Gene Symbol: woc
Description: without children
Alias: CG5965, Dmel\CG5965, WOC, Woc, without children, CG5965-PA, CG5965-PB, CG5965-PC, CG5965-PD, CG5965-PE, with out children, woc-PA, woc-PB, woc-PC, woc-PD, woc-PE
Species: fruit fly
Products:     woc

Top Publications

  1. Raffa G, Cenci G, Siriaco G, Goldberg M, Gatti M. The putative Drosophila transcription factor woc is required to prevent telomeric fusions. Mol Cell. 2005;20:821-31 pubmed
    b>Woc is a Drosophila zinc finger protein that shares homology with the human polypeptides ZNF261 and ZNF198 implicated in mental retardation and leukemia syndromes...
  2. Musarò M, Ciapponi L, Fasulo B, Gatti M, Cenci G. Unprotected Drosophila melanogaster telomeres activate the spindle assembly checkpoint. Nat Genet. 2008;40:362-6 pubmed publisher
    ..Our results collectively suggest that recruitment of BubR1 by dysfunctional telomeres inhibits Cdc20-APC function, preventing the metaphase-to-anaphase transition. ..
  3. Raffa G, Siriaco G, Cugusi S, Ciapponi L, Cenci G, Wojcik E, et al. The Drosophila modigliani (moi) gene encodes a HOAP-interacting protein required for telomere protection. Proc Natl Acad Sci U S A. 2009;106:2271-6 pubmed publisher
    ..HOAP, the components of the Mre11-Rad50-Nbs (MRN) complex, the ATM kinase, and the putative transcription factor Woc. Of these proteins, only HOAP has been shown to localize specifically at telomeres...
  4. Wismar J, Habtemichael N, Warren J, Dai J, Gilbert L, Gateff E. The mutation without children(rgl) causes ecdysteroid deficiency in third-instar larvae of Drosophila melanogaster. Dev Biol. 2000;226:1-17 pubmed
    Larvae homozygous for the recessive lethal allele without children(rgl) (woc(rgl)) fail to pupariate. Application of exogenous 20-hydroxyecdysone elicits puparium formation and pupation...
  5. Raffa G, Ciapponi L, Cenci G, Gatti M. Terminin: a protein complex that mediates epigenetic maintenance of Drosophila telomeres. Nucleus. 2011;2:383-91 pubmed publisher
    ..Based on these findings, we propose that concomitant with telomerase loss Drosophila rapidly evolved terminin to bind chromosome ends in a sequence-independent fashion, and that terminin is functionally analogous to shelterin. ..
  6. Neubueser D, Warren J, Gilbert L, Cohen S. molting defective is required for ecdysone biosynthesis. Dev Biol. 2005;280:362-72 pubmed
    ..Here, we report identification of one such gene, which we call molting defective, on the basis of its lethal phenotype. molting defective encodes a nuclear zinc finger protein required for ecdysone biosynthesis. ..
  7. Rong Y. Telomere capping in Drosophila: dealing with chromosome ends that most resemble DNA breaks. Chromosoma. 2008;117:235-42 pubmed publisher
    ..I review recent progress in Drosophila telomere studies, and challenge the notion that Drosophila may not be a relevant model for the study of telomere maintenance. ..
  8. Song Q, Sun X, Jin X. 20E-regulated USP expression and phosphorylation in Drosophila melanogaster. Insect Biochem Mol Biol. 2003;33:1211-8 pubmed
    ..Identification of the in vivo USP phosphorylation sites and signal transduction pathways that regulate the specific USP phosphorylation is currently underway. ..
  9. Jin X, Sun X, Song Q. Woc gene mutation causes 20E-dependent alpha-tubulin detyrosination in Drosophila melanogaster. Arch Insect Biochem Physiol. 2005;60:116-29 pubmed
    The mutation without children(rgl) (woc(rgl)) is a newly described ecdysone-deficient Drosophila mutant...

More Information


  1. Talamillo A, Sánchez J, Cantera R, Pérez C, Martin D, Caminero E, et al. Smt3 is required for Drosophila melanogaster metamorphosis. Development. 2008;135:1659-68 pubmed publisher
    ..In summary, our study indicates that Smt3 is required for the ecdysteroid synthesis pathway at the time of puparium formation. ..
  2. Burgio G, Cipressa F, Ingrassia A, Cenci G, Corona D. The histone deacetylase Rpd3 regulates the heterochromatin structure of Drosophila telomeres. J Cell Sci. 2011;124:2041-8 pubmed publisher
    ..Our work suggests that Drosophila telomere structure is epigenetically regulated by the histone deacetylase Rpd3. ..
  3. Maimon I, Popliker M, Gilboa L. Without children is required for Stat-mediated zfh1 transcription and for germline stem cell differentiation. Development. 2014;141:2602-10 pubmed publisher
    ..Here we show that the chromatin and telomere-binding factor Without children (Woc) is required for maintaining the association of escort cells (ECs) with germ cells in adult ovaries...
  4. Mendez D, Mandt R, Elgin S. Heterochromatin Protein 1a (HP1a) partner specificity is determined by critical amino acids in the chromo shadow domain and C-terminal extension. J Biol Chem. 2013;288:22315-23 pubmed publisher
  5. Hackney J, Zolali Meybodi O, Cherbas P. Tissue damage disrupts developmental progression and ecdysteroid biosynthesis in Drosophila. PLoS ONE. 2012;7:e49105 pubmed publisher
    ..Finally, we show that developmental delays induced by tissue damage are associated with decreased expression of genes involved in ecdysteroid synthesis and signaling. ..
  6. Xiang Y, Liu Z, Huang X. br regulates the expression of the ecdysone biosynthesis gene npc1. Dev Biol. 2010;344:800-8 pubmed publisher
    ..These results imply that ecdysone could potentially act through its early response gene br to achieve positive feedback regulation of ecdysone biosynthesis during development. ..
  7. Parvy J, Blais C, Bernard F, Warren J, Petryk A, Gilbert L, et al. A role for betaFTZ-F1 in regulating ecdysteroid titers during post-embryonic development in Drosophila melanogaster. Dev Biol. 2005;282:84-94 pubmed
    ..reduced in ftz transcription factor 1 (ftz-f1) mutant ring gland cells whereas there was no effect of the without children (woc) mutation, suggesting that FTZ-F1 regulates phm and dib expression...
  8. Ross B, Rosin L, Thomae A, Hiatt M, Vermaak D, de la Cruz A, et al. Stepwise evolution of essential centromere function in a Drosophila neogene. Science. 2013;340:1211-4 pubmed publisher
    ..Our evolutionary cell biology approach provides temporal and mechanistic detail about how young genes gain essential function. Such innovations may constantly alter the repertoire of centromeric proteins in eukaryotes...
  9. Abel J, Eskeland R, Raffa G, Kremmer E, Imhof A. Drosophila HP1c is regulated by an auto-regulatory feedback loop through its binding partner Woc. PLoS ONE. 2009;4:e5089 pubmed publisher
    ..Indeed, we found that HP1c interacts with the DNA binding factors Woc and Row and requires Woc to become targeted to chromatin in vivo...
  10. Cipressa F, Romano S, Centonze S, zur Lage P, Vernì F, Dimitri P, et al. Effete, a Drosophila chromatin-associated ubiquitin-conjugating enzyme that affects telomeric and heterochromatic position effect variegation. Genetics. 2013;195:147-58 pubmed publisher
    ..Eff is enriched at several euchromatic bands and interbands, the TAS regions, and the chromocenter. Our results suggest that Eff associates with different types of chromatin affecting their abilities to regulate gene expression. ..
  11. Morgunova V, Akulenko N, Radion E, Olovnikov I, Abramov Y, Olenina L, et al. Telomeric repeat silencing in germ cells is essential for early development in Drosophila. Nucleic Acids Res. 2015;43:8762-73 pubmed publisher
    ..Dysfunction of transcription factors Woc and Trf2, as well as RNA-binding protein Ars2, also results in the accumulation of excessively polyadenylated HeT-A ..
  12. Pahi Z, Kiss Z, Komonyi O, Borsos B, Tora L, Boros I, et al. dTAF10- and dTAF10b-Containing Complexes Are Required for Ecdysone-Driven Larval-Pupal Morphogenesis in Drosophila melanogaster. PLoS ONE. 2015;10:e0142226 pubmed publisher
    ..We propose that distinct forms of dTFIID and/or dSAGA exist during Drosophila metamorphosis, wherein different TAF compositions serve to target RNAPII at different developmental stages and tissues. ..
  13. Valzania L, Ono H, Ignesti M, Cavaliere V, Bernardi F, Gamberi C, et al. Drosophila 4EHP is essential for the larval-pupal transition and required in the prothoracic gland for ecdysone biosynthesis. Dev Biol. 2016;410:14-23 pubmed publisher
    ..Taken together, these results uncover a novel essential function for 4EHP in regulating ecdysone biosynthesis. ..
  14. Baï S, Herrera Abreu M, Rohn J, Racine V, Tajadura V, Suryavanshi N, et al. Identification and characterization of a set of conserved and new regulators of cytoskeletal organization, cell morphology and migration. BMC Biol. 2011;9:54 pubmed publisher
  15. Cenci G, Ciapponi L, Marzullo M, Raffa G, Morciano P, Raimondo D, et al. The Analysis of Pendolino (peo) Mutants Reveals Differences in the Fusigenic Potential among Drosophila Telomeres. PLoS Genet. 2015;11:e1005260 pubmed publisher
    ..Alternatively, it is possible that Peo plays a dual function being independently required for DNA replication and telomere capping. ..
  16. Raffa G, Cenci G, Ciapponi L, Gatti M. Organization and Evolution of Drosophila Terminin: Similarities and Differences between Drosophila and Human Telomeres. Front Oncol. 2013;3:112 pubmed publisher
    ..fusion in flies include HP1, Eff/UbcD1, ATM, the components of the Mre11-Rad50-Nbs (MRN) complex, and the Woc transcription factor...