Gene Symbol: Zip89B
Description: Zinc/iron regulated transporter-related protein 89B
Alias: CG6898, Dmel\CG6898, ZIP3, Zip3, cg6898, dZIP89B, dZip3, dZip89B, Zinc/iron regulated transporter-related protein 89B, CG6898-PA, Zinc-iron transporter, Zinc/iron regulated transporter-related protein 3, Zinc/iron transporter-related protein 3, Zip89B-PA
Species: fruit fly
Lye J, Richards C, Dechen K, Paterson D, de Jonge M, Howard D, et al
. Systematic functional characterization of putative zinc transport genes and identification of zinc toxicosis phenotypes in Drosophila melanogaster. J Exp Biol. 2012;215:3254-65 pubmed publisher
..Our findings show that a genetically based zinc toxicosis situation can be therapeutically treated or exacerbated by modifications to the diet, providing a sensitized background for future, more detailed studies of Zip/ZnT function. ..
Lye J, Richards C, Dechen K, Warr C, Burke R. In vivo zinc toxicity phenotypes provide a sensitized background that suggests zinc transport activities for most of the Drosophila Zip and ZnT genes. J Biol Inorg Chem. 2013;18:323-32 pubmed publisher
..Additionally, targeted suppression of each gene by RNA interference reveals several of the fly Zip and ZnT genes are required in the eye, indicating that numerous independent zinc transport genes are acting together in a single tissue. ..
Dechen K, Richards C, Lye J, Hwang J, Burke R. Compartmentalized zinc deficiency and toxicities caused by ZnT and Zip gene over expression result in specific phenotypes in Drosophila. Int J Biochem Cell Biol. 2015;60:23-33 pubmed publisher
..This research highlights the differential effects that redistribution of zinc can have within a particular tissue and identifies the Golgi as being particularly sensitive to both excess and insufficient zinc. ..
Richards C, Warr C, Burke R. A role for dZIP89B in Drosophila dietary zinc uptake reveals additional complexity in the zinc absorption process. Int J Biochem Cell Biol. 2015;69:11-9 pubmed publisher
..This study provides evidence that dZIP89B is an ideal candidate for this role in Drosophila, encoding a low-affinity zinc uptake transporter active in the ..
Wang J, Binks T, Warr C, Burke R. Vacuolar-type H(+)-ATPase subunits and the neurogenic protein big brain are required for optimal copper and zinc uptake. Metallomics. 2014;6:2100-8 pubmed publisher
..for the correct localization of the copper uptake transporters Ctr1A and Ctr1B and the zinc uptake protein dZip89B and hence necessary for optimal copper and zinc accumulation in vivo...
Castillo D, Mell J, Box K, Blumenstiel J. Molecular evolution under increasing transposable element burden in Drosophila: a speed limit on the evolutionary arms race. BMC Evol Biol. 2011;11:258 pubmed publisher
..Third, we test whether increasing TE abundance is correlated with greater codon bias in genes of the piRNA machinery. This is predicted if increasing TE abundance selects for increased efficiency in the machinery of genome defense...
Gutierrez L, Sabaratnam N, Aktar R, Bettedi L, Mandilaras K, Missirlis F. Zinc accumulation in heterozygous mutants of fumble, the pantothenate kinase homologue of Drosophila. FEBS Lett. 2010;584:2942-6 pubmed publisher
..Accordingly, zinc supplementation had an adverse impact on the development of fumble mutant larvae, but zinc chelation failed to protect. ..
Qin Q, Wang X, Zhou B. Functional studies of Drosophila zinc transporters reveal the mechanism for dietary zinc absorption and regulation. BMC Biol. 2013;11:101 pubmed publisher
..The knowledge gained will act as a reference for future mammalian studies, and also enable an appreciation of this important process from an evolutionary perspective. ..