Gene Symbol: HSM_RS07655
Description: cysteine protease
Species: Haemophilus somnus 2336
Tagawa Y, Sanders J, Uchida I, Bastida Corcuera F, Kawashima K, Corbeil L. Genetic and functional analysis of Haemophilus somnus high molecular weight-immunoglobulin binding proteins. Microb Pathog. 2005;39:159-70 pubmed
..This peptide and GST-IbpA5 (aa 2071-2730) reacted strongly with convalescent phase serum. In a small preliminary study, calves immunized with the purified GST-IbpA3 peptide were protected against an intrabronchial H. somnus challenge...
Worby C, Mattoo S, Kruger R, Corbeil L, Koller A, Mendez J, et al
. The fic domain: regulation of cell signaling by adenylylation. Mol Cell. 2009;34:93-103 pubmed publisher
..Thus, we classify Fic domain-containing proteins as a class of enzymes that mediate bacterial pathogenesis as well as a previously unrecognized eukaryotic posttranslational modification that may regulate key signaling events...
Cole S, Guiney D, Corbeil L. Molecular analysis of a gene encoding a serum-resistance-associated 76 kDa surface antigen of Haemophilus somnus. J Gen Microbiol. 1993;139:2135-43 pubmed publisher
..The 5' DR (DR1) included the start site for the 76 kDa protein, and DR2 had a flanking inverted repeat, suggestive of an insertion-sequence-like element...
Corbeil L, Bastida Corcuera F, Beveridge T. Haemophilus somnus immunoglobulin binding proteins and surface fibrils. Infect Immun. 1997;65:4250-7 pubmed
..Therefore, this study shows that H. somnus has two IgBPs, including a peripheral membrane protein and a fibrillar surface network...
Sanders J, Bastida Corcuera F, Arnold K, Wunderlich A, Corbeil L. Genetic manipulation of immunoglobulin binding proteins of Haemophilus somnus. Microb Pathog. 2003;34:131-9 pubmed
..It is probable that p76 and the missing peptides of the HMW IgBPs play a role in this aspect of virulence and perhaps other aspects. ..
Xiao J, Worby C, Mattoo S, Sankaran B, Dixon J. Structural basis of Fic-mediated adenylylation. Nat Struct Mol Biol. 2010;17:1004-10 pubmed publisher
..We also show that the nucleotide-binding mechanism is conserved among Fic proteins and propose a catalytic mechanism for this recently discovered family of enzymes...