Wnt5

Summary

Gene Symbol: Wnt5
Description: Wnt oncogene analog 5
Alias: CG6407, DWnt-3, DWnt-3/5, DWnt-5, DWnt3, DWnt3/5, DWnt5, Dm DWnt3/5, Dm-3, Dmel\CG6407, Dwnt-3, Dwnt-5, Dwnt3, Dwnt5, WNT5, Wnt, Wnt-3, Wnt3, Wnt3/5, anon-WO03040301.228, wnt3, wnt5, Wnt oncogene analog 5, CG6407-PA, CG6407-PB, Wnt5-PA, Wnt5-PB, wnt-oncogene-analog-3
Species: fruit fly

Top Publications

  1. Fradkin L, Dura J, Noordermeer J. Ryks: new partners for Wnts in the developing and regenerating nervous system. Trends Neurosci. 2010;33:84-92 pubmed publisher
    Conserved Ryk transmembrane proteins, tyrosine kinase-related Wnt receptors, are important during neurogenesis, axon guidance and synaptogenesis...
  2. Fradkin L, Noordermeer J, Nusse R. The Drosophila Wnt protein DWnt-3 is a secreted glycoprotein localized on the axon tracts of the embryonic CNS. Dev Biol. 1995;168:202-13 pubmed
    The Wnt gene family encodes highly conserved cysteine-rich proteins which appear to act as secreted developmental signals...
  3. Grillenzoni N, Flandre A, Lasbleiz C, Dura J. Respective roles of the DRL receptor and its ligand WNT5 in Drosophila mushroom body development. Development. 2007;134:3089-97 pubmed
    ..The WNT5 protein has been shown to act as a repulsive ligand for the DRL receptor in the embryonic central nervous system...
  4. Sakurai M, Aoki T, Yoshikawa S, Santschi L, Saito H, Endo K, et al. Differentially expressed Drl and Drl-2 play opposing roles in Wnt5 signaling during Drosophila olfactory system development. J Neurosci. 2009;29:4972-80 pubmed publisher
    ..This glomerular organization is regulated by Wnt5 signaling. In the embryonic CNS, Wnt5 signaling is transduced by the Drl receptor, a member of the Ryk family...
  5. Wouda R, Bansraj M, de Jong A, Noordermeer J, Fradkin L. Src family kinases are required for WNT5 signaling through the Derailed/RYK receptor in the Drosophila embryonic central nervous system. Development. 2008;135:2277-87 pubmed publisher
    ..Here, we show that the non-receptor Src family tyrosine kinases, SRC64B and SRC42A, are involved in WNT5-mediated signaling through Derailed in the Drosophila embryonic central nervous system...
  6. Port F, Kuster M, Herr P, Furger E, Bänziger C, Hausmann G, et al. Wingless secretion promotes and requires retromer-dependent cycling of Wntless. Nat Cell Biol. 2008;10:178-85 pubmed publisher
    b>Wnt ligands are lipid-modified, secreted glycoproteins that control multiple steps during embryogenesis and adult-tissue homeostasis. Little is known about the mechanisms underlying Wnt secretion...
  7. Taylor J, Abramova N, Charlton J, Adler P. Van Gogh: a new Drosophila tissue polarity gene. Genetics. 1998;150:199-210 pubmed
    ..In both cases the domineering nonautonomy was suppressed consistent with Van Gogh being essential for frizzled signaling. ..
  8. Fradkin L, van Schie M, Wouda R, de Jong A, Kamphorst J, Radjkoemar Bansraj M, et al. The Drosophila Wnt5 protein mediates selective axon fasciculation in the embryonic central nervous system. Dev Biol. 2004;272:362-75 pubmed
    ..We show that Wnt5, a member of the conserved Wnt secreted glycoprotein family, is required for the formation of the anterior of the ..
  9. Llimargas M, Lawrence P. Seven Wnt homologues in Drosophila: a case study of the developing tracheae. Proc Natl Acad Sci U S A. 2001;98:14487-92 pubmed
    ..The wg gene helps to pattern the developing trachea but is not responsible for all Wnt functions there...

More Information

Publications56

  1. Tanaka K, Kitagawa Y, Kadowaki T. Drosophila segment polarity gene product porcupine stimulates the posttranslational N-glycosylation of wingless in the endoplasmic reticulum. J Biol Chem. 2002;277:12816-23 pubmed
    b>Wnt is a family of cysteine-rich secreted glycoproteins, which controls the fate and behavior of the cells in multicellular organisms...
  2. Russell J, Gennissen A, Nusse R. Isolation and expression of two novel Wnt/wingless gene homologues in Drosophila. Development. 1992;115:475-85 pubmed
    Wingless (wg), the Drosophila homologue of the mouse Wnt-1 proto-oncogene, is a segment polarity gene essential in each segment for normal Drosophila development...
  3. Shimizu K, Sato M, Tabata T. The Wnt5/planar cell polarity pathway regulates axonal development of the Drosophila mushroom body neuron. J Neurosci. 2011;31:4944-54 pubmed publisher
    ..In addition, we suggest that Wnt5 functions as a ligand in the PCP pathway in this process...
  4. Harris K, Beckendorf S. Different Wnt signals act through the Frizzled and RYK receptors during Drosophila salivary gland migration. Development. 2007;134:2017-25 pubmed
    ..Analysis of a second Wnt signal, which acts through the atypical Wnt receptor Derailed, indicates a requirement for Wnt5 signaling late in salivary gland migration...
  5. Yoshikawa S, McKinnon R, Kokel M, Thomas J. Wnt-mediated axon guidance via the Drosophila Derailed receptor. Nature. 2003;422:583-8 pubmed
    ..Here we show that Derailed keeps these axons out of the posterior commissure by acting as a receptor for Wnt5, a member of the Wnt family of secreted signalling molecules...
  6. Siegfried E, Perrimon N. Drosophila wingless: a paradigm for the function and mechanism of Wnt signaling. Bioessays. 1994;16:395-404 pubmed
    The link between oncogenesis and normal development is well illustrated by the study of the Wnt family of proteins...
  7. Liebl F, Wu Y, Featherstone D, Noordermeer J, Fradkin L, Hing H. Derailed regulates development of the Drosophila neuromuscular junction. Dev Neurobiol. 2008;68:152-65 pubmed
    Neural function is dependent upon the proper formation and development of synapses. We show here that Wnt5 regulates the growth of the Drosophila neuromuscular junction (NMJ) by signaling through the Derailed receptor...
  8. Clark C, Liu Y, Cooper H. The Yin and Yang of Wnt/Ryk axon guidance in development and regeneration. Sci China Life Sci. 2014;57:366-71 pubmed publisher
    ..In this review we explore the essential and beneficial role played by the chemorepulsive Wnt receptor, Ryk/Derailed in axon navigation in the embryonic nervous system (the Yin function)...
  9. Bajpai R, Sambrani N, Stadelmayer B, Shashidhara L. Identification of a novel target of D/V signaling in Drosophila wing disc: Wg-independent function of the organizer. Gene Expr Patterns. 2004;5:113-21 pubmed
    ..The non-cell autonomous nature of Ubx-mediated repression of CG32062 expression suggests that the novel component of D/V signaling is also negatively regulated during haltere specification...
  10. Nechaev S, Fargo D, dos Santos G, Liu L, Gao Y, Adelman K. Global analysis of short RNAs reveals widespread promoter-proximal stalling and arrest of Pol II in Drosophila. Science. 2010;327:335-8 pubmed publisher
    ..These results indicate that the intrinsic efficiency of early elongation can greatly affect gene expression. ..
  11. Yao Y, Wu Y, Yin C, Ozawa R, Aigaki T, Wouda R, et al. Antagonistic roles of Wnt5 and the Drl receptor in patterning the Drosophila antennal lobe. Nat Neurosci. 2007;10:1423-32 pubmed
    ..From an overexpression screen, we have identified wnt5 as a potent organizer of the olfactory map in Drosophila melanogaster...
  12. Chen W, Antic D, Matis M, Logan C, Povelones M, Anderson G, et al. Asymmetric homotypic interactions of the atypical cadherin flamingo mediate intercellular polarity signaling. Cell. 2008;133:1093-105 pubmed publisher
  13. Blair S. Eye development: Notch lends a handedness. Curr Biol. 1999;9:R356-60 pubmed
    ..Notch signalling helps determine this handedness, first by establishing a signalling center at the eye equator, and second by mediating a choice between two photoreceptor fates ..
  14. Jockusch E, Ober K. Phylogenetic analysis of the Wnt gene family and discovery of an arthropod wnt-10 orthologue. J Exp Zool. 2000;288:105-19 pubmed
    b>Wnt genes encode a conserved family of secreted signaling proteins that play many roles in arthropod and vertebrate development. We have investigated both the phylogenetic history and molecular evolution of this gene family...
  15. Sidow A. Diversification of the Wnt gene family on the ancestral lineage of vertebrates. Proc Natl Acad Sci U S A. 1992;89:5098-102 pubmed
    Diversification of the Wnt genes, a family of powerful developmental regulator molecules, is inferred by molecular evolutionary analyses...
  16. Graba Y, Gieseler K, Aragnol D, Laurenti P, Mariol M, Berenger H, et al. DWnt-4, a novel Drosophila Wnt gene acts downstream of homeotic complex genes in the visceral mesoderm. Development. 1995;121:209-18 pubmed
    b>Wnt genes encode putative cell signalling proteins which play crucial roles during development. From a library of DNA fragments associated, in vivo, with Ultrabithorax proteins, we isolated a novel Drosophila Wnt gene, DWnt-4...
  17. Hamada Kawaguchi N, Nore B, Kuwada Y, Smith C, Yamamoto D. Btk29A promotes Wnt4 signaling in the niche to terminate germ cell proliferation in Drosophila. Science. 2014;343:294-7 pubmed publisher
    ..This signaling mechanism likely represents a versatile developmental switch. ..
  18. Linnemannstöns K, Ripp C, Honemann Capito M, Brechtel Curth K, Hedderich M, Wodarz A. The PTK7-related transmembrane proteins off-track and off-track 2 are co-receptors for Drosophila Wnt2 required for male fertility. PLoS Genet. 2014;10:e1004443 pubmed publisher
    b>Wnt proteins regulate many developmental processes and are required for tissue homeostasis in adult animals...
  19. Yasunaga K, Tezuka A, Ishikawa N, Dairyo Y, Togashi K, Koizumi H, et al. Adult Drosophila sensory neurons specify dendritic territories independently of dendritic contacts through the Wnt5-Drl signaling pathway. Genes Dev. 2015;29:1763-75 pubmed publisher
    ..We identify Wnt5 derived from sternites, the ventral-most part of the adult abdominal epidermis, as the critical determinant for the ..
  20. Muse G, Gilchrist D, Nechaev S, Shah R, Parker J, Grissom S, et al. RNA polymerase is poised for activation across the genome. Nat Genet. 2007;39:1507-11 pubmed
    ..This finding indicates a role for regulation of polymerase elongation in the transcriptional responses to dynamic environmental and developmental cues. ..
  21. Wehrli M, Tomlinson A. Independent regulation of anterior/posterior and equatorial/polar polarity in the Drosophila eye; evidence for the involvement of Wnt signaling in the equatorial/polar axis. Development. 1998;125:1421-32 pubmed
    ..Further, we show that the polarizing information acting in this equatorial/polar axis (Eq/Pl) is established in at least two steps - the activity of one signaling molecule functions to establish the graded activity of a second signal. ..
  22. Ching W, Hang H, Nusse R. Lipid-independent secretion of a Drosophila Wnt protein. J Biol Chem. 2008;283:17092-8 pubmed publisher
    b>Wnt proteins comprise a large class of secreted signaling molecules with key roles during embryonic development and throughout adult life...
  23. Ding Z, Wang Y, Luo Z, Lee H, Hwang J, Chien C, et al. Glial cell adhesive molecule unzipped mediates axon guidance in Drosophila. Dev Dyn. 2011;240:122-34 pubmed publisher
    ..defect, loss of uzip enhanced the axonal defects in the mutant of N-cadherin (CadN) and the Wnt gene family member wnt5. Overexpression of uzip could rescue the phenotype in the CadNuzip(D43) mutant...
  24. Yuan L, Hu S, Okray Z, Ren X, De Geest N, Claeys A, et al. The Drosophila neurogenin Tap functionally interacts with the Wnt-PCP pathway to regulate neuronal extension and guidance. Development. 2016;143:2760-6 pubmed publisher
    ..Genetic and expression analyses suggest that Tap inhibits excessive axonal growth by fine regulation of the levels of the Wnt signaling adaptor protein Dishevelled.
  25. Reynaud E, Lahaye L, Boulanger A, Petrova I, Marquilly C, Flandre A, et al. Guidance of Drosophila Mushroom Body Axons Depends upon DRL-Wnt Receptor Cleavage in the Brain Dorsomedial Lineage Precursors. Cell Rep. 2015;11:1293-304 pubmed publisher
    ..We show that the Ryk family WNT5 receptor, DRL (derailed), which is expressed in the dorsomedial lineages, brain structure precursors adjacent to ..
  26. Yang E, Tacchelly Benites O, Wang Z, Randall M, Tian A, Benchabane H, et al. Wnt pathway activation by ADP-ribosylation. Nat Commun. 2016;7:11430 pubmed publisher
    b>Wnt/β-catenin signalling directs fundamental processes during metazoan development and can be aberrantly activated in cancer...
  27. Srahna M, Leyssen M, Choi C, Fradkin L, Noordermeer J, Hassan B. A signaling network for patterning of neuronal connectivity in the Drosophila brain. PLoS Biol. 2006;4:e348 pubmed
    ..this question in the developing adult brain of Drosophila and find that it is regulated by crosstalk between Wnt, fibroblast growth factor (FGF) receptor, and Jun N-terminal kinase (JNK) signaling, but independent of neuronal ..
  28. Nusse R. Wnts and Hedgehogs: lipid-modified proteins and similarities in signaling mechanisms at the cell surface. Development. 2003;130:5297-305 pubmed
    This review compares the signaling mechanisms of the Wnt and the Hedgehog proteins...
  29. Yoshikawa S, Thomas J. Secreted cell signaling molecules in axon guidance. Curr Opin Neurobiol. 2004;14:45-50 pubmed
    ..These signaling molecules seem to act directly on the growth cone and thus are likely to activate non-canonical signaling pathways that are coupled to the cytoskeleton. ..
  30. Glise B, Miller C, Crozatier M, Halbisen M, Wise S, Olson D, et al. Shifted, the Drosophila ortholog of Wnt inhibitory factor-1, controls the distribution and movement of Hedgehog. Dev Cell. 2005;8:255-66 pubmed
    ..Surprisingly, shifted encodes the only Drosophila ortholog of the secreted vertebrate protein Wnt Inhibitory Factor-1 (WIF-1), whose known role is to bind to extracellular Wnts and inhibit their activity...
  31. Wu C, Nusse R. Ligand receptor interactions in the Wnt signaling pathway in Drosophila. J Biol Chem. 2002;277:41762-9 pubmed
    Secreted Wnt proteins have numerous signaling functions during development, mediated by Frizzled molecules that act as Wnt receptors on the cell surface...
  32. Gombos R, Migh E, Antal O, Mukherjee A, Jenny A, Mihály J. The Formin DAAM Functions as Molecular Effector of the Planar Cell Polarity Pathway during Axonal Development in Drosophila. J Neurosci. 2015;35:10154-67 pubmed publisher
    ..By using a combination of genetic and biochemical assays, we demonstrate that Wnt5 and the PCP signaling proteins Frizzled, Strabismus, and Dishevelled act in concert with the small GTPase Rac1 to ..
  33. Casal J, Lawrence P, Struhl G. Two separate molecular systems, Dachsous/Fat and Starry night/Frizzled, act independently to confer planar cell polarity. Development. 2006;133:4561-72 pubmed
    ..We consider how polarity may be propagated by Ds-Ft heterodimers acting as bridges between cells. ..
  34. Herr P, Basler K. Porcupine-mediated lipidation is required for Wnt recognition by Wls. Dev Biol. 2012;361:392-402 pubmed publisher
    b>Wnt proteins are members of a conserved family of secreted signaling ligands and play crucial roles during development and in tissue homeostasis...
  35. Schubert M, Holland L, Holland N, Jacobs D. A phylogenetic tree of the Wnt genes based on all available full-length sequences, including five from the cephalochordate amphioxus. Mol Biol Evol. 2000;17:1896-903 pubmed
    The WNT: gene family is large, and new members are still being discovered. We constructed a parsimony tree for the WNT: family based on all 82 of the full-length sequences currently available...
  36. Lahaye L, Wouda R, de Jong A, Fradkin L, Noordermeer J. WNT5 interacts with the Ryk receptors doughnut and derailed to mediate muscle attachment site selection in Drosophila melanogaster. PLoS ONE. 2012;7:e32297 pubmed publisher
    ..Here, we show that Wnt5 is needed in this process...
  37. Xie L, Ng C, Ali T, Valencia R, Ferreira B, Xue V, et al. Multiscale modeling of the causal functional roles of nsSNPs in a genome-wide association study: application to hypoxia. BMC Genomics. 2013;14 Suppl 3:S9 pubmed publisher
    ..and network levels allows us to identify driver mutations and their interactions (epistasis) in H, Rad51D, Ulp1, Wnt5, HDAC4, Sol, Dys, GalNAc-T2, and CG33714 genes, all of which are involved in the up-regulation of Notch and Gurken/..
  38. Charron F, Tessier Lavigne M. Novel brain wiring functions for classical morphogens: a role as graded positional cues in axon guidance. Development. 2005;132:2251-62 pubmed
    ..This review presents the roles identified for members of three prominent morphogen families--the Hedgehog, Wnt and TGFbeta/BMP families--in axon guidance, and discusses potential implications for the molecular mechanisms ..
  39. Wu Y, Helt J, Wexler E, Petrova I, Noordermeer J, Fradkin L, et al. Wnt5 and drl/ryk gradients pattern the Drosophila olfactory dendritic map. J Neurosci. 2014;34:14961-72 pubmed publisher
    ..During this period, a novel set of AL-extrinsic neurons express high levels of the Wnt5 protein and are tightly associated with the dorsolateral edge of the AL...
  40. Zlatic M, Li F, Strigini M, Grueber W, Bate M. Positional cues in the Drosophila nerve cord: semaphorins pattern the dorso-ventral axis. PLoS Biol. 2009;7:e1000135 pubmed publisher
    ..Together our findings support the idea that axons are delivered to particular regions of the neuropile by their responses to systems of positional cues in each dimension. ..
  41. Petrova I, Lahaye L, Martiáñez T, de Jong A, Malessy M, Verhaagen J, et al. Homodimerization of the Wnt receptor DERAILED recruits the Src family kinase SRC64B. Mol Cell Biol. 2013;33:4116-27 pubmed publisher
    ..DERAILED homodimerization levels increase significantly in the presence of its ligand, WNT5. In addition, DERAILED displays ligand-independent dimerization mediated by a motif in its transmembrane domain...
  42. Schnorrer F, Dickson B. Axon guidance: morphogens show the way. Curr Biol. 2004;14:R19-21 pubmed
    Hedgehog and Wnt family proteins can act as classic developmental morphogens to pattern a field of nai;ve cells...
  43. Veeman M, Axelrod J, Moon R. A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling. Dev Cell. 2003;5:367-77 pubmed
    More is becoming known about so-called noncanonical Wnt pathways that signal independently of beta-catenin. Here we review recent developments in both the functions and mechanisms of noncanonical Wnt signaling...
  44. Wodarz A, Nusse R. Mechanisms of Wnt signaling in development. Annu Rev Cell Dev Biol. 1998;14:59-88 pubmed
    b>Wnt genes encode a large family of secreted, cysteine-rich proteins that play key roles as intercellular signaling molecules in development...
  45. Eisenberg L, Ingham P, Brown A. Cloning and characterization of a novel Drosophila Wnt gene, Dwnt-5, a putative downstream target of the homeobox gene distal-less. Dev Biol. 1992;154:73-83 pubmed
    The Wnt gene family in vertebrates comprises at least 11 distinct genes but the only family member previously identified in Drosophila has been the segment polarity gene wingless (wg), the ortholog of vertebrate Wnt-1...
  46. Singh A, Vijayraghavan K, Rodrigues V. Dendritic refinement of an identified neuron in the Drosophila CNS is regulated by neuronal activity and Wnt signaling. Development. 2010;137:1351-60 pubmed publisher
    ..Our findings integrate sensory activity, NMDA receptors and Wingless/Wnt5 signaling pathways to advance our understanding of how dendritic refinement is established...
  47. Panganiban G, Rubenstein J. Developmental functions of the Distal-less/Dlx homeobox genes. Development. 2002;129:4371-86 pubmed
    ..We review what is known about the invertebrate and vertebrate Dll/Dlx genes and their varied roles during development. We propose revising the vertebrate nomenclature to reflect phylogenetic relationships among the Dlx genes. ..