Research Topics
| HPAG1_0089SummaryGene Symbol: HPAG1_0089 Description: RNA polymerase sigma factor RpoD Species: Top Publications
Research Grants
| Scientific Experts
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Detail Information
Publications
The major sigma factor (RpoD) from Helicobacter pylori and other gram-negative bacteria shows an enhanced rate of divergenceJ V Solnick
Department of Internal Medicine, School of Medicine, University of California, Davis 95616, USA
J Bacteriol 179:6196-200. 1997..This suggests that RpoD from gram-negative bacteria is functionally less constrained than that from gram-positive bacteria...- Functional analysis of the Helicobacter pylori principal sigma subunit of RNA polymerase reveals that the spacer region is important for efficient transcriptionD Beier
Department of Molecular Biology, Chiron SpA, IRIS Research Institute, Siena, Italy
Mol Microbiol 30:121-34. 1998..pylori may have evolved a spacer region of the sigma factor to modulate total transcription and to quickly respond to microenvironmental changes... - Activation of Helicobacter pylori ureA promoter by a hybrid Escherichia coli-H. pylori rpoD gene in E. coliM Shirai
Department of Microbiology, Yamaguchi University School of Medicine, Ube, Japan
Gene 239:351-9. 1999..coli and H. pylori indicated the existence of a -10 consensus sequence but little conservation of -35 sequences. Instead, the PureA in both H. pylori and E. coli contained an identical heptamer, GTTAATA, in the extended -35 region...
Research Grants
- Serum biomarkers for early detection of H. pylori-associated gastric cancerJAY SOLNICK; Fiscal Year: 2009..We propose to identify serum biomarkers of gastric cancer and its precursor lesions that would permit early detection and intervention before the disease has progressed to an advanced stage where it is rarely curable. ..
- Serum biomarkers for early detection of H. pylori-associated gastric cancerJay V Solnick; Fiscal Year: 2010..We propose to identify serum biomarkers of gastric cancer and its precursor lesions that would permit early detection and intervention before the disease has progressed to an advanced stage where it is rarely curable. ..
- Transmission of H. pylori infection in the rhesus monkeyJAY SOLNICK; Fiscal Year: 2005..pylori; 3) Determine the effects of H. pylori infection on the acquisition of Campylobacter jejuni; and 4) Determine the effects of the CagA pathogenicity island on colonization and shedding. ..
- DETERMINANTS OF H PYLORI INFECTION IN THE RHESUS MONKEYJAY SOLNICK; Fiscal Year: 2001..The results will be compared in juvenile and adult animals. These studies will further understanding of the host-pathogen relationship in acute and chronic H. pylori infection. ..
- Prophylactic and Therapeutic Immunization against H. pylori in Rhesus MacaquesJAY SOLNICK; Fiscal Year: 2007..These experiments could lead to development of a vaccine to prevent and treat Helicobacter pylori infection, which would likely reduce the frequency of peptic ulcer disease and gastric cancer. ..
- Gene expression during H. pylori-host interactionsJAY SOLNICK; Fiscal Year: 2007..These studies will provide a functional genomic understanding of the H. pylori host-pathogen relationship that may have implications for novel treatment or vaccine strategies. ..
- Transcription of H. pylori Genes in the Rhesus MonkeyJAY SOLNICK; Fiscal Year: 2002..An understanding of the dynamic interaction between host and pathogen may point the way toward critical proteins that may be useful as targets for therapy or vaccine development. ..
- Role of H. pylori Outer Membrane Proteins in Colonization and Host ResponseJay V Solnick; Fiscal Year: 2010..This project seeks to understand some of the factors that determine the expression of these surface proteins in H. pylori. ..
- Role of H. pylori Outer Membrane Proteins in Colonization and Host ResponseJAY SOLNICK; Fiscal Year: 2009..This project seeks to understand some of the factors that determine the expression of these surface proteins in H. pylori. ..
- Modulation of Outer Membrane Protein Expressin in Helicobacter pyloriJay V Solnick; Fiscal Year: 2010..This project seeks to understand some of the factors that determine the expression of these surface proteins in H. pylori. ..
- Gene expression during H. pylori-host interactionsJAY SOLNICK; Fiscal Year: 2006..These studies will provide a functional genomic understanding of the H. pylori host-pathogen relationship that may have implications for novel treatment or vaccine strategies. ..
- Gene expression during H. pylori-host interactionsJAY SOLNICK; Fiscal Year: 2003..These studies will provide a functional genomic understanding of the H. pylori host-pathogen relationship that may have implications for novel treatment or vaccine strategies. ..
- Prophylactic and Therapeutic Immunization against H. pylori in Rhesus MacaquesJAY SOLNICK; Fiscal Year: 2007..If the encouraging results from mouse studies can be replicated in non-human primates, they would serve as the basis for PhaseI/II clinical trials in humans. ..
- Animal Models of Infection Diseases Training ProgramJAY SOLNICK; Fiscal Year: 2007..Our goal is to become a pre-eminent training center in the use of animal models and the new genomic biology to better understand human infectious diseases. ..
- Modulation of Outer Membrane Protein Expressin in Helicobacter pyloriJAY SOLNICK; Fiscal Year: 2009..This project seeks to understand some of the factors that determine the expression of these surface proteins in H. pylori. ..
- Modulation of Outer Membrane Protein Expressin in Helicobacter pyloriJAY SOLNICK; Fiscal Year: 2009..This project seeks to understand some of the factors that determine the expression of these surface proteins in H. pylori. ..