GLE2

Summary

Gene Symbol: GLE2
Description: Gle2p
Alias: RAE1
Species:

Top Publications

  1. ncbi GLE2, a Saccharomyces cerevisiae homologue of the Schizosaccharomyces pombe export factor RAE1, is required for nuclear pore complex structure and function
    R Murphy
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Mol Biol Cell 7:1921-37. 1996
  2. ncbi The integral membrane protein Pom34p functionally links nucleoporin subcomplexes
    Mi Miao
    Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 8240, USA
    Genetics 172:1441-57. 2006
  3. ncbi The integral membrane protein snl1p is genetically linked to yeast nuclear pore complex function
    A K Ho
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Mol Biol Cell 9:355-73. 1998
  4. ncbi Nup116p and nup100p are interchangeable through a conserved motif which constitutes a docking site for the mRNA transport factor gle2p
    S M Bailer
    University of Heidelberg, Biochemie Zentrum Heidelberg BZH, Germany
    EMBO J 17:1107-19. 1998
  5. ncbi A novel fluorescence-based genetic strategy identifies mutants of Saccharomyces cerevisiae defective for nuclear pore complex assembly
    M Bucci
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Mol Biol Cell 9:2439-61. 1998
  6. ncbi Arx1 is a nuclear export receptor for the 60S ribosomal subunit in yeast
    Nai Jung Hung
    Section of Molecular Genetics and Microbiology and the Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, TX 78712, USA
    Mol Biol Cell 19:735-44. 2008
  7. ncbi Cytoplasmic inositol hexakisphosphate production is sufficient for mediating the Gle1-mRNA export pathway
    Aimee L Miller
    Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 8240, USA
    J Biol Chem 279:51022-32. 2004
  8. ncbi Gle2p is essential to induce adaptation of the export of bulk poly(A)+ mRNA to heat shock in Saccharomyces cerevisiae
    Shingo Izawa
    Laboratory of Molecular Microbiology, Graduate School of Agriculture, Kyoto University, Uji, Kyoto 611 0011, Japan
    J Biol Chem 279:35469-78. 2004
  9. ncbi The mRNA export machinery requires the novel Sac3p-Thp1p complex to dock at the nucleoplasmic entrance of the nuclear pores
    Tamas Fischer
    Biochemie Zentrum Heidelberg BZH, Im Neuenheimer Feld 328, Germany
    EMBO J 21:5843-52. 2002
  10. ncbi Nup116p associates with the Nup82p-Nsp1p-Nup159p nucleoporin complex
    S M Bailer
    Biochemie Zentrum Heidelberg, Im Neuenheimer Feld 328, D 69120 Heidelberg, Germany
    J Biol Chem 275:23540-8. 2000

Scientific Experts

  • Shingo Izawa
  • Ed Hurt
  • E Fabre
  • Susan R Wente
  • T Renee Dawson
  • Nai Jung Hung
  • S M Bailer
  • Mi Miao
  • S R Wente
  • Aimee L Miller
  • Tamas Fischer
  • Michelle D Lazarus
  • Martin W Hetzer
  • M Mann
  • Arlen W Johnson
  • Samir S Patel
  • A Podtelejnikov
  • Kara Helmke
  • Nai-Jung Hung
  • Kai Yin Lo
  • Kai-Yin Lo
  • Kathryn J Ryan
  • A K Ho
  • M Bucci
  • Scott D Emr
  • Mythili Suntharalingam
  • Sylvia L Johnson
  • M K Iovine
  • Anjon Audhya
  • Johannes Lechner
  • Katja Strasser
  • Marisa Oppizzi
  • Attila Rácz
  • Susana Rodriguez-Navarro
  • R Murphy
  • Petra Ihrig
  • C Rollenhagen
  • J Katahira
  • N Pante
  • C Balduf
  • E B Ives
  • S Siniossoglou
  • A Hellwig
  • G A Raczniak
  • J L Watkins

Detail Information

Publications13

  1. ncbi GLE2, a Saccharomyces cerevisiae homologue of the Schizosaccharomyces pombe export factor RAE1, is required for nuclear pore complex structure and function
    R Murphy
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Mol Biol Cell 7:1921-37. 1996
    ..In this report, the characterization of GLE2 is detailed. GLE2 encodes a 40.5-kDa polypeptide with striking similarity to that of Schizosaccharomyces pombe RAE1...
  2. ncbi The integral membrane protein Pom34p functionally links nucleoporin subcomplexes
    Mi Miao
    Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 8240, USA
    Genetics 172:1441-57. 2006
    ..We speculate that multiple integral membrane proteins, either within the nuclear pore domain or in the nuclear envelope, execute coordinated roles in NPC structure and function...
  3. ncbi The integral membrane protein snl1p is genetically linked to yeast nuclear pore complex function
    A K Ho
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Mol Biol Cell 9:355-73. 1998
    ..With regard to genetic specificity, the nup116-C lethality was also suppressed by high-copy GLE2 and NIC96. Moreover, high-copy SNL1 suppressed the temperature sensitivity of gle2-1 and nic96-G3 mutant cells...
  4. ncbi Nup116p and nup100p are interchangeable through a conserved motif which constitutes a docking site for the mRNA transport factor gle2p
    S M Bailer
    University of Heidelberg, Biochemie Zentrum Heidelberg BZH, Germany
    EMBO J 17:1107-19. 1998
    ..Thus, the in vivo function of Gle2p is strictly coupled to the short GLEBS within Nup116p which links this putative mRNA transport factor to the nuclear pores...
  5. ncbi A novel fluorescence-based genetic strategy identifies mutants of Saccharomyces cerevisiae defective for nuclear pore complex assembly
    M Bucci
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Mol Biol Cell 9:2439-61. 1998
    ..cells expressing GFP-Nup49p, three complementation groups were identified: two correspond to mutant nup120 and gle2 alleles that result in clusters of NPCs...
  6. ncbi Arx1 is a nuclear export receptor for the 60S ribosomal subunit in yeast
    Nai Jung Hung
    Section of Molecular Genetics and Microbiology and the Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, TX 78712, USA
    Mol Biol Cell 19:735-44. 2008
    ..These results show that Arx1 can directly bridge the interaction between the pre-60S particle and the NPC and thus is a third export receptor for the 60S subunit in yeast...
  7. ncbi Cytoplasmic inositol hexakisphosphate production is sufficient for mediating the Gle1-mRNA export pathway
    Aimee L Miller
    Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 8240, USA
    J Biol Chem 279:51022-32. 2004
    ..Enhanced lethality was observed with a specific subset of mutants, including nup42, nup116, nup159, dbp5, and gle2, all of which had been previously connected to Gle1 function...
  8. ncbi Gle2p is essential to induce adaptation of the export of bulk poly(A)+ mRNA to heat shock in Saccharomyces cerevisiae
    Shingo Izawa
    Laboratory of Molecular Microbiology, Graduate School of Agriculture, Kyoto University, Uji, Kyoto 611 0011, Japan
    J Biol Chem 279:35469-78. 2004
    ....
  9. ncbi The mRNA export machinery requires the novel Sac3p-Thp1p complex to dock at the nucleoplasmic entrance of the nuclear pores
    Tamas Fischer
    Biochemie Zentrum Heidelberg BZH, Im Neuenheimer Feld 328, Germany
    EMBO J 21:5843-52. 2002
    ..Significantly, mutations in Sac3p or Thp1p lead to strong mRNA export defects. Taken together, our data suggest that the novel Sac3p-Thp1p complex functions by docking the mRNP to specific nucleoporins at the nuclear entrance of the NPC...
  10. ncbi Nup116p associates with the Nup82p-Nsp1p-Nup159p nucleoporin complex
    S M Bailer
    Biochemie Zentrum Heidelberg, Im Neuenheimer Feld 328, D 69120 Heidelberg, Germany
    J Biol Chem 275:23540-8. 2000
    ....
  11. ncbi Yeast genetics to dissect the nuclear pore complex and nucleocytoplasmic trafficking
    E Fabre
    Institut Pasteur, Departement des Biotechnologies, Paris, France
    Annu Rev Genet 31:277-313. 1997
    ..We review here our current knowledge on the role of nucleoporins, and on the mechanism of nucleocytoplasmic transport, with emphasis on the yeast Saccharomyces cerevisiae...
  12. ncbi A nuclear export signal in Kap95p is required for both recycling the import factor and interaction with the nucleoporin GLFG repeat regions of Nup116p and Nup100p
    M K Iovine
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Cell Biol 137:797-811. 1997
    ..This finding highlights an important role for a subfamily of GLFG nucleoporins in nuclear export processes...
  13. ncbi ER membrane-bending proteins are necessary for de novo nuclear pore formation
    T Renee Dawson
    Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    J Cell Biol 184:659-75. 2009
    ..We hypothesize that these ER membrane-bending proteins mediate early NPC assembly steps...