hmuO

Summary

Gene Symbol: hmuO
Description: heme oxygenase
Species:

Top Publications

  1. ncbi Utilization of host iron sources by Corynebacterium diphtheriae: identification of a gene whose product is homologous to eukaryotic heme oxygenases and is required for acquisition of iron from heme and hemoglobin
    M P Schmitt
    Laboratory of Bacterial Toxins, Division of Bacterial Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA
    J Bacteriol 179:838-45. 1997
  2. ncbi Heme degradation as catalyzed by a recombinant bacterial heme oxygenase (Hmu O) from Corynebacterium diphtheriae
    G C Chu
    Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 4970, USA
    J Biol Chem 274:21319-25. 1999
  3. ncbi The crystal structures of the ferric and ferrous forms of the heme complex of HmuO, a heme oxygenase of Corynebacterium diphtheriae
    Shoko Hirotsu
    Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, Katahira, Aoba, Sendai 980 8577, Japan
    J Biol Chem 279:11937-47. 2004
  4. ncbi Crystal structure of the dioxygen-bound heme oxygenase from Corynebacterium diphtheriae: implications for heme oxygenase function
    Masaki Unno
    Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, Katahira, Aoba, Sendai 980 8577, Japan
    J Biol Chem 279:21055-61. 2004
  5. ncbi Roles of distal Asp in heme oxygenase from Corynebacterium diphtheriae, HmuO: A water-driven oxygen activation mechanism
    Toshitaka Matsui
    Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, Katahira, Aoba, Sendai 980 8577, Japan
    J Biol Chem 280:2981-9. 2005
  6. ncbi Design of metal cofactors activated by a protein-protein electron transfer system
    Takafumi Ueno
    Research Center for Materials Science, Graduate School of Science, Nagoya University, Furo cho, Chikusa ku, Nagoya 464 8602, Japan
    Proc Natl Acad Sci U S A 103:9416-21. 2006
  7. ncbi NMR assignments of cd-HO, a 24 kDa heme oxygenase from Corynebacterium diphtheria
    KELLIE HOM
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, 20 Penn Street, Baltimore, MD 21201, USA
    Biomol NMR Assign 1:55-6. 2007
  8. ncbi Solution 1H NMR characterization of substrate-free C. diphtheriae heme oxygenase: pertinence for determining magnetic axes in paramagnetic substrate complexes
    Zhenming Du
    Department of Chemistry, University of California, Davis, CA 95616, USA
    J Inorg Biochem 104:1063-70. 2010

Scientific Experts

  • Masaki Unno
  • M P Schmitt
  • Zhenming Du
  • Toshitaka Matsui
  • Masao Ikeda-Saito
  • KELLIE HOM
  • Takafumi Ueno
  • Shoko Hirotsu
  • G C Chu
  • Lena M Furci
  • Angela Wilks
  • Rahul Deshmukh
  • Yuichi Tokita
  • Hiroshi Nakajima
  • Masako Yamada
  • Norihiko Yokoi
  • Yoshihito Watanabe
  • Momoko Furukawa
  • Takeshi Tomita
  • Yoshitsugu Shiro
  • Grace C Chu
  • Sam Yong Park
  • Dong Sun Lee
  • Sam-Yong Park
  • Tadashi Yoshida
  • Dong-Sun Lee
  • M Ikeda-Saito
  • X Zhang
  • K Katakura
  • T Yoshida

Detail Information

Publications8

  1. ncbi Utilization of host iron sources by Corynebacterium diphtheriae: identification of a gene whose product is homologous to eukaryotic heme oxygenases and is required for acquisition of iron from heme and hemoglobin
    M P Schmitt
    Laboratory of Bacterial Toxins, Division of Bacterial Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA
    J Bacteriol 179:838-45. 1997
    ..ulcerans mutants and three of the C. diphtheriae mutants. The nucleotide sequence of the gene (hmuO) required for complementation was determined and shown to encode a protein with a predicted mass of 24,123 Da...
  2. ncbi Heme degradation as catalyzed by a recombinant bacterial heme oxygenase (Hmu O) from Corynebacterium diphtheriae
    G C Chu
    Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 4970, USA
    J Biol Chem 274:21319-25. 1999
    ..However, the considerably slow catalytic rate and low level of verdoheme recovery in the hydrogen peroxide reaction suggest that the active-site structure of Hmu O is different from that of its mammalian counterpart...
  3. ncbi The crystal structures of the ferric and ferrous forms of the heme complex of HmuO, a heme oxygenase of Corynebacterium diphtheriae
    Shoko Hirotsu
    Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, Katahira, Aoba, Sendai 980 8577, Japan
    J Biol Chem 279:11937-47. 2004
    Crystal structures of the ferric and ferrous heme complexes of HmuO, a 24-kDa heme oxygenase of Corynebacterium diphtheriae, have been refined to 1.4 and 1.5 A resolution, respectively...
  4. ncbi Crystal structure of the dioxygen-bound heme oxygenase from Corynebacterium diphtheriae: implications for heme oxygenase function
    Masaki Unno
    Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, Katahira, Aoba, Sendai 980 8577, Japan
    J Biol Chem 279:21055-61. 2004
    b>HmuO, a heme oxygenase of Corynebacterium diphtheriae, catalyzes degradation of heme using the same mechanism as the mammalian enzyme...
  5. ncbi Roles of distal Asp in heme oxygenase from Corynebacterium diphtheriae, HmuO: A water-driven oxygen activation mechanism
    Toshitaka Matsui
    Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, Katahira, Aoba, Sendai 980 8577, Japan
    J Biol Chem 280:2981-9. 2005
    ..Roles of distal Asp (Asp-136) residue in HmuO, a heme oxygenase of Corynebacterium diphtheriae, have been investigated by site-directed mutagenesis, enzyme ..
  6. ncbi Design of metal cofactors activated by a protein-protein electron transfer system
    Takafumi Ueno
    Research Center for Materials Science, Graduate School of Science, Nagoya University, Furo cho, Chikusa ku, Nagoya 464 8602, Japan
    Proc Natl Acad Sci U S A 103:9416-21. 2006
    ..Our Fe(Schiff-base).HO composite model system may provide insights with regard to design of ET biosystems for sensors, catalysts, and electronics devices...
  7. ncbi NMR assignments of cd-HO, a 24 kDa heme oxygenase from Corynebacterium diphtheria
    KELLIE HOM
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, 20 Penn Street, Baltimore, MD 21201, USA
    Biomol NMR Assign 1:55-6. 2007
    ....
  8. ncbi Solution 1H NMR characterization of substrate-free C. diphtheriae heme oxygenase: pertinence for determining magnetic axes in paramagnetic substrate complexes
    Zhenming Du
    Department of Chemistry, University of California, Davis, CA 95616, USA
    J Inorg Biochem 104:1063-70. 2010
    ..structure upon substrate loss for the heme oxygenase from the pathogenic bacterium Corynebacterium diphtheriae, HmuO. The chemical shifts for the conserved portion of the structure are assessed as references for the dipolar shifts ..