Gene Symbol: Zip42C.1
Description: Zinc/iron regulated transporter-related protein 42C.1
Alias: CG9428, Dmel\CG9428, ZIP1, Zip1, cg9428, dZIP1, dZIP42C.1, dZip1, dZip42C.1, Zinc/iron regulated transporter-related protein 42C.1, CG9428-PA, Zinc/iron regulated transporter-related protein 1, Zinc/iron transporter-related protein 1, Zip42C.1-PA
Species: fruit fly

Top Publications

  1. Lye J, Richards C, Dechen K, Warr C, Burke R. In vivo zinc toxicity phenotypes provide a sensitized background that suggests zinc transport activities for most of the Drosophila Zip and ZnT genes. J Biol Inorg Chem. 2013;18:323-32 pubmed publisher
    ..Additionally, targeted suppression of each gene by RNA interference reveals several of the fly Zip and ZnT genes are required in the eye, indicating that numerous independent zinc transport genes are acting together in a single tissue. ..
  2. Lang M, Wang L, Fan Q, Xiao G, Wang X, Zhong Y, et al. Genetic inhibition of solute-linked carrier 39 family transporter 1 ameliorates a? pathology in a Drosophila model of Alzheimer's disease. PLoS Genet. 2012;8:e1002683 pubmed publisher
    ..Using a genetically tractable Drosophila model, we found that the expression of dZip1, the orthologue of human Slc39 family transporter hZip1 in Drosophila, was altered in the brains of A?42-..
  3. Lye J, Richards C, Dechen K, Paterson D, de Jonge M, Howard D, et al. Systematic functional characterization of putative zinc transport genes and identification of zinc toxicosis phenotypes in Drosophila melanogaster. J Exp Biol. 2012;215:3254-65 pubmed publisher
    ..1 (CG9428: FBgn0033096), is a strong zinc importer in Drosophila. By combining over-expression of dZip42C...
  4. Huang Y, Wu Z, Cao Y, Lang M, Lu B, Zhou B. Zinc binding directly regulates tau toxicity independent of tau hyperphosphorylation. Cell Rep. 2014;8:831-42 pubmed publisher
    ..These results indicate zinc binding is a substantial contributor to tauopathy and have implications for therapy development. ..
  5. Richards C, Burke R. Local and systemic effects of targeted zinc redistribution in Drosophila neuronal and gastrointestinal tissues. Biometals. 2015;28:967-74 pubmed publisher
    ..Over expression of the uptake transporter dZIP42C.1 (dZIP1) combined with knockdown of the efflux transporter dZNT63C (dZNT1) causes a zinc toxicity phenotype, as does over ..
  6. Richards C, Warr C, Burke R. A role for dZIP89B in Drosophila dietary zinc uptake reveals additional complexity in the zinc absorption process. Int J Biochem Cell Biol. 2015;69:11-9 pubmed publisher
    ..In Drosophila, dual knockdown of the major dietary zinc uptake genes dZIP42C.1 (dZIP1) and dZIP42C.2 (dZIP2) results in a severe sensitivity to zinc-deficient media...
  7. Carrasco Rando M, Atienza Manuel A, Martin P, Burke R, Ruiz Gomez M. Fear-of-intimacy-mediated zinc transport controls the function of zinc-finger transcription factors involved in myogenesis. Development. 2016;143:1948-57 pubmed publisher
    ..Our results additionally suggest a possible explanation for the presence of large numbers of zinc transporters in organisms based on differences in ion transport specificity and/or degrees of activity among transporters. ..
  8. Mathews W, Wang F, Eide D, Van Doren M. Drosophila fear of intimacy encodes a Zrt/IRT-like protein (ZIP) family zinc transporter functionally related to mammalian ZIP proteins. J Biol Chem. 2005;280:787-95 pubmed
    ..In addition, this work indicates that the control of zinc by ZIP transporters may play a critical role in regulating developmental processes. ..
  9. Gutierrez L, Sabaratnam N, Aktar R, Bettedi L, Mandilaras K, Missirlis F. Zinc accumulation in heterozygous mutants of fumble, the pantothenate kinase homologue of Drosophila. FEBS Lett. 2010;584:2942-6 pubmed publisher
    ..Accordingly, zinc supplementation had an adverse impact on the development of fumble mutant larvae, but zinc chelation failed to protect. ..

More Information


  1. Qin Q, Wang X, Zhou B. Functional studies of Drosophila zinc transporters reveal the mechanism for dietary zinc absorption and regulation. BMC Biol. 2013;11:101 pubmed publisher
    ..b>dZip1 and dZip2, two functionally overlapping zinc importers, are responsible for absorbing zinc from the lumen into the ..
  2. Dechen K, Richards C, Lye J, Hwang J, Burke R. Compartmentalized zinc deficiency and toxicities caused by ZnT and Zip gene over expression result in specific phenotypes in Drosophila. Int J Biochem Cell Biol. 2015;60:23-33 pubmed publisher
    ..1 (dZip1) combined with knockdown of dZnT63C (dZnT1)...
  3. Soriano S, Calap Quintana P, Llorens J, Al Ramahi I, Gutierrez L, Martínez Sebastián M, et al. Metal Homeostasis Regulators Suppress FRDA Phenotypes in a Drosophila Model of the Disease. PLoS ONE. 2016;11:e0159209 pubmed publisher
    ..Taken together, these results demonstrate that the metal dysregulation in FRDA includes other metals besides iron, therefore providing a new set of potential therapeutic targets. ..