Gene Symbol: FUS1
- Lrg1p Is a Rho1 GTPase-activating protein required for efficient cell fusion in yeastPamela G Fitch
The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
Genetics 168:733-46. 2004..Higher dosage of three genes, BEM1, LRG1, and FUS1, partially suppressed the fus2Delta cell fusion defect...
- Two genes required for cell fusion during yeast conjugation: evidence for a pheromone-induced surface proteinJ Trueheart
Mol Cell Biol 7:2316-28. 1987We characterized two genes, FUS1 and FUS2, which are required for fusion of Saccharomyces cerevisiae cells during conjugation...
- Fus1p interacts with components of the Hog1p mitogen-activated protein kinase and Cdc42p morphogenesis signaling pathways to control cell fusion during yeast matingBryce Nelson
Department of Biology, Queen s University, Kingston, Ontario K7L 3N6, Canada
Genetics 166:67-77. 2004..We identified Sho1p, an osmosensor for the HOG MAPK pathway, as a binding partner for Fus1 in a two-hybrid screen...
- Regulation of polarized growth initiation and termination cycles by the polarisome and Cdc42 regulatorsScott Bidlingmaier
Department of Molecular, Cellular, and Developmental Biology, Yale University, P O Box 208103, New Haven, CT 06520 8103, USA
J Cell Biol 164:207-18. 2004..We found that polarisome components and the cell fusion proteins Fus1 and Fus2 are important for the termination of projection growth...
- Rvs161p interacts with Fus2p to promote cell fusion in Saccharomyces cerevisiaeV Brizzio
Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544 1014, USA
J Cell Biol 141:567-84. 1998....
- Distinct morphological phenotypes of cell fusion mutantsA E Gammie
Princeton University, Princeton, New Jersey 08544 1014, USA
Mol Biol Cell 9:1395-410. 1998..of cell fusion, we phenotypically and genetically characterized four cell fusion mutants, fus6/spa2, fus7/rvs161, fus1, and fus2. First, we examined the complete array of single and double mutants...
- The yeast cell fusion protein FUS1 is O-glycosylated and spans the plasma membraneJ Trueheart
Department of Biology, Massachusetts Institute of Technology, Cambridge 02139
Proc Natl Acad Sci U S A 86:9916-20. 1989..cell fusion during conjugation in Saccharomyces cerevisiae requires a pheromone-induced surface protein encoded by FUS1. We show that the FUS1 protein migrates on SDS/polyacrylamide gels with an apparent molecular mass of 80 kDa, ..
- CHS5, a gene involved in chitin synthesis and mating in Saccharomyces cerevisiaeB Santos
Instituto de Microbiologia Bioquimica, Consejo Superior de Investigaciones Cientificas Universidad de Salamanca, Spain
Mol Cell Biol 17:2485-96. 1997..The chs5 mating defect can be partially rescued by FUS1 and/or FUS2, two genes which have been implicated previously in cell fusion, but not by FUS3...
- Dynamic localization of yeast Fus2p to an expanding ring at the cell fusion junction during matingJoanna Mathis Paterson
Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
J Cell Biol 181:697-709. 2008..In zygotes, Fus2p-GFP forms a dilating ring at the cell junction, returning to the nucleus at the completion of cell fusion...
- Recognition of non-canonical peptides by the yeast Fus1p SH3 domain: elucidation of a common mechanism for diverse SH3 domain specificitiesJungmin Kim
Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada
J Mol Biol 377:889-901. 2008..Within this framework, dramatic alterations in SH3 domain specificity can be simply explained as a modulation of the binding strengths of these two surfaces...
- Plasma membrane polarization during mating in yeast cellsTomasz J Proszynski
Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany
J Cell Biol 173:861-6. 2006..Furthermore, we provide evidence that the lipid bilayer at the mating projection is more condensed than the plasma membrane enclosing the cell body, and that sphingolipids are required for this lipid organization...
- The exomer coat complex transports Fus1p to the plasma membrane via a novel plasma membrane sorting signal in yeastRobyn M Barfield
Department of Molecular and Cell Biology and Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA, 94720, USA
Mol Biol Cell 20:4985-96. 2009..These defects are suppressed by disruption of AP-1. We suggest that IXTPK comprises a novel sorting signal that is recognized and bound by exomer leading to the capture of Fus1p into coated vesicles en route to the cell surface...
- The class V myosin Myo2p is required for Fus2p transport and actin polarization during the yeast mating responseJason M Sheltzer
Department of Molecular Biology, Princeton University, Princeton, NJ 08544 1014, USA
Mol Biol Cell 20:2909-19. 2009..The different velocities, differential sensitivity to mutation and lack of colocalization suggest that Fus2p and Sec4p, another Myo2p cargo associated with exocytotic vesicles, reside predominantly on different cellular organelles...
- Secretion is required for late events in the cell-fusion pathway of mating yeastEric Grote
Department of Biochemistry and Molecular Biology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe Street, Baltimore, MD 21205
J Cell Sci 123:1902-12. 2010....
- Mutations in the YRB1 gene encoding yeast ran-binding-protein-1 that impair nucleocytoplasmic transport and suppress yeast mating defectsM Kunzler
Department of Molecular and Cell Biology, Division of Biochemistry and Molecular Biology, University of California, Berkeley, California 94720 3202, USA
Genetics 157:1089-105. 2001..Our results suggest that reimport of Ste5 into the nucleus is important in downregulating mating response...
- Identification of Kel1p, a kelch domain-containing protein involved in cell fusion and morphology in Saccharomyces cerevisiaeJ Philips
Department of Biochemistry and Biophysics, University of California, San Francisco, California 94143 0448, USA
J Cell Biol 143:375-89. 1998..KEL1 exhibited a moderate defect in cell fusion that was exacerbated by activated alleles of Pkc1p or loss of FUS1, FUS2, or FPS1, but not by loss of SPA2...
- A role for a protease in morphogenic responses during yeast cell fusionL Elia
Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
J Cell Biol 142:1473-85. 1998....
- Identification and regulation of a gene required for cell fusion during mating of the yeast Saccharomyces cerevisiaeG McCaffrey
Department of Biology, University of Oregon, Eugene 97403
Mol Cell Biol 7:2680-90. 1987..From this screen we identified a gene, FUS1, whose pattern of expression revealed interesting regulatory strategies and whose product was required for ..
- Cell surface polarization during yeast matingMichel Bagnat
Max Planck Institute for Molecular Cell Biology and Genetics, 01307 Dresden, Germany
Proc Natl Acad Sci U S A 99:14183-8. 2002..Our results show that membrane microdomain clustering at the mating projection is involved in the generation and maintenance of polarity during mating...