Gene Symbol: HP1228
Description: RNA pyrophosphohydrolase
Species: Helicobacter pylori 26695
Bj rkholm B, Lundin A, Sill n A, Guillemin K, Salama N, Rubio C, et al
. Comparison of genetic divergence and fitness between two subclones of Helicobacter pylori. Infect Immun. 2001;69:7832-8 pubmed publisher
..Together, these results reveal that the H. pylori population infecting one individual can undergo significant divergence, creating stable subclones with substantial genotypic and phenotypic differences...
Bj rkholm B, Guruge J, Oh J, Syder A, Salama N, Guillemin K, et al
. Colonization of germ-free transgenic mice with genotyped Helicobacter pylori strains from a case-control study of gastric cancer reveals a correlation between host responses and HsdS components of type I restriction-modification systems. J Biol Chem. 2002;277:34191-7 pubmed publisher
..This suggests that the functions of these HsdS homologs may include control of expression of microbial determinants that affect the extent of gastric responses to this potentially virulent pathogen...
Bischler T, Hsieh P, Resch M, Liu Q, Tan H, Foley P, et al
. Identification of the RNA Pyrophosphohydrolase RppH of Helicobacter pylori and Global Analysis of Its RNA Targets. J Biol Chem. 2017;292:1934-1950 pubmed publisher
..Here we present evidence that one of them, HP1228 (renamed HpRppH), is an RNA pyrophosphohydrolase that triggers RNA degradation in H...
Lundin A, Nilsson C, Gerhard M, Andersson D, Krabbe M, Engstrand L. The NudA protein in the gastric pathogen Helicobacter pylori is an ubiquitous and constitutively expressed dinucleoside polyphosphate hydrolase. J Biol Chem. 2003;278:12574-8 pubmed publisher
..Given that H. pylori is a diverse species and that all the H. pylori strains tested in this study harbor the nudA gene and show protein expression, we consider NudA to be an important enzyme in this bacterium...