Gene Symbol: ZnT35C
Description: Zinc transporter 35C
Alias: BG:DS07295.1, CG3994, Dmel\CG3994, cg3994, dZnT35C, zinc transporter 35C, CG3994-PA, CG3994-PB, ZnT35C-PA, ZnT35C-PB
Species: fruit fly

Top Publications

  1. Qin Q, Wang X, Zhou B. Functional studies of Drosophila zinc transporters reveal the mechanism for dietary zinc absorption and regulation. BMC Biol. 2013;11:101 pubmed publisher
    ..The knowledge gained will act as a reference for future mammalian studies, and also enable an appreciation of this important process from an evolutionary perspective. ..
  2. Lye J, Richards C, Dechen K, Paterson D, de Jonge M, Howard D, et al. Systematic functional characterization of putative zinc transport genes and identification of zinc toxicosis phenotypes in Drosophila melanogaster. J Exp Biol. 2012;215:3254-65 pubmed publisher
    ..Our findings show that a genetically based zinc toxicosis situation can be therapeutically treated or exacerbated by modifications to the diet, providing a sensitized background for future, more detailed studies of Zip/ZnT function. ..
  3. Wang X, Wu Y, Zhou B. Dietary zinc absorption is mediated by ZnT1 in Drosophila melanogaster. FASEB J. 2009;23:2650-61 pubmed publisher
    ..This study will be helpful in understanding the fundamental process of acquiring dietary zinc in higher eukaryotes. ..
  4. Lye J, Richards C, Dechen K, Warr C, Burke R. In vivo zinc toxicity phenotypes provide a sensitized background that suggests zinc transport activities for most of the Drosophila Zip and ZnT genes. J Biol Inorg Chem. 2013;18:323-32 pubmed publisher
    ..Additionally, targeted suppression of each gene by RNA interference reveals several of the fly Zip and ZnT genes are required in the eye, indicating that numerous independent zinc transport genes are acting together in a single tissue. ..
  5. Fergestad T, Sale H, Bostwick B, Schaffer A, Ho L, Robertson G, et al. A Drosophila behavioral mutant, down and out (dao), is defective in an essential regulator of Erg potassium channels. Proc Natl Acad Sci U S A. 2010;107:5617-21 pubmed publisher
    ..These results indicate that Dao has an important role in establishing the proper level of neuronal membrane excitability by regulating functional expression of Erg channels. ..
  6. Dechen K, Richards C, Lye J, Hwang J, Burke R. Compartmentalized zinc deficiency and toxicities caused by ZnT and Zip gene over expression result in specific phenotypes in Drosophila. Int J Biochem Cell Biol. 2015;60:23-33 pubmed publisher
    ..This research highlights the differential effects that redistribution of zinc can have within a particular tissue and identifies the Golgi as being particularly sensitive to both excess and insufficient zinc. ..
  7. Chi T, Kim M, Lang S, Bose N, Kahn A, Flechner L, et al. A Drosophila model identifies a critical role for zinc in mineralization for kidney stone disease. PLoS ONE. 2015;10:e0124150 pubmed publisher
    ..Our findings open a novel perspective on the etiology of urinary stones and related diseases, which may lead to the identification of new preventive and therapeutic approaches. ..
  8. Saini N, Schaffner W. Zinc supplement greatly improves the condition of parkin mutant Drosophila. Biol Chem. 2010;391:513-8 pubmed publisher
  9. Georgiev P, Okkenhaug H, Drews A, Wright D, Lambert S, Flick M, et al. TRPM channels mediate zinc homeostasis and cellular growth during Drosophila larval development. Cell Metab. 2010;12:386-397 pubmed publisher
    ..We propose that regulation of Zn(2+) homeostasis through dTRPM channels is required to support molecular processes that mediate class I PI3K-regulated cell growth. ..

More Information


  1. Tritto P, Palumbo V, Micale L, Marzulli M, Bozzetti M, Specchia V, et al. Loss of Pol32 in Drosophila melanogaster causes chromosome instability and suppresses variegation. PLoS ONE. 2015;10:e0120859 pubmed publisher
    ..In addition we found that pol32 mutants suppress position effect variegation, suggesting a role for Pol32 in chromatin architecture. ..
  2. Soriano S, Calap Quintana P, Llorens J, Al Ramahi I, Gutierrez L, Martínez Sebastián M, et al. Metal Homeostasis Regulators Suppress FRDA Phenotypes in a Drosophila Model of the Disease. PLoS ONE. 2016;11:e0159209 pubmed publisher
    ..Taken together, these results demonstrate that the metal dysregulation in FRDA includes other metals besides iron, therefore providing a new set of potential therapeutic targets. ..
  3. Yin S, Qin Q, Zhou B. Functional studies of Drosophila zinc transporters reveal the mechanism for zinc excretion in Malpighian tubules. BMC Biol. 2017;15:12 pubmed publisher
    ..Zip71B (CG10006, most homologous to hZIP5), in addition to the previously characterized ZnT35C (CG3994), was identified as being critical in zinc excretion...