wts

Summary

Gene Symbol: wts
Description: warts
Alias: CG12072, Dlats, Dmel\CG12072, LATS, LATS1, Lats, Lats/Warts, MENE (3R)-G, WTS/LATS, Warts, Warts/Lats, Wts, Wts/Lats, dmLATS, l(3)100Aa, lats, lts, wart, warts/lats, wts/lats, warts, CG12072-PA, Warts/Lats, large tumor suppressor, large tumor supressor, miracle-gro, warts kinase, warts/D-lats, warts/large tumour suppressor, wts-PA
Species: fruit fly

Top Publications

  1. Hamaratoglu F, Gajewski K, Sansores Garcia L, Morrison C, Tao C, Halder G. The Hippo tumor-suppressor pathway regulates apical-domain size in parallel to tissue growth. J Cell Sci. 2009;122:2351-9 pubmed publisher
    ..observed in Hippo pathway mutants, its elimination did not significantly reverse the overgrowth phenotype of warts mutant cells...
  2. Varelas X, Miller B, Sopko R, Song S, Gregorieff A, Fellouse F, et al. The Hippo pathway regulates Wnt/beta-catenin signaling. Dev Cell. 2010;18:579-91 pubmed publisher
    ..These results uncover a cytoplasmic function of TAZ in regulating Wnt signaling and highlight the role of the Hippo pathway in coordinating morphogenetic signaling with growth control. ..
  3. Sprecher S, Pichaud F, Desplan C. Adult and larval photoreceptors use different mechanisms to specify the same Rhodopsin fates. Genes Dev. 2007;21:2182-95 pubmed
    ..However, the stochastic choice of adult color PRs and the bistable loop of the warts and melted tumor suppressor genes that unambiguously specify rh5 and rh6 in R8 PRs are not involved in ..
  4. Chen C, Gajewski K, Hamaratoglu F, Bossuyt W, Sansores Garcia L, Tao C, et al. The apical-basal cell polarity determinant Crumbs regulates Hippo signaling in Drosophila. Proc Natl Acad Sci U S A. 2010;107:15810-5 pubmed publisher
    ..Taken together, our data show that Crb regulates growth through Hippo signaling, and thus identify Crb as a previously undescribed upstream input into the Hippo pathway. ..
  5. Zhao M, Szafranski P, Hall C, Goode S. Basolateral junctions utilize warts signaling to control epithelial-mesenchymal transition and proliferation crucial for migration and invasion of Drosophila ovarian epithelial cells. Genetics. 2008;178:1947-71 pubmed publisher
    ..lethal giant larvae (lgl) and scribble (scrib), and several not previously associated with BLJ function, including warts (wts) and roughened eye (roe), which encode a serine-threonine kinase and a transcription factor, respectively...
  6. Ghabrial A, Levi B, Krasnow M. A systematic screen for tube morphogenesis and branching genes in the Drosophila tracheal system. PLoS Genet. 2011;7:e1002087 pubmed publisher
  7. Sun G, Irvine K. Regulation of Hippo signaling by Jun kinase signaling during compensatory cell proliferation and regeneration, and in neoplastic tumors. Dev Biol. 2011;350:139-51 pubmed publisher
    ..Our observations identify Jnk signaling as a modulator of Hippo pathway activity in wing imaginal discs, and implicate Yorkie activation in compensatory cell proliferation and disc regeneration. ..
  8. Zhang X, Milton C, Poon C, Hong W, Harvey K. Wbp2 cooperates with Yorkie to drive tissue growth downstream of the Salvador-Warts-Hippo pathway. Cell Death Differ. 2011;18:1346-55 pubmed publisher
    The Salvador-Warts-Hippo (SWH) pathway is a key controller of tissue growth in both flies and mammals, and deregulation of pathway activity contributes to tumour formation...
  9. Ho L, Wei X, Shimizu T, Lai Z. Mob as tumor suppressor is activated at the cell membrane to control tissue growth and organ size in Drosophila. Dev Biol. 2010;337:274-83 pubmed publisher
    ..However, the cellular mechanism by which the core components like Mob as tumor suppressor (Mats) and Warts (Wts) protein kinase are activated is poorly understood...

More Information

Publications80

  1. Mao Y, Kucuk B, Irvine K. Drosophila lowfat, a novel modulator of Fat signaling. Development. 2009;136:3223-33 pubmed publisher
    The Fat-Hippo-Warts signaling network regulates both transcription and planar cell polarity...
  2. Igaki T, Pagliarini R, Xu T. Loss of cell polarity drives tumor growth and invasion through JNK activation in Drosophila. Curr Biol. 2006;16:1139-46 pubmed
    ..Similar oncogenic cooperation mediated through these evolutionarily conserved signaling pathways could contribute to human cancer progression. ..
  3. Doggett K, Grusche F, Richardson H, Brumby A. Loss of the Drosophila cell polarity regulator Scribbled promotes epithelial tissue overgrowth and cooperation with oncogenic Ras-Raf through impaired Hippo pathway signaling. BMC Dev Biol. 2011;11:57 pubmed publisher
    ..In contrast, warts mutant overgrowth does not require aPKC activity...
  4. Wu S, Liu Y, Zheng Y, Dong J, Pan D. The TEAD/TEF family protein Scalloped mediates transcriptional output of the Hippo growth-regulatory pathway. Dev Cell. 2008;14:388-98 pubmed publisher
    ..Our results uncover a heretofore missing link in the Hpo signaling pathway and provide a glimpse of the molecular events on a Hpo-responsive enhancer element. ..
  5. Ling C, Zheng Y, Yin F, Yu J, Huang J, Hong Y, et al. The apical transmembrane protein Crumbs functions as a tumor suppressor that regulates Hippo signaling by binding to Expanded. Proc Natl Acad Sci U S A. 2010;107:10532-7 pubmed publisher
    ..Furthermore, our studies implicate Crb as a putative cell surface receptor for Hippo signaling by uncovering a transmembrane protein that directly binds to an apical component of the Hippo pathway. ..
  6. Pan G, Feng Y, Ambegaonkar A, Sun G, Huff M, Rauskolb C, et al. Signal transduction by the Fat cytoplasmic domain. Development. 2013;140:831-42 pubmed publisher
  7. Oh H, Irvine K. In vivo regulation of Yorkie phosphorylation and localization. Development. 2008;135:1081-8 pubmed publisher
    Yorkie (Yki), a transcription factor of the Fat and Hippo signaling pathways, is negatively regulated by the Warts kinase. Here, we use Phos-tag gels to characterize Warts-dependent phosphorylation of Yki in vivo, and show that Warts ..
  8. Grusche F, Degoutin J, Richardson H, Harvey K. The Salvador/Warts/Hippo pathway controls regenerative tissue growth in Drosophila melanogaster. Dev Biol. 2011;350:255-66 pubmed publisher
    ..Here we explore the role of one such checkpoint, the Salvador-Warts-Hippo pathway, in tissue regeneration...
  9. Oh H, Irvine K. In vivo analysis of Yorkie phosphorylation sites. Oncogene. 2009;28:1916-27 pubmed publisher
    The co-activator Yorkie (Yki) mediates transcriptional regulation effected by the Drosophila Fat-Warts (Wts)-Hippo (Hpo) pathways...
  10. Huang J, Wu S, Barrera J, Matthews K, Pan D. The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP. Cell. 2005;122:421-34 pubmed
    ..two processes are regulated by a pathway involving the Ste20-like kinase Hippo (Hpo) and the NDR family kinase Warts (Wts; also called Lats)...
  11. Reddy B, Irvine K. Regulation of Drosophila glial cell proliferation by Merlin-Hippo signaling. Development. 2011;138:5201-12 pubmed publisher
    ..Moreover, as several of the genes we studied have been linked to human gliomas, our results suggest that this linkage could reflect their organization into a conserved pathway for the control of glial cell proliferation. ..
  12. Chen H, Wang C, Wang T, Liaw G, Hsu T, Lin T, et al. The Hippo pathway controls polar cell fate through Notch signaling during Drosophila oogenesis. Dev Biol. 2011;357:370-9 pubmed publisher
    ..Consistently, polar cells mutant for hippo (hpo) or warts (wts) are not properly specified, leading to egg chamber fusion...
  13. Fernández B, Gaspar P, Bras Pereira C, Jezowska B, Rebelo S, Janody F. Actin-Capping Protein and the Hippo pathway regulate F-actin and tissue growth in Drosophila. Development. 2011;138:2337-46 pubmed publisher
    ..Taken together, these findings indicate a novel interplay between Hippo pathway activity and actin filament dynamics that is essential for normal growth control. ..
  14. Yu J, Poulton J, Huang Y, Deng W. The hippo pathway promotes Notch signaling in regulation of cell differentiation, proliferation, and oocyte polarity. PLoS ONE. 2008;3:e1761 pubmed publisher
    ..Disruption of the Hippo pathway, including major components Hippo, Salvador, and Warts, results in aberrant follicle-cell differentiation and proliferation and dramatic disruption of the oocyte ..
  15. Zhai B, Villen J, Beausoleil S, Mintseris J, Gygi S. Phosphoproteome analysis of Drosophila melanogaster embryos. J Proteome Res. 2008;7:1675-82 pubmed publisher
    ..63% at the peptide level. Because of the large size of the data set, both novel and known phosphorylation motifs were extracted using the Motif-X algorithm, including those representative of potential ordered phosphorylation events. ..
  16. Ribeiro P, Josué F, Wepf A, Wehr M, Rinner O, Kelly G, et al. Combined functional genomic and proteomic approaches identify a PP2A complex as a negative regulator of Hippo signaling. Mol Cell. 2010;39:521-34 pubmed publisher
    ..of the pathway is a kinase cascade composed of an upstream kinase Hpo (MST1/2 in mammals) and a downstream kinase Warts (Wts, Lats1/2 in mammals), as well as several scaffold proteins, Sav, dRASSF, and Mats...
  17. Polesello C, Tapon N. Salvador-warts-hippo signaling promotes Drosophila posterior follicle cell maturation downstream of notch. Curr Biol. 2007;17:1864-70 pubmed
    The Salvador Warts Hippo (SWH) network limits tissue size in Drosophila and vertebrates [1]. Decreased SWH pathway activity gives rise to excess proliferation and reduced apoptosis...
  18. Straßburger K, Tiebe M, Pinna F, Breuhahn K, Teleman A. Insulin/IGF signaling drives cell proliferation in part via Yorkie/YAP. Dev Biol. 2012;367:187-96 pubmed publisher
    ..Interestingly, we also find the converse--that Yorkie signaling activates components of the insulin/TOR pathway. In sum, this crosstalk between IIS and Yorkie leads to coordinated regulation of these two oncogenic pathways. ..
  19. Edgar B. From cell structure to transcription: Hippo forges a new path. Cell. 2006;124:267-73 pubmed
    ..adhesion and structure, control the activation of the Hippo/Salvador kinase complex, which in turn activates the Warts/Mats kinase complex...
  20. Grzeschik N, Parsons L, Allott M, Harvey K, Richardson H. Lgl, aPKC, and Crumbs regulate the Salvador/Warts/Hippo pathway through two distinct mechanisms. Curr Biol. 2010;20:573-81 pubmed publisher
    ..of lgl in eye epithelial tissue, where polarity is maintained, results in upregulation of targets of the Salvador/Warts/Hippo (SWH) tumor suppressor pathway...
  21. Chen C, Schroeder M, Kango Singh M, Tao C, Halder G. Tumor suppression by cell competition through regulation of the Hippo pathway. Proc Natl Acad Sci U S A. 2012;109:484-9 pubmed publisher
    ..Thus, cell competition acts as a tumor-suppressing mechanism by regulating the Hippo pathway in scrib(-) cells. ..
  22. Zhang J, Ji J, Yu M, Overholtzer M, Smolen G, Wang R, et al. YAP-dependent induction of amphiregulin identifies a non-cell-autonomous component of the Hippo pathway. Nat Cell Biol. 2009;11:1444-50 pubmed publisher
    ..Suppression of the negative YAP regulators LATS1 and 2 (large tumour suppressor 1 and 2) is sufficient to induce AREG expression, consistent with physiological ..
  23. Dutta S, Baehrecke E. Warts is required for PI3K-regulated growth arrest, autophagy, and autophagic cell death in Drosophila. Curr Biol. 2008;18:1466-75 pubmed publisher
    ..Although the Warts (Wts) tumor suppressor is a critical regulator of tissue growth in animals, it is not clear how this signaling ..
  24. Nicolay B, Frolov M. Context-dependent requirement for dE2F during oncogenic proliferation. PLoS Genet. 2008;4:e1000205 pubmed publisher
    ..Thus, we uncovered a critical requirement for the dE2F family during inappropriate proliferation of Hippo pathway mutant cells. ..
  25. Meignin C, Alvarez Garcia I, Davis I, Palacios I. The salvador-warts-hippo pathway is required for epithelial proliferation and axis specification in Drosophila. Curr Biol. 2007;17:1871-8 pubmed
    ..We show that the Salvador Warts Hippo (SWH) tumor-suppressor pathway is required in the follicle cells in order to induce their Gurken- and Notch-..
  26. Tapon N, Harvey K, Bell D, Wahrer D, Schiripo T, Haber D, et al. salvador Promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines. Cell. 2002;110:467-78 pubmed
    ..Salvador contains two WW domains and binds to the Warts (or LATS) protein kinase. The human ortholog of salvador (hWW45) is mutated in three cancer cell lines...
  27. Badouel C, Gardano L, Amin N, Garg A, Rosenfeld R, Le Bihan T, et al. The FERM-domain protein Expanded regulates Hippo pathway activity via direct interactions with the transcriptional activator Yorkie. Dev Cell. 2009;16:411-20 pubmed publisher
    ..The Hippo/Mst kinase phosphorylates and activates the NDR family kinase Warts/Lats, which phosphorylates and inhibits the transcriptional activator Yorkie/YAP...
  28. Oh H, Reddy B, Irvine K. Phosphorylation-independent repression of Yorkie in Fat-Hippo signaling. Dev Biol. 2009;335:188-97 pubmed publisher
    ..mediated directly by the kinase Warts and indirectly by upstream tumor suppressors that promote Warts kinase activity...
  29. Jukam D, Xie B, Rister J, TERRELL D, Charlton Perkins M, Pistillo D, et al. Opposite feedbacks in the Hippo pathway for growth control and neural fate. Science. 2013;342:1238016 pubmed publisher
    ..In the Drosophila eye, cross-repression between the Hippo pathway kinase LATS/Warts (Wts) and growth regulator Melted generates mutually exclusive photoreceptor subtypes...
  30. Yu J, Zheng Y, Dong J, Klusza S, Deng W, Pan D. Kibra functions as a tumor suppressor protein that regulates Hippo signaling in conjunction with Merlin and Expanded. Dev Cell. 2010;18:288-99 pubmed publisher
    ..this pathway is a kinase cascade wherein Hippo (Hpo), in complex with Salvador (Sav), phosphorylates and activates Warts (Wts), which in turn phosphorylates and inactivates the Yorkie (Yki) oncoprotein, known as the YAP coactivator in ..
  31. Hamaratoglu F, Willecke M, Kango Singh M, Nolo R, Hyun E, Tao C, et al. The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis. Nat Cell Biol. 2006;8:27-36 pubmed
    ..Our genetic and biochemical data place Merlin and Expanded upstream of Hippo and identify a pathway through which they act as tumour-suppressor genes. ..
  32. Mikeladze Dvali T, Wernet M, Pistillo D, Mazzoni E, Teleman A, Chen Y, et al. The growth regulators warts/lats and melted interact in a bistable loop to specify opposite fates in Drosophila R8 photoreceptors. Cell. 2005;122:775-87 pubmed
    ..Here, we show that warts, encoding large tumor suppressor (Lats) and melted encoding a PH-domain protein, play opposite roles in defining the yR 8 or pR8 fates...
  33. Marcinkevicius E, Zallen J. Regulation of cytoskeletal organization and junctional remodeling by the atypical cadherin Fat. Development. 2013;140:433-43 pubmed publisher
    ..by mutations in Expanded, an upstream regulator of the conserved Hippo pathway, and mutations in Hippo and Warts, two kinases in the Hippo kinase cascade...
  34. Wehr M, Holder M, Gailite I, Saunders R, Maile T, Ciirdaeva E, et al. Salt-inducible kinases regulate growth through the Hippo signalling pathway in Drosophila. Nat Cell Biol. 2013;15:61-71 pubmed
    ..The pathway core is a kinase cassette, comprising the kinases Hpo and Warts (Wts) and the scaffold proteins Salvador (Sav) and Mats, which inactivates the pro-growth transcriptional co-..
  35. Xu T, Wang W, Zhang S, Stewart R, Yu W. Identifying tumor suppressors in genetic mosaics: the Drosophila lats gene encodes a putative protein kinase. Development. 1995;121:1053-63 pubmed
    ..One of the identified genes, lats, has been cloned and encodes a putative protein kinase that shares high levels of sequence similarity with three ..
  36. Cho E, Feng Y, Rauskolb C, Maitra S, Fehon R, Irvine K. Delineation of a Fat tumor suppressor pathway. Nat Genet. 2006;38:1142-50 pubmed
    ..melanogaster tumor suppressors and identify the kinases Discs overgrown and Warts as components of a Fat signaling pathway...
  37. Sun S, Zhao S, Wang Z. Genes of Hippo signaling network act unconventionally in the control of germline proliferation in Drosophila. Dev Dyn. 2008;237:270-5 pubmed
    ..when we generated germline mutant clones of Hippo-network genes such as fat, expanded, hippo, salvador, and warts, we did not observe any overgrowth of these mutant cells...
  38. Lai Z, Wei X, Shimizu T, Ramos E, Rohrbaugh M, Nikolaidis N, et al. Control of cell proliferation and apoptosis by mob as tumor suppressor, mats. Cell. 2005;120:675-85 pubmed
    ..Disruption of these processes can cause cancer. Recent studies have identified the Large tumor suppressor (Lats)/Warts (Wts) protein kinase as a key component of a pathway that controls the coordination between ..
  39. Zecca M, Struhl G. A feed-forward circuit linking wingless, fat-dachsous signaling, and the warts-hippo pathway to Drosophila wing growth. PLoS Biol. 2010;8:e1000386 pubmed publisher
    ..Here, we identify the protocadherins Fat (Ft) and Dachsous (Ds), the Warts-Hippo tumor suppressor pathway, and the transcriptional co-activator Yorkie (Yki, a YES associated protein, or YAP)..
  40. Menut L, Vaccari T, Dionne H, Hill J, Wu G, Bilder D. A mosaic genetic screen for Drosophila neoplastic tumor suppressor genes based on defective pupation. Genetics. 2007;177:1667-77 pubmed
    ..The isolation of additional loci that affect hyperplastic as well as neoplastic growth indicates the utility of this screening strategy for studying epithelial growth control. ..
  41. Rauskolb C, Pan G, Reddy B, Oh H, Irvine K. Zyxin links fat signaling to the hippo pathway. PLoS Biol. 2011;9:e1000624 pubmed publisher
    ..for Zyx within the Fat branch of Hippo signaling, downstream of Fat and Dco, and upstream of the Yorkie kinase Warts, and we find that Zyx is required for the influence of Fat on Warts protein levels...
  42. Wei X, Shimizu T, Lai Z. Mob as tumor suppressor is activated by Hippo kinase for growth inhibition in Drosophila. EMBO J. 2007;26:1772-81 pubmed
    ..Mats phosphorylation by Hpo increases its affinity with Warts (Wts)/large tumor suppressor (Lats) serine/threonine protein kinase and ability to upregulate Wts catalytic activity to target ..
  43. Colombani J, Polesello C, Josué F, Tapon N. Dmp53 activates the Hippo pathway to promote cell death in response to DNA damage. Curr Biol. 2006;16:1453-8 pubmed
    ..The Hippo (Hpo) pathway comprises the kinases Hpo and Warts/Lats (Wts), the adaptors Salvador (Sav) and Mob1 as a tumor suppressor (Mats), the cytoskeletal proteins Expanded ..
  44. Willecke M, Hamaratoglu F, Kango Singh M, Udan R, Chen C, Tao C, et al. The fat cadherin acts through the hippo tumor-suppressor pathway to regulate tissue size. Curr Biol. 2006;16:2090-100 pubmed
    ..Fat acts genetically and biochemically upstream of other Hippo pathway components such as Expanded, the Hippo and Warts kinases, and the transcriptional coactivator Yorkie...
  45. Genevet A, Wehr M, Brain R, Thompson B, Tapon N. Kibra is a regulator of the Salvador/Warts/Hippo signaling network. Dev Cell. 2010;18:300-8 pubmed publisher
    The Salvador (Sav)/Warts (Wts)/Hippo (Hpo) (SWH) network controls tissue growth by inhibiting cell proliferation and promoting apoptosis...
  46. Simcox A, Mitra S, Truesdell S, Paul L, Chen T, Butchar J, et al. Efficient genetic method for establishing Drosophila cell lines unlocks the potential to create lines of specific genotypes. PLoS Genet. 2008;4:e1000142 pubmed publisher
    ..for deriving Drosophila cell lines of a specific genotype by establishing cultures from embryos in which the warts (wts) tumor suppressor gene was targeted...
  47. Hariharan I. Growth regulation: a beginning for the hippo pathway. Curr Biol. 2006;16:R1037-9 pubmed
    A signaling pathway involving two protein kinases, Hippo and Warts, restricts the growth of imaginal discs in Drosophila. Four recent studies taken together show that the protocadherin Fat can regulate Warts in two different ways.
  48. Reddy B, Irvine K. Regulation of Hippo signaling by EGFR-MAPK signaling through Ajuba family proteins. Dev Cell. 2013;24:459-71 pubmed publisher
    ..subject to MAPK-dependent phosphorylation, and EGFR-Ras-MAPK signaling enhances Jub binding to the Yorkie kinase Warts and the adaptor protein Salvador...
  49. Poon C, Lin J, Zhang X, Harvey K. The sterile 20-like kinase Tao-1 controls tissue growth by regulating the Salvador-Warts-Hippo pathway. Dev Cell. 2011;21:896-906 pubmed publisher
    The Salvador-Warts-Hippo (SWH) pathway is a complex signaling network that controls both developmental and regenerative tissue growth...
  50. Genevet A, Polesello C, Blight K, Robertson F, Collinson L, Pichaud F, et al. The Hippo pathway regulates apical-domain size independently of its growth-control function. J Cell Sci. 2009;122:2360-70 pubmed publisher
    ..well-characterised overproliferation phenotype, adult Drosophila epithelial cells mutant for the kinases Hippo and Warts have hypertrophic apical domains...
  51. Dong J, Feldmann G, Huang J, Wu S, Zhang N, Comerford S, et al. Elucidation of a universal size-control mechanism in Drosophila and mammals. Cell. 2007;130:1120-33 pubmed
    ..These results uncover a universal size-control mechanism in metazoan. ..
  52. Tao W, Zhang S, Turenchalk G, Stewart R, St John M, Chen W, et al. Human homologue of the Drosophila melanogaster lats tumour suppressor modulates CDC2 activity. Nat Genet. 1999;21:177-81 pubmed
    ..Here, we have isolated mammalian homologues of Drosophila lats. Human LATS1 suppresses tumour growth and rescues all developmental defects, including embryonic lethality in flies...
  53. Potter C, Xu T. Mechanisms of size control. Curr Opin Genet Dev. 2001;11:279-86 pubmed
    ..The mechanisms of organ size control could also be critical targets for evolutionary events or disease processes such as tumorigenesis. ..
  54. Harvey K, Pfleger C, Hariharan I. The Drosophila Mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosis. Cell. 2003;114:457-67 pubmed
    ..Two genes that function together to regulate growth, proliferation, and apoptosis in Drosophila are warts (wts), encoding a serine/threonine kinase, and salvador (sav), encoding a WW domain containing Wts-interacting ..
  55. Pantalacci S, Tapon N, Leopold P. The Salvador partner Hippo promotes apoptosis and cell-cycle exit in Drosophila. Nat Cell Biol. 2003;5:921-7 pubmed
    ..Thus, Hpo may promote apoptosis by reducing cellular amounts of DIAP1. In addition, we show that Sav is an unstable protein that is stabilized by Hpo. We propose that Hpo and Sav function together to restrict tissue growth in vivo...
  56. Ren F, Wang B, Yue T, Yun E, Ip Y, Jiang J. Hippo signaling regulates Drosophila intestine stem cell proliferation through multiple pathways. Proc Natl Acad Sci U S A. 2010;107:21064-9 pubmed publisher
    ..Finally, we show that the Hpo pathway mediator Yorkie (Yki) is also required in precursor cells for injury-induced ISC proliferation in response to tissue-damaging reagent DSS. ..
  57. Emoto K, Parrish J, Jan L, Jan Y. The tumour suppressor Hippo acts with the NDR kinases in dendritic tiling and maintenance. Nature. 2006;443:210-3 pubmed
    ..Here we report that the other NDR family kinase, the tumour suppressor Warts/Lats (Wts), regulates the maintenance of dendrites; in wts mutants, dendrites initially tile the body wall ..
  58. Hafezi Y, Bosch J, Hariharan I. Differences in levels of the transmembrane protein Crumbs can influence cell survival at clonal boundaries. Dev Biol. 2012;368:358-69 pubmed publisher
    ..alter Crb levels, including loss-of-function mutations in hyperplastic tumour suppressors in the Hippo-Salvador-Warts pathway and in neoplastic tumour suppressor genes, such as scribble...
  59. Das Thakur M, Feng Y, Jagannathan R, Seppa M, Skeath J, Longmore G. Ajuba LIM proteins are negative regulators of the Hippo signaling pathway. Curr Biol. 2010;20:657-62 pubmed publisher
    ..In mammalian and Drosophila cells, Ajuba LIM proteins/dJub interact with LATS/Warts (Wts) and WW45/Sav to inhibit phosphorylation of YAP/Yki...
  60. Shaw R, Kohlmaier A, Polesello C, Veelken C, Edgar B, Tapon N. The Hippo pathway regulates intestinal stem cell proliferation during Drosophila adult midgut regeneration. Development. 2010;137:4147-58 pubmed publisher
    ..Our results suggest that the Hpo pathway is a mediator of the regenerative response in the Drosophila midgut. ..
  61. Feng Y, Irvine K. Processing and phosphorylation of the Fat receptor. Proc Natl Acad Sci U S A. 2009;106:11989-94 pubmed publisher
    ..and phosphorylation as post-translational modifications of Fat, correlate the phosphorylation of Fat with its activation by Dachsous in the Fat-Warts pathway, and enhance our understanding of the requirement for Dco in Fat signaling.
  62. Peng H, Slattery M, Mann R. Transcription factor choice in the Hippo signaling pathway: homothorax and yorkie regulation of the microRNA bantam in the progenitor domain of the Drosophila eye imaginal disc. Genes Dev. 2009;23:2307-19 pubmed publisher
    ..In the eye disc, Hth and Tsh provide spatial information to this pathway, promoting cell proliferation and survival in the progenitor domain. ..
  63. Polesello C, Huelsmann S, Brown N, Tapon N. The Drosophila RASSF homolog antagonizes the hippo pathway. Curr Biol. 2006;16:2459-65 pubmed
    ..1 proteins, Expanded (Ex) and Merlin (Mer), two serine/threonine kinases, Hpo and Warts (Wts), the scaffold proteins Salvador (Sav) and Mats, and the transcriptional coactivator Yorkie (Yki)...
  64. Bennett F, Harvey K. Fat cadherin modulates organ size in Drosophila via the Salvador/Warts/Hippo signaling pathway. Curr Biol. 2006;16:2101-10 pubmed
    ..A newly emerging signaling pathway that controls organ size during development is the Salvador/Warts/Hippo pathway...
  65. Ryoo H, Steller H. Hippo and its mission for growth control. Nat Cell Biol. 2003;5:853-5 pubmed
  66. Zhang L, Ren F, Zhang Q, Chen Y, Wang B, Jiang J. The TEAD/TEF family of transcription factor Scalloped mediates Hippo signaling in organ size control. Dev Cell. 2008;14:377-87 pubmed publisher
    ..Finally, Sd recruits Yki to the enhancer of the pathway-responsive gene diap1, suggesting that diap1 is a direct transcriptional target of the Hpo pathway. ..
  67. Poon C, Zhang X, Lin J, Manning S, Harvey K. Homeodomain-interacting protein kinase regulates Hippo pathway-dependent tissue growth. Curr Biol. 2012;22:1587-94 pubmed publisher
    The Salvador-Warts-Hippo (SWH) pathway is an evolutionarily conserved regulator of tissue growth that is deregulated in human cancer...
  68. Sansores Garcia L, Bossuyt W, Wada K, Yonemura S, Tao C, Sasaki H, et al. Modulating F-actin organization induces organ growth by affecting the Hippo pathway. EMBO J. 2011;30:2325-35 pubmed publisher
    ..The core of the Hpo pathway is a kinase cascade, which in Drosophila involves the Hpo and Warts kinases that negatively regulate the activity of the transcriptional coactivator Yorkie...
  69. Feng Y, Irvine K. Fat and expanded act in parallel to regulate growth through warts. Proc Natl Acad Sci U S A. 2007;104:20362-7 pubmed
    ..Drosophila tumor suppressors Fat and Expanded have both recently been implicated in regulating the activity of the Warts tumor suppressor...
  70. Salah Z, Aqeilan R. WW domain interactions regulate the Hippo tumor suppressor pathway. Cell Death Dis. 2011;2:e172 pubmed publisher
    ..We further discuss new insights and future directions on the emerging role of such regulation. ..
  71. Neto Silva R, de Beco S, Johnston L. Evidence for a growth-stabilizing regulatory feedback mechanism between Myc and Yorkie, the Drosophila homolog of Yap. Dev Cell. 2010;19:507-20 pubmed publisher
    ..We propose that the codependent regulatory relationship functionally coordinates the cellular activities of Yki and Myc and provides a mechanism of growth control that regulates organ size and has broad implications for cancer. ..