ERVW-1

Summary

Gene Symbol: ERVW-1
Description: endogenous retrovirus group W member 1, envelope
Alias: syncytin-1, endogenous retrovirus group W member 1
Species: gorilla

Top Publications

  1. Mallet F, Bouton O, Prudhomme S, Cheynet V, Oriol G, Bonnaud B, et al. The endogenous retroviral locus ERVWE1 is a bona fide gene involved in hominoid placental physiology. Proc Natl Acad Sci U S A. 2004;101:1731-6 pubmed publisher
    ..This functional preservation among humans and during evolution strongly argued for the involvement of this recently acquired retroviral envelope glycoprotein in hominoid placental physiology...
  2. Bonnaud B, Bouton O, Oriol G, Cheynet V, Duret L, Mallet F. Evidence of selection on the domesticated ERVWE1 env retroviral element involved in placentation. Mol Biol Evol. 2004;21:1895-901 pubmed publisher
    ..The identification of selective constraints on env ERVWE1 confirms that this retroviral locus has been recruited in the hominoid lineage to become a bona fide gene...
  3. Cáceres M, Thomas J. The gene of retroviral origin Syncytin 1 is specific to hominoids and is inactive in Old World monkeys. J Hered. 2006;97:100-6 pubmed
    b>Syncytin 1 is one of the best known examples of recent acquisition of a new gene from an endogenous retrovirus (HERV) in the human genome and has been implicated in placental physiology...