Gene Symbol: z
Description: zeste
Alias: CG7803, Dmel\CG7803, EG:BACH59J11.3, e(bx), en-bx, zeste, CG7803-PA, CG7803-PB, CG7803-PC, enhancer-of-bithorax, z-PA, z-PB, z-PC
Species: fruit fly
Products:     z

Top Publications

  1. Kostyuchenko M, Savitskaya E, Koryagina E, Melnikova L, Karakozova M, Georgiev P. Zeste can facilitate long-range enhancer-promoter communication and insulator bypass in Drosophila melanogaster. Chromosoma. 2009;118:665-74 pubmed publisher
    ..In particular, the Drosophila transcription factor Zeste was hypothesized to facilitate long-distance associations between enhancers and promoters...
  2. Henikoff S, Comai L. Trans-sensing effects: the ups and downs of being together. Cell. 1998;93:329-32 pubmed
  3. Mulholland N, King I, Kingston R. Regulation of Polycomb group complexes by the sequence-specific DNA binding proteins Zeste and GAGA. Genes Dev. 2003;17:2741-6 pubmed
    ..GAGA factor and Zeste bind specifically to PREs/TREs and have been shown to act as both activators and repressors...
  4. Fauvarque M, Dura J. polyhomeotic regulatory sequences induce developmental regulator-dependent variegation and targeted P-element insertions in Drosophila. Genes Dev. 1993;7:1508-20 pubmed
    ..This transvection is abolished in a ph but not in a zeste mutant background...
  5. Gelbart W, Wu C. Interactions of zeste mutations with loci exhibiting transvection effects in Drosophila melanogaster. Genetics. 1982;102:179-89 pubmed
    b>Zeste (1-1.0; 3A3) mutations have been known to modify the expression of two gene complexes: white (1-1.5; 3C1.5) and bithorax (3-58.8; 89E1-4) in Drosophila melanogaster...
  6. Biggin M, Bickel S, Benson M, Pirrotta V, Tjian R. Zeste encodes a sequence-specific transcription factor that activates the Ultrabithorax promoter in vitro. Cell. 1988;53:713-22 pubmed
    b>Zeste is a Drosophila regulatory gene that is required for transvection at the bithorax complex. Here we find that purified zeste protein binds to multiple sites just 5' of the initiation site of Ubx RNA...
  7. Ou S, Chang E, Lee S, So K, Wu C, Morris J. Effects of chromosomal rearrangements on transvection at the yellow gene of Drosophila melanogaster. Genetics. 2009;183:483-96 pubmed publisher
    ..These results provide a formal demonstration of the pairing-dependent nature of yellow transvection and suggest that yellow pairing, as measured by transvection, reflects the extent of contiguous homology flanking the locus. ..
  8. Brown J, Fritsch C, Mueller J, Kassis J. The Drosophila pho-like gene encodes a YY1-related DNA binding protein that is redundant with pleiohomeotic in homeotic gene silencing. Development. 2003;130:285-94 pubmed
    ..In contrast to Pho and Pho-like, removal of Trithorax-like/GAGA factor or Zeste, two other DNA-binding proteins implicated in PRE function, does not cause misexpression of homeotic genes or ..
  9. Gohl D, Muller M, Pirrotta V, Affolter M, Schedl P. Enhancer blocking and transvection at the Drosophila apterous locus. Genetics. 2008;178:127-43 pubmed publisher
    ..We demonstrate that this is unlikely to be due to insulator bypass. The transvection effects described here may provide insight into the role that boundary element pairing plays in enhancer blocking both in cis and in trans. ..

More Information


  1. Toth J, Biggin M. The specificity of protein-DNA crosslinking by formaldehyde: in vitro and in drosophila embryos. Nucleic Acids Res. 2000;28:e4 pubmed
    ..Here we show that formaldehyde crosslinking of Drosophila embryos maps an interaction of the transcription factor Zeste to a known target element in the Ultrabithorax promoter...
  2. Hopmann R, Duncan D, Duncan I. Transvection in the iab-5,6,7 region of the bithorax complex of Drosophila: homology independent interactions in trans. Genetics. 1995;139:815-33 pubmed
    ..Also, we show that iab-5,6,7 transvection is independent of the allelic state of zeste, a gene that influences several other cases of transvection...
  3. Hendrickson J, Sakonju S. Cis and trans interactions between the iab regulatory regions and abdominal-A and abdominal-B in Drosophila melanogaster. Genetics. 1995;139:835-48 pubmed
    ..We propose that the iab-7 breaks prevent both iab trans regulation and target specificity by disrupting a mechanism that targets the iab regions to the Abd-B promoter. ..
  4. Sipos L, Mihaly J, Karch F, Schedl P, Gausz J, Gyurkovics H. Transvection in the Drosophila Abd-B domain: extensive upstream sequences are involved in anchoring distant cis-regulatory regions to the promoter. Genetics. 1998;149:1031-50 pubmed
    ..in contrast to Ubx, the transvection we observed in the Abd-B locus is insensitive to the allelic status of zeste. Analysis of different deletion alleles of Abd-B that enhance trans-regulation suggests that an extensive upstream ..
  5. Pirrotta V, Manet E, Hardon E, Bickel S, Benson M. Structure and sequence of the Drosophila zeste gene. EMBO J. 1987;6:791-9 pubmed
    The zeste gene of Drosophila affects the expression of other genes in a manner that depends on the homologous pairing of the chromosomes bearing the target gene...
  6. Benson M, Pirrotta V. The Drosophila zeste protein binds cooperatively to sites in many gene regulatory regions: implications for transvection and gene regulation. EMBO J. 1988;7:3907-15 pubmed
    The Drosophila zeste protein binds in vitro to several sites in the white, Ultrabithorax, decapentaplegic, Antennapedia, and engrailed genes and to at least one site in the zeste gene itself...
  7. Bickel S, Pirrotta V. Self-association of the Drosophila zeste protein is responsible for transvection effects. EMBO J. 1990;9:2959-67 pubmed
    The zeste gene product is required for transvection effects that imply the ability of regulatory elements on one chromosome to affect the expression of the homologous gene in a somatically paired chromosome...
  8. Hagstrom K, Muller M, Schedl P. A Polycomb and GAGA dependent silencer adjoins the Fab-7 boundary in the Drosophila bithorax complex. Genetics. 1997;146:1365-80 pubmed
    ..Pairing-sensitive silencing is relieved by removing the transvection protein Zeste, but is enhanced in a novel pairing-independent manner by the zeste' allele...
  9. Moses A, Pollard D, Nix D, Iyer V, Li X, Biggin M, et al. Large-scale turnover of functional transcription factor binding sites in Drosophila. PLoS Comput Biol. 2006;2:e130 pubmed
    ..this model to study the evolutionary dynamics of binding sites of the Drosophila melanogaster transcription factor Zeste, using genome-wide in vivo (ChIP-chip) binding data to identify functional Zeste binding sites, and the genome ..
  10. Erokhin M, Davydova A, Kyrchanova O, Parshikov A, Georgiev P, Chetverina D. Insulators form gene loops by interacting with promoters in Drosophila. Development. 2011;138:4097-106 pubmed publisher
    ..Both insulators support basal activity of the yellow and white promoters in eyes. Thus, the ability of insulators to interact with promoters might play an important role in the regulation of basal gene transcription...
  11. Shu J, Li Y. A statistical fat-tail test of predicting regulatory regions in the Drosophila genome. Comput Biol Med. 2012;42:935-41 pubmed publisher
    ..These two fatness coefficients may serve as valuable filtering indexes to predict CRMs experimentally. ..
  12. Leiserson W, Bonini N, Benzer S. Transvection at the eyes absent gene of Drosophila. Genetics. 1994;138:1171-9 pubmed
    ..Moreover, like transvection in those cases, the interaction at eya depends on the presence of normal zeste function...
  13. Benson M, Pirrotta V. The product of the Drosophila zeste gene binds to specific DNA sequences in white and Ubx. EMBO J. 1987;6:1387-92 pubmed
    Three different segments of the zeste coding sequence were inserted in an expression vector and antibodies were raised against the resulting zeste-beta galactosidase hybrid proteins...
  14. Geyer P, Green M, Corces V. Tissue-specific transcriptional enhancers may act in trans on the gene located in the homologous chromosome: the molecular basis of transvection in Drosophila. EMBO J. 1990;9:2247-56 pubmed
  15. Casares F, Bender W, Merriam J, Sánchez Herrero E. Interactions of Drosophila Ultrabithorax regulatory regions with native and foreign promoters. Genetics. 1997;145:123-37 pubmed
    ..The deletion derivatives also stimulate transvection, a pairing-dependent interaction with the Ubx promoter on the homologous chromosome. ..
  16. Henikoff S, Henikoff J, Sakai A, Loeb G, Ahmad K. Genome-wide profiling of salt fractions maps physical properties of chromatin. Genome Res. 2009;19:460-9 pubmed publisher
    ..3 and correspond closely to profiles of histone H2Av (H2A.Z) and RNA polymerase II. This correspondence suggests that transcription can result in loss of H3...
  17. Muller M, Hagstrom K, Gyurkovics H, Pirrotta V, Schedl P. The mcp element from the Drosophila melanogaster bithorax complex mediates long-distance regulatory interactions. Genetics. 1999;153:1333-56 pubmed
    ..Finally, this pairing element can also mediate long-distance interactions between enhancers and promoters, activating mini-white expression. ..
  18. Pirrotta V, Steller H, Bozzetti M. Multiple upstream regulatory elements control the expression of the Drosophila white gene. EMBO J. 1985;4:3501-8 pubmed
    ..Another sequence located greater than 1080 bp upstream of the transcription start is the target of zeste interaction...
  19. Déjardin J, Cavalli G. Chromatin inheritance upon Zeste-mediated Brahma recruitment at a minimal cellular memory module. EMBO J. 2004;23:857-68 pubmed
    ..Within this CMM, DNA-binding sites for the Zeste protein are necessary for the inheritance of active chromatin through Zeste-dependent recruitment of BRM, while ..
  20. Qian S, Varjavand B, Pirrotta V. Molecular analysis of the zeste-white interaction reveals a promoter-proximal element essential for distant enhancer-promoter communication. Genetics. 1992;131:79-90 pubmed
    ..It also contains five binding sites for the zeste protein while the immediately adjacent testis element contains none...
  21. Mahmoudi T, Zuijderduijn L, Mohd Sarip A, Verrijzer C. GAGA facilitates binding of Pleiohomeotic to a chromatinized Polycomb response element. Nucleic Acids Res. 2003;31:4147-56 pubmed
    ..a high-resolution map of sites for the sequence- specific DNA-binding PcG protein PHO, trxG proteins GAGA and Zeste and the gap protein Hunchback (HB) on the 1.6 kb Ultrabithorax (Ubx) PRE...
  22. Pattatucci A, Kaufman T. The homeotic gene Sex combs reduced of Drosophila melanogaster is differentially regulated in the embryonic and imaginal stages of development. Genetics. 1991;129:443-61 pubmed
    ..extent of Scr expression is influenced by mutations at the Polycomb (Pc) locus but not by mutant alleles of the zeste (z) gene...
  23. Kaufman T, Tasaka S, Suzuki D. The interaction of two complex loci, zeste and bithorax in Drosophila melanogaster. Genetics. 1973;75:299-321 pubmed
    It has been found that certain alleles of the zeste locus (z(a) 1-1.0) have no phenotype of their own, but interact with certain alleles at the bithorax locus (bx 3-58.8)...
  24. Goldsborough A, Kornberg T. Reduction of transcription by homologue asynapsis in Drosophila imaginal discs. Nature. 1996;381:807-10 pubmed
    ..Our findings indicate a more complex level of trans regulation that may have implications for the aetiology of genetic disorders that are influenced by chromosome rearrangements. ..
  25. Walter J, Dever C, Biggin M. Two homeo domain proteins bind with similar specificity to a wide range of DNA sites in Drosophila embryos. Genes Dev. 1994;8:1678-92 pubmed
    ..In contrast, a non-homeo domain transcription factor, zeste, is only detected on short DNA elements within a target promoter and not on other genes...
  26. Goto T, Sato K, Sone H, Koganezawa M, Ito H, Yamamoto D. Zeste tunes the timing of ecdysone actions in triggering programmed tissue degeneration in Drosophila. J Neurogenet. 2015;29:169-73 pubmed publisher
    ..We found that knockdown of zeste (z), a gene encoding a sequence-specific DNA-binding protein implicated in transvection, in salivary gland cells ..
  27. Vogel E. Tests for recombinagens in somatic cells of Drosophila. Mutat Res. 1992;284:159-75 pubmed
  28. Rasmuson A, Larsson J. Somatic and germline mutagenesis assayed by the unstable zeste-white test in Drosophila melanogaster. Mutagenesis. 1992;7:219-23 pubmed
    This investigation is an attempt to compare mutation rates in germinal and somatic cells by the use of the unstable zeste-white assay in Drosophila melanogaster...
  29. Noor M, Kliman R. Variability on the dot chromosome in the Drosophila simulans clade. Genetica. 2003;118:51-8 pubmed
    ..Overall, none of the data analyzed were consistent with recent introgression exclusively between D. simulans and D. mauritiana...
  30. Micol J, Garcia Bellido A. Genetic analysis of "transvection" effects involving contrabithorax mutations in Drosophila melanogaster. Proc Natl Acad Sci U S A. 1988;85:1146-50 pubmed
    ..The genetic analysis of these transvection effects suggests that the transcription of the CbxIRM and Cbx2 alleles depends on RNAs of short radius of action from the homologous Ubx gene. ..
  31. Sorsa V, Green M, Beermann W. Cytogenetic fine structure and chromosomal localization of the white gene in Drosophila melanogaster. Nat New Biol. 1973;245:34-7 pubmed
  32. Kennison J. Transcriptional activation of Drosophila homeotic genes from distant regulatory elements. Trends Genet. 1993;9:75-9 pubmed
    ..Some of the trans-acting proteins may facilitate interactions between cis-regulatory elements and the promoter by bringing together distant chromosomal elements. ..
  33. Sollars V, Lu X, Xiao L, Wang X, Garfinkel M, Ruden D. Evidence for an epigenetic mechanism by which Hsp90 acts as a capacitor for morphological evolution. Nat Genet. 2003;33:70-4 pubmed
    ..These findings suggest that Hsp90 acts as a capacitor for morphological evolution through epigenetic and genetic mechanisms. ..
  34. Melnikova L, Kostyuchenko M, Georgiev P. Functional organization of the white gene enhancer in Drosophila melanogaster. Dokl Biochem Biophys. 2015;461:89-93 pubmed publisher
  35. Lespinet O, Wolf Y, Koonin E, Aravind L. The role of lineage-specific gene family expansion in the evolution of eukaryotes. Genome Res. 2002;12:1048-59 pubmed
    ..LSEs seem to be one of the principal means of adaptation and one of the most important sources of organizational and regulatory diversity in crown-group eukaryotes. ..
  36. Gemkow M, Verveer P, Arndt Jovin D. Homologous association of the Bithorax-Complex during embryogenesis: consequences for transvection in Drosophila melanogaster. Development. 1998;125:4541-52 pubmed
    ..We determined the effects of translocations and a zeste protein null mutation, both of which strongly diminish transvection phenotypes, on the extent of diploid homologue ..
  37. Tang C, Sun Y. Use of mini-white as a reporter gene to screen for GAL4 insertions with spatially restricted expression pattern in the developing eye in drosophila. Genesis. 2002;34:39-45 pubmed
  38. Fuse N, Matakatsu H, Taniguchi M, Hayashi S. Snail-type zinc finger proteins prevent neurogenesis in Scutoid and transgenic animals of Drosophila. Dev Genes Evol. 1999;209:573-80 pubmed
    ..We have also shown that the expressivity of Scutoid is enhanced by zeste mutations...
  39. Hauenschild A, Ringrose L, Altmutter C, Paro R, Rehmsmeier M. Evolutionary plasticity of polycomb/trithorax response elements in Drosophila species. PLoS Biol. 2008;6:e261 pubmed publisher
    ..By demonstrating that PRE evolution is not limited to the adaptation of preexisting elements, these findings document a novel dimension of cis-regulatory evolution. ..
  40. Bhadra U, Bhadra M, Birchler J. Interactions among dosage-dependent trans-acting modifiers of gene expression and position-effect variegation in Drosophila. Genetics. 1998;150:251-63 pubmed
    ..The highly multigenic nature of dosage-sensitive modulation of both gene expression and PEV suggests that dosage effects can be progressively transduced through a series of steps in a hierarchical manner...
  41. Eggert H, Bergemann K, Saumweber H. Molecular screening for P-element insertions in a large genomic region of Drosophila melanogaster using polymerase chain reaction mediated by the vectorette. Genetics. 1998;149:1427-34 pubmed
    ..We detected a single transposition to a 13-kb region close to the BJ1 gene among 6650 progeny that were analyzed. Southern analysis of the homozygous line confirmed the integration 3 kb downstream of BJ1. ..
  42. Zheng X, Mann R, Sever N, Beachy P. Genetic and biochemical definition of the Hedgehog receptor. Genes Dev. 2010;24:57-71 pubmed publisher
    ..On the basis of their joint roles in ligand binding, signal transduction, and receptor trafficking, we conclude that Ihog and Ptc together constitute the Drosophila Hh receptor. ..
  43. Fourel G, Lebrun E, Gilson E. Protosilencers as building blocks for heterochromatin. Bioessays. 2002;24:828-35 pubmed
    ..cerevisiae. It may also account for the silencing that occurs when multiple copies of a transgene are inserted in tandem. ..
  44. Tartof K, Henikoff S. Trans-sensing effects from Drosophila to humans. Cell. 1991;65:201-3 pubmed
  45. Laney J, Biggin M. zeste, a nonessential gene, potently activates Ultrabithorax transcription in the Drosophila embryo. Genes Dev. 1992;6:1531-41 pubmed
    The GAGA, NTF-1, and zeste proteins have been purified previously from Drosophila embryo extracts and shown to activate the Ultrabithorax (Ubx) promoter in vitro...
  46. Karess R, Rubin G. A small tandem duplication is responsible for the unstable white-ivory mutation in Drosophila. Cell. 1982;30:63-9 pubmed
  47. Birchler J, Bhadra U, Rabinow L, Linsk R, Nguyen Huynh A. Weakener of white (Wow), a gene that modifies the expression of the white eye color locus and that suppresses position effect variegation in Drosophila melanogaster. Genetics. 1994;137:1057-70 pubmed
    ..There are many dosage sensitive suppressors of position effect variegation and many dosage-sensitive modifiers of gene expression. The Wow mutations provide evidence for an overlap between the two types of modifiers...
  48. Arcos Teran L. [DNA replication and the nature of late replicating loci in the X-chromosome of Drosophila melanogaster]. Chromosoma. 1972;37:233-96 pubmed
  49. Gubb D, Ashburner M, Roote J, Davis T. A novel transvection phenomenon affecting the white gene of Drosophila melanogaster. Genetics. 1990;126:167-76 pubmed
    The zeste mutation of Drosophila melanogaster suppresses the expression of white genes in the eye...
  50. Williams J, Scott I, Atkin A, Brook W, Russell M, Bell J. Genetic and molecular analysis of vgU and vgW: two dominant vg alleles associated with gene fusions in Drosophila. Genetics. 1990;125:833-44 pubmed
    ..The results are consistent with a model in which inappropriate expression of inv causes the dominant homeotic effects seen in vgW. ..
  51. Zobacheva P, Kulliev A, Georgiev P, Mel nikova L. Interaction between zeste binding sites does not block isolated yellow enhancers in Drosophila melanogaster. Dokl Biochem Biophys. 2003;391:229-31 pubmed
  52. Benevolenskaya E, Frolov M, Birchler J. Krüppel homolog (Kr h) is a dosage-dependent modifier of gene expression in Drosophila. Genet Res. 2000;75:137-42 pubmed
    ..Genetic analysis of different white alleles suggests that enhancer sequences are necessary for interaction with KR H. Thus, the Kr h gene is a member of the dosage-dependent hierarchy effective upon white...
  53. Gubb D, Roote J, McGill S, Shelton M, Ashburner M. Interactions between WHITE Genes Carried by a Large Transposing Element and the ZESTE Allele in DROSOPHILA MELANOGASTER. Genetics. 1986;112:551-75 pubmed
    ..In consequence, z(1)w( 11E4); TE146(Z)/+ flies have a zeste (lemon-yellow) eye color. However, one in 10(3)TE146 chromosomes mutates to a red-eyed form...
  54. Montell I, Rasmuson A, Rasmuson B, Holmgren P. Uptake and incorporation in pteridines of externally supplied GTP in normal and pigment-deficient eyes of Drosophila melanogaster. Biochem Genet. 1992;30:61-75 pubmed
    ..We suggest that this is caused by a hampered transport of precursor (possibly GTP) in white and zeste eyes through the membrane of red pigment granules.
  55. Young M, Judd B. Nonessential Sequences, Genes, and the Polytene Chromosome Bands of DROSOPHILA MELANOGASTER. Genetics. 1978;88:723-42 pubmed
    ..Among this series of mutants, only four loci, zeste, white, roughest and verticals, have no known lethal alleles...
  56. Brunk B, Adler P. Aristapedioid: a gain of function, homeotic mutation in Drosophila melanogaster. Genetics. 1990;124:145-56 pubmed
    ..Aristapedioid is the result of a P element mediated inversion which juxtaposes unrelated DNA adjacent to Suppressor 2 of zeste, causing a gain of function mutation in that gene.
  57. Zimmering S, Osgood C, Mason J. Aneuploidy in Drosophila, I. Genetic test systems in the female Drosophila melanogaster for the rapid detection of chemically induced chromosome gain and chromosome loss. Mutat Res. 1990;234:319-26 pubmed
    ..is referred to as FIX, in which the female carried free (heterozygously) inverted X (chromosomes) and the other, ZESTE, where females do not carry inversions and the X-linked sexually dimorphic zeste mutation plays the key role in ..
  58. Wu C. Transvection, nuclear structure, and chromatin proteins. J Cell Biol. 1993;120:587-90 pubmed
  59. Lin H, Wolfner M. Cloning and analysis of fs(1) Ya, a maternal effect gene required for the initiation of Drosophila embryogenesis. Mol Gen Genet. 1989;215:257-65 pubmed
    ..The transcript is not detected in later stages of embryonic development. This expression pattern correlates closely with the genetic and developmental characteristics expected of the fs(1) Ya gene product. ..
  60. Batiste Alentorn M, Xamena N, Creus A, Marcos R. Genotoxicity testing of five compounds in three Drosophila short-term somatic assays. Mutat Res. 1995;341:161-7 pubmed
    ..mutation and/or recombination tests in Drosophila melanogaster, we have evaluated the response in 3 assays (zeste-white, white-ivory and wing spot) of 5 chemicals classified by the U.S...
  61. Hazelrigg T, Petersen S. An unusual genomic position effect on Drosophila white gene expression: pairing dependence, interactions with zeste, and molecular analysis of revertants. Genetics. 1992;130:125-38 pubmed
    ..X-ray mutagenesis led to the isolation of six revertants mapping to chromosome 2, which are wild type in a zeste+ background, and three extreme derivatives, in which white gene expression is repressed in ventral regions of the ..
  62. Pirrotta V. Transvection and long-distance gene regulation. Bioessays. 1990;12:409-14 pubmed
    ..These various examples of long-distance effects suggest that, in all cases, related forms of chromatin packaging may be involved. ..
  63. Thummel C. The Drosophila E74 promoter contains essential sequences downstream from the start site of transcription. Genes Dev. 1989;3:782-92 pubmed
    ..Two transcription factors that interact with the E74 promoter, zeste and GAGA, were studied in DNA-binding assays. zeste binds to two sites within the E74 promoter...
  64. Braunschweig U, Hogan G, Pagie L, van Steensel B. Histone H1 binding is inhibited by histone variant H3.3. EMBO J. 2009;28:3635-45 pubmed publisher
    ..These changes are independent of transcriptional changes. Our results show that the H3.3 protein counteracts association of H1, providing a mechanism to keep diverse genomic sites in an open chromatin conformation. ..
  65. Simonelig M, Elliott K, Mitchelson A, O Hare K. Interallelic complementation at the suppressor of forked locus of Drosophila reveals complementation between suppressor of forked proteins mutated in different regions. Genetics. 1996;142:1225-35 pubmed
    ..Our results suggest protein-protein interaction between or within wild-type Su(f) molecules. ..
  66. Osgood C, Cyr K. Induction by nitriles of sex chromosome aneuploidy: tests of mechanism. Mutat Res. 1998;403:149-57 pubmed
    ..The implications of these findings for structural alert based pre-screening of mutagens are discussed. ..
  67. Georgiev P, Corces V. The su(Hw) protein bound to gypsy sequences in one chromosome can repress enhancer-promoter interactions in the paired gene located in the other homolog. Proc Natl Acad Sci U S A. 1995;92:5184-8 pubmed
    ..These results indicate that, in the absence of mod-(mdg4) product, the su(Hw) protein present in one chromosome can act in trans and inactivate enhancers located in the other homolog. ..
  68. Georgiev P. Identification of mutations in three genes that interact with zeste in the control of white gene expression in Drosophila melanogaster. Genetics. 1994;138:733-9 pubmed
    Three previously described genes, enhancer of yellow, 1, 2 and 3, are shown to cooperate with the zeste gene in the control of white gene expression...
  69. Peterson K, Davis P, Judd B. The determined state of white expression in the Drosophila eye is modified by zeste1 in the wzm family of mutants. Mol Gen Genet. 1994;242:717-26 pubmed
    Analysis of the whitezeste mottled (wzm) mutant family suggests that the zeste gene product functions in establishing and stabilizing a transcriptionally active chromatin domain for white locus expression...
  70. Sun Y, Tsai C, Green M, Chao J, Yu C, Jaw T, et al. White as a reporter gene to detect transcriptional silencers specifying position-specific gene expression during Drosophila melanogaster eye development. Genetics. 1995;141:1075-86 pubmed
    ..teashirt is also implicated as a candidate gene. We propose that this "silencer trap"' may be an efficient way of identifying genes involved in imaginal pattern formation...
  71. Gisselbrecht S, Barrera L, Porsch M, Aboukhalil A, Estep P, Vedenko A, et al. Highly parallel assays of tissue-specific enhancers in whole Drosophila embryos. Nat Methods. 2013;10:774-80 pubmed publisher
    ..Application of eFS to other cell types and organisms should accelerate the cataloging of enhancers and understanding how transcriptional regulation is encoded in them. ..
  72. Krivega M, Krivega I, Golovnin A, Georgiev P. Study of the role of Zeste protein in distant inactivation of the white gene by the Pc-dependent repression complex. Dokl Biochem Biophys. 2008;421:227-30 pubmed
  73. Levis R, Hazelrigg T, Rubin G. Separable cis-acting control elements for expression of the white gene of Drosophila. EMBO J. 1985;4:3489-99 pubmed
    ..was expressed to give essentially wild-type pigmentation in all of these tissues and interacted in trans with the zeste-1 allele. In contrast, transformants having segments with 1...
  74. Schuettengruber B, Ganapathi M, Leblanc B, Portoso M, Jaschek R, Tolhuis B, et al. Functional anatomy of polycomb and trithorax chromatin landscapes in Drosophila embryos. PLoS Biol. 2009;7:e13 pubmed publisher
    ..Furthermore, several DNA sequence features discriminate between PcG- and TRX-N-bound regions, indicating that underlying DNA sequence contains critical information to drive PREs and TREs towards silencing or activation. ..
  75. Pirrotta V, Bickel S, Mariani C. Developmental expression of the Drosophila zeste gene and localization of zeste protein on polytene chromosomes. Genes Dev. 1988;2:1839-50 pubmed
    The expression of the zeste gene varies through the life cycle of the fly. Its transcription is most abundant in maternal RNA, declines to very low levels during larval growth, but rises again in late third instar larvae and pupae...
  76. Stocker R, Gendre N, Batterham P. Analysis of the antennal phenotype in the Drosophila mutant lozenge. J Neurogenet. 1993;9:29-53 pubmed
  77. Carrington E, Jones R. The Drosophila Enhancer of zeste gene encodes a chromosomal protein: examination of wild-type and mutant protein distribution. Development. 1996;122:4073-83 pubmed
    The Drosophila Enhancer of zeste [E(z)] gene is a member of the Polycomb-group and, as such, is involved in maintaining the transcriptional repression of the homeotic genes of the Antennapedia (ANT-C) and bithorax (BX-C) complexes...
  78. Muller J, Hart C, Francis N, Vargas M, Sengupta A, Wild B, et al. Histone methyltransferase activity of a Drosophila Polycomb group repressor complex. Cell. 2002;111:197-208 pubmed
    ..The Extra Sex Combs (ESC) and Enhancer of Zeste [E(Z)] proteins are partners in an essential PcG complex, but its full composition and biochemical activities are ..