Gene Symbol: Yp1
Description: Yolk protein 1
Alias: CG2985, DmYP1, Dmel\CG2985, GH19966p, VG1, VIT1Dm, YP-1, YP1, YPI, YP[[1]], fs(1)1163, fs(1)A1163, yp-1, yp1, yolk protein 1, CG2985-PA, CG2985-PB, Yok protein 1, Yp1-PA, Yp1-PB, vitellogenin, yolk protein, yolk protein I, yolk-protein 1
Species: fruit fly

Top Publications

  1. Shopland L, Hirayoshi K, Fernandes M, Lis J. HSF access to heat shock elements in vivo depends critically on promoter architecture defined by GAGA factor, TFIID, and RNA polymerase II binding sites. Genes Dev. 1995;9:2756-69 pubmed
    ..We propose that a complex promoter architecture is established by multiple interdependent factors, including GAGA factor, TFIID, and RNA polymerase II, and that this structure is critical for HSF binding in vivo. ..
  2. Compagnon J, Gervais L, Roman M, Chamot Boeuf S, Guichet A. Interplay between Rab5 and PtdIns(4,5)P2 controls early endocytosis in the Drosophila germline. J Cell Sci. 2009;122:25-35 pubmed publisher
    ..Hence, our results argue strongly in favor of the hypothesis that the Rab5-dependant release of PtdIns(4,5)P(2) from endosomes that we discovered in this study is crucial for endocytosis to proceed. ..
  3. Sommer B, Oprins A, Rabouille C, Munro S. The exocyst component Sec5 is present on endocytic vesicles in the oocyte of Drosophila melanogaster. J Cell Biol. 2005;169:953-63 pubmed
    ..In oocytes, the major substrate for clathrin-dependent endocytosis is the vitellogenin receptor Yolkless...
  4. Bownes M. The regulation of the yolk protein genes, a family of sex differentiation genes in Drosophila melanogaster. Bioessays. 1994;16:745-52 pubmed
    ..pathway and the downstream sex differentiation genes, namely the regulation of the female-specific yolk protein genes...
  5. Bownes M, Hurd H, Büsgen T, Servay D, Alvis S, Popovic B, et al. Drosophila yolk protein produced in E. coli is accumulated by mosquito ovaries. Insect Mol Biol. 2002;11:487-96 pubmed
    ..We cloned the Drosophila yp1 gene into an E. coli expression vector and showed that the yolk protein produced by E...
  6. Vanzo N, Oprins A, Xanthakis D, Ephrussi A, Rabouille C. Stimulation of endocytosis and actin dynamics by Oskar polarizes the Drosophila oocyte. Dev Cell. 2007;12:543-55 pubmed
    ..We propose that Oskar maintains its localization at the posterior pole through dual functions in regulating endocytosis and F-actin dynamics. ..
  7. Flatt T, Tu M, Tatar M. Hormonal pleiotropy and the juvenile hormone regulation of Drosophila development and life history. Bioessays. 2005;27:999-1010 pubmed
    ..In particular, we illustrate the role of JH as a key mediator of life history trade-offs. ..
  8. Richard D, Rybczynski R, Wilson T, Wang Y, Wayne M, Zhou Y, et al. Insulin signaling is necessary for vitellogenesis in Drosophila melanogaster independent of the roles of juvenile hormone and ecdysteroids: female sterility of the chico1 insulin signaling mutation is autonomous to the ovary. J Insect Physiol. 2005;51:455-64 pubmed
    ..The ovary transplant experiments corroborate the endocrine results and demonstrate that insulin/insulin-like signaling (IIS) is necessary for vitellogenesis even when sufficient levels of JH, ecdysteroids or other factors are present. ..
  9. Bownes M. Hormonal and genetic regulation of vitellogenesis in Drosophila. Q Rev Biol. 1982;57:247-74 pubmed

More Information


  1. Sanchez L, Guerrero I. The development of the Drosophila genital disc. Bioessays. 2001;23:698-707 pubmed
    ..This input acts by modulating the response to Hedgehog, Wingless, and Decapentaplegic morphogenetic signals. ..
  2. Kpebe A, Rabinow L. Dissection of darkener of apricot kinase isoform functions in Drosophila. Genetics. 2008;179:1973-87 pubmed publisher
    ..Maternal effects in which the survival of heteroallelic adults depends upon the direction of the cross are consistent with a role for a 105-kDa cytoplasmic kinase in oogenesis or early larval development. ..
  3. Baker M. Is vitellogenin an ancestor of apolipoprotein B-100 of human low-density lipoprotein and human lipoprotein lipase?. Biochem J. 1988;255:1057-60 pubmed
    Vitellogenin, an ancient animal protein, is the major yolk protein of eggs, where it is used as a food source during embryogenesis...
  4. Bownes M, Lineruth K, Mauchline D. Egg production and fertility in Drosophila depend upon the number of yolk-protein gene copies. Mol Gen Genet. 1991;228:324-7 pubmed
    ..furthermore that the probability of an egg hatching into an adult also critically depends upon the number of yolk protein genes present in the mother...
  5. Maside X, Charlesworth B. Patterns of molecular variation and evolution in Drosophila americana and its relatives. Genetics. 2007;176:2293-305 pubmed
    ..americana and D. virilis. We also find that base composition at neutral sites appears to be in overall equilibrium among these species, but there is evidence for departure from equilibrium for codon usage in some lineages. ..
  6. Butterworth F, Bownes M, Burde V. Genetically modified yolk proteins precipitate in the adult Drosophila fat body. J Cell Biol. 1991;112:727-37 pubmed
    ..and genetic studies were carried out on the fat body of a female sterile mutant fs(1)1163 to ascertain why yolk protein 1 (YP1) is not secreted from this tissue...
  7. Yang Y, Graze R, Walts B, Lopez C, Baker H, Wayne M, et al. Partitioning transcript variation in Drosophila: abundance, isoforms, and alleles. G3 (Bethesda). 2011;1:427-36 pubmed publisher
    ..melanogaster and in closely related species. The SNP module can be used for allele specific expression and genotyping of D. simulans. ..
  8. Chung Y, Kwon H, Chung K, Kim S, Kim K, Lee C. Identification of ovarian enhancer-binding factors which bind to ovarian enhancer 1 of the Drosophila genes yp1 and yp2. Mol Gen Genet. 1996;251:347-51 pubmed
    ..different DNA regions-the fat body enhancer and ovarian enhancers 1 and 2-direct the tissue-specific expression of yp1 and yp2 in Drosophila melanogaster...
  9. Andersen D, Horne Badovinac S. Influence of ovarian muscle contraction and oocyte growth on egg chamber elongation in Drosophila. Development. 2016;143:1375-87 pubmed publisher
    ..These findings highlight how physical contributions from several cell types are integrated to shape an organ. ..
  10. Postlethwait J, Jowett T. Genetic analysis of the hormonally regulated yolk polypeptide genes in D. melanogaster. Cell. 1980;20:671-8 pubmed
    ..These variants are expressed codominantly and they are sex-linked: Yp1 and Yp2 map to region 8E to 9B1 (locus 30) and Yp3 is in 12A6-7 to 12D3 (locus 44)...
  11. Abrahamsen N, Martinez A, Kjaer T, Søndergaard L, Bownes M. Cis-regulatory sequences leading to female-specific expression of yolk protein genes 1 and 2 in the fat body of Drosophila melanogaster. Mol Gen Genet. 1993;237:41-8 pubmed
    The three yolk protein genes (yp) of Drosophila melanogaster are transcribed in a sex- and tissue-limited fashion...
  12. Coschigano K, Wensink P. Sex-specific transcriptional regulation by the male and female doublesex proteins of Drosophila. Genes Dev. 1993;7:42-54 pubmed
    ..pathway, bind to three sites within a 127-bp enhancer that directs sex- and tissue-specific transcription of Yolk protein genes...
  13. Yamamoto R, Bai H, Dolezal A, Amdam G, Tatar M. Juvenile hormone regulation of Drosophila aging. BMC Biol. 2013;11:85 pubmed publisher
    ..yolked eggs, and this may arise because juvenile hormone is required for the post-eclosion development of the vitellogenin-producing adult fat body...
  14. Warren T, Brennan M, Mahowald A. Two processing steps in maturation of vitellogenin polypeptides in Drosophila melanogaster. Proc Natl Acad Sci U S A. 1979;76:2848-52 pubmed
    Synthesis of the three vitellogenin polypeptides (molecular weights of 44,000, 45,000, and 46,000) of Drosophila melanogaster has been analyzed in vivo and in a cell-free system...
  15. Burtis K, Coschigano K, Baker B, Wensink P. The doublesex proteins of Drosophila melanogaster bind directly to a sex-specific yolk protein gene enhancer. EMBO J. 1991;10:2577-82 pubmed
    ..DNA sequences located in an enhancer region that regulates female-specific expression of two target genes, the yolk protein genes 1 and 2...
  16. De Loof A, Geysen J, Cardoen J, Verachtert B. Comparative developmental physiology and molecular cytology of the polytrophic ovarian follicles of the blowfly Sarcophaga bullata and the fruitfly Drosophila melanogaster. Comp Biochem Physiol A Comp Physiol. 1990;96:309-21 pubmed
    ..6. Most of the vitellogenin is synthesized by the fat body but some follicle cells also synthesize small amounts. 7...
  17. Pebusque M, Coulier F, Birnbaum D, Pontarotti P. Ancient large-scale genome duplications: phylogenetic and linkage analyses shed light on chordate genome evolution. Mol Biol Evol. 1998;15:1145-59 pubmed
    ..Linkage of some of these genes can be found in the Drosophila melanogaster and Caenorhabditis elegans genomes, suggesting that they were linked in the triploblast Metazoa ancestor. ..
  18. Abel T, Bhatt R, Maniatis T. A Drosophila CREB/ATF transcriptional activator binds to both fat body- and liver-specific regulatory elements. Genes Dev. 1992;6:466-80 pubmed
    ..a Drosophila transcription factor that binds to fat body-specific enhancers of alcohol dehydrogenase (Adh) and yolk protein genes...
  19. Falb D, Maniatis T. Drosophila transcriptional repressor protein that binds specifically to negative control elements in fat body enhancers. Mol Cell Biol. 1992;12:4093-103 pubmed
    ..The AEF-1 protein contains four zinc fingers and an alanine-rich sequence. The latter motif is found in other eukaryotic proteins known to be transcriptional repressors. ..
  20. Sharma A, Singh P. Detection of transgenerational spermatogenic inheritance of adult male acquired CNS gene expression characteristics using a Drosophila systems model. PLoS ONE. 2009;4:e5763 pubmed publisher
    ..The finding that adult acquired transcriptomic alteration in soma is spermatogenically inherited across generations has potential implications in human health and evolution. ..
  21. Logan S, Wensink P. Ovarian follicle cell enhancers from the Drosophila yolk protein genes: different segments of one enhancer have different cell-type specificities that interact to give normal expression. Genes Dev. 1990;4:613-23 pubmed
    This paper examines ovarian transcription of the divergently oriented yolk protein genes 1 and 2 (yp1 and yp2) of Drosophila melanogaster...
  22. Rasmussen E, Lis J. Short transcripts of the ternary complex provide insight into RNA polymerase II elongational pausing. J Mol Biol. 1995;252:522-35 pubmed
    ..genes (Gapdh-1 and Gapdh-2), where paused polymerases were thought to be present, plus two other genes (Mtn and yp1), where polymerase pausing has not been detected in the past...
  23. Wieschaus E, Audit C, Masson M. A clonal analysis of the roles of somatic cells and germ line during oogenesis in Drosophila. Dev Biol. 1981;88:92-103 pubmed
  24. Carlson K, Harshman L. Extended longevity lines of Drosophila melanogaster: abundance of yolk protein gene mRNA in fat body and ovary. Exp Gerontol. 1999;34:173-84 pubmed
    ..b>Yolk protein is one of the most abundant proteins used for female reproduction...
  25. Giorgi F, Lucchesi P, Morelli A, Bownes M. Ultrastructural analysis of Drosophila ovarian follicles differing in yolk polypeptide (yps) composition. Development. 1993;117:319-28 pubmed
  26. Hovemann B, Galler R. Vitellogenin in Drosophila melanogaster: a comparison of the YPI and YPII genes and their transcription products. Nucleic Acids Res. 1982;10:2261-74 pubmed
    Clones of genes coding for two of the yolk protein precursors from Drosophila melanogaster, YPI and YPII have been isolated. A single small intron was located in the YPII coding region at about the same position as it is found in YPI (6)...
  27. Søndergaard L, Mauchline D, Egetoft P, White N, Wulff P, Bownes M. Nutritional response in a Drosophila yolk protein gene promoter. Mol Gen Genet. 1995;248:25-32 pubmed
    The yolk protein genes (yps) of Drosophila melanogaster are only expressed in the ovary and fat body of female flies if they are supplied with proteinaceous food. This nutritional response is specific to the yp genes...
  28. Yan Y, Postlethwait J. Vitellogenesis in Drosophila: sequestration of a yolk polypeptide/invertase fusion protein into developing oocytes. Dev Biol. 1990;140:281-90 pubmed
    ..into developing oocytes of Drosophila was investigated by following the fate of a reporter protein fused to a vitellogenin, or yolk polypeptide (YP)...
  29. Bownes M, Dempster M, Blair M. Expression of the yolk-protein genes in the mutant doublesex dominant (dsxD) of Drosophila melanogaster. J Embryol Exp Morphol. 1983;75:241-57 pubmed
    ..We suggest that the dsxD locus regulates the expression of the yolk-protein genes from within the fat body cells and does not operate by modulating ecdysteroid titres in the adults. ..
  30. Tarone A, Nasser Y, Nuzhdin S. Genetic variation for expression of the sex determination pathway genes in Drosophila melanogaster. Genet Res. 2005;86:31-40 pubmed
  31. Papassideri I, Trougakos I, Leonard K, Margaritis L. Crystalline yolk spheroids in Drosophila melanogaster oocyte: freeze fracture and two-dimensional reconstruction analysis. J Insect Physiol. 2007;53:370-6 pubmed
  32. Williams J, Bownes M. Reduced stability of RNA coding for yolk polypeptide 3 in Drosophila melanogaster ovary. Eur J Biochem. 1986;161:95-101 pubmed
    ..level of YP3 RNA is significantly reduced in the ovary in comparison with the fat body, and that none of the yolk protein genes is amplified either in the fat body or the follicle cells...
  33. Markaki M, Craig R, Savakis C. Insect population control using female specific pro-drug activation. Insect Biochem Mol Biol. 2004;34:131-7 pubmed
  34. Baker D, Russell S. Gene expression during Drosophila melanogaster egg development before and after reproductive diapause. BMC Genomics. 2009;10:242 pubmed publisher
    ..We believe that our dataset will facilitate further exploration of the developmental and evolutionary characteristics of oogenesis as well as the nature of reproductive arrest in Drosophila. ..
  35. Garabedian M, Shirras A, Bownes M, Wensink P. The nucleotide sequence of the gene coding for Drosophila melanogaster yolk protein 3. Gene. 1987;55:1-8 pubmed
    ..to extensive homology between the protein coding regions, we found two small regions of homology between yp3 flanking sequences and a segment of DNA required for normal expression of the yolk protein 1 gene in adult female fat bodies.
  36. An W, Wensink P. Integrating sex- and tissue-specific regulation within a single Drosophila enhancer. Genes Dev. 1995;9:256-66 pubmed
    ..A single copy of the o-r enhancer from yolk protein genes directs female- and fat body-specific transcription...
  37. Baeuerle P, Lottspeich F, Huttner W. Purification of yolk protein 2 of Drosophila melanogaster and identification of its site of tyrosine sulfation. J Biol Chem. 1988;263:14925-9 pubmed
    ..Yolk proteins were purified from [35S]sulfate-labeled flies, and yolk protein 2 was separated from yolk protein 1 and yolk protein 3 by preparative two-dimensional polyacrylamide gel electrophoresis...
  38. Rina M, Savakis C. A cluster of vitellogenin genes in the Mediterranean fruit fly Ceratitis capitata: sequence and structural conservation in dipteran yolk proteins and their genes. Genetics. 1991;127:769-80 pubmed
    ..The transcribed part is very similar to that of the Drosophila melanogaster yolk protein genes Yp1, Yp2 and Yp3. The Vg1 genes have two introns at the same positions as those in D...
  39. Eissenberg J, Elgin S. Boundary functions in the control of gene expression. Trends Genet. 1991;7:335-40 pubmed
    ..These studies will lead to an analysis of boundary structure, and in addition will provide clues to the mechanism(s) of gene regulation by higher order chromatin packaging. ..
  40. Mitsis P, Wensink P. Identification of yolk protein factor 1, a sequence-specific DNA-binding protein from Drosophila melanogaster. J Biol Chem. 1989;264:5188-94 pubmed
    ..DNA-binding protein, yolk protein factor 1 (YPF1), that has high affinity for a 31-bp sequence in the yolk protein 1 gene...
  41. Martinez A, Bownes M. The specificity of yolk protein uptake in cyclorrhaphan diptera is conserved through evolution. J Mol Evol. 1992;35:444-53 pubmed
  42. Haussmann I, Hemani Y, Wijesekera T, Dauwalder B, Soller M. Multiple pathways mediate the sex-peptide-regulated switch in female Drosophila reproductive behaviours. Proc Biol Sci. 2013;280:20131938 pubmed publisher
    ..Hence, the SP-induced postmating switch incorporates shared, but also distinct circuitry of fruitless, doublesex and pickpocket neurons and additional receptors. ..
  43. Belote J, Handler A, Wolfner M, Livak K, Baker B. Sex-specific regulation of yolk protein gene expression in Drosophila. Cell. 1985;40:339-48 pubmed
    ..These results provide a paradigm for the way this regulatory hierarchy controls the terminal differentiation functions for sexually dimorphic development. ..
  44. Deshpande G, Calhoun G, Schedl P. The N-terminal domain of Sxl protein disrupts Sxl autoregulation in females and promotes female-specific splicing of tra in males. Development. 1999;126:2841-53 pubmed
    ..This novel activity is discussed in light of the blockage model for the tra splicing regulation. ..
  45. Kellum R, Schedl P. A group of scs elements function as domain boundaries in an enhancer-blocking assay. Mol Cell Biol. 1992;12:2424-31 pubmed
    ..In the experiments reported here, we have used the yolk protein-1 enhancer element and an hsp70 promoter:lacZ fusion gene to test putative boundary DNA segments for enhancer-..
  46. Lee T, Huang S, Lee C, Lee H, Chan H, Lin K, et al. Proteome reference map of Drosophila melanogaster head. Proteomics. 2012;12:1875-8 pubmed publisher
    ..melanogaster model. In summary, the fundamental head proteomic database and bioinformatic analysis will be useful for further elucidating the biological mechanisms such as memory formation and neurodegenerative diseases. ..
  47. Garabedian M, Shepherd B, Wensink P. A tissue-specific transcription enhancer from the Drosophila yolk protein 1 gene. Cell. 1986;45:859-67 pubmed
    The yolk protein 1 gene (yp1) of Drosophila melanogaster is expressed only in the ovarian follicle cells and the fat bodies of adult females...
  48. Logan S, Garabedian M, Wensink P. DNA regions that regulate the ovarian transcriptional specificity of Drosophila yolk protein genes. Genes Dev. 1989;3:1453-61 pubmed
    b>Yolk protein genes 1 and 2 (yp1 and yp2) of Drosophila melanogaster are divergently transcribed neighboring genes. Both are transcribed in only two tissues, the ovarian follicle cells and the fat bodies of adult females...
  49. Toxopeus J, Jakobs R, Ferguson L, Gariépy T, Sinclair B. Reproductive arrest and stress resistance in winter-acclimated Drosophila suzukii. J Insect Physiol. 2016;89:37-51 pubmed publisher
    ..The traits of this 'winter morph', however, likely facilitate overwintering in southern Canada, and have probably contributed to the global success of this fly as an invasive species...
  50. Jubeaux G, Audouard Combe F, Simon R, Tutundjian R, Salvador A, Geffard O, et al. Vitellogenin-like proteins among invertebrate species diversity: potential of proteomic mass spectrometry for biomarker development. Environ Sci Technol. 2012;46:6315-23 pubmed publisher
    ..We assessed the potential of absolute quantification of proteins using mass spectrometry to develop vitellogenin (Vg)-like protein assays for invertebrates...
  51. Kubli E. Sex-peptides: seminal peptides of the Drosophila male. Cell Mol Life Sci. 2003;60:1689-704 pubmed publisher
    ..Sps bind to sperm. Together with sperm they are responsible for the persistence of the two post-mating responses. But Sps are the molecular basis of the sperm effect; sperm is merely the carrier...
  52. Hediger M, Burghardt G, Siegenthaler C, Buser N, Hilfiker Kleiner D, Dübendorfer A, et al. Sex determination in Drosophila melanogaster and Musca domestica converges at the level of the terminal regulator doublesex. Dev Genes Evol. 2004;214:29-42 pubmed
    ..MdDSX(F) expression can activate the vitellogenin genes in Drosophila and Musca males, and MdDSX(M) expression in Drosophila females can cause male-like ..
  53. Shirras A, Bownes M. Separate DNA sequences are required for normal female and ecdysone-induced male expression of Drosophila melanogaster yolk protein 1. Mol Gen Genet. 1987;210:153-5 pubmed
    ..flies show a stage, tissue and sex-specific pattern of alcohol dehydrogenase (ADH) activity characteristic of yolk protein genes...
  54. Hung M, Wensink P. The sequence of the Drosophila melanogaster gene for yolk protein 1. Nucleic Acids Res. 1981;9:6407-19 pubmed
    We have determined the complete nucleotide sequence of the hormonally regulated yolk protein 1 (YP1) gene of Drosophila melanogaster...
  55. Jacoby D, Wensink P. DNA binding specificities of YPF1, a Drosophila homolog to the DNA binding subunit of human DNA-dependent protein kinase, Ku. J Biol Chem. 1996;271:16827-32 pubmed
    ..The strong binding of YPF1 has also allowed us to detect underlying binding specificities that may be specific to YPF1 and its function. ..
  56. Gelti Douka H, Gingeras T, Kambysellis M. Yolk proteins in Drosophila: identification and site of synthesis. J Exp Zool. 1974;187:167-72 pubmed
  57. Kraus K, Lee Y, Lis J, Wolfner M. Sex-specific control of Drosophila melanogaster yolk protein 1 gene expression is limited to transcription. Mol Cell Biol. 1988;8:4756-64 pubmed
    ..For one of the best-characterized target genes, that encoding female-specific yolk protein 1 (YP1), sex-specific transcriptional controls have been clearly demonstrated...
  58. Sury M, Chen J, Selbach M. The SILAC fly allows for accurate protein quantification in vivo. Mol Cell Proteomics. 2010;9:2173-83 pubmed publisher
    ..The approach is simple, fast, and cost-effective, making SILAC flies an attractive model system for the emerging field of in vivo quantitative proteomics. ..
  59. Majewska M, Suszczynska A, Kotwica Rolinska J, Czerwik T, Paterczyk B, Polanska M, et al. Yolk proteins in the male reproductive system of the fruit fly Drosophila melanogaster: spatial and temporal patterns of expression. Insect Biochem Mol Biol. 2014;47:23-35 pubmed publisher
    ..Sequencing of peptides derived from this spot by mass spectrometry revealed identity with three yolk proteins (YP1-3)...
  60. Trougakos I, Papassideri I, Waring G, Margaritis L. Differential sorting of constitutively co-secreted proteins in the ovarian follicle cells of Drosophila. Eur J Cell Biol. 2001;80:271-84 pubmed
    ..These findings illuminate new details concerning the follicle cells secretory and oocyte endocytic pathways and provide for the first time evidence for condensation-mediated sorting of constitutively secreted proteins in Drosophila...
  61. Maside X, Lee A, Charlesworth B. Selection on codon usage in Drosophila americana. Curr Biol. 2004;14:150-4 pubmed
    ..americana lineage are in approximate equilibrium. Biased gene conversion may also contribute to the observed patterns. ..
  62. Aprison B, Osterbur D, Bonner J. Use of promoter fusions in Drosophila genetics: characterization of a YP1-ADH fusion gene. Dev Genet. 1989;10:24-32 pubmed
    In Drosophila melanogaster the yolk protein (YP) genes are normally expressed only in the fat body and follicular epithelium of adult females--never in males or in larvae...
  63. Walker V. Yolk polypeptide gene expression in Minute Drosophila females. Biochem Genet. 1985;23:363-78 pubmed
    ..These results suggest that the low protein levels are due to the slower maturation of M(3)w, and not to less efficient translation machinery. ..
  64. Bownes M, Hames B. Genetic analysis of vitellogenesis in Drosophila melanogaster: the identification of a temperature-sensitive mutation affecting one of the yolk proteins. J Embryol Exp Morphol. 1978;47:111-20 pubmed
    ..Two new mutants were identified. 6m45 accumulates all three yolk proteins (YP1, YP2 and YP3) in the haemolymph but they are all absent from the ovaries suggesting it is a yolk-protein-uptake ..
  65. Udvardy A. Dividing the empire: boundary chromatin elements delimit the territory of enhancers. EMBO J. 1999;18:1-8 pubmed
  66. Yan Y, Kunert C, Postlethwait J. Sequence homologies among the three yolk polypeptide (Yp) genes in Drosophila melanogaster. Nucleic Acids Res. 1987;15:67-85 pubmed
    ..sequenced a 4278 bp DNA fragment containing the Yp3 gene, compared Yp3 region sequences to corresponding parts of Yp1 and Yp2, and compared the predicted amino acid sequence of YP3 to YP1 and YP2...
  67. Hutson S, Bownes M. The regulation of yp3 expression in the Drosophila melanogaster fat body. Dev Genes Evol. 2003;213:1-8 pubmed
    The regulation of the Drosophila melanogaster yolk protein genes 1 and 2 have been well characterised. Cis-acting DNA elements and trans-acting factors regulating ovarian fat body and sex-specific expression have been identified...
  68. Søndergaard L. Homology between the mammalian liver and the Drosophila fat body. Trends Genet. 1993;9:193 pubmed
  69. Carney G, Bender M. The Drosophila ecdysone receptor (EcR) gene is required maternally for normal oogenesis. Genetics. 2000;154:1203-11 pubmed
    ..Our results demonstrate a requirement for EcR during female reproduction and suggest that EcR is required for normal oogenesis. ..
  70. Christiansen A, Keisman E, Ahmad S, Baker B. Sex comes in from the cold: the integration of sex and pattern. Trends Genet. 2002;18:510-6 pubmed
  71. Nakahara K, Kim K, Sciulli C, Dowd S, Minden J, Carthew R. Targets of microRNA regulation in the Drosophila oocyte proteome. Proc Natl Acad Sci U S A. 2005;102:12023-8 pubmed
    ..The preponderance of genes that control global protein abundance suggests this process is under tight control by miRNAs at the onset of fertilization. ..
  72. Jacoby D, Wensink P. Yolk protein factor 1 is a Drosophila homolog of Ku, the DNA-binding subunit of a DNA-dependent protein kinase from humans. J Biol Chem. 1994;269:11484-91 pubmed
    b>Yolk protein factor 1 (YPF1) is a heterodimeric DNA-binding protein from Drosophila melanogaster...
  73. Lim D, Oh C, Lee L, Hong J, Noh S, Hwang S, et al. The endogenous siRNA pathway in Drosophila impacts stress resistance and lifespan by regulating metabolic homeostasis. FEBS Lett. 2011;585:3079-85 pubmed publisher
    ..Furthermore, loss of dcr-2 function led to abnormal lipid and carbohydrate metabolism. Our results suggest roles for the endo-siRNA pathway in metabolic regulation and defense against stress and aging in Drosophila. ..
  74. Hens K, Feuz J, Isakova A, Iagovitina A, Massouras A, Bryois J, et al. Automated protein-DNA interaction screening of Drosophila regulatory elements. Nat Methods. 2011;8:1065-70 pubmed publisher
    ..Finally, we biologically validated several interactions and identified two new regulators of sine oculis gene expression and hence eye development. ..
  75. Arbeitman M, New F, Fear J, Howard T, Dalton J, Graze R. Sex Differences in Drosophila Somatic Gene Expression: Variation and Regulation by doublesex. G3 (Bethesda). 2016;6:1799-808 pubmed publisher
    ..These results provide insights into a more complete pool of potential DSX targets, as well as revealing the molecular flexibility of DSX regulation. ..
  76. Herren J, Paredes J, Schüpfer F, Lemaitre B. Vertical transmission of a Drosophila endosymbiont via cooption of the yolk transport and internalization machinery. MBio. 2013;4: pubmed publisher
    ..The uptake of yolk is a female germ line-specific feature and therefore an attractive target for cooption by endosymbionts that need to maintain high-fidelity maternal transmission. ..
  77. Hung M, Barnett T, Woolford C, Wensink P. Transcript maps of Drosophila yolk protein genes. J Mol Biol. 1982;154:581-602 pubmed
  78. Sirot L, Findlay G, Sitnik J, Frasheri D, Avila F, Wolfner M. Molecular characterization and evolution of a gene family encoding both female- and male-specific reproductive proteins in Drosophila. Mol Biol Evol. 2014;31:1554-67 pubmed publisher
    ..After duplication and male co-option of one paralog, the evolution of the interacting proteins could have resulted in differential strengths or effects of each paralog. ..
  79. Shopland L, Lis J. HSF recruitment and loss at most Drosophila heat shock loci is coordinated and depends on proximal promoter sequences. Chromosoma. 1996;105:158-71 pubmed
    ..Finally, the distribution of the heat shock protein HSP70 is examined for its role in regulating the attenuated response of HSF to heat shock. ..
  80. Duncker B, Davies P, Walker V. Introns boost transgene expression in Drosophila melanogaster. Mol Gen Genet. 1997;254:291-6 pubmed
    ..When the deleted intron was replaced by a 70 bp intervening sequence originating from the yolk protein 1 gene, mRNA accumulation was restored to its original level...
  81. Peng J, Zipperlen P, Kubli E. Drosophila sex-peptide stimulates female innate immune system after mating via the Toll and Imd pathways. Curr Biol. 2005;15:1690-4 pubmed
    ..Mating may physically damage females and pathogens may be transferred. Thus, endogenous stimulation of AMP transcription by SP at mating might be considered as a preventive step to encounter putative immunogenic attacks. ..
  82. Brennan M, Warren T, Mahowald A. Signal peptides and signal peptidase in Drosophila melanogaster. J Cell Biol. 1980;87:516-20 pubmed
    ..when this RNA is translated in the presence of EDTA-stripped microsomal membranes from the dog pancreas, vitellogenin precursors are produced that, upon SDS-polyacrylamide gel electrophoresis, comigrate with the in vivo forms (..
  83. Butterworth F, Burde V, Bownes M. Mutant yolk proteins lead to female sterility in Drosophila. Dev Biol. 1992;154:182-94 pubmed
    Specific mutations in the yolk protein genes, yp1 and yp2, of Drosophila melanogaster cause the yolk proteins (YPs) they encode to precipitate, ultimately resulting in female sterility...
  84. Sun S, Cline T. Effects of Wolbachia infection and ovarian tumor mutations on Sex-lethal germline functioning in Drosophila. Genetics. 2009;181:1291-301 pubmed publisher
    ..b>Yolk protein gene transcript levels were most affected, being reduced by infection, but no genes showed significantly more ..
  85. Falb D, Maniatis T. A conserved regulatory unit implicated in tissue-specific gene expression in Drosophila and man. Genes Dev. 1992;6:454-65 pubmed
    ..In addition, AEF-1 prevents C/EBP binding in vitro, and displaces prebound C/EBP. Thus, a tissue-specific regulatory unit consisting of one positive and one negative regulatory element has been conserved between Drosophila and man. ..
  86. Bownes M, Nothiger R. Sex determining genes and vitellogenin synthesis in Drosophila melanogaster. Mol Gen Genet. 1981;182:222-8 pubmed
    This study investigates the relationship between sexual phenotype and ability to synthesize vitellogenin (yolk proteins, YPs) in Drosophila...
  87. An W, Wensink P. Three protein binding sites form an enhancer that regulates sex- and fat body-specific transcription of Drosophila yolk protein genes. EMBO J. 1995;14:1221-30 pubmed
    Transcription of the Drosophila yolk protein (Yp) genes is regulated by the somatic sex determination pathway...
  88. Liu G, Sanghavi P, Bollinger K, Perry L, Marshall B, Roon P, et al. Efficient Endocytic Uptake and Maturation in Drosophila Oocytes Requires Dynamitin/p50. Genetics. 2015;201:631-49 pubmed publisher
    ..Our results suggest a model whereby endocytic activity recruits Dynein to the oocyte cortex. The motor along with its regulators, Dynactin and Lis1, functions to ensure efficient endocytic uptake and maturation. ..