ZnT63C

Summary

Gene Symbol: ZnT63C
Description: Zinc transporter 63C
Alias: CG17723, Dmel\CG17723, ZnT1, cg17723, dZNT63C, dZnT1, dZnT63C, zinc transporter 63C, CG17723-PA, CG17723-PB, CG17723-PC, CG17723-PD, CG17723-PE, CG17723-PF, CG17723-PG, ZnT63C-PA, ZnT63C-PB, ZnT63C-PC, ZnT63C-PD, ZnT63C-PE, ZnT63C-PF, ZnT63C-PG
Species: fruit fly

Top Publications

  1. Qin Q, Wang X, Zhou B. Functional studies of Drosophila zinc transporters reveal the mechanism for dietary zinc absorption and regulation. BMC Biol. 2013;11:101 pubmed publisher
    ..Exit of zinc to the circulation is mediated through another two functionally overlapping zinc exporters, dZnT1, and its homolog CG5130 (dZnT77C)...
  2. Wang X, Wu Y, Zhou B. Dietary zinc absorption is mediated by ZnT1 in Drosophila melanogaster. FASEB J. 2009;23:2650-61 pubmed publisher
    ..Here, we report the identification and characterization of the Drosophila ZnT1 orthologue, dZnT1, for its role in Drosophila dietary zinc absorption...
  3. Lye J, Richards C, Dechen K, Paterson D, de Jonge M, Howard D, et al. Systematic functional characterization of putative zinc transport genes and identification of zinc toxicosis phenotypes in Drosophila melanogaster. J Exp Biol. 2012;215:3254-65 pubmed publisher
    ..Our findings reaffirm the previously proposed function of dZnT63C (CG17723: FBgn005432) as an important zinc efflux protein and indicate that the fly homolog of hZip1, dZip42C...
  4. Lye J, Richards C, Dechen K, Warr C, Burke R. In vivo zinc toxicity phenotypes provide a sensitized background that suggests zinc transport activities for most of the Drosophila Zip and ZnT genes. J Biol Inorg Chem. 2013;18:323-32 pubmed publisher
    ..1, with suppression of a zinc efflux gene, dZnT63C. Here we show that these phenotypes can be used as a sensitized in vivo system to detect subtle alterations in ..
  5. Dechen K, Richards C, Lye J, Hwang J, Burke R. Compartmentalized zinc deficiency and toxicities caused by ZnT and Zip gene over expression result in specific phenotypes in Drosophila. Int J Biochem Cell Biol. 2015;60:23-33 pubmed publisher
    ..1 (dZip1) combined with knockdown of dZnT63C (dZnT1)...
  6. Richards C, Burke R. Local and systemic effects of targeted zinc redistribution in Drosophila neuronal and gastrointestinal tissues. Biometals. 2015;28:967-74 pubmed publisher
    ..Over expression of the uptake transporter dZIP42C.1 (dZIP1) combined with knockdown of the efflux transporter dZNT63C (dZNT1) causes a zinc toxicity phenotype, as does over expression of dZIP71B or dZNT86D...
  7. Carrasco Rando M, Atienza Manuel A, Martin P, Burke R, Ruiz Gomez M. Fear-of-intimacy-mediated zinc transport controls the function of zinc-finger transcription factors involved in myogenesis. Development. 2016;143:1948-57 pubmed publisher
    ..Our results additionally suggest a possible explanation for the presence of large numbers of zinc transporters in organisms based on differences in ion transport specificity and/or degrees of activity among transporters. ..
  8. Vilmos P, Bujna A, Szuperák M, Havelda Z, Várallyay E, Szabad J, et al. Viability, longevity, and egg production of Drosophila melanogaster are regulated by the miR-282 microRNA. Genetics. 2013;195:469-80 pubmed publisher
  9. Huang Y, Wu Z, Cao Y, Lang M, Lu B, Zhou B. Zinc binding directly regulates tau toxicity independent of tau hyperphosphorylation. Cell Rep. 2014;8:831-42 pubmed publisher
    ..These results indicate zinc binding is a substantial contributor to tauopathy and have implications for therapy development. ..

More Information

Publications14

  1. Richards C, Warr C, Burke R. A role for dZIP89B in Drosophila dietary zinc uptake reveals additional complexity in the zinc absorption process. Int J Biochem Cell Biol. 2015;69:11-9 pubmed publisher
    ..We postulate that dZIP89B works in concert with the closely related dZIP42C.1 and 2 to ensure optimal zinc absorption under a range of dietary conditions. ..
  2. Soriano S, Calap Quintana P, Llorens J, Al Ramahi I, Gutierrez L, Martínez Sebastián M, et al. Metal Homeostasis Regulators Suppress FRDA Phenotypes in a Drosophila Model of the Disease. PLoS ONE. 2016;11:e0159209 pubmed publisher
    ..Taken together, these results demonstrate that the metal dysregulation in FRDA includes other metals besides iron, therefore providing a new set of potential therapeutic targets. ..
  3. Saini N, Schaffner W. Zinc supplement greatly improves the condition of parkin mutant Drosophila. Biol Chem. 2010;391:513-8 pubmed publisher
  4. Chi T, Kim M, Lang S, Bose N, Kahn A, Flechner L, et al. A Drosophila model identifies a critical role for zinc in mineralization for kidney stone disease. PLoS ONE. 2015;10:e0124150 pubmed publisher
    ..Our findings open a novel perspective on the etiology of urinary stones and related diseases, which may lead to the identification of new preventive and therapeutic approaches. ..
  5. Yin S, Qin Q, Zhou B. Functional studies of Drosophila zinc transporters reveal the mechanism for zinc excretion in Malpighian tubules. BMC Biol. 2017;15:12 pubmed publisher
    ..We also characterized the role of dZnT1 (CG17723) in zinc reabsorption in Malpighian tubules...