcinomas to evaluate any clinical significance...
  41. Prigent G, Ait Ammar N, Levesque E, Fekkar A, Costa J, El Anbassi S, et al. Echinocandin Resistance in Candida Species Isolates from Liver Transplant Recipients. Antimicrob Agents Chemother. 2017;61: pubmed publisher
    ..Candida dubliniensis, and one by resistant Candida albicans Molecular analysis found three mutations in FKS2 HS1 (F659S, S663A, and D666E) for C. glabrata and one mutation in FKS1 HS1 (S645P) for C. dubliniensis and C...
  42. Lv C, Wang H, Tong Y, Yin H, Wang D, Yan Z, et al. The function of BTG3 in colorectal cancer cells and its possible signaling pathway. J Cancer Res Clin Oncol. 2018;144:295-308 pubmed publisher
    ..BTG3 expression might contribute to CRC carcinogenesis. BTG3 knockdown might strengthen the aggressive colorectal cancer behavior. ..
  43. Magalhães D, Zanoni F, Correia C, Simas R, Soares R, Sannomiya P, et al. Hypertonic Saline Modulates Heart Function and Myocardial Inflammatory Alterations in Brain-Dead Rats. J Surg Res. 2019;235:8-15 pubmed publisher
    ..9%, 4 mL/kg; n = 6), and treated animals were divided to receive HS (NaCl, 7.5% 4 mL/kg) at 1 min (HS1, n = 6) or 60 min (HS60, n = 6) thereafter...
  44. Kleiderlein J, Nisson P, Jessee J, Li W, Becker K, Derby M, et al. CCG repeats in cDNAs from human brain. Hum Genet. 1998;103:666-73 pubmed
    ..This list of cDNAs should expedite the search for expansion mutations associated with diseases of the central nervous system. ..
  45. Graves P, Yu L, Schwarz J, Gales J, Sausville E, O Connor P, et al. The Chk1 protein kinase and the Cdc25C regulatory pathways are targets of the anticancer agent UCN-01. J Biol Chem. 2000;275:5600-5 pubmed
    ..Taken together our results identify the Chk1 kinase and the Cdc25C pathway as potential targets of G(2) checkpoint abrogation by UCN-01. ..
  46. Yuryev A, Ono M, Goff S, Macaluso F, Wennogle L. Isoform-specific localization of A-RAF in mitochondria. Mol Cell Biol. 2000;20:4870-8 pubmed
    ..This information is discussed in view of the important role of mitochondria in cellular functions involving energy balance, proliferation, and apoptosis and the potential role of A-RAF in regulating these systems. ..
  47. Merla G, Howald C, Antonarakis S, Reymond A. The subcellular localization of the ChoRE-binding protein, encoded by the Williams-Beuren syndrome critical region gene 14, is regulated by 14-3-3. Hum Mol Genet. 2004;13:1505-14 pubmed
    ..This translocation is contingent upon the ability to bind 14-3-3. Through this mechanism the 14-3-3 isotypes directly affect the WBSCR14:Mlx complexes, which activate the transcription of lipogenic genes. ..
  48. Reinhardt H, Aslanian A, Lees J, Yaffe M. p53-deficient cells rely on ATM- and ATR-mediated checkpoint signaling through the p38MAPK/MK2 pathway for survival after DNA damage. Cancer Cell. 2007;11:175-89 pubmed
    ..We show that the Chk1 inhibitor UCN-01 also potently inhibits MK2, suggesting that its clinical efficacy results from the simultaneous disruption of two critical checkpoint pathways in p53-defective cells. ..
  49. Nagar R, Sinha S, Raman R. Genotype-phenotype correlation and report of novel mutations in β-globin gene in thalassemia patients. Blood Cells Mol Dis. 2015;55:10-4 pubmed publisher
    ..Analysis of the regulatory regions (LCR) exhibited new combinations (CA(15)TA(5) and CA(13)TA(8)) in HS1 region and one (AT)(10)T(3) in (AT)(x)T(y )silencer region...
  50. Bendell A, Williamson E, Chen C, Burkhardt J, Hammer D. The Arp2/3 complex binding protein HS1 is required for efficient dendritic cell random migration and force generation. Integr Biol (Camb). 2017;9:695-708 pubmed publisher
    ..the contribution of the Arp2/3 complex binding protein, haematopoietic lineage cell-specific protein 1 (HS1), to DC migration and force generation...
  51. Jansson D, Ng A, Fu A, Depatie C, Al Azzabi M, Screaton R. Glucose controls CREB activity in islet cells via regulated phosphorylation of TORC2. Proc Natl Acad Sci U S A. 2008;105:10161-6 pubmed publisher
  52. Millier A, Horvath M, Ma F, Kóczián K, Götze A, Toumi M. Healthcare resource use in schizophrenia, EuroSC findings. J Mark Access Health Policy. 2017;5:1372027 pubmed publisher
    ..outcome measure: We classified patients into eight health states, according to the Lenert classification (HS1-HS8), and estimated 6-month healthcare resource use (outpatient and day clinic visits, and hospitalisations) across ..
  53. Furlanetto R, Dey B, Lopaczynski W, Nissley S. 14-3-3 proteins interact with the insulin-like growth factor receptor but not the insulin receptor. Biochem J. 1997;327 ( Pt 3):765-71 pubmed
    ..Our findings suggest that 14-3-3 proteins may play a role in IGFIR signal transduction and may contribute to the differences in IGF and IR signalling capabilities. ..
  54. Okamoto K, Kashima K, Pereg Y, Ishida M, Yamazaki S, Nota A, et al. DNA damage-induced phosphorylation of MdmX at serine 367 activates p53 by targeting MdmX for Mdm2-dependent degradation. Mol Cell Biol. 2005;25:9608-20 pubmed
    ..We propose that Mdmx phosphorylation at S367 plays an important role in p53 activation after DNA damage by triggering Mdm2-dependent degradation of Mdmx. ..
  55. Daitoku H, Sakamaki J, Fukamizu A. Regulation of FoxO transcription factors by acetylation and protein-protein interactions. Biochim Biophys Acta. 2011;1813:1954-60 pubmed publisher
    ..This article is part of a Special Issue entitled: PI3K-AKT-FoxO axis in cancer and aging. ..
  56. Salisbury R, Sulentic C. The AhR and NF-κB/Rel Proteins Mediate the Inhibitory Effect of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin on the 3' Immunoglobulin Heavy Chain Regulatory Region. Toxicol Sci. 2015;148:443-59 pubmed publisher
    ..elements including the 3'Igh regulatory region (3'IghRR), which is composed of at least 4 enhancers (hs3A, hs1.2, hs3B, and hs4). The hs1...
  57. Saintamand A, Vincent Fabert C, Garot A, Rouaud P, Oruc Z, Magnone V, et al. Deciphering the importance of the palindromic architecture of the immunoglobulin heavy-chain 3' regulatory region. Nat Commun. 2016;7:10730 pubmed publisher
    ..The mouse 3'RR contains four enhancer elements with hs1,2 flanked by inverted repeated sequences and the centre of a 25-kb palindrome bounded by two hs3 enhancer inverted ..
  58. Selby K, Michel M, Gildengorin G, Karliner L, Pramanik R, Fontil V, et al. Disparities in Hypertension Control Across and Within Three Health Systems Participating in a Data-Sharing Collaborative. J Am Board Fam Med. 2018;31:897-904 pubmed publisher
    We aimed to standardize data collection from 3 health systems (HS1, HS2, HS3) participating in the San Francisco Bay Collaborative Research Network, and compare rates and predictors of uncontrolled blood pressure among hypertensive ..
  59. Zhu B, Zhai J, Zhu H, Kyprianou N. Prohibitin regulates TGF-beta induced apoptosis as a downstream effector of Smad-dependent and -independent signaling. Prostate. 2010;70:17-26 pubmed publisher
    ..These findings suggest a dual role for PHB as a downstream determinant of the cellular response to TGF-beta via Smad-dependent pathway (apoptosis) and MAPK intracellular signaling (survival). ..
  60. Fukasawa M, Ge Q, Wynn R, Ishii S, Uyeda K. Coordinate regulation/localization of the carbohydrate responsive binding protein (ChREBP) by two nuclear export signal sites: discovery of a new leucine-rich nuclear export signal site. Biochem Biophys Res Commun. 2010;391:1166-9 pubmed publisher
  61. Moghaieb R, Abdelhadi A, El Sadawy H, Allam N, Baiome B, Soliman M. Molecular identification and genetic diversity among Photorhabdus and Xenorhabdus isolates. 3 Biotech. 2017;7:6 pubmed publisher
    ..S II). Strains were identified as Photorhabdus luminescens HRM1, P. luminescens HS1, P. luminescens HP88, Xenorhabdus indica and X. nematophila ATTC19061 using 16S rDNA sequence analysis...
  62. Bordallo Cardona M, Escribano P, Marcos Zambrano L, Díaz García J, de la Pedrosa E, Canton R, et al. Low and constant micafungin concentrations may be sufficient to lead to resistance mutations in FKS2 gene of Candida glabrata. Med Mycol. 2017;: pubmed publisher
    ..05). Mutations in the HS1 region of the FKS2 gene were found in all isolates...
  63. Scherer A, Anand N, Koleske A. Cortactin stabilization of actin requires actin-binding repeats and linker, is disrupted by specific substitutions, and is independent of nucleotide state. J Biol Chem. 2018;293:13022-13032 pubmed publisher
    ..Cortactin bound actin with higher affinity than did its paralog, hematopoietic cell-specific Lyn substrate 1 (HS1), and the effects on actin stability were specific to cortactin...
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    ..Thus, our experiments characterized PBF as a new cellular factor mediating the effects of PI3K/Akt signaling and 14-3-3 on cell growth. ..
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    ..and DNA melting curve analysis following asymmetric PCR, a duplex ERG11 assay and a simplex FKS1 HS1 assay were developed to identify the most prominent resistance-associated mutations (Y132F and K143R in ERG11..
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    ..These findings suggest that 14-3-3 proteins interact with the IGFIR in vivo and that this interaction may play a role in a transformation pathway signaled by the IGFIR. ..
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    ..We hypothesize that Hippo signaling is required for normal pronephros development in zebrafish and that Scribble is a candidate link between Fat and the Hippo signaling cascade in vertebrates. ..
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  84. Zheng Q, Yin G, Yan C, Cavet M, Berk B. 14-3-3beta binds to big mitogen-activated protein kinase 1 (BMK1/ERK5) and regulates BMK1 function. J Biol Chem. 2004;279:8787-91 pubmed
    ..These data demonstrate an inhibitory function for 14-3-3beta binding to BMK1 and show that serine 486 phosphorylation represents a novel regulatory mechanism for BMK1. ..
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    ..Therefore, while it is known that AKAP-Lbc activity can be stimulated by Galpha12, in this study we demonstrated that it is inhibited by the anchoring of both PKA and 14-3-3. ..
  86. Ohman T, Lietzén N, Välimäki E, Melchjorsen J, Matikainen S, Nyman T. Cytosolic RNA recognition pathway activates 14-3-3 protein mediated signaling and caspase-dependent disruption of cytokeratin network in human keratinocytes. J Proteome Res. 2010;9:1549-64 pubmed publisher
    ..In addition, we show that viral infection activates 14-3-3 protein mediated signaling pathways in human keratinocytes which suggest an important role of 14-3-3 proteins in antiviral innate immune response. ..
  87. Nichols R, Dzamko N, Morrice N, Campbell D, Deak M, Ordureau A, et al. 14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization. Biochem J. 2010;430:393-404 pubmed publisher
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