Gene Symbol: zip
Description: zipper
Alias: CG15792, DROMHC, Dm nmII, Dmel\CG15792, DmnmII, Dronm-MII, E(br), MHC, Mhc-c, Mhc-c[1], Myo, Myo II, Myo-II, Myo-II HC, Myo15, Myo2, MyoII, NMM, NMMII, ZIP, Zip, anon-WO0140519.37, l(2)02957, l(2)17F1, myo II, myoII, myosin-II, nmMHC, nmy-2, zip/MyoII, zpr, zipper, CG15792-PA, CG15792-PB, CG15792-PC, CG15792-PD, CG15792-PE, CG15792-PF, CG15792-PG, CG15792-PH, CG15792-PI, Myo-II heavy chain, MyoII heavy chain, Myosin-2, Myosin-II, cytoplasmic myosin, cytoplasmic myosin II, cytoplasmic myosin heavy chain, cytoplasmic myosin-II, enhancer of broad, lethal (2) 17F1, myosin, myosin 2, myosin HC, myosin II, myosin II heavy chain, myosin heavy chain, myosin heavy chain-cytoplasmic, myosin-heavy-chain-cytoplasmic, myosins II, non muscle myosin, non-muscle myosin, non-muscle myosin II, non-muscle myosin II heavy chain, non-muscle myosin heavy-chain, non-muscle myosin-II, nonmuscle myosin II, nonmuscle myosin II heavy chain, nonmuscle myosin II heavychain, nonmuscle myosin heavy chain, nonmuscle myosin-II, nonmuscle myosin-II heavy chain, zip-PA, zip-PB, zip-PC, zip-PD, zip-PE, zip-PF, zip-PG, zip-PH, zip-PI, zipper heavy chain
Species: fruit fly

Top Publications

  1. Giansanti M, Gatti M, Bonaccorsi S. The role of centrosomes and astral microtubules during asymmetric division of Drosophila neuroblasts. Development. 2001;128:1137-45 pubmed
    ..This suggests that astral microtubules mediate proper spindle rotation during neuroblast division. ..
  2. Blake K, Myette G, Jack J. ribbon, raw, and zipper have distinct functions in reshaping the Drosophila cytoskeleton. Dev Genes Evol. 1999;209:555-9 pubmed
    ..Mutations of zip, which encodes the nonmuscle myosin heavy chain, suppress the phenotypes of rib and raw, suggesting that rib and raw are not directly required for ..
  3. Sokac A, Wieschaus E. Zygotically controlled F-actin establishes cortical compartments to stabilize furrows during Drosophila cellularization. J Cell Sci. 2008;121:1815-24 pubmed publisher
    ..At the same time, cortical components that should concentrate in furrow canals, such as Myosin 2 (Zipper) and Anillin (Scraps), are missing from some furrows...
  4. Verdier V, Guang Chao Chen -, Settleman J. Rho-kinase regulates tissue morphogenesis via non-muscle myosin and LIM-kinase during Drosophila development. BMC Dev Biol. 2006;6:38 pubmed
    ..Drok interacts with multiple downstream effectors of the Rho GTPase signaling pathway, including non-muscle myosin heavy chain, adducin, and Diaphanous in those developmental processes...
  5. Sawyer J, Harris N, Slep K, Gaul U, Peifer M. The Drosophila afadin homologue Canoe regulates linkage of the actin cytoskeleton to adherens junctions during apical constriction. J Cell Biol. 2009;186:57-73 pubmed publisher
    ..Instead, Cno localizes to AJs by a Rap1- and actin-dependent mechanism. These data suggest that Cno regulates linkage between AJs and the actin cytoskeleton during morphogenesis. ..
  6. Martin Blanco E, Gampel A, Ring J, Virdee K, Kirov N, Tolkovsky A, et al. puckered encodes a phosphatase that mediates a feedback loop regulating JNK activity during dorsal closure in Drosophila. Genes Dev. 1998;12:557-70 pubmed
  7. Wei H, Sanny J, Shu H, Baillie D, Brill J, Price J, et al. The Sac1 lipid phosphatase regulates cell shape change and the JNK cascade during dorsal closure in Drosophila. Curr Biol. 2003;13:1882-7 pubmed
    ..This study is the first report of a role for Sac1 in the development of a multicellular organism. ..
  8. Kirchner J, Gross S, Bennett D, Alphey L. The nonmuscle myosin phosphatase PP1beta (flapwing) negatively regulates Jun N-terminal kinase in wing imaginal discs of Drosophila. Genetics. 2007;175:1741-9 pubmed
    ..the nonmuscle myosin regulatory light chain, Spaghetti Squash (Sqh); this inactivates the nonmuscle myosin heavy chain, Zipper (Zip)...
  9. Laplante C, Nilson L. Differential expression of the adhesion molecule Echinoid drives epithelial morphogenesis in Drosophila. Development. 2006;133:3255-64 pubmed
    ..We propose that local modulation of the cytoskeleton at Ed expression borders may represent a general mechanism for promoting epithelial morphogenesis. ..

More Information


  1. Glise B, Bourbon H, Noselli S. hemipterous encodes a novel Drosophila MAP kinase kinase, required for epithelial cell sheet movement. Cell. 1995;83:451-61 pubmed
    ..These data suggest that hep functions in a novel Drosophila MAPK pathway, controlling puckered expression and morphogenetic activity of the dorsal epidermis. ..
  2. Kaplan N, Tolwinski N. Spatially defined Dsh-Lgl interaction contributes to directional tissue morphogenesis. J Cell Sci. 2010;123:3157-65 pubmed publisher
    ..has a novel function in the planar organization of the embryonic epidermis, and this function depends on Dsh and myosin. We conclude that apical-basal proteins, used to establish polarity within a cell, can be independently co-opted ..
  3. Rogers S, Wiedemann U, Hacker U, Turck C, Vale R. Drosophila RhoGEF2 associates with microtubule plus ends in an EB1-dependent manner. Curr Biol. 2004;14:1827-33 pubmed
    ..S2 cells as a model system, we show that DRhoGEF2 induces contractile cell shape changes by stimulating myosin II via the Rho1 pathway...
  4. Hunter C, Wieschaus E. Regulated expression of nullo is required for the formation of distinct apical and basal adherens junctions in the Drosophila blastoderm. J Cell Biol. 2000;150:391-401 pubmed
    ..These observations reveal differences in the formation of the apical and basal junctions, and offer insight into the role of Nullo in basal junction formation. ..
  5. Uehara R, Goshima G, Mabuchi I, Vale R, Spudich J, Griffis E. Determinants of myosin II cortical localization during cytokinesis. Curr Biol. 2010;20:1080-5 pubmed publisher
    ..accumulation at three different stages: (1) turnover of thick filaments throughout the cell cycle, (2) myosin heavy chain-based control of myosin assembly at the metaphase-anaphase transition, and (3) redistribution and/or ..
  6. Hickson G, Echard A, O Farrell P. Rho-kinase controls cell shape changes during cytokinesis. Curr Biol. 2006;16:359-70 pubmed
    ..Using RNAi and live video microscopy in Drosophila S2 cells, we implicate Rho-kinase (Rok) and myosin II in anaphase cell elongation...
  7. Tan C, Stronach B, Perrimon N. Roles of myosin phosphatase during Drosophila development. Development. 2003;130:671-81 pubmed
    Myosins are a superfamily of actin-dependent molecular motor proteins, among which the bipolar filament forming myosins II have been the most studied...
  8. Winter C, Wang B, Ballew A, Royou A, Karess R, Axelrod J, et al. Drosophila Rho-associated kinase (Drok) links Frizzled-mediated planar cell polarity signaling to the actin cytoskeleton. Cell. 2001;105:81-91 pubmed regulating the phosphorylation of nonmuscle myosin regulatory light chain, and hence the activity of myosin II. Drosophila myosin VIIA, the homolog of the human Usher Syndrome 1B gene, also functions in conjunction with ..
  9. Simões S, Blankenship J, Weitz O, Farrell D, Tamada M, Fernandez Gonzalez R, et al. Rho-kinase directs Bazooka/Par-3 planar polarity during Drosophila axis elongation. Dev Cell. 2010;19:377-88 pubmed publisher
    ..We show that Bazooka/Par-3 (Baz) is required for the planar polarized distribution of myosin II and adherens junction proteins and polarized intercalary behavior is disrupted in baz mutants...
  10. David D, Wang Q, Feng J, Harris T. Bazooka inhibits aPKC to limit antagonism of actomyosin networks during amnioserosa apical constriction. Development. 2013;140:4719-29 pubmed publisher
    ..This later impact of aPKC inhibition is supported by mathematical modelling of the system. Overall, this work illustrates how shifting chemical signals can tune actomyosin network behaviour during development. ..
  11. Gotwals P, Fristrom J. Three neighboring genes interact with the Broad-Complex and the Stubble-stubbloid locus to affect imaginal disc morphogenesis in Drosophila. Genetics. 1991;127:747-59 pubmed
    ..b>Enhancer of broad (E(br)) was identified as a dominant enhancer of the br1 allele of the BR-C and is a recessive lethal...
  12. Pope K, Harris T. Control of cell flattening and junctional remodeling during squamous epithelial morphogenesis in Drosophila. Development. 2008;135:2227-38 pubmed publisher
    ..As amnioserosa cells elongate, they maintain their original cell-cell contacts and develop planar polarity. Myosin II localizes to anterior-posterior contacts, while the polarity protein Bazooka (PAR-3) localizes to dorsoventral ..
  13. Vereshchagina N, Bennett D, Szoor B, Kirchner J, Gross S, Vissi E, et al. The essential role of PP1beta in Drosophila is to regulate nonmuscle myosin. Mol Biol Cell. 2004;15:4395-405 pubmed
    Reversible phosphorylation of myosin regulatory light chain (MRLC) is a key regulatory mechanism controlling myosin activity and thus regulating the actin/myosin cytoskeleton...
  14. Bertet C, Sulak L, Lecuit T. Myosin-dependent junction remodelling controls planar cell intercalation and axis elongation. Nature. 2004;429:667-71 pubmed
    ..b>Myosin II is specifically enriched in disassembling junctions, and its planar polarized localization and activity are ..
  15. Escudero L, Bischoff M, Freeman M. Myosin II regulates complex cellular arrangement and epithelial architecture in Drosophila. Dev Cell. 2007;13:717-29 pubmed
    Remodeling epithelia is a primary driver of morphogenesis. Here, we report a central role of myosin II in regulating several aspects of complex epithelial architecture in the Drosophila eye imaginal disc...
  16. Laplante C, Nilson L. Asymmetric distribution of Echinoid defines the epidermal leading edge during Drosophila dorsal closure. J Cell Biol. 2011;192:335-48 pubmed publisher
    ..The planar polarized distribution of Ed in the DME cells thus provides a spatial cue that polarizes the DME cell actin cytoskeleton, defining the epidermal leading edge and establishing its contractile properties. ..
  17. Levayer R, Pelissier Monier A, Lecuit T. Spatial regulation of Dia and Myosin-II by RhoGEF2 controls initiation of E-cadherin endocytosis during epithelial morphogenesis. Nat Cell Biol. 2011;13:529-40 pubmed publisher
    ..In the early Drosophila embryo, Myosin-II (Myo-II) controls the planar polarized remodelling of cell junctions and tissue extension...
  18. Field C, Alberts B. Anillin, a contractile ring protein that cycles from the nucleus to the cell cortex. J Cell Biol. 1995;131:165-78 pubmed
    ..cytoplasm and cortex, and during anaphase-telophase it becomes highly enriched in the cleavage furrow along with myosin II. In the syncytial embryo, anillin, along with myosin-II, is enriched in cortical areas undergoing cell cycle ..
  19. Larsen C, Hirst E, Alexandre C, Vincent J. Segment boundary formation in Drosophila embryos. Development. 2003;130:5625-35 pubmed
    ..In addition, Wingless signalling at the anterior of the domains of engrailed (and hedgehog) expression represses groove formation and thus ensures that segment boundaries form only at the posterior. ..
  20. Silver D, Montell D. Paracrine signaling through the JAK/STAT pathway activates invasive behavior of ovarian epithelial cells in Drosophila. Cell. 2001;107:831-41 pubmed
    ..Ectopic expression of either UPD or JAK is sufficient to induce extra epithelial cells to migrate. Thus, a localized signal activates the JAK/STAT pathway in neighboring epithelial cells, causing them to become invasive. ..
  21. Dobens L, Jaeger A, Peterson J, Raftery L. Bunched sets a boundary for Notch signaling to pattern anterior eggshell structures during Drosophila oogenesis. Dev Biol. 2005;287:425-37 pubmed
  22. Eggert U, Kiger A, Richter C, Perlman Z, Perrimon N, Mitchison T, et al. Parallel chemical genetic and genome-wide RNAi screens identify cytokinesis inhibitors and targets. PLoS Biol. 2004;2:e379 pubmed
    ..Our study shows that parallel RNA interference and small molecule screening is a generally useful approach to identifying active small molecules and their target pathways...
  23. Bayer C, Halsell S, Fristrom J, Kiehart D, von Kalm L. Genetic interactions between the RhoA and Stubble-stubbloid loci suggest a role for a type II transmembrane serine protease in intracellular signaling during Drosophila imaginal disc morphogenesis. Genetics. 2003;165:1417-32 pubmed
    ..RhoA enhance leg and wing defects associated with mutations in zipper, the gene encoding the heavy chain of nonmuscle myosin II. We demonstrate here that mutations affecting the RhoA signaling pathway also interact genetically with ..
  24. Albertson R, Doe C. Dlg, Scrib and Lgl regulate neuroblast cell size and mitotic spindle asymmetry. Nat Cell Biol. 2003;5:166-70 pubmed
    ..We conclude that Dlg/Scrib/Lgl are important in regulating cortical polarity, cell size asymmetry and mitotic spindle asymmetry in Drosophila neuroblasts. ..
  25. Somers W, Saint R. A RhoGEF and Rho family GTPase-activating protein complex links the contractile ring to cortical microtubules at the onset of cytokinesis. Dev Cell. 2003;4:29-39 pubmed
  26. Jacinto A, Wood W, Woolner S, Hiley C, Turner L, Wilson C, et al. Dynamic analysis of actin cable function during Drosophila dorsal closure. Curr Biol. 2002;12:1245-50 pubmed
    ..GFP-actin-expressing embryos in which the cable is disrupted by modulating Rho1 signaling or by loss of non-muscle myosin (Zipper) function. We show that the cable serves a dual role during dorsal closure...
  27. Straight A, Field C, Mitchison T. Anillin binds nonmuscle myosin II and regulates the contractile ring. Mol Biol Cell. 2005;16:193-201 pubmed
    We demonstrate that the contractile ring protein anillin interacts directly with nonmuscle myosin II and that this interaction is regulated by myosin light chain phosphorylation...
  28. Majumder P, Aranjuez G, Amick J, McDonald J. Par-1 controls myosin-II activity through myosin phosphatase to regulate border cell migration. Curr Biol. 2012;22:363-72 pubmed publisher
    ..of Drosophila border cells, a genetically tractable model for collective cell migration, requires nonmuscle myosin-II (Myo-II)...
  29. Chen G, Gajowniczek P, Settleman J. Rho-LIM kinase signaling regulates ecdysone-induced gene expression and morphogenesis during Drosophila metamorphosis. Curr Biol. 2004;14:309-13 pubmed
    ..Together, these findings indicate a link between Rho-LIMK signaling and steroid hormone-induced gene expression in the context of metamorphosis and thereby establish a novel role for the Rho GTPase in development. ..
  30. D Avino P, Takeda T, Capalbo L, Zhang W, Lilley K, Laue E, et al. Interaction between Anillin and RacGAP50C connects the actomyosin contractile ring with spindle microtubules at the cell division site. J Cell Sci. 2008;121:1151-8 pubmed publisher
    Anillin, one of the first factors recruited to the cleavage site during cytokinesis, interacts with actin, myosin II and septins, and is essential for proper organization of the actomyosin contractile ring...
  31. Kiehart D, Lutz M, Chan D, Ketchum A, Laymon R, Nguyen B, et al. Identification of the gene for fly non-muscle myosin heavy chain: Drosophila myosin heavy chains are encoded by a gene family. EMBO J. 1989;8:913-22 pubmed
    ..Flies also contain a cytoplasmic myosin heavy chain polypeptide that by immunological and peptide mapping criteria is clearly different from the major ..
  32. Zarnescu D, Thomas G. Apical spectrin is essential for epithelial morphogenesis but not apicobasal polarity in Drosophila. J Cell Biol. 1999;146:1075-86 pubmed
  33. Simoes S, Denholm B, Azevedo D, Sotillos S, Martin P, Skaer H, et al. Compartmentalisation of Rho regulators directs cell invagination during tissue morphogenesis. Development. 2006;133:4257-67 pubmed
  34. Blake K, Myette G, Jack J. The products of ribbon and raw are necessary for proper cell shape and cellular localization of nonmuscle myosin in Drosophila. Dev Biol. 1998;203:177-88 pubmed
    ..Furthermore, mutations of zipper, the gene encoding the nonmuscle myosin heavy chain, exhibit mutant phenotypes in most of the same tissues affected by rib and raw, and many of the ..
  35. Sokac A, Wieschaus E. Local actin-dependent endocytosis is zygotically controlled to initiate Drosophila cellularization. Dev Cell. 2008;14:775-86 pubmed publisher
    ..We propose that developmentally regulated endocytosis can coordinate actin/PM remodeling to directly drive furrow dynamics during morphogenesis. ..
  36. Noselli S. JNK signaling and morphogenesis in Drosophila. Trends Genet. 1998;14:33-8 pubmed
  37. Martin A, Kaschube M, Wieschaus E. Pulsed contractions of an actin-myosin network drive apical constriction. Nature. 2009;457:495-9 pubmed publisher
    ..thought to be driven by the continuous purse-string-like contraction of a circumferential actin and non-muscle myosin-II (myosin) belt underlying adherens junctions...
  38. Franke J, Montague R, Kiehart D. Nonmuscle myosin II is required for cell proliferation, cell sheet adhesion and wing hair morphology during wing morphogenesis. Dev Biol. 2010;345:117-32 pubmed publisher
    Metazoan development involves a myriad of dynamic cellular processes that require cytoskeletal function. Nonmuscle myosin II plays essential roles in embryonic development; however, knowledge of its role in post-embryonic development, ..
  39. David D, Tishkina A, Harris T. The PAR complex regulates pulsed actomyosin contractions during amnioserosa apical constriction in Drosophila. Development. 2010;137:1645-55 pubmed publisher
    ..We have analyzed the relationship between myosin and the polarity regulators Par-6, aPKC and Bazooka (Par-3) (the PAR complex) during amnioserosa apical ..
  40. Ward R, Evans J, Thummel C. Genetic modifier screens in Drosophila demonstrate a role for Rho1 signaling in ecdysone-triggered imaginal disc morphogenesis. Genetics. 2003;165:1397-415 pubmed
  41. Speck O, Hughes S, Noren N, Kulikauskas R, Fehon R. Moesin functions antagonistically to the Rho pathway to maintain epithelial integrity. Nature. 2003;421:83-7 pubmed
    ..Furthermore, our results show that there is negative feedback between ERM activation and activity of the Rho pathway. ..
  42. Franke J, Montague R, Kiehart D. Nonmuscle myosin II generates forces that transmit tension and drive contraction in multiple tissues during dorsal closure. Curr Biol. 2005;15:2208-21 pubmed publisher
    ..We document dorsal closure in living embryos to show that mutations in nonmuscle myosin II (encoded by zipper; zip/MyoII) disrupt the integrity of multiple tissues during closure...
  43. Swan L, Schmidt M, Schwarz T, Ponimaskin E, Prange U, Boeckers T, et al. Complex interaction of Drosophila GRIP PDZ domains and Echinoid during muscle morphogenesis. EMBO J. 2006;25:3640-51 pubmed
    ..We propose that Ed and DGrip form a signaling complex, where competition between N-terminal and the C-terminal PDZDs of DGrip for Ed binding controls signaling function. ..
  44. Köppen M, Fernández B, Carvalho L, Jacinto A, Heisenberg C. Coordinated cell-shape changes control epithelial movement in zebrafish and Drosophila. Development. 2006;133:2671-81 pubmed
    ..Here evidence is provided for a conserved mechanism of local actin and myosin 2 recruitment during theses events...
  45. Riesgo Escovar J, Jenni M, Fritz A, Hafen E. The Drosophila Jun-N-terminal kinase is required for cell morphogenesis but not for DJun-dependent cell fate specification in the eye. Genes Dev. 1996;10:2759-68 pubmed
    ..Although DJNK efficiently phosphorylates DJun in vitro, bsk function is not required for the specification of cell fate in the developing eye, a process that requires MAP kinase and DJun function. ..
  46. Bloor J, Kiehart D. Drosophila RhoA regulates the cytoskeleton and cell-cell adhesion in the developing epidermis. Development. 2002;129:3173-83 pubmed
    ..We show that defects in actin organization, nonmuscle myosin II localization, the regulation of gene transcription, DE-cadherin-based cell-cell adhesion and cell polarity ..
  47. Mizuno T, Tsutsui K, Nishida Y. Drosophila myosin phosphatase and its role in dorsal closure. Development. 2002;129:1215-23 pubmed
    Myosin phosphatase negatively regulates nonmuscle myosin II through dephosphorylation of the myosin regulatory light chain (MRLC)...
  48. Franke J, Boury A, Gerald N, Kiehart D. Native nonmuscle myosin II stability and light chain binding in Drosophila melanogaster. Cell Motil Cytoskeleton. 2006;63:604-22 pubmed
    ..By immunodepletion we find that the majority of both light chains are associated with the nonmuscle myosin II heavy chain but pools of free light chain and/or light chain bound to other proteins are present...
  49. Lee A, Treisman J. Excessive Myosin activity in mbs mutants causes photoreceptor movement out of the Drosophila eye disc epithelium. Mol Biol Cell. 2004;15:3285-95 pubmed
    ..chain Spaghetti squash rather than another potential substrate, Moesin, and that it requires the nonmuscle myosin II heavy chain Zipper...
  50. Spahn P, Ott A, Reuter R. The PDZ-GEF protein Dizzy regulates the establishment of adherens junctions required for ventral furrow formation in Drosophila. J Cell Sci. 2012;125:3801-12 pubmed publisher
    ..We propose that Dzy and Rap1 are crucial factors regulating the dynamics of AJs during gastrulation. ..
  51. He B, Doubrovinski K, Polyakov O, Wieschaus E. Apical constriction drives tissue-scale hydrodynamic flow to mediate cell elongation. Nature. 2014;508:392-6 pubmed publisher
  52. Wei S, Escudero L, Yu F, Chang L, Chen L, Ho Y, et al. Echinoid is a component of adherens junctions that cooperates with DE-Cadherin to mediate cell adhesion. Dev Cell. 2005;8:493-504 pubmed
    ..Finally, cells lacking either Echinoid or DE-Cadherin accumulate a high density of the reciprocal protein, further suggesting that Echinoid and DE-Cadherin play similar and complementary roles in cell adhesion. ..
  53. Homem C, Peifer M. Diaphanous regulates myosin and adherens junctions to control cell contractility and protrusive behavior during morphogenesis. Development. 2008;135:1005-18 pubmed publisher
    ..This revealed an unexpected role in regulating myosin levels and activity at adherens junctions during cell shape change, suggesting that Diaphanous helps coordinate ..
  54. Young P, Pesacreta T, Kiehart D. Dynamic changes in the distribution of cytoplasmic myosin during Drosophila embryogenesis. Development. 1991;111:1-14 pubmed
    ..with both whole immune serum and affinity-purified antibodies directed against Drosophila non-muscle myosin heavy chain. They are not detected in embryos stained with anti-Drosophila muscle myosin antiserum or with preimmune ..
  55. Dean S, Rogers S, Stuurman N, Vale R, Spudich J. Distinct pathways control recruitment and maintenance of myosin II at the cleavage furrow during cytokinesis. Proc Natl Acad Sci U S A. 2005;102:13473-8 pubmed
    The correct localization of myosin II to the equatorial cortex is crucial for proper cell division...
  56. Bloor J, Kiehart D. zipper Nonmuscle myosin-II functions downstream of PS2 integrin in Drosophila myogenesis and is necessary for myofibril formation. Dev Biol. 2001;239:215-28 pubmed publisher
    Nonmuscle myosin-II is a key motor protein that drives cell shape change and cell movement. Here, we analyze the function of nonmuscle myosin-II during Drosophila embryonic myogenesis...
  57. Warner S, Yashiro H, Longmore G. The Cdc42/Par6/aPKC polarity complex regulates apoptosis-induced compensatory proliferation in epithelia. Curr Biol. 2010;20:677-86 pubmed publisher
    ..Cdc42/Par6/aPKC leads to activation of JNK through increased Rho1 and Rok activity and Rok's capacity to activate myosin but not F-actin...
  58. Bertet C, Rauzi M, Lecuit T. Repression of Wasp by JAK/STAT signalling inhibits medial actomyosin network assembly and apical cell constriction in intercalating epithelial cells. Development. 2009;136:4199-212 pubmed publisher
    ..Both processes require force generation by an actomyosin network. The subcellular localization of Myosin-II (Myo-II) dictates these different morphogenetic processes...
  59. Landsberg K, Farhadifar R, Ranft J, Umetsu D, Widmann T, Bittig T, et al. Increased cell bond tension governs cell sorting at the Drosophila anteroposterior compartment boundary. Curr Biol. 2009;19:1950-5 pubmed publisher
    ..Cell bond tension is decreased in the presence of Y-27632 [7], an inhibitor of Rho-kinase whose main effector is Myosin II [8]. Simulations using a vertex model [9] demonstrate that a 2...
  60. Halsell S, Kiehart D. Second-site noncomplementation identifies genomic regions required for Drosophila nonmuscle myosin function during morphogenesis. Genetics. 1998;148:1845-63 pubmed
    ..The nonmuscle myosin heavy chain is encoded by a single locus, zipper...
  61. Hatan M, Shinder V, Israeli D, Schnorrer F, Volk T. The Drosophila blood brain barrier is maintained by GPCR-dependent dynamic actin structures. J Cell Biol. 2011;192:307-19 pubmed publisher
    ..ARS formation and association with nonmuscle myosin is regulated by Moody/GPCR signaling and requires myosin activation...
  62. Ricos M, Harden N, Sem K, Lim L, Chia W. Dcdc42 acts in TGF-beta signaling during Drosophila morphogenesis: distinct roles for the Drac1/JNK and Dcdc42/TGF-beta cascades in cytoskeletal regulation. J Cell Sci. 1999;112 ( Pt 8):1225-35 pubmed
    ..Signaling in the transforming-growth-factor-beta-like pathway is mediated by Dcdc42, and acts during the closure process to control the mechanics of the migration process, most likely via its putative effector kinase DPAK. ..
  63. Edwards K, Kiehart D. Drosophila nonmuscle myosin II has multiple essential roles in imaginal disc and egg chamber morphogenesis. Development. 1996;122:1499-511 pubmed
    ..The nonmuscle myosin II heavy chain (MHC encoded by zipper is required for cell sheet movements in Drosophila embryos...
  64. Halsell S, Chu B, Kiehart D. Genetic analysis demonstrates a direct link between rho signaling and nonmuscle myosin function during Drosophila morphogenesis. Genetics. 2000;155:1253-65 pubmed
    ..Specifically, we screened for second-site noncomplementors of a mutation in the zipper gene that encodes the nonmuscle myosin-II heavy chain...
  65. Patel N. Imaging neuronal subsets and other cell types in whole-mount Drosophila embryos and larvae using antibody probes. Methods Cell Biol. 1994;44:445-87 pubmed
  66. Pouille P, Ahmadi P, Brunet A, Farge E. Mechanical signals trigger Myosin II redistribution and mesoderm invagination in Drosophila embryos. Sci Signal. 2009;2:ra16 pubmed publisher
    ..Complete mesoderm invagination requires redistribution of the motor protein Myosin II to the apical side of the constricting cells...
  67. Royou A, Field C, Sisson J, Sullivan W, Karess R. Reassessing the role and dynamics of nonmuscle myosin II during furrow formation in early Drosophila embryos. Mol Biol Cell. 2004;15:838-50 pubmed
    ..Both involve actin cytoskeleton rearrangements, and both have myosin II at or near the forming furrow...
  68. Arquier N, Perrin L, Manfruelli P, Semeriva M. The Drosophila tumor suppressor gene lethal(2)giant larvae is required for the emission of the Decapentaplegic signal. Development. 2001;128:2209-20 pubmed required for the dpp-dependent transcriptional activation of zipper (zip), which encodes the non-muscle myosin heavy chain (NMHC), in the dorsalmost ectodermal cells - the leading edge cells...
  69. Brodu V, Casanova J. The RhoGAP crossveinless-c links trachealess and EGFR signaling to cell shape remodeling in Drosophila tracheal invagination. Genes Dev. 2006;20:1817-28 pubmed
    ..cell behavior at invagination and show that it is associated with, and requires, a distinct recruitment of Myosin II to the apical surface of cells at the invaginating edge...
  70. Blankenship J, Backovic S, Sanny J, Weitz O, Zallen J. Multicellular rosette formation links planar cell polarity to tissue morphogenesis. Dev Cell. 2006;11:459-70 pubmed
    ..We find that planar polarity in the Drosophila embryo is established through a sequential enrichment of actin-myosin cables and adherens junction proteins in complementary surface domains...
  71. Baumann O. Spatial pattern of nonmuscle myosin-II distribution during the development of the Drosophila compound eye and implications for retinal morphogenesis. Dev Biol. 2004;269:519-33 pubmed
    Nonmuscle myosin-II is a motor protein that drives cell movement and changes in cell shape during tissue and organ development...
  72. Lecuit T, Wieschaus E. Polarized insertion of new membrane from a cytoplasmic reservoir during cleavage of the Drosophila embryo. J Cell Biol. 2000;150:849-60 pubmed
    ..We thus identify a tightly regulated scheme of polarized membrane insertion during cellularization. We propose that such a mechanism could participate in the progressive emergence of apical-basal polarity. ..
  73. Monier B, Pélissier Monier A, Brand A, Sanson B. An actomyosin-based barrier inhibits cell mixing at compartmental boundaries in Drosophila embryos. Nat Cell Biol. 2010;12:60-9 pubmed publisher
    ..When MyoII (non-muscle myosin II) function is inhibited, including locally at the cable by chromophore-assisted laser inactivation (CALI), in ..
  74. Jacinto A, Martinez Arias A, Martin P. Mechanisms of epithelial fusion and repair. Nat Cell Biol. 2001;3:E117-23 pubmed
    ..We are also gaining insight into the nature of the brakes and stop signals, and the mechanisms by which the confronting epithelial sheets knit together to form a seam. ..
  75. Harden N, Ricos M, Ong Y, Chia W, Lim L. Participation of small GTPases in dorsal closure of the Drosophila embryo: distinct roles for Rho subfamily proteins in epithelial morphogenesis. J Cell Sci. 1999;112 ( Pt 3):273-84 pubmed
    ..Rather, our results suggest that while all &Rgr; subfamily p21s tested are required for dorsal closure, they act largely in parallel. ..
  76. Fox D, Peifer M. Abelson kinase (Abl) and RhoGEF2 regulate actin organization during cell constriction in Drosophila. Development. 2007;134:567-78 pubmed
    ..Although these regulators act to promote stable myosin accumulation and apical cell constriction, loss-of-function phenotypes for each of these pathway members is not ..