z

Summary

Gene Symbol: z
Description: zeste
Alias: CG7803, Dmel\CG7803, EG:BACH59J11.3, e(bx), en-bx, CG7803-PA, CG7803-PB, CG7803-PC, enhancer-of-bithorax, z-PA, z-PB, z-PC
Species: fruit fly

Top Publications

  1. pmc A trans-acting regulatory gene that inversely affects the expression of the white, brown and scarlet loci in Drosophila
    L Rabinow
    Biological Laboratories, Harvard University, Cambridge, Massachusetts 02138
    Genetics 129:463-80. 1991
  2. ncbi Genotoxicity studies with the unstable zeste-white (UZ) system of Drosophila melanogaster: results with ten carcinogenic compounds
    M Batiste-Alentorn
    Departament de Genetica i de Microbiologia, Facultat de Ciencies, Universitat Autonoma de Barcelona, Bellaterra, Spain
    Environ Mol Mutagen 18:120-5. 1991
  3. doi Zeste can facilitate long-range enhancer-promoter communication and insulator bypass in Drosophila melanogaster
    Margarita Kostyuchenko
    Department of the Control of Genetic Processes, Institute of Gene Biology, Russian Academy of Sciences, Moscow 119334, Russia
    Chromosoma 118:665-74. 2009
  4. pmc Tissue-specific transcriptional enhancers may act in trans on the gene located in the homologous chromosome: the molecular basis of transvection in Drosophila
    P K Geyer
    Department of Biology, Johns Hopkins University, Baltimore, MD 21218
    EMBO J 9:2247-56. 1990
  5. pmc Effects of chromosomal rearrangements on transvection at the yellow gene of Drosophila melanogaster
    Sharon A Ou
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Genetics 183:483-96. 2009
  6. pmc Genome-wide profiling of salt fractions maps physical properties of chromatin
    Steven Henikoff
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Genome Res 19:460-9. 2009
  7. pmc Transvection in the iab-5,6,7 region of the bithorax complex of Drosophila: homology independent interactions in trans
    R Hopmann
    Department of Biology, Washington University, St Louis, Missouri 63130, USA
    Genetics 139:815-33. 1995
  8. pmc Self-association of the Drosophila zeste protein is responsible for transvection effects
    S Bickel
    Department of Cell Biology, Baylor College of Medicine, Houston, TX 77030
    EMBO J 9:2959-67. 1990
  9. pmc TAFII40 protein is encoded by the e(y)1 gene: biological consequences of mutations
    A Soldatov
    Department of the Control of Genetic Processes, Institute of Gene Biology, Russian Academy of Sciences, Russia
    Mol Cell Biol 19:3769-78. 1999
  10. pmc Transvection at the eyes absent gene of Drosophila
    W M Leiserson
    Division of Biology, California Institute of Technology, Pasadena 91125
    Genetics 138:1171-9. 1994

Scientific Experts

  • P Georgiev
  • V Pirrotta
  • David J Mellert
  • O B Simonova
  • E B Lewis
  • K Hagstrom
  • S Henikoff
  • M Simonelig
  • H Eggert
  • D Gubb
  • Laurent Perrin
  • Richard M Kliman
  • M D Biggin
  • AMAR J KLAR
  • Der Hwa Huang
  • Mohamed A F Noor
  • V Lloyd
  • M L Balasov
  • D Dorsett
  • Irwin Jungreis
  • Maksim Erokhin
  • D J Grau
  • U Bhadra
  • Sharon A Ou
  • Ulrich Braunschweig
  • Margarita Kostyuchenko
  • Naoto Juni
  • Sa Chen
  • Daryl Gohl
  • Alan M Moses
  • J A Birchler
  • Jérôme Déjardin
  • J Lesley Brown
  • Tokameh Mahmoudi
  • Niveen M Mulholland
  • Robert E Kingston
  • C Peter Verrijzer
  • Chiou Yang Tang
  • Lisette Mohrmann
  • Jurg Muller
  • Man Wook Hur
  • M Pal-Bhadra
  • Yuri M Moshkin
  • Clara S Chan
  • Anna Davydova
  • Olga Kyrchanova
  • Rebecca Spokony
  • Darya Chetverina
  • Nicolas Negre
  • Kevin P White
  • Alec Victorsen
  • Michael F Lin
  • Manolis Kellis
  • Alexander Parshikov
  • R E Kingston
  • J Toth
  • J M Antao
  • Elaine Chang
  • Marina Karakozova
  • Elizaveta Koryagina
  • Katherine So
  • Ekaterina Savitskaya
  • C ting Wu
  • Bas van Steensel
  • Szexian Lee
  • Daisuke Yamamoto
  • James R Morris
  • Larisa Melnikova
  • Greg J Hogan
  • Ludo Pagie
  • Anna Birve
  • A Soldatov
  • Paul Schedl
  • Markus Affolter
  • Martin Muller
  • Asa Rasmuson-Lestander
  • Xiao Yong Li
  • David A Nix
  • Venky N Iyer
  • Michael B Eisen
  • L Sipos
  • D Bornemann
  • Daniel A Pollard
  • S Georgieva
  • T Dray
  • Giacomo Cavalli
  • J Vieira
  • F Casares
  • G Laible
  • Judith A Kassis

Detail Information

Publications93

  1. pmc A trans-acting regulatory gene that inversely affects the expression of the white, brown and scarlet loci in Drosophila
    L Rabinow
    Biological Laboratories, Harvard University, Cambridge, Massachusetts 02138
    Genetics 129:463-80. 1991
    ..These experiments demonstrate that a single regulatory gene can exert an inverse effect on a target structural locus, a situation postulated from segmental aneuploid studies of gene expression and dosage compensation...
  2. ncbi Genotoxicity studies with the unstable zeste-white (UZ) system of Drosophila melanogaster: results with ten carcinogenic compounds
    M Batiste-Alentorn
    Departament de Genetica i de Microbiologia, Facultat de Ciencies, Universitat Autonoma de Barcelona, Bellaterra, Spain
    Environ Mol Mutagen 18:120-5. 1991
    ..That is in agreement with data previously reported by other authors...
  3. doi Zeste can facilitate long-range enhancer-promoter communication and insulator bypass in Drosophila melanogaster
    Margarita Kostyuchenko
    Department of the Control of Genetic Processes, Institute of Gene Biology, Russian Academy of Sciences, Moscow 119334, Russia
    Chromosoma 118:665-74. 2009
    ..Zeste is also required for insulator bypass by the eye enhancer. Taken together, these results show that Zeste can support specific long-range interactions between enhancers and promoters...
  4. pmc Tissue-specific transcriptional enhancers may act in trans on the gene located in the homologous chromosome: the molecular basis of transvection in Drosophila
    P K Geyer
    Department of Biology, Johns Hopkins University, Baltimore, MD 21218
    EMBO J 9:2247-56. 1990
    ....
  5. pmc Effects of chromosomal rearrangements on transvection at the yellow gene of Drosophila melanogaster
    Sharon A Ou
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Genetics 183:483-96. 2009
    ..These results provide a formal demonstration of the pairing-dependent nature of yellow transvection and suggest that yellow pairing, as measured by transvection, reflects the extent of contiguous homology flanking the locus...
  6. pmc Genome-wide profiling of salt fractions maps physical properties of chromatin
    Steven Henikoff
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Genome Res 19:460-9. 2009
    ..3 and correspond closely to profiles of histone H2Av (H2A.Z) and RNA polymerase II. This correspondence suggests that transcription can result in loss of H3...
  7. pmc Transvection in the iab-5,6,7 region of the bithorax complex of Drosophila: homology independent interactions in trans
    R Hopmann
    Department of Biology, Washington University, St Louis, Missouri 63130, USA
    Genetics 139:815-33. 1995
    ..Transvection may, therefore, be of more general significance than previously suspected...
  8. pmc Self-association of the Drosophila zeste protein is responsible for transvection effects
    S Bickel
    Department of Cell Biology, Baylor College of Medicine, Houston, TX 77030
    EMBO J 9:2959-67. 1990
    ....
  9. pmc TAFII40 protein is encoded by the e(y)1 gene: biological consequences of mutations
    A Soldatov
    Department of the Control of Genetic Processes, Institute of Gene Biology, Russian Academy of Sciences, Russia
    Mol Cell Biol 19:3769-78. 1999
    ..The su(Hw)-binding region, Drosophila insulator, stabilizes the expression of the white gene and makes it independent of the e(y)1(u1) mutation...
  10. pmc Transvection at the eyes absent gene of Drosophila
    W M Leiserson
    Division of Biology, California Institute of Technology, Pasadena 91125
    Genetics 138:1171-9. 1994
    ..The discovery of transvection at eya suggests that transvection interactions of this type may be more prevalent than generally thought...
  11. pmc GAGA facilitates binding of Pleiohomeotic to a chromatinized Polycomb response element
    Tokameh Mahmoudi
    Department of Molecular and Cell Biology, Center for Biomedical Genetics, Leiden University Medical Center, PO Box 9503, 2300 RA, Leiden, The Netherlands
    Nucleic Acids Res 31:4147-56. 2003
    ..These results provide a biochemical explanation for the in vivo cooperation between GAGA and PHO and suggest that PRE function involves the integrated activities of genetically antagonistic trxG and PcG proteins...
  12. ncbi Zeste encodes a sequence-specific transcription factor that activates the Ultrabithorax promoter in vitro
    M D Biggin
    Howard Hughes Medical Institute, Department of Biochemistry, University of California Berkeley 94720
    Cell 53:713-22. 1988
    ..These findings are consistent with the hypothesis that zeste may play a more important role in the normal regulation of Ubx and its other target genes than current genetic evidence implies...
  13. pmc The interaction of two complex loci, zeste and bithorax in Drosophila melanogaster
    T C Kaufman
    Genetics 75:299-321. 1973
    It has been found that certain alleles of the zeste locus (z(a) 1-1.0) have no phenotype of their own, but interact with certain alleles at the bithorax locus (bx 3-58.8)...
  14. ncbi Trans-sensing effects: the ups and downs of being together
    S Henikoff
    Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Cell 93:329-32. 1998
  15. pmc Multiple upstream regulatory elements control the expression of the Drosophila white gene
    V Pirrotta
    EMBO J 4:3501-8. 1985
    ....
  16. pmc The Drosophila zeste protein binds cooperatively to sites in many gene regulatory regions: implications for transvection and gene regulation
    M Benson
    Department of Cell Biology, Baylor College of Medicine, Houston, TX 77030
    EMBO J 7:3907-15. 1988
    ..These results suggest a general role for zeste in bringing together distant regulatory elements controlling the activity of a target gene. In this model, transvection effects are a by-product of normal intragenic zeste action...
  17. pmc Large-scale turnover of functional transcription factor binding sites in Drosophila
    Alan M Moses
    Graduate Group in Biophysics, University of California Berkeley, Berkeley, California, United States of America
    PLoS Comput Biol 2:e130. 2006
    ..Finally, we show that binding-site gains and losses are asymmetrically distributed with respect to D. melanogaster, consistent with lineage-specific acquisition and loss of Zeste-responsive regulatory elements...
  18. pmc Interactions of zeste mutations with loci exhibiting transvection effects in Drosophila melanogaster
    W M Gelbart
    Genetics 102:179-89. 1982
    ..z1 interacts with white, za alleles interact with bithorax and all tested zeste mutants interact with decapentaplegic. These differential effects of zeste mutations may be a reflection of the neomorphic nature of the z1 allele...
  19. pmc Interactions of Drosophila Ultrabithorax regulatory regions with native and foreign promoters
    F Casares
    Centro de Biologia Molecular Severo Ochoa, Facultad de Ciencias, Universidad Autonoma de Madrid, Spain
    Genetics 145:123-37. 1997
    ..The deletion derivatives also stimulate transvection, a pairing-dependent interaction with the Ubx promoter on the homologous chromosome...
  20. ncbi Two homeo domain proteins bind with similar specificity to a wide range of DNA sites in Drosophila embryos
    J Walter
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520
    Genes Dev 8:1678-92. 1994
    ..We propose that these data favor the model that eve, ftz, and closely related homeo domain proteins act by directly regulating mostly the same target genes...
  21. pmc A Polycomb and GAGA dependent silencer adjoins the Fab-7 boundary in the Drosophila bithorax complex
    K Hagstrom
    Department of Molecular Biology, Princeton University, New Jersey 08544, USA
    Genetics 146:1365-80. 1997
    ..The iab-7 PRE silencer is contained within a 0.8-kb fragment that spans a nuclease hypersensitive site, and silencing appears to depend on the chromatin remodeling protein, the GAGA factor...
  22. pmc Enhancer blocking and transvection at the Drosophila apterous locus
    Daryl Gohl
    Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, New Jersey 08854, USA
    Genetics 178:127-43. 2008
    ..We demonstrate that this is unlikely to be due to insulator bypass. The transvection effects described here may provide insight into the role that boundary element pairing plays in enhancer blocking both in cis and in trans...
  23. pmc Cis and trans interactions between the iab regulatory regions and abdominal-A and abdominal-B in Drosophila melanogaster
    J E Hendrickson
    Department of Human Genetics, Howard Hughes Medical Institute, University of Utah, Salt Lake City 84112, USA
    Genetics 139:835-48. 1995
    ..We propose that the iab-7 breaks prevent both iab trans regulation and target specificity by disrupting a mechanism that targets the iab regions to the Abd-B promoter...
  24. pmc Transvection in the Drosophila Abd-B domain: extensive upstream sequences are involved in anchoring distant cis-regulatory regions to the promoter
    L Sipos
    Hungarian Academy of Sciences, Biological Research Center, Institute of Genetics, H 6701 Szeged, Hungary
    Genetics 149:1031-50. 1998
    ..In addition, we present evidence that the tenacity of trans-interactions in the Abd-B gene may vary, depending upon the tissue and stage of development...
  25. ncbi polyhomeotic regulatory sequences induce developmental regulator-dependent variegation and targeted P-element insertions in Drosophila
    M O Fauvarque
    Centre National de la Recherche Scientifique CNRS URA 1134, Universite Paris XI, Orsay, France
    Genes Dev 7:1508-20. 1993
    ..We suggest that a multimeric complex containing PH and PC proteins, at a minimum, causes a local and clonally inherited heterochromatinization, which maintains the repressed state of transcription of the homeotic genes...
  26. ncbi The Drosophila pho-like gene encodes a YY1-related DNA binding protein that is redundant with pleiohomeotic in homeotic gene silencing
    J Lesley Brown
    Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Development 130:285-94. 2003
    ..Pc, Psc, Scm, E(z) and Ph remain bound to polytene chromosomes at most sites in the absence of Pho and Pho-like...
  27. pmc Chromatin inheritance upon Zeste-mediated Brahma recruitment at a minimal cellular memory module
    Jérôme Déjardin
    Institute of Human Genetics, CNRS, Montpellier Cedex 5, France
    EMBO J 23:857-68. 2004
    ..Thus, epigenetic inheritance of active chromatin states involves the recruitment of multiple cooperative chromatin-modifying complexes at closely spaced but distinct sites within a CMM...
  28. pmc The specificity of protein-DNA crosslinking by formaldehyde: in vitro and in drosophila embryos
    J Toth
    Department of Molecular Biophysics and Biochemistry, Yale University, PO Box 208114, New Haven, CT 06520 8114, USA
    Nucleic Acids Res 28:e4. 2000
    ..Our results suggest that crosslinking by formaldehyde, and possibly also by methylene blue, provide an accurate guide to the interaction of proteins with their high affinity target sites in cells...
  29. pmc The homeotic gene Sex combs reduced of Drosophila melanogaster is differentially regulated in the embryonic and imaginal stages of development
    A M Pattatucci
    Howard Hughes Medical Institute, Indiana University, Bloomington 47405
    Genetics 129:443-61. 1991
    ..of Scr expression is influenced by mutations at the Polycomb (Pc) locus but not by mutant alleles of the zeste (z) gene...
  30. pmc Evidence of abundant stop codon readthrough in Drosophila and other metazoa
    Irwin Jungreis
    MIT Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Genome Res 21:2096-113. 2011
    ....
  31. doi Insulators form gene loops by interacting with promoters in Drosophila
    Maksim Erokhin
    Department of the Control of Genetic Processes, Institute of Gene Biology, Russian Academy of Sciences, 34 5 Vavilov St, Moscow, 119334 Russia
    Development 138:4097-106. 2011
    ..Both insulators support basal activity of the yellow and white promoters in eyes. Thus, the ability of insulators to interact with promoters might play an important role in the regulation of basal gene transcription...
  32. doi Functional dissection of Polycomb repressive complex 1 reveals the importance of a charged domain
    D J Grau
    Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Cold Spring Harb Symp Quant Biol 75:61-70. 2010
    ..Our results suggest that one aspect of PRC1 repression is likely to be mediated by charge-charge interactions...
  33. ncbi Zeste maintains repression of Ubx transgenes: support for a new model of Polycomb repression
    Man Wook Hur
    Department of Biochemistry and Molecular Biology, Yonsei University School of Medicine, 134 Shinchon dong, Seodaemoon ku, Seoul, Korea 120 752
    Development 129:1339-43. 2002
    ..We present a model in which the dual transcriptional activities of Zeste and GAGA are an essential component of the mechanism that chooses which maintenance system is to be targeted to a given promoter...
  34. pmc Histone H1 binding is inhibited by histone variant H3.3
    Ulrich Braunschweig
    Division of Gene Regulation, Netherlands Cancer Institute, Amsterdam, The Netherlands
    EMBO J 28:3635-45. 2009
    ..These changes are independent of transcriptional changes. Our results show that the H3.3 protein counteracts association of H1, providing a mechanism to keep diverse genomic sites in an open chromatin conformation...
  35. ncbi Cosuppression in Drosophila: gene silencing of Alcohol dehydrogenase by white-Adh transgenes is Polycomb dependent
    M Pal-Bhadra
    Division of Biological Sciences, University of Missouri, Columbia 65211, USA
    Cell 90:479-90. 1997
    ..Polycomb and polyhomeotic proteins are bound to the chromatin at the sites of the repressed w-Adh transgenes...
  36. ncbi Chromatin-silencing mechanisms in Drosophila maintain patterns of gene expression
    V Pirrotta
    Department of Zoology, University of Geneva, Switzerland
    Trends Genet 13:314-8. 1997
    ..In vivo, complexes formed at one genomic site can interact with those at other sites, suggesting that they, like heterochromatin complexes, affect the folding of chromatin and the organization of chromosomes in the nucleus...
  37. ncbi Nuclear organization and gene expression: homologous pairing and long-range interactions
    S Henikoff
    Howard Hughes Medical Institute, Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98104, USA
    Curr Opin Cell Biol 9:388-95. 1997
    ..Recent work has revealed that such influences are widespread in eukaryotes and that chromosome architecture is likely to be of fundamental importance for nuclear structure and function...
  38. ncbi Population genetics of silent and replacement variation in Drosophila simulans and D. melanogaster: X/autosome differences?
    D J Begun
    Mol Biol Evol 13:1405-7. 1996
  39. pmc Interallelic complementation at the suppressor of forked locus of Drosophila reveals complementation between suppressor of forked proteins mutated in different regions
    M Simonelig
    Institut Jacques Monod, Universite Paris, France
    Genetics 142:1225-35. 1996
    ..Our results suggest protein-protein interaction between or within wild-type Su(f) molecules...
  40. pmc Homology requirements for targeting heterologous sequences during P-induced gap repair in Drosophila melanogaster
    T Dray
    Department of Biochemistry, University of Western Ontario, London, Canada
    Genetics 147:689-99. 1997
    ..Several aberrant conversion tracts, which arose from templates that contained reduced homology, also were examined and characterized...
  41. doi Genetic analysis of chaste, a new mutation of Drosophila melanogaster characterized by extremely low female sexual receptivity
    Naoto Juni
    Advanced Institute of Science and Engineering, Waseda University, Nishi Tokyo, Japan
    J Neurogenet 23:329-40. 2009
    ..of the sexual receptivity phenotype in the mbl locus disappears in the presence of a mutant copy of zeste (z), a gene encoding a protein that mediates transvection...
  42. ncbi In vivo analysis of Drosophila SU(Z)12 function
    Sa Chen
    Department of Molecular Biology, Umea University, Umea, Sweden
    Mol Genet Genomics 279:159-70. 2008
    ..Mutants in the PcG gene Supressor of zeste 12 (Su(z)12) exhibit strong homeotic transformations caused by widespread misexpression of several homeotic genes in embryos ..
  43. ncbi Characterization of the extended Myb-like DNA-binding domain of trithorax group protein Zeste
    Lisette Mohrmann
    Department of Molecular and Cell Biology, Center for Biomedical Genetics, Leiden University Medical Center, P O Box 9503, 2300 RA Leiden, The Netherlands
    J Biol Chem 277:47385-92. 2002
    ..We compare the DNA-binding properties of Zeste with those of classical tri-helical DBDs harboring a helix-turn-helix motif and suggest a model for Zeste-DNA recognition...
  44. pmc Histone acetylation and gene expression analysis of sex lethal mutants in Drosophila
    U Bhadra
    Division of Biological Sciences, University of Missouri, Columbia 65211, USA
    Genetics 155:753-63. 2000
    ..In both cases we find relatively little effect upon X chromosomal gene expression...
  45. pmc Histone chaperone ASF1 cooperates with the Brahma chromatin-remodelling machinery
    Yuri M Moshkin
    Department of Zoology and Animal Biology, University of Geneva, 1211 Geneva 4, Switzerland
    Genes Dev 16:2621-6. 2002
    ..These findings suggest that ASF1 plays a crucial role in both chromatin assembly and SWI/SNF-mediated chromatin remodelling...
  46. ncbi Histone methyltransferase activity of a Drosophila Polycomb group repressor complex
    Jurg Muller
    EMBL, Gene Expression Programme, Meyerhofstr 1, 69117 Heidelberg, Germany
    Cell 111:197-208. 2002
    ..The Extra Sex Combs (ESC) and Enhancer of Zeste [E(Z)] proteins are partners in an essential PcG complex, but its full composition and biochemical activities are not ..
  47. ncbi Genetic factors controlling white gene expression of the transposon A(R) 4-24 at a telomere in Drosophila melanogaster
    M L Balasov
    Institute of Cytology and Genetics, Siberian Division of Russia Academy of Sciences, Novosibirsk 630090, Russia
    Genome 45:1025-34. 2002
    ..It was found that E(Pc)1, TrlR85, and mutations of Su(z)2C relieve A(R) 4-24-silencing and z1 enhances it...
  48. ncbi Transvection and chromosomal trans-interaction effects
    V Pirrotta
    Department of Zoology, University of Geneva, Switzerland
    Biochim Biophys Acta 1424:M1-8. 1999
  49. pmc Regulation of Polycomb group complexes by the sequence-specific DNA binding proteins Zeste and GAGA
    Niveen M Mulholland
    Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Genes Dev 17:2741-6. 2003
    ..GAGA does not stably associate with PCC, but nucleosomal templates bound by GAGA are more efficiently bound and more efficiently inhibited by PCC. Thus Zeste and GAGA factor use distinct means to increase repression mediated by PRC1...
  50. pmc Expression and properties of wild-type and mutant forms of the Drosophila sex comb on midleg (SCM) repressor protein
    D Bornemann
    Department of Biochemistry and Department of Genetics and Cell Biology, University of Minnesota, St Paul, Minnesota 55108, USA
    Genetics 150:675-86. 1998
    ..pupal development. We suggest that the mbt repeat alleles produce altered SCM proteins that incorporate into and impair function of PcG protein complexes...
  51. ncbi [A novel trans-regulatory locus in Drosophila]
    O B Simonova
    Institute of Gene Biology, Russian Academy of Sciences, Moscow, Russia
    Genetika 36:1464-74. 2000
    ..A possible role of the new locus in organogenesis, neurogenesis, and embryonic development is discussed on the basis of experimental findings...
  52. ncbi The Polycomb and trithorax group proteins of Drosophila: trans-regulators of homeotic gene function
    J A Kennison
    Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 2785, USA
    Annu Rev Genet 29:289-303. 1995
    ..The ZESTE protein may help to activate transcription by bringing distant cis-regulatory elements closer to promoter-bound proteins...
  53. pmc Complementation analysis of methyl methane-sulfonate-induced recessive lethal mutations in the zeste-white region of the X chromosome of Drosophila melanogaster
    C P Liu
    Genetics 79:601-11. 1975
    ....
  54. ncbi The nature of radiation-induced mutations at the white locus of Drosophila melanogaster
    A Pastink
    Mutat Res 177:101-15. 1987
    ..In 4 mutants a small deletion could indeed be detected in this way. Thus it seems that by far the main part of X-ray- and neutron-induced white mutants have arisen through large changes in the white gene, especially deletions...
  55. ncbi Somatic reversion of P transposable element insertion mutations in the singed locus of Drosophila melanogaster requiring specific P insertions and a trans- acting factor
    J F Brookfield
    Genet Res 54:101-12. 1989
    ..Movements appear to occur preferentially in attached-X stocks. However, the maternal effect component maps to the central region of chromosome 2...
  56. ncbi Transcriptional enhancers can act in trans
    H P Muller
    Institut fur Molekularbiologie II, Universitat Zurich, Switzerland
    Trends Genet 6:300-4. 1990
    ..In addition, the findings, together with genetic studies in Drosophila, strongly suggest that enhancer action in trans could underlie phenomena such as 'transvection', where one chromosome affects gene expression in the paired homolog...
  57. pmc A novel spatial transcription pattern associated with the segmentation gene, giant, of Drosophila
    J Mohler
    Department of Cell Biology, Baylor College of Medicine, Houston, TX 77030
    EMBO J 8:1539-48. 1989
    ..The effect of mutations in three other gap loci, Kr, kni and hb, were also analyzed...
  58. pmc Interaction of the Enhancer of white-apricot with transposable element alleles at the white locus in Drosophila melanogaster
    J A Birchler
    Biological Laboratories, Harvard University, Cambridge, Massachusetts 02138
    Genetics 122:129-38. 1989
    ..Total copia RNA was also examined on Northern analyses from the segregating population but no quantitative change in the major copia RNA was produced by E(wa) homozygotes compared to normal...
  59. pmc A novel transvection phenomenon affecting the white gene of Drosophila melanogaster
    D Gubb
    Department of Genetics, University of Cambridge, England
    Genetics 126:167-76. 1990
    ..e. on homologous chromosomes. Duplicated w+ genes carried by a giant transposing element, TE146(Z), are suppressed by z whether they are in direct (tandem) or inverted order...
  60. ncbi Inference of haplotypes from PCR-amplified samples of diploid populations
    A G Clark
    Department of Biology, Pennsylvania State University, University Park 16802
    Mol Biol Evol 7:111-22. 1990
    ..The algorithm also applies to the problem of inferring haplotype frequencies of closely linked restriction-site polymorphisms...
  61. pmc Genetic analysis of the enhancer of zeste locus and its role in gene regulation in Drosophila melanogaster
    R S Jones
    Department of Cellular and Developmental Biology, Harvard University, Cambridge, Massachusetts 02138 2097
    Genetics 126:185-99. 1990
    The Enhancer of zeste [E(z)] locus of Drosophila melanogaster is implicated in multiple examples of gene regulation during development...
  62. pmc Genetic and molecular analysis of vgU and vgW: two dominant vg alleles associated with gene fusions in Drosophila
    J A Williams
    Department of Genetics, University of Alberta, Edmonton, Canada
    Genetics 125:833-44. 1990
    ..The results are consistent with a model in which inappropriate expression of inv causes the dominant homeotic effects seen in vgW...
  63. ncbi Tissue specific effects of ommochrome pathway mutations in Drosophila melanogaster
    R Tearle
    Department of Genetics and Human Variation, La Trobe University, Bundoora, Victoria, Australia
    Genet Res 57:257-66. 1991
    ..the eyes and ocelli; kar affects the eyes, ocelli and fat body; car causes excretion of pigment from tubules; and z affects pigmentation of the eyes alone...
  64. ncbi The nature of X-ray-induced mutations after recovery in excision repair-deficient (mus-201) Drosophila females
    J C Eeken
    Department of Radiation Genetics and Chemical Mutagenesis, State University of Leiden, The Netherlands
    Mutat Res 247:129-40. 1991
    ..In addition, lesions that apparently cannot be bypassed by DNA replication lead to a decrease in the fraction of mutations due to gross chromosomal aberrations among the whole-body mutations...
  65. ncbi Aneuploidy in Drosophila, IV. Inhalation studies on the induction of aneuploidy by nitriles
    C Osgood
    Department of Biological Sciences, Old Dominion University, Norfolk, VA 23529
    Mutat Res 259:165-76. 1991
    ..Possible mechanisms by which nitriles may disrupt chromosome segregation in Drosophila oocytes are considered...
  66. ncbi Chrysotile and amosite asbestos induce germ-line aneuploidy in Drosophila
    C Osgood
    Department of Biological Sciences, Old Dominion University, Norfolk, VA 23529
    Mutat Res 261:9-13. 1991
    ..Two other asbestiform minerals, crocidolite and tremolite, were ineffective in this assay system. These results suggest that possible germ-line effects of asbestos should be considered in evaluating its potential impact on human health...
  67. pmc Properties of promoter regions of mdg1 Drosophila retrotransposon indicate that it belongs to a specific class of promoters
    I R Arkhipova
    V A Engelhardt Institute of Molecular Biology, Academy of Sciences of the USSR, Moscow
    EMBO J 10:1169-77. 1991
    ..The identified sequence-specific downstream initiation factor may be responsible for transcription initiation on promoters of some genes which belong to this class...
  68. pmc The effects of chromosomal rearrangements on the zeste-white interaction in Drosophila melanogaster
    S M Smolik-Utlaut
    Genetics 116:285-98. 1987
    ..Given these results, we suggest that the zeste-white interaction and transvection are two different proximity-dependent phenomena...
  69. ncbi A genetic assay to detect chromosome gain and/or loss in somatic cells of Drosophila melanogaster
    J Szabad
    Institute of Genetics, Biological Research Center, Szeged, Hungary
    Mutat Res 180:201-6. 1987
    ..In this somatic aneuploidy test (SAT) larvae of the genotype z w-/w+J Y are exposed to the test compound...
  70. ncbi Regulation of white locus expression: the structure of mutant alleles at the white locus of Drosophila melanogaster
    Z Zachar
    Cell 30:529-41. 1982
    ..This putative transposon apparently carries genetic elements that act at a distance to repress expression of the white locus...
  71. pmc Prevalence of localized rearrangements vs. transpositions among events induced by Drosophila P element transposase on a P transgene
    M Delattre
    Département Dynamique du Génome et Evolution, Institut Jacques Monod, Paris, France
    Genetics 141:1407-24. 1995
    ..We propose that the P transposase induces mainly localized events. Some of these could result from frequent changes of template during gap-repair DNA synthesis, and/or from abortive transposition...
  72. pmc White as a reporter gene to detect transcriptional silencers specifying position-specific gene expression during Drosophila melanogaster eye development
    Y H Sun
    Institute of Molecular Biology, Academia Sinica, Nankang Taipei, Republic of China
    Genetics 141:1075-86. 1995
    ..teashirt is also implicated as a candidate gene. We propose that this "silencer trap"' may be an efficient way of identifying genes involved in imaginal pattern formation...
  73. pmc Empirical tests of some predictions from coalescent theory with applications to intraspecific phylogeny reconstruction
    K A Crandall
    Department of Biology, Washington University, St Louis, Missouri 63130 4899
    Genetics 134:959-69. 1993
    ....
  74. pmc Mammalian homologues of the Polycomb-group gene Enhancer of zeste mediate gene silencing in Drosophila heterochromatin and at S. cerevisiae telomeres
    G Laible
    Research Institute of Molecular Pathology IMP, Vienna, Austria
    EMBO J 16:3219-32. 1997
    ..of human (EZH2) and mouse (Ezh1) homologues of the Drosophila Polycomb-group (Pc-G) gene Enhancer of zeste [E(z)], a crucial regulator of homeotic gene expression implicated in the assembly of repressive protein complexes in ..
  75. ncbi Characterization of a sex-influenced modifier of gene expression and suppressor of position-effect variegation in Drosophila
    U Bhadra
    Division of Biological Sciences, University of Missouri Columbia, Columbia, Missouri 65211, USA
    Mol Gen Genet 250:601-13. 1996
    ..In addition, Mow acts as a weak suppressor of position effect variegation (PEV). These observations suggest a connection between dosage modulation of gene expression and suppression of position-effect variegation...
  76. pmc Cooperative binding at a distance by even-skipped protein correlates with repression and suggests a mechanism of silencing
    A TenHarmsel
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06511
    Mol Cell Biol 13:2742-52. 1993
    ..Cooperative binding of further repressor molecules to distant low-affinity sites, and competition with activators bound at these sites lead to repression at a distance...
  77. ncbi White gene expression, repressive chromatin domains and homeotic gene regulation in Drosophila
    V Pirrotta
    Department of Zoology, University of Geneva, Switzerland
    Bioessays 16:549-56. 1994
    ..Such complexes, which normally regulate the expression of many genes, including the homeotic loci, are responsible for silencing, white gene variegation, pairing-dependent effects and insertional targeting...
  78. pmc The Drosophila trithorax protein binds to specific chromosomal sites and is co-localized with Polycomb at many sites
    V Chinwalla
    Department of Genetics, School of Medicine, Case Western Reserve University, Cleveland, OH 44106 4955, USA
    EMBO J 14:2056-65. 1995
    ..Co-localization with Polycomb also suggests that interactions between these activators and repressors of the homeotic genes may be a significant feature of their mode of action...
  79. pmc Paralog, a control mutant in Drosophila melanogaster
    D Thierry-Mieg
    Genetics 100:209-37. 1982
    ..We interpret the data by postulating that the expression of sets of dispersed genes might be controlled by the local topology of the chromosome, itself constrained by pairing of dispersed repeated elements. We call the mutation paralog...
  80. pmc Sequence analysis of the cis-regulatory regions of the bithorax complex of Drosophila
    E B Lewis
    Division of Biology, California Institute of Technology, Pasadena 91125, USA
    Proc Natl Acad Sci U S A 92:8403-7. 1995
    ..5 case is expected. Expected values are based on a third-order Markov chain, which is the optimal order for representing the BXCALL sequence...
  81. pmc pipsqueak encodes a factor essential for sequence-specific targeting of a polycomb group protein complex
    Der Hwa Huang
    Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan 115, Republic of China
    Mol Cell Biol 22:6261-71. 2002
    ..The functional relevance of psq to the silencing mechanism is strongly supported by its synergistic interactions with a subset of Pc-G that cause misexpression of homeotic genes...
  82. ncbi Uptake and incorporation in pteridines of externally supplied GTP in normal and pigment-deficient eyes of Drosophila melanogaster
    I Montell
    Department of Genetics, University of Umea, Sweden
    Biochem Genet 30:61-75. 1992
    ..We suggest that this is caused by a hampered transport of precursor (possibly GTP) in white and zeste eyes through the membrane of red pigment granules...
  83. ncbi Somatic and germline mutagenesis assayed by the unstable zeste-white test in Drosophila melanogaster
    A Rasmuson
    Department of Genetics, University of Umea, Sweden
    Mutagenesis 7:219-23. 1992
    ..We also found that spontaneous mutation rate among germinal cells is 200 times higher than that in somatic cells, which presumably is due to the involvement of a mobile element...
  84. pmc Transcription of the Drosophila white locus and some of its mutants
    V Pirrotta
    EMBO J 3:563-8. 1984
    ..These and the results of S1 mapping reveal the presence of at least four introns. One of these, a micro-intron of 30-50 nucleotides contains the site of copia insertion in the wa mutant...
  85. pmc Conserved DNA binding and self-association domains of the Drosophila zeste protein
    J D Chen
    Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030
    Mol Cell Biol 12:598-608. 1992
    ..A model is proposed according to which the hydrophobic ridges induce the formation of open-ended coiled-coil structures holding together many hundreds of zeste molecules and possibly anchoring these complexes to other nuclear structures...
  86. ncbi Phenotypic reversion of the gypsy-induced mutation scD1 of Drosophila melanogaster by replicative transposition of a sc enhancer to the yellow gene and by mutations in the enhancer of yellow and zeste loci
    M Gause
    Institute of Gene Biology, Russian Academy of Sciences, Moscow, Russia
    Mol Gen Genet 253:370-6. 1996
    ..In addition, we found that mutations in the e(y)1, e(y)3 and zeste genes may interfere with transcriptional insulation by the su(Hw)-binding region in the scD1 allele...
  87. ncbi Use of mini-white as a reporter gene to screen for GAL4 insertions with spatially restricted expression pattern in the developing eye in drosophila
    Chiou Yang Tang
    Institute of Molecular Biology, Academia Sinica, Nankang, Taipei, Taiwan, Republic of China
    Genesis 34:39-45. 2002
  88. ncbi Analysis of the antennal phenotype in the Drosophila mutant lozenge
    R F Stocker
    Institute of Zoology, University of Fribourg, Switzerland
    J Neurogenet 9:29-53. 1993
    ....
  89. ncbi Interaction of the mottler of white with transposable element alleles at the white locus in Drosophila melanogaster
    J A Birchler
    Harvard University, Biological Laboratories, Cambridge, Massachusetts 02138
    Genes Dev 3:73-84. 1989
    ..These results suggest that several retrotransposon-induced alleles share an RNA processing function encoded by mw...
  90. ncbi Neutralism and selectionism face up to DNA data
    J F Brookfield
    Department of Genetics, University of Nottingham, Queens Medical Centre, UK
    Trends Genet 10:109-11. 1994
  91. pmc The su(Hw) protein bound to gypsy sequences in one chromosome can repress enhancer-promoter interactions in the paired gene located in the other homolog
    P G Georgiev
    Institute of Gene Biology, Russian Academy of Sciences, Moscow
    Proc Natl Acad Sci U S A 92:5184-8. 1995
    ..These results indicate that, in the absence of mod-(mdg4) product, the su(Hw) protein present in one chromosome can act in trans and inactivate enhancers located in the other homolog...
  92. ncbi A framework physical map of Drosophila virilis based on P1 clones: applications in genome evolution
    J Vieira
    Department of Organismic and Evolutionary Biology, The Biological Laboratories, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
    Chromosoma 106:99-107. 1997
    ..virilis X chromosome. However, a block of four functionally unrelated genes, including white, roughest, Notch, and dunce, seems to be conserved between the two species...
  93. pmc Chromosome rearrangement by ectopic recombination in Drosophila melanogaster: genome structure and evolution
    E A Montgomery
    Laboratory of Genetics, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709
    Genetics 129:1085-98. 1991
    ....

Research Grants29

  1. ALIGNMENT BASED METHODS FOR MOLECULAR SEQUENCE ANALYSIS
    Steven Henikoff; Fiscal Year: 2001
    ..This effort could yield new eukaryotic family members of great importance for understanding epigenetic phenomena, some of which, such as parental imprinting, are relevant to human disease. ..
  2. Maintenance of blocks-based tools for functional genomic
    Steven Henikoff; Fiscal Year: 2006
    ..These various components will be packaged to facilitate updates and local implementations. ..
  3. Genome-wide profiling of histone variants in Drosophila and Caenorhabditis
    Steven Henikoff; Fiscal Year: 2007
    ..Given that the same histone variants are thought to play similar roles in essentially all complex eukaryotes, our basic approach can be immediately applied to the human genome. ..
  4. GENE REGULATION OF THE PURINE SYNTHETIC PATHWAY
    Steven Henikoff; Fiscal Year: 1993
    ..It is likely that some of these other genes that we identify by this approach will correspond to loci that were previously identified by mutation, thus furthering our understanding of the relationship between phenotype and gene function...
  5. Epigenomic profiling of histone turnover kinetics in mammalian cells
    Steven Henikoff; Fiscal Year: 2010
    ..Our project will explore the application of CATCH-IT to measuring dynamic changes in the epigenome involved developmental regulation, cancer, and DNA damage, with broad diagnostic potential. ..