Gene Symbol: HP0775
Description: penta-phosphate guanosine-3'-pyrophosphohydrolase
Species: Helicobacter pylori 26695

Top Publications

  1. Zhou Y, Coleman W, Yang Z, Yang Y, Hodgson N, Chen F, et al. Regulation of cell growth during serum starvation and bacterial survival in macrophages by the bifunctional enzyme SpoT in Helicobacter pylori. J Bacteriol. 2008;190:8025-32 pubmed publisher
    ..The unique role of (p)ppGpp in cell growth during serum starvation, in the stress response, and in the persistence of H. pylori is discussed. ..
  2. Sun Y, Li X, Li W, Zhao M, Wang L, Liu S, et al. Proteomic analysis of the function of spot in Helicobacter pylori anti-oxidative stress in vitro and colonization in vivo. J Cell Biochem. 2012;113:3393-402 pubmed publisher
    ..Conclusively, we speculate that spoT is a key regulator of the genes for H. pylori spreading in the air and colonization in host stomach. ..
  3. Geng X, Li W, Chen Z, Gao S, Hong W, Ge X, et al. The Bifunctional Enzyme SpoT Is Involved in the Clarithromycin Tolerance of Helicobacter pylori by Upregulating the Transporters HP0939, HP1017, HP0497, and HP0471. Antimicrob Agents Chemother. 2017;61: pubmed publisher
    ..Taken together, our results revealed a novel molecular mechanism of H. pylori adaption to CLA stress. ..