X

Summary

Gene Symbol: X
Description: X protein; HBx; X; HBx; peptide X; pX
Alias: X protein, HBx, HBx, peptide X
Species: Hepatitis B virus
Products:     X

Top Publications

  1. Li B, Gao B, Ye L, Han X, Wang W, Kong L, et al. Hepatitis B virus X protein (HBx) activates ATF6 and IRE1-XBP1 pathways of unfolded protein response. Virus Res. 2007;124:44-9 pubmed
    ..In this study, the role of the multifunctional regulatory protein of HBV (HBx protein) in activation of UPR was investigated...
  2. Kim H, Kim S, Kim J, Lee H, Choi M, Kim J, et al. Hepatitis B virus X protein induces apoptosis by enhancing translocation of Bax to mitochondria. IUBMB Life. 2008;60:473-80 pubmed publisher
    Hepatitis B virus X protein (HBx) is essential for viral replication and plays an important role in viral pathogenesis...
  3. Belloni L, Pollicino T, De Nicola F, Guerrieri F, Raffa G, Fanciulli M, et al. Nuclear HBx binds the HBV minichromosome and modifies the epigenetic regulation of cccDNA function. Proc Natl Acad Sci U S A. 2009;106:19975-9 pubmed publisher
    ..We also found that the HBx regulatory protein produced in HBV replicating cells is recruited onto the cccDNA minichromosome, and the kinetics ..
  4. Chung T, Lee Y, Kim C. Hepatitis B viral HBx induces matrix metalloproteinase-9 gene expression through activation of ERK and PI-3K/AKT pathways: involvement of invasive potential. FASEB J. 2004;18:1123-5 pubmed
    Hepatitis B virus (HBV) X protein (HBx) has been shown to be essential for the development of hepatocellular carcinoma (HCC)...
  5. Rakotomalala L, Studach L, Wang W, Gregori G, Hullinger R, Andrisani O. Hepatitis B virus X protein increases the Cdt1-to-geminin ratio inducing DNA re-replication and polyploidy. J Biol Chem. 2008;283:28729-40 pubmed publisher
    Hepatitis B virus X protein (pX) is implicated in hepatocellular carcinoma pathogenesis by an unknown mechanism...
  6. Lee J, Kwun H, Jung J, Choi K, Min D, Jang K. Hepatitis B virus X protein represses E-cadherin expression via activation of DNA methyltransferase 1. Oncogene. 2005;24:6617-25 pubmed
    ..Here, we report that HBV X protein (HBx) represses E-cadherin expression at the transcription level...
  7. Wei C, Ni C, Song T, Liu Y, Yang X, Zheng Z, et al. The hepatitis B virus X protein disrupts innate immunity by downregulating mitochondrial antiviral signaling protein. J Immunol. 2010;185:1158-68 pubmed publisher
    ..Specifically, hepatitis B virus X (HBX) interacted with MAVS and promoted the degradation of MAVS through Lys(136) ubiquitin in MAVS protein, thus ..
  8. Iyer S, Groopman J. Interaction of mutant hepatitis B X protein with p53 tumor suppressor protein affects both transcription and cell survival. Mol Carcinog. 2011;50:972-80 pubmed publisher
    This study examines the differential activities between wild-type Hepatitis B virus X protein (WtHBx) and a mutant HBx (MutHBx), which bears a hotspot mutation at nucleotides 1,762 and 1,764, resulting in a lysine to methionine change at ..
  9. Liu X, Zhang S, Lin J, Zhang S, Feitelson M, Gao H, et al. Hepatitis B virus X protein mutants exhibit distinct biological activities in hepatoma Huh7 cells. Biochem Biophys Res Commun. 2008;373:643-7 pubmed publisher
    The role of the hepatitis B virus X protein (HBx) in hepatocarcinogenesis remains controversial...

More Information

Publications66

  1. Keasler V, Hodgson A, Madden C, Slagle B. Hepatitis B virus HBx protein localized to the nucleus restores HBx-deficient virus replication in HepG2 cells and in vivo in hydrodynamically-injected mice. Virology. 2009;390:122-9 pubmed publisher
    Identifying the requirements for the regulatory HBx protein in hepatitis B virus (HBV) replication is an important goal...
  2. Wang Q, Zhang W, Ye L, Zhang X. A mutant of HBx (HBxDelta127) promotes hepatoma cell growth via sterol regulatory element binding protein 1c involving 5-lipoxygenase. Acta Pharmacol Sin. 2010;31:367-74 pubmed publisher
    Previously, we identified a natural mutant of hepatitis B virus X gene (HBx) with a deletion from 382 to 401 base pairs (termed HBxDelta127), which could potently enhance growth of hepatoma cells...
  3. Kuzhandaivelu N, Cong Y, Inouye C, Yang W, Seto E. XAP2, a novel hepatitis B virus X-associated protein that inhibits X transactivation. Nucleic Acids Res. 1996;24:4741-50 pubmed
    The hepatitis B virus X protein is a promiscuous transcriptional transactivator. Transactivation by the X protein is most likely mediated through binding to different cellular factors...
  4. Liu X, Wang L, Zhang S, Lin J, Zhang S, Feitelson M, et al. Mutations in the C-terminus of the X protein of hepatitis B virus regulate Wnt-5a expression in hepatoma Huh7 cells: cDNA microarray and proteomic analyses. Carcinogenesis. 2008;29:1207-14 pubmed publisher
    The hepatitis B virus x gene (HBx) is a promiscuous transactivator implicated in the development of hepatocellular carcinoma (HCC). The present study was designed to investigate the molecular events regulated by HBx...
  5. Yen C, Lin Y, Yen C, Tsai H, Tsai T, Chang K, et al. Hepatitis B virus X protein upregulates mTOR signaling through IKKβ to increase cell proliferation and VEGF production in hepatocellular carcinoma. PLoS ONE. 2012;7:e41931 pubmed publisher
    ..HBV X protein (HBx), encoded by a viral non-structural gene, is a multifunctional regulator in HBV-associated tumor ..
  6. You X, Liu F, Zhang T, Li Y, Ye L, Zhang X. Hepatitis B virus X protein upregulates oncogene Rab18 to result in the dysregulation of lipogenesis and proliferation of hepatoma cells. Carcinogenesis. 2013;34:1644-52 pubmed publisher
    Hepatitis B virus X protein (HBx) contributes to the development of hepatocellular carcinoma (HCC) through inducing dysregulation of lipogenesis. However, the mechanism by which HBx induces the abnormal lipogenesis is not well known...
  7. Yu F, Liu H, Lee J, Liao M, Shih W. Hepatitis B virus X protein promotes cell migration by inducing matrix metalloproteinase-3. J Hepatol. 2005;42:520-7 pubmed
    Hepatitis B virus (HBV), a major causative agent of hepatocellular carcinoma (HCC), encodes an oncogenic X protein (HBx) that transcriptionally activates multiple viral and cellular promoters...
  8. Melegari M, Scaglioni P, Wands J. Cloning and characterization of a novel hepatitis B virus x binding protein that inhibits viral replication. J Virol. 1998;72:1737-43 pubmed
    ..Expression of the protein product (HBx) appears necessary for establishment of natural infection...
  9. Luo N, Cai Y, Zhang J, Tang W, Slagle B, Wu X, et al. The C-terminal region of the hepatitis B virus X protein is required for its stimulation of HBV replication in primary mouse hepatocytes. Virus Res. 2012;165:170-8 pubmed publisher
    ..The hepatitis B virus X protein (HBx), a multifunctional regulatory protein encoded by HBV, is known to be involved in stimulation of viral ..
  10. Ren M, Qin D, Li K, Qu J, Wang L, Wang Z, et al. Correlation between hepatitis B virus protein and microRNA processor Drosha in cells expressing HBV. Antiviral Res. 2012;94:225-31 pubmed publisher
    ..This was associated with a reduction in the activity of the Drosha gene promoter. Gene silencing of HBx by RNA interference significantly restored the expression of Drosha...
  11. Lim K, Kim K, Choi S, Park E, Park S, Ryu K, et al. RPS3a over-expressed in HBV-associated hepatocellular carcinoma enhances the HBx-induced NF-?B signaling via its novel chaperoning function. PLoS ONE. 2011;6:e22258 pubmed publisher
    ..Hepatitis B virus X protein (HBx) is known to play a key role in the development of hepatocellular carcinoma (HCC)...
  12. Qadri I, Fatima K, Abdel Hafiz H. Hepatitis B virus X protein impedes the DNA repair via its association with transcription factor, TFIIH. BMC Microbiol. 2011;11:48 pubmed publisher
    ..HBV X protein (HBx) is a multifunctional protein that can modulate various cellular processes and plays a crucial role in the ..
  13. Kim W, Hong F, Jaruga B, Zhang Z, Fan S, Liang T, et al. Hepatitis B virus X protein sensitizes primary mouse hepatocytes to ethanol- and TNF-alpha-induced apoptosis by a caspase-3-dependent mechanism. Cell Mol Immunol. 2005;2:40-8 pubmed
    ..In this paper, we demonstrated that primary hepatocytes from transgenic mice overexpressing hepatitis B virus X protein (HBX) were more susceptible to ethanol- and TNF-alpha-induced apoptotic killing...
  14. Han Q, Zhang C, Zhang J, Tian Z. Involvement of activation of PKR in HBx-siRNA-mediated innate immune effects on HBV inhibition. PLoS ONE. 2011;6:e27931 pubmed publisher
    ..Recent studies have revealed that siRNAs can induce an innate immune response in vitro and in vivo. Here, HBVx (HBx) mRNA expression and HBV replication were significantly inhibited, followed by the enhancement of expression of ..
  15. Shan C, Xu F, Zhang S, You J, You X, Qiu L, et al. Hepatitis B virus X protein promotes liver cell proliferation via a positive cascade loop involving arachidonic acid metabolism and p-ERK1/2. Cell Res. 2010;20:563-75 pubmed publisher
    Hepatitis B virus X protein (HBx) plays a crucial role in the development of hepatocellular carcinoma. Here, we sought to identify the mechanisms by which HBx mediates liver cell proliferation...
  16. Hong A, Han D, Wright C, Burch T, Piper J, Osiowy C, et al. The interaction between hepatitis B virus X protein and AIB1 oncogene is required for the activation of NF?B signal transduction. Biochem Biophys Res Commun. 2012;423:6-12 pubmed publisher
    We identified the interaction between HBV X (HBx) protein and the oncogene AIB1 (amplified in breast cancer 1). A serine/proline motif (SSPSPS) in HBx was found to be required for the interaction...
  17. Wang Y, Jiang L, Ji X, Yang B, Zhang Y, Fu X. Hepatitis B viral RNA directly mediates down-regulation of the tumor suppressor microRNA miR-15a/miR-16-1 in hepatocytes. J Biol Chem. 2013;288:18484-93 pubmed publisher
    ..but in contrast to various indirect mechanisms mediated by viral proteins, we unexpectedly found that the HBx transcript directly triggers the down-regulation of miR-15a/miR-16-1 via the microRNA targeting sequences in the ..
  18. CLIPPINGER A, Gearhart T, Bouchard M. Hepatitis B virus X protein modulates apoptosis in primary rat hepatocytes by regulating both NF-kappaB and the mitochondrial permeability transition pore. J Virol. 2009;83:4718-31 pubmed publisher
    The hepatitis B virus (HBV) X protein (HBx) is a multifunctional protein that regulates numerous cellular signal transduction pathways, including those that modulate apoptosis...
  19. CLIPPINGER A, Bouchard M. Hepatitis B virus HBx protein localizes to mitochondria in primary rat hepatocytes and modulates mitochondrial membrane potential. J Virol. 2008;82:6798-811 pubmed publisher
    ..HBV encodes seven viral proteins, including the nonstructural X (HBx) protein...
  20. Lee T, Elledge S, Butel J. Hepatitis B virus X protein interacts with a probable cellular DNA repair protein. J Virol. 1995;69:1107-14 pubmed
    The mechanism of action of hepatitis B virus (HBV) X protein in transcriptional transactivation and in tumorigenesis remains obscure...
  21. Murata M, Matsuzaki K, Yoshida K, Sekimoto G, Tahashi Y, Mori S, et al. Hepatitis B virus X protein shifts human hepatic transforming growth factor (TGF)-beta signaling from tumor suppression to oncogenesis in early chronic hepatitis B. Hepatology. 2009;49:1203-17 pubmed publisher
    Hepatitis B virus X (HBx) protein is suspected to participate in oncogenesis during chronic hepatitis B progression. Transforming growth factor beta (TGF-beta) signaling involves both tumor suppression and oncogenesis...
  22. Hodgson A, Hyser J, Keasler V, Cang Y, Slagle B. Hepatitis B virus regulatory HBx protein binding to DDB1 is required but is not sufficient for maximal HBV replication. Virology. 2012;426:73-82 pubmed publisher
    Robust hepatitis B virus (HBV) replication is stimulated by the regulatory HBx protein. HBx binds the cellular protein DDB1; however, the importance of this interaction for HBV replication remains unknown...
  23. Studach L, Rakotomalala L, Wang W, Hullinger R, Cairo S, Buendia M, et al. Polo-like kinase 1 inhibition suppresses hepatitis B virus X protein-induced transformation in an in vitro model of liver cancer progression. Hepatology. 2009;50:414-23 pubmed publisher
    Chronic hepatitis B virus (HBV) infection is linked to development of hepatocellular carcinoma (HCC). The HBV X protein (pX) is implicated in HCC pathogenesis acting as a weak oncogene or a cofactor in hepatocarcinogenesis...
  24. Wei Y, Neuveut C, Tiollais P, Buendia M. Molecular biology of the hepatitis B virus and role of the X gene. Pathol Biol (Paris). 2010;58:267-72 pubmed publisher
    ..However, the transcriptional regulatory protein HBx encoded by the X gene is endowed with weak oncogenic activity...
  25. Na T, Shin Y, Roh K, Kang S, Hong I, Oh S, et al. Liver X receptor mediates hepatitis B virus X protein-induced lipogenesis in hepatitis B virus-associated hepatocellular carcinoma. Hepatology. 2009;49:1122-31 pubmed publisher
    Although hepatitis B virus X protein (HBx) has been implicated in abnormal lipid metabolism in hepatitis B virus (HBV)-associated hepatic steatosis, its underlying molecular mechanism remains unclear...
  26. Sze K, Chu G, Lee J, Ng I. C-terminal truncated hepatitis B virus x protein is associated with metastasis and enhances invasiveness by C-Jun/matrix metalloproteinase protein 10 activation in hepatocellular carcinoma. Hepatology. 2013;57:131-9 pubmed publisher
    ..carcinoma (HCC) and this leads to truncation of the HBV DNA, particularly at the C-terminal end of the HBV X protein (HBx)...
  27. Cheng A, Yu J, Lai P, Chan H, Sung J. COX-2 mediates hepatitis B virus X protein abrogation of p53-induced apoptosis. Biochem Biophys Res Commun. 2008;374:175-80 pubmed publisher
    The oncogenic hepatitis B virus X protein (HBx) and cyclooxygenase (COX)-2 are highly co-expressed in chronic hepatitis, cirrhosis and well-differentiated hepatocellular carcinoma (HCC)...
  28. Chen G, Li M, Ho R, Chak E, Lau W, Lai P. Identification of hepatitis B virus X gene mutation in Hong Kong patients with hepatocellular carcinoma. J Clin Virol. 2005;34:7-12 pubmed
    ..The viral transactivator HBV X (HBx) gene plays a critical role in the molecular pathogenesis of HBV-related HCC...
  29. Ng S, Lee C. Hepatitis B virus X gene and hepatocarcinogenesis. J Gastroenterol. 2011;46:974-90 pubmed publisher
    ..Evidence suggests that the HBV X protein (HBx) plays a crucial role in HCC development...
  30. Wang Q, Zhang W, Liu Q, Zhang X, Lv N, Ye L, et al. A mutant of hepatitis B virus X protein (HBxDelta127) promotes cell growth through a positive feedback loop involving 5-lipoxygenase and fatty acid synthase. Neoplasia. 2010;12:103-15 pubmed
    Hepatocellular carcinoma (HCC) is one of the most common malignant tumors worldwide. Hepatitis B virus X protein (HBx) contributes to the development of HCC, whereas HBx with COOH-terminal deletion is a frequent event in the HCC tissues...
  31. Zhou Y, Wang S, Ma J, Lei Z, Zhu H, Lei P, et al. Hepatitis B virus protein X-induced expression of the CXC chemokine IP-10 is mediated through activation of NF-kappaB and increases migration of leukocytes. J Biol Chem. 2010;285:12159-68 pubmed publisher
    ..In the present study, we demonstrate that hepatitis B virus protein X (HBx) increases IP-10 expression in a dose-dependent manner...
  32. Xu J, Yun X, Jiang J, Wei Y, Wu Y, Zhang W, et al. Hepatitis B virus X protein blunts senescence-like growth arrest of human hepatocellular carcinoma by reducing Notch1 cleavage. Hepatology. 2010;52:142-54 pubmed publisher
    ..Among all the proteins encoded by the HBV genome, hepatitis B virus X protein (HBx) is highly associated with the development of HCC...
  33. Jiao B, Lin W, She F, Chen W, Lin X. Hepatitis B virus X protein enhances activation of nuclear factor ?B through interaction with valosin-containing protein. Arch Virol. 2011;156:2015-21 pubmed publisher
    Hepatitis B virus X protein (HBx protein) is a multifunctional regulatory protein. The transactivation of nuclear factor kappa B (NF-?B) by HBx protein has been shown to be of importance in the pathogenesis of HBV-related diseases...
  34. Wang J, Yun C, Kim S, Chae S, Lee Y, Kim W, et al. Reactivation of p53 in cells expressing hepatitis B virus X-protein involves p53 phosphorylation and a reduction of Hdm2. Cancer Sci. 2008;99:888-93 pubmed publisher
    Multifunctional activities of the hepatitis B virus X-protein (HBx) in cells have been largely implicated in the development of liver cancer; one of these activities is the loss of p53 function by sequestering p53 in the cytoplasm...
  35. Zhang X, Dong N, Yin L, Cai N, Ma H, You J, et al. Hepatitis B virus X protein upregulates survivin expression in hepatoma tissues. J Med Virol. 2005;77:374-81 pubmed
    The hepatitis B virus X protein (HBx) plays an important role in the development of hepatocellular carcinoma (HCC). The relationship was examined between HBV antigens and IAP (inhibitor of apoptosis) family in development of HCC...
  36. Wang C, Yang W, Yan H, Luo T, Zhang J, Tang L, et al. Hepatitis B virus X (HBx) induces tumorigenicity of hepatic progenitor cells in 3,5-diethoxycarbonyl-1,4-dihydrocollidine-treated HBx transgenic mice. Hepatology. 2012;55:108-20 pubmed publisher
    Hepatitis B virus X (HBx) protein is implicated in hepatitis B virus (HBV)-associated liver carcinogenesis. However, it remains unclear whether HBx-expressing hepatic progenitor cells (HPCs) are attributed to liver tumor formation...
  37. Benhenda S, Cougot D, Buendia M, Neuveut C. Hepatitis B virus X protein molecular functions and its role in virus life cycle and pathogenesis. Adv Cancer Res. 2009;103:75-109 pubmed publisher
    ..This chapter focuses on the regulatory protein HBx which is thought to play a central role in HBV regulation and pathogenesis...
  38. Xie H, Song J, Liu K, Ji H, Shen H, Hu S, et al. The expression of hypoxia-inducible factor-1alpha in hepatitis B virus-related hepatocellular carcinoma: correlation with patients' prognosis and hepatitis B virus X protein. Dig Dis Sci. 2008;53:3225-33 pubmed publisher
    ..HIF-1alpha expression was also found to be significantly correlated with the expression of hepatitis B virus X protein (HBx), and over-expressed HBx upregulated HIF-1alpha protein expression in vitro...
  39. Choi C, Cho E, Park R, Kim S, Cho J, Kim H. X gene mutations in hepatitis B patients with cirrhosis, with and without hepatocellular carcinoma. J Med Virol. 2009;81:1721-5 pubmed publisher
    ..The goal of this study was to determine whether mutations in the HBV X gene are associated with the development of HCC in hepatitis B patients with cirrhosis...
  40. Wang W, Hullinger R, Andrisani O. Hepatitis B virus X protein via the p38MAPK pathway induces E2F1 release and ATR kinase activation mediating p53 apoptosis. J Biol Chem. 2008;283:25455-67 pubmed publisher
    Hepatitis B virus (HBV) X protein (pX) is implicated in hepatocellular carcinoma (HCC) pathogenesis by an unknown mechanism...
  41. Kim K, Kim K, Cheong J. Hepatitis B virus X protein impairs hepatic insulin signaling through degradation of IRS1 and induction of SOCS3. PLoS ONE. 2010;5:e8649 pubmed publisher
    ..The expressions of insulin signaling components were investigated in HBx-transgenic mice, HBx-constitutive expressing cells, and transiently HBx-transfected cells...
  42. Xu X, Fan Z, Kang L, Han J, Jiang C, Zheng X, et al. Hepatitis B virus X protein represses miRNA-148a to enhance tumorigenesis. J Clin Invest. 2013;123:630-45 pubmed publisher
    ..Here, we report that miR-148a is repressed by hepatitis B virus (HBV) X protein (HBx) to promote cancer growth and metastasis in a mouse model of hepatocellular carcinoma (HCC)...
  43. Asim M, Malik A, Sarma M, Polipalli S, Begum N, Ahmad I, et al. Hepatitis B virus BCP, Precore/core, X gene mutations/genotypes and the risk of hepatocellular carcinoma in India. J Med Virol. 2010;82:1115-25 pubmed publisher
    The study aims to characterize mutations of the HBV genome involving BCP, Precore/core and X regions and also defines HBV genotypes in patients of hepatocellular carcinoma (HCC)...
  44. Gao J, Chen C, Hong L, Wang J, Du Y, Song J, et al. Expression of Jagged1 and its association with hepatitis B virus X protein in hepatocellular carcinoma. Biochem Biophys Res Commun. 2007;356:341-7 pubmed
    ..in hepatocellular carcinoma (HCC) has not been elucidated, nor whether it is associated with hepatitis B virus X protein (HBx). In this study, we found that Jagged1 was highly expressed in 79...
  45. Lizzano R, Yang B, CLIPPINGER A, Bouchard M. The C-terminal region of the hepatitis B virus X protein is essential for its stability and function. Virus Res. 2011;155:231-9 pubmed publisher
    ..of a continuous inflammatory response to HBV-infected hepatocytes and activities of HBV proteins such as the HBV X protein (HBx)...
  46. Bouchard M, Wang L, Schneider R. Activation of focal adhesion kinase by hepatitis B virus HBx protein: multiple functions in viral replication. J Virol. 2006;80:4406-14 pubmed
    The hepatitis B virus (HBV) X protein (HBx) is a multifunctional regulator of cellular signal transduction and transcription pathways and has a critical role in HBV replication...
  47. Lee S, Mun H, Kim H, Lee H, Kim B, Hwang E, et al. Naturally occurring hepatitis B virus X deletions and insertions among Korean chronic patients. J Med Virol. 2011;83:65-70 pubmed publisher
    ..5%, 2/135) (P = 0.017). All deletions in six strains were concentrated at the C terminal end of HBx, encompassing the 113th to 154th codons...
  48. Cha M, Ryu D, Jung H, Chang H, Ryu W. Stimulation of hepatitis B virus genome replication by HBx is linked to both nuclear and cytoplasmic HBx expression. J Gen Virol. 2009;90:978-86 pubmed publisher
    b>HBx, a small regulatory protein of hepatitis B virus, plays an important role in stimulating viral genome replication. HBx was shown to be associated with diverse subcellular locations, such as the nucleus, cytoplasm and mitochondria...
  49. Tang H, Oishi N, Kaneko S, Murakami S. Molecular functions and biological roles of hepatitis B virus x protein. Cancer Sci. 2006;97:977-83 pubmed
    ..Hepatitis B virus X protein (HBx) has been long suspected to be involved in hepatocarcinogenesis, although its oncogenic role remains ..
  50. Zhang F, Wang Q, Ye L, Feng Y, Zhang X. Hepatitis B virus X protein upregulates expression of calpain small subunit 1 via nuclear factor-kappaB/p65 in hepatoma cells. J Med Virol. 2010;82:920-8 pubmed publisher
    ..is closely correlated with the development of hepatocellular carcinoma (HCC), in which hepatitis B virus X protein (HBx) plays crucial roles. HBx is believed to be a multifunctional oncoprotein...
  51. Le T, Zhang S, Hayashi N, Yasukawa M, Delgermaa L, Murakami S. Mutational analysis of human RNA polymerase II subunit 5 (RPB5): the residues critical for interactions with TFIIF subunit RAP30 and hepatitis B virus X protein. J Biochem. 2005;138:215-24 pubmed
    ..Hepatitis B virus X protein (HBx) binds the central part of RPB5 to modulate activated transcription, and TFIIF subunit RAP30 interacts with ..
  52. Ou D, Tao Y, Tang F, Yang L. The hepatitis B virus X protein promotes hepatocellular carcinoma metastasis by upregulation of matrix metalloproteinases. Int J Cancer. 2007;120:1208-14 pubmed
    ..report, we present clinical data obtained from HCC patients indicating that the expression of hepatitis B virus X protein (HBx) in HCC is associated with an increased expression of membrane-type 1 matrix metalloproteinase (MT1-MMP), ..
  53. Kim K, Shin H, Kim K, Choi H, Rhee S, Moon H, et al. Hepatitis B virus X protein induces hepatic steatosis via transcriptional activation of SREBP1 and PPARgamma. Gastroenterology. 2007;132:1955-67 pubmed
    ..Here, we show the molecular mechanism by which hepatitis B virus X protein (HBx) induces hepatic steatosis...
  54. Hu L, Chen L, Li L, Sun H, Yang G, Chang Y, et al. Hepatitis B virus X protein enhances cisplatin-induced hepatotoxicity via a mechanism involving degradation of Mcl-1. J Virol. 2011;85:3214-28 pubmed publisher
    Hepatitis B virus X protein (HBx) is implicated in the pathogenesis of hepatitis B virus (HBV)-associated liver diseases...
  55. Leupin O, Bontron S, Schaeffer C, Strubin M. Hepatitis B virus X protein stimulates viral genome replication via a DDB1-dependent pathway distinct from that leading to cell death. J Virol. 2005;79:4238-45 pubmed
    The hepatitis B virus (HBV) X protein (HBx) is essential for virus infection and has been implicated in the development of liver cancer associated with chronic infection...
  56. Park S, Chung C, Kang H, Kim J, Jung G. Up-regulation of cyclin D1 by HBx is mediated by NF-kappaB2/BCL3 complex through kappaB site of cyclin D1 promoter. J Biol Chem. 2006;281:31770-7 pubmed
    ..It has also been known that the hepatitis Bx (HBx) protein is strongly associated with HCC development and progression...
  57. Wei X, Xiang T, Ren G, Tan C, Liu R, Xu X, et al. miR-101 is down-regulated by the hepatitis B virus x protein and induces aberrant DNA methylation by targeting DNA methyltransferase 3A. Cell Signal. 2013;25:439-46 pubmed publisher
    The hepatitis B virus x (HBx) protein has been implicated in HBV-related hepatocellular carcinoma (HCC) pathogenesis...