Research Topics

Genomes and Genes

Gene Symbol: VNG_RS09430

Description: cell division control protein Cdc6

Alias: VNG2411G

Species: Halobacterium sp. NRC-1

Berquist B, Dassarma S. An archaeal chromosomal autonomously replicating sequence element from an extreme halophile, Halobacterium sp. strain NRC-1. J Bacteriol. 2003;185:5959-66 pubmed

..We discuss the finding of a functional haloarchaeal origin in relation to the large number of orc1-cdc6 homologs identified in the genomes of all haloarchaea to date...
Berquist B, DasSarma P, Dassarma S. Essential and non-essential DNA replication genes in the model halophilic Archaeon, Halobacterium sp. NRC-1. BMC Genet. 2007;8:31 pubmed publisher

..The essential genes code for two of ten Orc/Cdc6 proteins, two out of three DNA polymerases, the MCM helicase, two DNA primase subunits, the DNA polymerase sliding clamp, and the flap endonuclease...
Coker J, DasSarma P, Capes M, Wallace T, McGarrity K, Gessler R, et al. Multiple replication origins of Halobacterium sp. strain NRC-1: properties of the conserved orc7-dependent oriC1. J Bacteriol. 2009;191:5253-61 pubmed publisher

..Our results suggest that replication in this model system is intriguing and more complex than previously thought. We discuss these results from the perspective of the replication strategy and evolution of haloarchaeal genomes...