Gene Symbol: Yeti
Description: yeti
Alias: 41Aa, BCNT, BEST:GH01620, BcDNA:RE36623, CG40218, Dmel\CG40218, GroupI, YETI, l(2)41Aa, l(2)EMS31, l(2R)B, l(2R)EMS-31, yeti, CG40218-PA, CG40218-PB, Yeti-PA, Yeti-PB, lethal (2) 41Aa
Species: fruit fly

Top Publications

  1. Hilliker A. Genetic analysis of the centromeric heterochromatin of chromosome 2 of Drosophila melanogaster: deficiency mapping of EMS-induced lethal complementation groups. Genetics. 1976;83:765-82 pubmed
    ..Thus functional genetic loci are found in heterochromatin, albeit at a very low density relative to euchromatin. ..
  2. Gatti M, Pimpinelli S. Functional elements in Drosophila melanogaster heterochromatin. Annu Rev Genet. 1992;26:239-75 pubmed
  3. Messina G, Damia E, Fanti L, Atterrato M, Celauro E, Mariotti F, et al. Yeti, an essential Drosophila melanogaster gene, encodes a protein required for chromatin organization. J Cell Sci. 2014;127:2577-88 pubmed publisher
    ..Drosophila melanogaster as a model organism, we investigated the in vivo role of the Drosophila BCNT member called YETI. We report that loss of YETI causes lethality before pupation and defects in higher-order chromatin organization, ..
  4. Dimitri P, Corradini N, Rossi F, Vernì F, Cenci G, Belloni G, et al. Vital genes in the heterochromatin of chromosomes 2 and 3 of Drosophila melanogaster. Genetica. 2003;117:209-15 pubmed
    ..Repetitive loci, such as Responder and the ABO elements, which are also located in the heterochromatin of chromosome 2, are not discussed here because they have been reviewed in detail elsewhere. ..
  5. Dimitri P. Cytogenetic analysis of the second chromosome heterochromatin of Drosophila melanogaster. Genetics. 1991;127:553-64 pubmed
    ..The l(2)41Aa, l(2)41Ab, rolled (l(2)41Ac) and l(2)41Ad loci are located within the proximal heterochromatin of 2R, while the ..
  6. Cenci G, Belloni G, Dimitri P. 1(2)41Aa, a heterochromatic gene of Drosophila melanogaster, is required for mitotic and meiotic chromosome condensation. Genet Res. 2003;81:15-24 pubmed
    ..analysis of mitotic and meiotic cell divisions in mutants carrying different allelic combinations of 1(2)41Aa, a gene located in the proximal heterochromatin of chromosome 2...
  7. Ganetzky B. On the components of segregation distortion in Drosophila melanogaster. Genetics. 1977;86:321-55 pubmed
    ..The results of these studies allow a reinterpretation of results from earlier analyses of the SD system and serve to limit the possible mechanisms to account for segregation distortion. ..
  8. Messina G, Celauro E, Atterrato M, Giordano E, Iwashita S, Dimitri P. The Bucentaur (BCNT) protein family: a long-neglected class of essential proteins required for chromatin/chromosome organization and function. Chromosoma. 2015;124:153-62 pubmed publisher
    The evolutionarily conserved Bucentaur (BCNT) protein superfamily was identified about two decades ago in bovines, but its biological role has long remained largely unknown...
  9. Moschetti R, Celauro E, Cruciani F, Caizzi R, Dimitri P. On the evolution of Yeti, a Drosophila melanogaster heterochromatin gene. PLoS ONE. 2014;9:e113010 pubmed publisher
    ..Here, we report the results of the evolutionary analysis of Yeti, an essential gene of Drosophila melanogaster located in the deep pericentromeric region of chromosome 2R...

More Information


  1. Wisniewski T, Tanzi C, Gindhart J. The Drosophila kinesin-I associated protein YETI binds both kinesin subunits. Biol Cell. 2003;95:595-602 pubmed
    ..One of the proteins we have identified is YETI. Interestingly, YETI has the unique ability to bind specifically to both subunits of the kinesin tail domain...
  2. Hilliker A, Holm D. Genetic analysis of the proximal region of chromosome 2 of Drosophila melanogaster. I. Detachment products of compound autosomes. Genetics. 1975;81:705-21 pubmed
    ..The data further demonstrate that rolled, and probably light, are located within the proximal heterochromatin. Thus, functional genetic loci are found in heterochromatin, albeit at low density. ..
  3. Messina G, Atterrato M, Fanti L, Giordano E, Dimitri P. Expression of human Cfdp1 gene in Drosophila reveals new insights into the function of the evolutionarily conserved BCNT protein family. Sci Rep. 2016;6:25511 pubmed publisher
    The Bucentaur (BCNT) protein family is widely distributed in eukaryotes and is characterized by a highly conserved C-terminal domain. This family was identified two decades ago in ruminants, but its role(s) remained largely unknown...
  4. Lyttle T. The effect of novel chromosome position and variable dose on the genetic behavior of the Responder (Rsp) element of the Segregation distorter (SD) system of Drosophila melanogaster. Genetics. 1989;121:751-63 pubmed
    ..Possible explanations for such behavior are discussed. ..
  5. Dimitri P. Constitutive heterochromatin and transposable elements in Drosophila melanogaster. Genetica. 1997;100:85-93 pubmed
    ..The implications of these findings on the possible impact of heterochromatic TEs on the function and evolution of the host genome are also discussed. ..
  6. Dimitri P, Arca B, Berghella L, Mei E. High genetic instability of heterochromatin after transposition of the LINE-like I factor in Drosophila melanogaster. Proc Natl Acad Sci U S A. 1997;94:8052-7 pubmed
    ..Together, these data indicate that I factors transpose with high frequency into pericentric regions of chromosome 2 and may play a role in the evolution of constitutive heterochromatin. ..
  7. Eberl D, Duyf B, Hilliker A. The role of heterochromatin in the expression of a heterochromatic gene, the rolled locus of Drosophila melanogaster. Genetics. 1993;134:277-92 pubmed
  8. Brittnacher J, Ganetzky B. On the components of segregation distortion in Drosophila melanogaster. IV. Construction and analysis of free duplications for the Responder locus. Genetics. 1989;121:739-50 pubmed
    ..The bearing of these results on present models of segregation distortion are discussed. ..