GCY1

Summary

Gene Symbol: GCY1
Description: Gcy1p
Species:

Top Publications

  1. ncbi Functional genomic studies of aldo-keto reductases
    J M Petrash
    Departments of Ophthalmology and Visual Sciences and of Genetics, Washington University School of Medicine, 660 S Euclid Avenue, Campus Box 8096, MO 63110, St Louis, USA
    Chem Biol Interact 130:673-83. 2001
  2. ncbi Putative xylose and arabinose reductases in Saccharomyces cerevisiae
    K L Träff
    Department of Applied Microbiology, Lund University, PO Box 124, SE 221 00 Lund, Sweden
    Yeast 19:1233-41. 2002
  3. ncbi Intracellular glycerol influences resistance to freeze stress in Saccharomyces cerevisiae: analysis of a quadruple mutant in glycerol dehydrogenase genes and glycerol-enriched cells
    Shingo Izawa
    Laboratory of Molecular Microbiology, Graduate School of Agriculture, Kyoto University, Kyoto 611 0011, Japan
    Appl Microbiol Biotechnol 66:108-14. 2004
  4. ncbi Functional studies of aldo-keto reductases in Saccharomyces cerevisiae
    Qing Chang
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, 660 South Euclid Avenue Campus Box 8096, St Louis, MO 63110, USA
    Biochim Biophys Acta 1773:321-9. 2007
  5. ncbi Disruption of aldo-keto reductase genes leads to elevated markers of oxidative stress and inositol auxotrophy in Saccharomyces cerevisiae
    Qing Chang
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO 63110 3018, USA
    Biochim Biophys Acta 1783:237-45. 2008
  6. ncbi Reaction and strain engineering for improved stereo-selective whole-cell reduction of a bicyclic diketone
    Ted Johanson
    Department of Applied Microbiology, Lund University, P O Box 124, SE 22100, Lund, Sweden
    Appl Microbiol Biotechnol 77:1111-8. 2008
  7. ncbi Metabolic and regulatory changes associated with growth of Saccharomyces cerevisiae in 1.4 M NaCl. Evidence for osmotic induction of glycerol dissimilation via the dihydroxyacetone pathway
    J Norbeck
    Department of General and Marine Microbiology, Goteborg University, Medicinaregatan 9 C, 413 90 Goteborg, Sweden
    J Biol Chem 272:5544-54. 1997
  8. ncbi Crystallization and aldo-keto reductase activity of Gcy1p from Saccharomyces cerevisiae
    E Hur
    Section of Molecular and Cellular Biology, University of California, Davis 95616, USA
    Acta Crystallogr D Biol Crystallogr 56:763-5. 2000

Research Grants

  1. Aldose Reductade and Diabetic Eye Disease
    J Petrash; Fiscal Year: 2006

Scientific Experts

  • J M Petrash
  • J Norbeck
  • Qing Chang
  • Ted Johanson
  • Shingo Izawa
  • K L Träff
  • E Hur
  • Magnus Carlquist
  • Marie F Gorwa-Grauslund
  • Cecilia Olsson
  • Andreas Rudolf
  • Torbjorn Frejd
  • Theresa M Harter
  • Terry A Griest
  • Machiko Sato
  • Yoshiharu Inoue
  • Kumio Yokoigawa
  • B Hahn-Hägerdal
  • L J Jönsson
  • D K Wilson

Detail Information

Publications9

  1. ncbi Functional genomic studies of aldo-keto reductases
    J M Petrash
    Departments of Ophthalmology and Visual Sciences and of Genetics, Washington University School of Medicine, 660 S Euclid Avenue, Campus Box 8096, MO 63110, St Louis, USA
    Chem Biol Interact 130:673-83. 2001
    ..Ongoing studies are aimed at characterizing the phenotypes of yeast strains containing single and multiple knockouts of the AR-like genes...
  2. ncbi Putative xylose and arabinose reductases in Saccharomyces cerevisiae
    K L Träff
    Department of Applied Microbiology, Lund University, PO Box 124, SE 221 00 Lund, Sweden
    Yeast 19:1233-41. 2002
    ..cerevisiae. Both the D-xylose reductase and the L-arabinose reductase activities exclusively used NADPH as co-factor...
  3. ncbi Intracellular glycerol influences resistance to freeze stress in Saccharomyces cerevisiae: analysis of a quadruple mutant in glycerol dehydrogenase genes and glycerol-enriched cells
    Shingo Izawa
    Laboratory of Molecular Microbiology, Graduate School of Agriculture, Kyoto University, Kyoto 611 0011, Japan
    Appl Microbiol Biotechnol 66:108-14. 2004
    ..Through analysis of a quadruple-knockout mutant of glycerol dehydrogenase genes (ara1 Delta gcy1 Delta gre3 Delta ypr1 Delta) in Saccharomyces cerevisiae, we revealed that the decrease in glycerol dehydrogenase ..
  4. ncbi Functional studies of aldo-keto reductases in Saccharomyces cerevisiae
    Qing Chang
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, 660 South Euclid Avenue Campus Box 8096, St Louis, MO 63110, USA
    Biochim Biophys Acta 1773:321-9. 2007
    ..These results suggest that multiple aldo-keto reductases fulfill functionally redundant roles in the stress response in yeast...
  5. ncbi Disruption of aldo-keto reductase genes leads to elevated markers of oxidative stress and inositol auxotrophy in Saccharomyces cerevisiae
    Qing Chang
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO 63110 3018, USA
    Biochim Biophys Acta 1783:237-45. 2008
    ..Taken together, these results suggest potential roles for AKRs in oxidative defense and transcriptional regulation...
  6. ncbi Reaction and strain engineering for improved stereo-selective whole-cell reduction of a bicyclic diketone
    Ted Johanson
    Department of Applied Microbiology, Lund University, P O Box 124, SE 22100, Lund, Sweden
    Appl Microbiol Biotechnol 77:1111-8. 2008
    ....
  7. ncbi Metabolic and regulatory changes associated with growth of Saccharomyces cerevisiae in 1.4 M NaCl. Evidence for osmotic induction of glycerol dissimilation via the dihydroxyacetone pathway
    J Norbeck
    Department of General and Marine Microbiology, Goteborg University, Medicinaregatan 9 C, 413 90 Goteborg, Sweden
    J Biol Chem 272:5544-54. 1997
    ..encoding the two enzymes involved; dihydroxyacetone kinase (DAK1 and DAK2) and glycerol dehydrogenase (YPR1 and GCY1). The GPD1, GPP2, GCY1, DAK1, and ENO1 genes all displayed a halometric increase in the amount of transcript...
  8. ncbi Crystallization and aldo-keto reductase activity of Gcy1p from Saccharomyces cerevisiae
    E Hur
    Section of Molecular and Cellular Biology, University of California, Davis 95616, USA
    Acta Crystallogr D Biol Crystallogr 56:763-5. 2000
    ..Additionally, a kinetic study performed by measuring the rate of oxidation of NADPH in the presence of several substrates indicates that both wild-type and double-mutant proteins are enzymes possessing NADPH-dependent reductase activity...

Research Grants1

  1. Aldose Reductade and Diabetic Eye Disease
    J Petrash; Fiscal Year: 2006
    ..Similar comparisons will be made for lens transparency to determine the influence of individual AKR genes on diabetic cataract. ..