yki

Summary

Gene Symbol: yki
Description: yorkie
Alias: CG4005, Dmel\CG4005, YAP, YKI, Yki, yap, CG4005 gene product from transcript CG4005-RG, CG4005-PD, CG4005-PF, CG4005-PG, yki-PD, yki-PF, yki-PG, yorki
Species: fruit fly

Top Publications

  1. pmc In vivo regulation of Yorkie phosphorylation and localization
    Hyangyee Oh
    Howard Hughes Medical Institute, Waksman Institute, Department of Molecular Biology and Biochemistry, Rutgers The State University of New Jersey, Piscataway, NJ 08854, USA
    Development 135:1081-8. 2008
  2. pmc Transcription factor choice in the Hippo signaling pathway: homothorax and yorkie regulation of the microRNA bantam in the progenitor domain of the Drosophila eye imaginal disc
    H Wayne Peng
    Department of Biochemistry and Molecular Biophysics, Columbia University Medical Center, New York, New York 10032, USA
    Genes Dev 23:2307-19. 2009
  3. doi The FERM-domain protein Expanded regulates Hippo pathway activity via direct interactions with the transcriptional activator Yorkie
    Caroline Badouel
    Samuel Lunenfeld Research Institute, Mt Sinai Hospital, Toronto, ON M5G 1X5, Canada
    Dev Cell 16:411-20. 2009
  4. ncbi The tumor-suppressor gene fat controls tissue growth upstream of expanded in the hippo signaling pathway
    Elizabeth Silva
    Samuel Lunenfeld Research Institute and Department of Medical Genetics and Microbiology, University of Toronto, Toronto M5G 1X5, Canada
    Curr Biol 16:2081-9. 2006
  5. pmc The Hippo pathway regulates intestinal stem cell proliferation during Drosophila adult midgut regeneration
    Rachael L Shaw
    Apoptosis and Proliferation Control Laboratory, Cancer Research UK, London Research Institute, 44 Lincoln s Inn Fields, London, WC2A 3LY, UK
    Development 137:4147-58. 2010
  6. pmc Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control
    Bin Zhao
    Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, USA
    Genes Dev 21:2747-61. 2007
  7. ncbi The fat cadherin acts through the hippo tumor-suppressor pathway to regulate tissue size
    Maria Willecke
    Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Curr Biol 16:2090-100. 2006
  8. pmc Morphogen control of wing growth through the Fat signaling pathway
    Dragana Rogulja
    Howard Hughes Medical Institute, Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Dev Cell 15:309-21. 2008
  9. pmc Warts is required for PI3K-regulated growth arrest, autophagy, and autophagic cell death in Drosophila
    Sudeshna Dutta
    Molecular and Cell Biology Program, University of Maryland, College Park, Maryland 20742, USA
    Curr Biol 18:1466-75. 2008
  10. pmc Functional interactions between the erupted/tsg101 growth suppressor gene and the DaPKC and rbf1 genes in Drosophila imaginal disc tumors
    M Melissa Gilbert
    Department of Cell Biology, Emory University School of Medicine, Atlanta, Georgia, United States of America
    PLoS ONE 4:e7039. 2009

Research Grants

  1. Cell Cycle and Development
    BRUCE EDGAR; Fiscal Year: 2004
  2. Growth-regulatory targets of Drosophila Cyclin D/Cdk4
    BRUCE EDGAR; Fiscal Year: 2007

Scientific Experts

  • ISWAR HARIHARAN
  • Patrick Laprise
  • Peter A Lawrence
  • Bertrand Mollereau
  • Marc Amoyel
  • Jacob D Kagey
  • Phillip Karpowicz
  • Hugo Stocker
  • M Melissa Gilbert
  • D Grifoni
  • BRUCE EDGAR
  • Kenneth D Irvine
  • Georg Halder
  • Hyangyee Oh
  • Cedric Polesello
  • Kieran F Harvey
  • Chunyao Tao
  • Duojia Pan
  • Zhi Chun Lai
  • Bin Zhao
  • Nicolas Tapon
  • Xiaomeng Zhang
  • Jin Jiang
  • Chiao Lin Chen
  • Fangfang Ren
  • Jianzhong Yu
  • Brian S Robinson
  • B V V G Reddy
  • Leticia Sansores-Garcia
  • Lei Zhang
  • Brandon N Nicolay
  • Alice Genevet
  • Cordelia Rauskolb
  • Barry J Thompson
  • Fisun Hamaratoglu
  • Takeshi Shimizu
  • Jixin Dong
  • Xiaomu Wei
  • Shian Wu
  • Felix A Grusche
  • Ingrid Poernbacher
  • Tao Yue
  • Catarina Bras-Pereira
  • Tianyi Zhang
  • Roland Baumgartner
  • Yonggang Zheng
  • Li Lun Ho
  • Luis Alberto Baena-Lopez
  • Clayton M Morrison
  • Helen McNeill
  • Kun Liang Guan
  • Jianbin Huang
  • Clara M Sidor
  • D Denton
  • Arnau Sebé-Pedrós
  • Yunyun Jin
  • Joanna Chen
  • Raghavendra Nagaraj
  • Hillary K Graves
  • Katrin Straßburger
  • Ruth Brain
  • Francesca Pignoni
  • Gongping Sun
  • Julian C Boggiano
  • X Zhang
  • Florence Janody
  • M Willecke
  • Carole L C Poon
  • Abigail R Gerhold
  • Beatriz García Fernández
  • Kenneth H Moberg
  • Wouter Bossuyt
  • Richard G Fehon
  • Helena E Richardson
  • Matthew Slattery
  • Myriam Zecca
  • Nicola A Grzeschik
  • Xiaolan Fang
  • Marcello Ziosi
  • Chad A Hall
  • Xaralabos Varelas
  • Lorena B Benseñor
  • Meghna Das Thakur
  • Carolyn K Beam
  • Rachael L Shaw
  • Binnaz Kucuk Staley
  • Ricardo M Neto-Silva
  • Javier Menendez
  • Maxim V Frolov
  • Caroline Badouel

Detail Information

Publications95

  1. pmc In vivo regulation of Yorkie phosphorylation and localization
    Hyangyee Oh
    Howard Hughes Medical Institute, Waksman Institute, Department of Molecular Biology and Biochemistry, Rutgers The State University of New Jersey, Piscataway, NJ 08854, USA
    Development 135:1081-8. 2008
    Yorkie (Yki), a transcription factor of the Fat and Hippo signaling pathways, is negatively regulated by the Warts kinase...
  2. pmc Transcription factor choice in the Hippo signaling pathway: homothorax and yorkie regulation of the microRNA bantam in the progenitor domain of the Drosophila eye imaginal disc
    H Wayne Peng
    Department of Biochemistry and Molecular Biophysics, Columbia University Medical Center, New York, New York 10032, USA
    Genes Dev 23:2307-19. 2009
    ..both of these parameters by controlling the nuclear availability of the transcriptional coactivator Yorkie (Yki), which regulates downstream target genes together with Scalloped (Sd), a DNA-binding protein...
  3. doi The FERM-domain protein Expanded regulates Hippo pathway activity via direct interactions with the transcriptional activator Yorkie
    Caroline Badouel
    Samuel Lunenfeld Research Institute, Mt Sinai Hospital, Toronto, ON M5G 1X5, Canada
    Dev Cell 16:411-20. 2009
    ..activates the NDR family kinase Warts/Lats, which phosphorylates and inhibits the transcriptional activator Yorkie/YAP. Current models place the FERM-domain protein Expanded upstream of Hippo kinase in growth control...
  4. ncbi The tumor-suppressor gene fat controls tissue growth upstream of expanded in the hippo signaling pathway
    Elizabeth Silva
    Samuel Lunenfeld Research Institute and Department of Medical Genetics and Microbiology, University of Toronto, Toronto M5G 1X5, Canada
    Curr Biol 16:2081-9. 2006
    ..The cytoskeletal proteins Merlin and Expanded colocalize at apical junctions and function redundantly upstream of Hippo. It is not clear how they regulate growth or how they are localized to apical junctions...
  5. pmc The Hippo pathway regulates intestinal stem cell proliferation during Drosophila adult midgut regeneration
    Rachael L Shaw
    Apoptosis and Proliferation Control Laboratory, Cancer Research UK, London Research Institute, 44 Lincoln s Inn Fields, London, WC2A 3LY, UK
    Development 137:4147-58. 2010
    ..In addition, Yki, the pro-growth transcription factor target of the Hpo pathway, is required in ISCs to drive the proliferative ..
  6. pmc Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control
    Bin Zhao
    Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, USA
    Genes Dev 21:2747-61. 2007
    ..Here we show that in mammalian cells, the transcription coactivator YAP (Yes-associated protein), is inhibited by cell density via the Hippo pathway...
  7. ncbi The fat cadherin acts through the hippo tumor-suppressor pathway to regulate tissue size
    Maria Willecke
    Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Curr Biol 16:2090-100. 2006
    ..However, components acting upstream of Expanded and Merlin, such as transmembrane receptors, have not yet been identified...
  8. pmc Morphogen control of wing growth through the Fat signaling pathway
    Dragana Rogulja
    Howard Hughes Medical Institute, Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Dev Cell 15:309-21. 2008
    ..These observations identify Fat as a signaling pathway that links the morphogen-mediated establishment of gradients of positional values across developing organs to the regulation of organ growth...
  9. pmc Warts is required for PI3K-regulated growth arrest, autophagy, and autophagic cell death in Drosophila
    Sudeshna Dutta
    Molecular and Cell Biology Program, University of Maryland, College Park, Maryland 20742, USA
    Curr Biol 18:1466-75. 2008
    ..Although the Warts (Wts) tumor suppressor is a critical regulator of tissue growth in animals, it is not clear how this signaling pathway controls cell growth...
  10. pmc Functional interactions between the erupted/tsg101 growth suppressor gene and the DaPKC and rbf1 genes in Drosophila imaginal disc tumors
    M Melissa Gilbert
    Department of Cell Biology, Emory University School of Medicine, Atlanta, Georgia, United States of America
    PLoS ONE 4:e7039. 2009
    ..Excess cell division is postulated to be a primary cause of these 'neoplastic' phenotypes, but the autonomous effect of these mutations on cell cycle control has not been examined...
  11. doi Transcriptional output of the Salvador/warts/hippo pathway is controlled in distinct fashions in Drosophila melanogaster and mammalian cell lines
    Xiaomeng Zhang
    Cell Growth and Proliferation Laboratory and Cell Cycle and Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
    Cancer Res 69:6033-41. 2009
    ..regulates tissue growth by restricting the activity of the transcriptional coactivator protein known as Yorkie (Yki) in Drosophila melanogaster and Yes-associated protein (YAP) in mammals...
  12. pmc The hippo pathway promotes Notch signaling in regulation of cell differentiation, proliferation, and oocyte polarity
    Jianzhong Yu
    Department of Biological Science, Florida State University, Tallahassee, Florida, United States of America
    PLoS ONE 3:e1761. 2008
    ....
  13. ncbi Dmp53 activates the Hippo pathway to promote cell death in response to DNA damage
    Julien Colombani
    Apoptosis and Proliferation Control Laboratory, Cancer Research UK, London Research Institute
    Curr Biol 16:1453-8. 2006
    ..a tumor suppressor (Mats), the cytoskeletal proteins Expanded and Merlin, and the transcriptional cofactor Yorkie (Yki) . This pathway has been shown to restrict cell division and promote apoptosis...
  14. pmc The tumor suppressor genes dachsous and fat modulate different signalling pathways by regulating dally and dally-like
    Luis Alberto Baena-Lopez
    Developmental Neurobiology, National Institute of Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, United Kingdom
    Proc Natl Acad Sci U S A 105:9645-50. 2008
    ....
  15. pmc Mob as tumor suppressor is activated by Hippo kinase for growth inhibition in Drosophila
    Xiaomu Wei
    Intercollege Graduate Program in Genetics, The Pennsylvania State University, University Park, PA 16802, USA
    EMBO J 26:1772-81. 2007
    ..protein kinase and ability to upregulate Wts catalytic activity to target downstream molecules such as Yorkie (Yki). Consistently, our epistatic analysis suggests that mats acts downstream of hpo...
  16. pmc Evidence for a growth-stabilizing regulatory feedback mechanism between Myc and Yorkie, the Drosophila homolog of Yap
    Ricardo M Neto-Silva
    Gulbenkian PhD Program in Biomedicine, P 2780 156 Oeiras, Portugal
    Dev Cell 19:507-20. 2010
    ..We find that Yorkie (Yki), the Drosophila homolog of the Hippo pathway transducer, Yap, regulates the transcription of Myc, and that Myc ..
  17. pmc Hippo pathway effector Yap is an ovarian cancer oncogene
    Chad A Hall
    Department of Molecular and Human Genetics, Dan L Duncan Cancer Center, Baylor College of Medicine, Houston, Texas 77030, USA
    Cancer Res 70:8517-25. 2010
    ..Here we show that the key targets of Hippo signaling, transcriptional coactivators Yki and Yap, play a conserved role in promoting ovarian cancer in flies and humans, respectively...
  18. pmc Warts and Yorkie mediate intestinal regeneration by influencing stem cell proliferation
    Binnaz Kucuk Staley
    Howard Hughes Medical Institute, Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Curr Biol 20:1580-7. 2010
    ..Our observations uncover a role for Hippo pathway components in regulating stem cell proliferation and intestinal regeneration...
  19. pmc dMyc functions downstream of Yorkie to promote the supercompetitive behavior of hippo pathway mutant cells
    Marcello Ziosi
    Dipartimento di Patologia Sperimentale, Alma Mater Studiorum, Bologna, Italy
    PLoS Genet 6:e1001140. 2010
    ..hyperplastic disease from flies to humans by restricting the activity of the transcriptional cofactor Yorkie (yki)...
  20. pmc The apical-basal cell polarity determinant Crumbs regulates Hippo signaling in Drosophila
    Chiao Lin Chen
    Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, Houston, 77030, USA
    Proc Natl Acad Sci U S A 107:15810-5. 2010
    ..Taken together, our data show that Crb regulates growth through Hippo signaling, and thus identify Crb as a previously undescribed upstream input into the Hippo pathway...
  21. pmc The Hippo tumor suppressor pathway regulates intestinal stem cell regeneration
    Phillip Karpowicz
    Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Development 137:4135-45. 2010
    ..Here, we show that the Hippo pathway target, Yorkie (Yki), also plays a crucial and cell-autonomous role in ISCs...
  22. pmc A tumor-suppressing mechanism in Drosophila involving cell competition and the Hippo pathway
    Javier Menendez
    Centro de Biologia Molecular, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, Madrid 28049, Spain
    Proc Natl Acad Sci U S A 107:14651-6. 2010
    ..The formation of a tumor requires in addition the formation of a microenvironment that allows mutant cells to evade cell competition...
  23. pmc A feed-forward circuit linking wingless, fat-dachsous signaling, and the warts-hippo pathway to Drosophila wing growth
    Myriam Zecca
    Howard Hughes Medical Institute, Columbia University College of Physicians and Surgeons, New York, New York, USA
    PLoS Biol 8:e1000386. 2010
    ..tumor suppressor pathway, and the transcriptional co-activator Yorkie (Yki, a YES associated protein, or YAP) as components of the feed-forward signaling mechanism, and we show how this mechanism promotes wing growth in ..
  24. pmc Notch signaling activates Yorkie non-cell autonomously in Drosophila
    Hillary K Graves
    Department of Biochemistry and Molecular Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
    PLoS ONE 7:e37615. 2012
    ..Our data identify a novel mechanism by which Notch promotes cell survival non-cell autonomously and by which neoplastic tumor cells generate a supportive microenvironment for tumor growth...
  25. doi The Hippo pathway regulates Wnt/beta-catenin signaling
    Xaralabos Varelas
    Center for Systems Biology, Mount Sinai Hospital, 600 University Avenue, Toronto, ON M5G 1X5, Canada
    Dev Cell 18:579-91. 2010
    ..These results uncover a cytoplasmic function of TAZ in regulating Wnt signaling and highlight the role of the Hippo pathway in coordinating morphogenetic signaling with growth control...
  26. pmc Regulation of Yorkie activity in Drosophila imaginal discs by the Hedgehog receptor gene patched
    Jacob D Kagey
    Department of Biology, University of Detroit Mercy, Detroit, MI, USA
    Mech Dev 129:339-49. 2012
    ..p-Mad functions with the Hippo pathway oncoprotein Yorkie (Yki) to induce expression of the pro-growth/anti-apoptotic microRNA bantam...
  27. pmc Ajuba LIM proteins are negative regulators of the Hippo signaling pathway
    Meghna Das Thakur
    Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Curr Biol 20:657-62. 2010
    ..This phenocopies tissues deficient for Yorkie (Yki), the downstream target of the Hippo pathway...
  28. ncbi The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP
    Jianbin Huang
    Department of Physiology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA
    Cell 122:421-34. 2005
    ..Here we identify Yorkie (Yki), the Drosophila ortholog of the mammalian transcriptional coactivator yes-associated protein (YAP), as a missing ..
  29. doi Actin-Capping Protein and the Hippo pathway regulate F-actin and tissue growth in Drosophila
    Beatriz García Fernández
    Instituto Gulbenkian de Ciencia, Rua da Quinta Grande 6, P 2780 156 Oeiras, Portugal
    Development 138:2337-46. 2011
    ..Taken together, these findings indicate a novel interplay between Hippo pathway activity and actin filament dynamics that is essential for normal growth control...
  30. doi Drosophila Pez acts in Hippo signaling to restrict intestinal stem cell proliferation
    Ingrid Poernbacher
    Institute of Molecular Systems Biology, ETH Zurich, Wolfgang Pauli Strasse 16, 8093 Zurich, Switzerland
    Curr Biol 22:389-96. 2012
    ..requires deactivation of the Hippo pathway and consequential activation of the transcriptional coactivator Yorkie (Yki) in both ECs and ISCs...
  31. pmc The cell adhesion molecule echinoid functions as a tumor suppressor and upstream regulator of the Hippo signaling pathway
    Tao Yue
    Department of Developmental Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
    Dev Cell 22:255-67. 2012
    ..of the Hpo/Warts (Wts) kinase cassette that phosphorylates and inactivates the transcriptional coactivator Yorkie (Yki)...
  32. pmc Tumor suppression by cell competition through regulation of the Hippo pathway
    Chiao Lin Chen
    Department of Biochemistry and Molecular Biology and Program in Genes and Development, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 109:484-9. 2012
    ..When all cells in imaginal discs are mutant for scrib, they hyperactivate the Hippo pathway effector Yorkie (Yki), which drives growth of the discs into large neoplastic masses...
  33. doi The sterile 20-like kinase Tao-1 controls tissue growth by regulating the Salvador-Warts-Hippo pathway
    Carole L C Poon
    Cell Growth and Proliferation Laboratory, Peter MacCallum Cancer Centre, 7 St Andrews Place, East Melbourne, Victoria 3002, Australia
    Dev Cell 21:896-906. 2011
    ..SWH pathway activity is evolutionarily conserved because human TAO1 can suppress activity of the Yorkie ortholog, YAP. Human TAO1 controls SWH pathway activity by phosphorylating, and activating, the Hippo ortholog, MST2...
  34. pmc Tao-1 phosphorylates Hippo/MST kinases to regulate the Hippo-Salvador-Warts tumor suppressor pathway
    Julian C Boggiano
    Department of Molecular Genetics and Cell Biology, The University of Chicago, Chicago, IL 60637, USA
    Dev Cell 21:888-95. 2011
    ..These results demonstrate that one family of Ste20 kinases can activate another and identify Tao-1 as a component of the regulatory network controlling HSW pathway signaling, and therefore tissue growth, during development...
  35. pmc Regulation of Drosophila glial cell proliferation by Merlin-Hippo signaling
    B V V G Reddy
    Howard Hughes Medical Institute, Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers The State University of New Jersey, Piscataway, NJ 08854, USA
    Development 138:5201-12. 2011
    ..Moreover, as several of the genes we studied have been linked to human gliomas, our results suggest that this linkage could reflect their organization into a conserved pathway for the control of glial cell proliferation...
  36. pmc Zyxin links fat signaling to the hippo pathway
    Cordelia Rauskolb
    Howard Hughes Medical Institute, Waksman Institute, and Department of Molecular Biology and Biochemistry, Rutgers, The State University of New Jersey, Piscataway, New Jersey, United States of America
    PLoS Biol 9:e1000624. 2011
    ..Our identification of Zyx as a regulator of Hippo signaling thus also raises the possibility that mechanical strain could be linked to the regulation of gene expression and growth through Hippo signaling...
  37. pmc Modulating F-actin organization induces organ growth by affecting the Hippo pathway
    Leticia Sansores-Garcia
    Department of Biochemistry and Molecular Biology, University of Texas, MD Anderson Cancer Center, Houston, TX, USA
    EMBO J 30:2325-35. 2011
    ..between F-actin and Hpo signalling is evolutionarily conserved, as the activity of the mammalian Yorkie-orthologue Yap is modulated by changes in F-actin...
  38. pmc Hippo signaling regulates Drosophila intestine stem cell proliferation through multiple pathways
    Fangfang Ren
    Department of Developmental Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 107:21064-9. 2010
    ..Finally, we show that the Hpo pathway mediator Yorkie (Yki) is also required in precursor cells for injury-induced ISC proliferation in response to tissue-damaging reagent DSS...
  39. doi Loss of PI3K blocks cell-cycle progression in a Drosophila tumor model
    M Willecke
    Institute of Molecular Life Sciences, University of Zurich, Switzerland
    Oncogene 30:4067-74. 2011
    ..The results presented here broaden our insights into the intricate mechanisms underling tumorigenesis and illustrate the power of Drosophila genetics in revealing weak points of tumor progression...
  40. pmc Cooperation between dE2F1 and Yki/Sd defines a distinct transcriptional program necessary to bypass cell cycle exit
    Brandon N Nicolay
    Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, Illinois 60607, USA
    Genes Dev 25:323-35. 2011
    ..The transcriptional coactivator Yorkie (Yki) mediates transcriptional output of the Hippo signaling...
  41. pmc Wbp2 cooperates with Yorkie to drive tissue growth downstream of the Salvador-Warts-Hippo pathway
    X Zhang
    Cell Growth and Proliferation Laboratory, Peter MacCallum Cancer Centre, 7 St Andrews Place, East Melbourne, Victoria 3002, Australia
    Cell Death Differ 18:1346-55. 2011
    ..Collectively, these studies define an important role for Wbp2 as a downstream component of the SWH tissue growth-control pathway...
  42. pmc Cooperative regulation of growth by Yorkie and Mad through bantam
    Hyangyee Oh
    Howard Hughes Medical Institute, Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, NJ 08854, USA
    Dev Cell 20:109-22. 2011
    ..Our results indicate that in promoting the growth of Drosophila tissues, Fat-Hippo and Dpp signaling contribute distinct subunits of a shared transcriptional activation complex, Yorkie:Mad...
  43. doi Insulin/IGF signaling drives cell proliferation in part via Yorkie/YAP
    Katrin Straßburger
    German Cancer Research Center, DKFZ, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    Dev Biol 367:187-96. 2012
    ..The Hippo signaling pathway regulates cell proliferation via the transcriptional co-activator Yorkie/YAP, however the signaling inputs regulating Hippo activity are not fully elucidated...
  44. pmc Regulation of Hippo signaling by Jun kinase signaling during compensatory cell proliferation and regeneration, and in neoplastic tumors
    Gongping Sun
    Howard Hughes Medical Institute, Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Dev Biol 350:139-51. 2011
    ..Our observations identify Jnk signaling as a modulator of Hippo pathway activity in wing imaginal discs, and implicate Yorkie activation in compensatory cell proliferation and disc regeneration...
  45. doi The Salvador/Warts/Hippo pathway controls regenerative tissue growth in Drosophila melanogaster
    Felix A Grusche
    Cell Growth and Proliferation Laboratory, Peter MacCallum Cancer Centre, St Andrews Place, East Melbourne, Victoria, Australia
    Dev Biol 350:255-66. 2011
    ....
  46. pmc YAP-dependent induction of amphiregulin identifies a non-cell-autonomous component of the Hippo pathway
    Jianmin Zhang
    Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA
    Nat Cell Biol 11:1444-50. 2009
    ..The pivotal effector of this pathway is YAP (yes-associated protein), a transcriptional co-activator amplified in mouse and human cancers, where it promotes ..
  47. pmc The Drosophila RASSF homolog antagonizes the hippo pathway
    Cedric Polesello
    Apoptosis and Proliferation Control Laboratory, Cancer Research UK, London Institute, 44 Lincoln s Inn Fields, London, United Kingdom
    Curr Biol 16:2459-65. 2006
    ..Hpo and Warts (Wts), the scaffold proteins Salvador (Sav) and Mats, and the transcriptional coactivator Yorkie (Yki). It has been proposed that Ex and Mer act upstream of Hpo, which in turn phosphorylates and activates Wts...
  48. doi SCALLOPED interacts with YORKIE, the nuclear effector of the hippo tumor-suppressor pathway in Drosophila
    Youlian Goulev
    Department of Developmental Biology, Unite Mixte de Recherche 7592, Universite Paris 7 Denis Diderot, Tour 43 2, place Jussieu, F 75251 Paris Cedex 05, France
    Curr Biol 18:435-41. 2008
    ..Recently, YORKIE (YKI) was identified as a transcriptional coactivator that is the downstream effector of the Hippo signaling pathway, ..
  49. doi The TEAD/TEF family protein Scalloped mediates transcriptional output of the Hippo growth-regulatory pathway
    Shian Wu
    Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Dev Cell 14:388-98. 2008
    The Hippo (Hpo) kinase cascade restricts tissue growth by inactivating the transcriptional coactivator Yorkie (Yki), which regulates the expression of target genes such as the cell death inhibitor diap1 by unknown mechanisms...
  50. pmc The TEAD/TEF family of transcription factor Scalloped mediates Hippo signaling in organ size control
    Lei Zhang
    Department of Developmental Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Dev Cell 14:377-87. 2008
    ..evidence that the TEAD/TEF family transcription factor Scalloped (Sd) acts together with the coactivator Yorkie (Yki) to regulate Hpo pathway-responsive genes...
  51. doi The WW domain protein Kibra acts upstream of Hippo in Drosophila
    Roland Baumgartner
    Institute of Molecular Systems Biology, ETH Zurich, Wolfgang Pauli Strasse 16, 8093 Zurich, Switzerland
    Dev Cell 18:309-16. 2010
    ..Kibra acts synergistically with Expanded, and it physically interacts with Merlin. Thus, Kibra predominantly acts in the Merlin branch upstream of the core kinase cascade to regulate Hippo signaling...
  52. ncbi Genes of Hippo signaling network act unconventionally in the control of germline proliferation in Drosophila
    Shuguo Sun
    Key Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, P R China
    Dev Dyn 237:270-5. 2008
    ..Furthermore, we demonstrate that expanded functions nonautonomously to regulate spermatogonial proliferation. It appears that expanded acts from the somatic support cells surrounding the germline to restrict spermatogonial amplification...
  53. ncbi Salvador-warts-hippo signaling promotes Drosophila posterior follicle cell maturation downstream of notch
    Cedric Polesello
    Apoptosis and Proliferation Control Laboratory, Cancer Research UK, London Research Institute, 44 Lincoln s Inn Fields, London WC2 3PX, United Kingdom
    Curr Biol 17:1864-70. 2007
    ..Hpo) and Warts (Wts), the scaffold proteins Salvador (Sav) and Mats, and the transcriptional coactivator Yorkie (Yki) [1]. Two band 4...
  54. pmc The salvador-warts-hippo pathway is required for epithelial proliferation and axis specification in Drosophila
    Carine Meignin
    Wellcome Trust Centre for Cell Biology, Kings Buildings, University of Edinburgh, Edinburgh EH9 3JR, United Kingdom
    Curr Biol 17:1871-8. 2007
    ..This work highlights a novel connection between cell proliferation, cell growth, and axis specification in egg chambers...
  55. pmc Elucidation of a universal size-control mechanism in Drosophila and mammals
    Jixin Dong
    Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cell 130:1120-33. 2007
    ..We further delineate a mammalian Hippo signaling pathway that culminates in the phosphorylation of YAP, the mammalian homolog of Yki...
  56. pmc Control of mitochondrial structure and function by the Yorkie/YAP oncogenic pathway
    Raghavendra Nagaraj
    Department of Molecular, Cell, and Developmental Biology, Broad Stem Cell Research Center, University of California at Los Angeles, Los Angeles, California 90095, USA
    Genes Dev 26:2027-37. 2012
    ..Here, we show that the conserved Yorkie/YAP signaling pathway implicated in the control of organ size also functions in the regulation of mitochondria in ..
  57. ncbi Growth regulation: a beginning for the hippo pathway
    Iswar K Hariharan
    Department of Molecular and Cell Biology, 361 LSA, University of California Berkeley, Berkeley, California 94720, USA
    Curr Biol 16:R1037-9. 2006
    ..A signaling pathway involving two protein kinases, Hippo and Warts, restricts the growth of imaginal discs in Drosophila. Four recent studies taken together show that the protocadherin Fat can regulate Warts in two different ways...
  58. ncbi Fat cadherin modulates organ size in Drosophila via the Salvador/Warts/Hippo signaling pathway
    F Christian Bennett
    Cell Growth and Proliferation Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia
    Curr Biol 16:2101-10. 2006
    ..A newly emerging signaling pathway that controls organ size during development is the Salvador/Warts/Hippo pathway...
  59. ncbi Delineation of a Fat tumor suppressor pathway
    Eunjoo Cho
    Howard Hughes Medical Institute and Department of Molecular Biology and Biochemistry, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA
    Nat Genet 38:1142-50. 2006
    ..melanogaster tumor suppressors, establish a basic framework for Fat signaling from receptor to transcription factor and implicate Warts as an integrator of multiple growth control signals...
  60. ncbi The bantam microRNA is a target of the hippo tumor-suppressor pathway
    Riitta Nolo
    Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Curr Biol 16:1895-904. 2006
    ..However, how Yorkie regulates growth, and thus the identities of downstream target genes that mediate the effects of Hippo signaling, are largely unknown...
  61. ncbi The Hippo pathway regulates the bantam microRNA to control cell proliferation and apoptosis in Drosophila
    Barry J Thompson
    European Molecular Biology Laboratory, Meyerhofstrasse 1, Heidelberg 69117, Germany
    Cell 126:767-74. 2006
    ..In summary, the results show that the Hippo pathway regulates expression of bantam to control tissue growth in Drosophila...
  62. ncbi From cell structure to transcription: Hippo forges a new path
    Bruce A Edgar
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle WA 98109, USA
    Cell 124:267-73. 2006
    ..This conserved signaling pathway contains several tumor-suppressor genes and regulates the contact inhibition of proliferation in cultured cells...
  63. doi Mask proteins are cofactors of Yorkie/YAP in the Hippo pathway
    Clara M Sidor
    Cancer Research UK, London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3LY, UK
    Curr Biol 23:223-8. 2013
    The Hippo signaling pathway acts via the Yorkie (Yki)/Yes-associated protein (YAP) transcriptional coactivator family to control tissue growth in both Drosophila and mammals [1-3]...
  64. pmc Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF-beta pathways
    Claudio Alarcon
    Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Cell 139:757-69. 2009
    ..phosphorylations promote Smad transcriptional action, which in the case of Smad1 is mediated by the recruitment of YAP to the phosphorylated linker sites...
  65. pmc Kibra is a regulator of the Salvador/Warts/Hippo signaling network
    Alice Genevet
    Apoptosis and Proliferation Control Laboratory, Cancer Research UK, London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Dev Cell 18:300-8. 2010
    ..consists of a MST and LATS family kinase cascade that ultimately phosphorylates and inactivates the YAP/Yorkie (Yki) transcription coactivator...
  66. pmc Kibra functions as a tumor suppressor protein that regulates Hippo signaling in conjunction with Merlin and Expanded
    Jianzhong Yu
    Department of Biological Science, Florida State University, Tallahassee, FL 32306, USA
    Dev Cell 18:288-99. 2010
    ..Salvador (Sav), phosphorylates and activates Warts (Wts), which in turn phosphorylates and inactivates the Yorkie (Yki) oncoprotein, known as the YAP coactivator in mammalian cells...
  67. pmc TEAD mediates YAP-dependent gene induction and growth control
    Bin Zhao
    Department of Pharmacology and Moores Cancer Center, University of California at San Diego, La Jolla, California 92093, USA
    Genes Dev 22:1962-71. 2008
    ..Moreover, the functional relationship between YAP and TEAD is conserved in Drosophila Yki (the YAP homolog) and Scalloped (the TEAD homolog)...
  68. doi Mob as tumor suppressor is activated at the cell membrane to control tissue growth and organ size in Drosophila
    Li Lun Ho
    Intercollege Graduate Degree Program in Cell and Developmental Biology, The Pennsylvania State University, University Park, PA 16802, USA
    Dev Biol 337:274-83. 2010
    ..with the idea that Mats is a key component of the Hpo pathway, Mats is required and sufficient to regulate Yki nuclear localization...
  69. pmc Hippo signaling regulates Yorkie nuclear localization and activity through 14-3-3 dependent and independent mechanisms
    Fangfang Ren
    Department of Developmental Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Dev Biol 337:303-12. 2010
    ..gene expression by inhibiting a transcription complex consisting of the transcriptional coactivator Yorkie (Yki) and the TEAD/TEF family of transcription factor Scalloped (Sd)...
  70. doi Homeodomain-interacting protein kinase regulates Yorkie activity to promote tissue growth
    Joanna Chen
    Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada
    Curr Biol 22:1582-6. 2012
    ..of the pathway, Hpo, Salvador, Warts (Wts), and Mats, form a kinase cascade to inhibit the activity of Yorkie (Yki), the transcriptional effector of the pathway...
  71. pmc Phosphorylation-independent repression of Yorkie in Fat-Hippo signaling
    Hyangyee Oh
    Howard Hughes Medical Institute, Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, NJ 08854, USA
    Dev Biol 335:188-97. 2009
    ....
  72. pmc The Hippo pathway regulates apical-domain size independently of its growth-control function
    Alice Genevet
    Apoptosis and Proliferation Control Laboratory, Cancer Research UK, London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    J Cell Sci 122:2360-70. 2009
    ..Therefore, Hippo signalling controls growth and apical domain size by distinct mechanisms...
  73. pmc The Hippo tumor-suppressor pathway regulates apical-domain size in parallel to tissue growth
    Fisun Hamaratoglu
    Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA
    J Cell Sci 122:2351-9. 2009
    ..kinase cascade that culminates in the regulation of gene expression through the transcriptional coactivator Yorkie (Yki)...
  74. pmc In vivo analysis of Yorkie phosphorylation sites
    H Oh
    Department of Molecular Biology and Biochemistry, Waksman Institute, Howard Hughes Medical Institute, Rutgers The State University of New Jersey, Piscataway, NJ 8854, USA
    Oncogene 28:1916-27. 2009
    The co-activator Yorkie (Yki) mediates transcriptional regulation effected by the Drosophila Fat-Warts (Wts)-Hippo (Hpo) pathways...
  75. doi Both TEAD-binding and WW domains are required for the growth stimulation and oncogenic transformation activity of yes-associated protein
    Bin Zhao
    Department of Pharmacology and Moores Cancer Center, University of California at San Diego, La Jolla, California 92093 0815, USA
    Cancer Res 69:1089-98. 2009
    The Yes-associated protein (YAP) transcription coactivator is a candidate human oncogene and a key regulator of organ size. It is phosphorylated and inhibited by the Hippo tumor suppressor pathway...
  76. pmc Context-dependent requirement for dE2F during oncogenic proliferation
    Brandon N Nicolay
    Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Illinois, United States of America
    PLoS Genet 4:e1000205. 2008
    ..Thus, we uncovered a critical requirement for the dE2F family during inappropriate proliferation of Hippo pathway mutant cells...
  77. ncbi The tumour suppressor Hippo acts with the NDR kinases in dendritic tiling and maintenance
    Kazuo Emoto
    Howard Hughes Medical Institute, Departments of Physiology, Biochemistry, and Biophysics, University of California San Francisco, San Francisco, California 94143 0725, USA
    Nature 443:210-3. 2006
    ....
  78. pmc Relationship between growth arrest and autophagy in midgut programmed cell death in Drosophila
    D Denton
    Centre for Cancer Biology, SA Pathology, Adelaide, South Australia, Australia
    Cell Death Differ 19:1299-307. 2012
    ..Despite the roles of autophagy in both survival and death, our findings suggest that autophagy induction occurs in response to similar signals in both scenarios...
  79. pmc Control of tissue growth and cell transformation by the Salvador/Warts/Hippo pathway
    Xiaomeng Zhang
    Cell Growth and Proliferation Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
    PLoS ONE 7:e31994. 2012
    ..The key oncoprotein of the SWH pathway is the transcriptional co-activator, Yes-associated protein (YAP)...
  80. pmc Identification and characterization of genes required for compensatory growth in Drosophila
    Abigail R Gerhold
    Department of Molecular and Cell Biology, University of California, Berkeley, California 94720 3200, USA
    Genetics 189:1309-26. 2011
    ..Finally, the approach we describe is applicable to the study of compensatory growth in diverse tissues in Drosophila...
  81. pmc Homeostasis of the Drosophila adult retina by actin-capping protein and the Hippo pathway
    Catarina Bras-Pereira
    Instituto Gulbenkian de Ciência Oeiras, Portugal
    Commun Integr Biol 4:612-5. 2011
    ..We propose a model by which F-actin dynamics might be involved in all processes that require the activity of the core Hippo kinase module...
  82. pmc Microtubule-mediated transport of the tumor-suppressor protein Merlin and its mutants
    Lorena B Benseñor
    Department of Cell and Molecular Biology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Proc Natl Acad Sci U S A 107:7311-6. 2010
    ..These results demonstrate the requirement of microtubule-dependent transport for Merlin function...
  83. pmc Premetazoan origin of the hippo signaling pathway
    Arnau Sebé-Pedrós
    Institut de Biologia Evolutiva UPF CSIC, Passeig Marítim de la Barceloneta 37 49, 08003 Barcelona, Spain
    Cell Rep 1:13-20. 2012
    ..Our findings show that the Hippo pathway evolved well before the origin of Metazoa and highlight the importance of Hippo signaling as a key developmental mechanism predating the origin of Metazoa...
  84. pmc Drosophila endocytic neoplastic tumor suppressor genes regulate Sav/Wts/Hpo signaling and the c-Jun N-terminal kinase pathway
    Brian S Robinson
    Department of Cell Biology, Emory University School of Medicine, Atlanta, GA, USA
    Cell Cycle 10:4110-8. 2011
    ..of the endolysosomal pathway lead to autonomous activation of the Sav/Wts/Hpo (SWH) transcriptional effector Yki (YAP/TAZ in vertebrates) and the Jun N-terminal kinase (JNK), which is known to promote Yki activity in cells with ..
  85. pmc Dimerization and cytoplasmic localization regulate Hippo kinase signaling activity in organ size control
    Yunyun Jin
    State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China
    J Biol Chem 287:5784-96. 2012
    ....
  86. pmc Regulation of cell shape, wing hair initiation and the actin cytoskeleton by Trc/Fry and Wts/Mats complexes
    Xiaolan Fang
    Department of Biology, University of Virginia, Charlottesville, VA 22903, USA
    Dev Biol 341:360-74. 2010
    ..In addition, we showed that the effects on cell shape and the timing of differentiation appear to be not linked to changes in relative growth rate of cells compared to their neighbors...
  87. pmc Yki/YAP, Sd/TEAD and Hth/MEIS control tissue specification in the Drosophila eye disc epithelium
    Tianyi Zhang
    Department of Ophthalmology, Center for Vision Research, and SUNY Eye Institute, SUNY Upstate Medical University, Syracuse, New York, United States of America
    PLoS ONE 6:e22278. 2011
    ..We show here that the Yorkie (Yki) pathway plays a major role in tissue specification within the developing fly eye disc epithelium at a time when ..
  88. pmc A screen for conditional growth suppressor genes identifies the Drosophila homolog of HD-PTP as a regulator of the oncoprotein Yorkie
    M Melissa Gilbert
    Department of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Dev Cell 20:700-12. 2011
    ..These data establish Myopic as a Yorkie regulator and implicate Myopic-dependent association of Yorkie with endosomal compartments as a regulatory step in nuclear outputs of the SWH pathway...
  89. doi Growth control: Myc and Yorkie get connected
    Hugo Stocker
    Institute of Molecular Systems Biology, ETH Zurich, Wolfgang Pauli Strasse 16, CH 8093 Zurich, Switzerland
    Curr Biol 21:R37-9. 2011
    ..In turn, Myc keeps the concentration of Yorkie in check via negative feedback regulation...
  90. pmc The gang of four gene regulates growth and patterning of the developing Drosophila eye
    Carolyn K Beam
    Emory University School of Medicine, Department of Cell Biology, Atlanta, GA, USA
    Fly (Austin) 4:104-16. 2010
    ..Genetic reduction of bru-3 suppresses phenotypes caused by gfr alleles, and like gfr alleles, overexpression of bru-3 depresses levels of Cic protein, indicating that overexpression of bru-3 is central to gfr mutant phenotypes...
  91. doi Lgl, aPKC, and Crumbs regulate the Salvador/Warts/Hippo pathway through two distinct mechanisms
    Nicola A Grzeschik
    Cell Cycle and Development, Peter MacCallum Cancer Centre, Victoria, Australia
    Curr Biol 20:573-81. 2010
    ..Here we investigate how these cell polarity regulators control proliferation and survival...
  92. pmc Crumbs regulates Salvador/Warts/Hippo signaling in Drosophila via the FERM-domain protein Expanded
    Brian S Robinson
    Department of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Curr Biol 20:582-90. 2010
    ....
  93. pmc Characterization of a dorsal-eye Gal4 Line in Drosophila
    Clayton M Morrison
    Program in Developmental Biology, Baylor College of Medicine, Houston, Texas, USA
    Genesis 48:3-7. 2010
    ..Furthermore, we use functional tests to show that the DE-Gal4 line is a useful tool with which to manipulate gene expression in half of the developing eye...
  94. pmc The mob as tumor suppressor gene is essential for early development and regulates tissue growth in Drosophila
    Takeshi Shimizu
    Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Genetics 178:957-65. 2008
    ..Although mats depletion leads to aberrant mitoses, this does not seem to be due to compromised mitotic spindle checkpoint function...
  95. ncbi Drosophila models for cancer research
    Marcos Vidal
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, 660 South Euclid Avenue, Saint Louis, MO 63110, USA
    Curr Opin Genet Dev 16:10-6. 2006
    ..In the future, Drosophila models can be extended beyond basic research in the search for human therapeutics...

Research Grants3

  1. Cell Cycle and Development
    BRUCE EDGAR; Fiscal Year: 2004
    ....
  2. Growth-regulatory targets of Drosophila Cyclin D/Cdk4
    BRUCE EDGAR; Fiscal Year: 2007
    ..Some of the identified genes could be useful targets for cancer diagnosis or anti-cancer chemotherapeutics. [unreadable] [unreadable]..