Gene Symbol: Wnt4
Description: Wnt oncogene analog 4
Alias: CG4698, DWnt-4, DWnt4, Dm DWnt4, Dmel\CG4698, Dwnt4, WNT4, Wnt, Wnt-4, anon-EST:Liang-2.4, clone 2.4, wnt-4, wnt4, Wnt oncogene analog 4, CG4698-PA, CG4698-PB, Wnt4-PA, Wnt4-PB
Species: fruit fly

Top Publications

  1. Harris K, Beckendorf S. Different Wnt signals act through the Frizzled and RYK receptors during Drosophila salivary gland migration. Development. 2007;134:2017-25 pubmed
    ..Early in migration, the salivary gland responds to a WNT4-Frizzled signal for proper positioning within the embryo...
  2. Taylor J, Abramova N, Charlton J, Adler P. Van Gogh: a new Drosophila tissue polarity gene. Genetics. 1998;150:199-210 pubmed
    ..In both cases the domineering nonautonomy was suppressed consistent with Van Gogh being essential for frizzled signaling. ..
  3. Llimargas M, Lawrence P. Seven Wnt homologues in Drosophila: a case study of the developing tracheae. Proc Natl Acad Sci U S A. 2001;98:14487-92 pubmed
    ..The wg gene helps to pattern the developing trachea but is not responsible for all Wnt functions there...
  4. Inaki M, Yoshikawa S, Thomas J, Aburatani H, Nose A. Wnt4 is a local repulsive cue that determines synaptic target specificity. Curr Biol. 2007;17:1574-9 pubmed
    ..a number of potential target cues that are differentially expressed between the two muscles, including M13-enriched Wnt4. When the functions of Wnt4, or putative receptors Frizzled 2 and Derailed-2 or Dishevelled were inhibited, motor ..
  5. Casal J, Lawrence P, Struhl G. Two separate molecular systems, Dachsous/Fat and Starry night/Frizzled, act independently to confer planar cell polarity. Development. 2006;133:4561-72 pubmed
    ..We consider how polarity may be propagated by Ds-Ft heterodimers acting as bridges between cells. ..
  6. Yoshikawa S, McKinnon R, Kokel M, Thomas J. Wnt-mediated axon guidance via the Drosophila Derailed receptor. Nature. 2003;422:583-8 pubmed
    ..that Derailed keeps these axons out of the posterior commissure by acting as a receptor for Wnt5, a member of the Wnt family of secreted signalling molecules...
  7. Gieseler K, Wilder E, Mariol M, Buratovitch M, Berenger H, Graba Y, et al. DWnt4 and wingless elicit similar cellular responses during imaginal development. Dev Biol. 2001;232:339-50 pubmed
    ..We previously reported that DWnt4 and wingless (wg), two divergent clustered Wnt genes, can have either antagonist or distinct functions during ..
  8. Cohen E, Mariol M, Wallace R, Weyers J, Kamberov Y, Pradel J, et al. DWnt4 regulates cell movement and focal adhesion kinase during Drosophila ovarian morphogenesis. Dev Cell. 2002;2:437-48 pubmed
    ..Dfrizzled2, Disheveled, and protein kinase C are also required. The DWnt4 cell motility pathway is distinct from both the canonical Wnt pathway and the planar polarity pathway...
  9. Chen W, Antic D, Matis M, Logan C, Povelones M, Anderson G, et al. Asymmetric homotypic interactions of the atypical cadherin flamingo mediate intercellular polarity signaling. Cell. 2008;133:1093-105 pubmed publisher

More Information


  1. Wu C, Nusse R. Ligand receptor interactions in the Wnt signaling pathway in Drosophila. J Biol Chem. 2002;277:41762-9 pubmed
    Secreted Wnt proteins have numerous signaling functions during development, mediated by Frizzled molecules that act as Wnt receptors on the cell surface...
  2. Fradkin L, Dura J, Noordermeer J. Ryks: new partners for Wnts in the developing and regenerating nervous system. Trends Neurosci. 2010;33:84-92 pubmed publisher
    Conserved Ryk transmembrane proteins, tyrosine kinase-related Wnt receptors, are important during neurogenesis, axon guidance and synaptogenesis...
  3. Gieseler K, Graba Y, Mariol M, Wilder E, Martinez Arias A, Lemaire P, et al. Antagonist activity of DWnt-4 and wingless in the Drosophila embryonic ventral ectoderm and in heterologous Xenopus assays. Mech Dev. 1999;85:123-31 pubmed
    b>Wnt genes encode secreted signalling molecules involved in a number of basic developmental processes...
  4. Lim J, Norga K, Chen Z, Choi K. Control of planar cell polarity by interaction of DWnt4 and four-jointed. Genesis. 2005;42:150-61 pubmed
    ..Here we examined the function of a Drosophila homolog of Wnt4 (DWnt4) in the control of planar polarity...
  5. Sato A, Kojima T, Ui Tei K, Miyata Y, Saigo K. Dfrizzled-3, a new Drosophila Wnt receptor, acting as an attenuator of Wingless signaling in wingless hypomorphic mutants. Development. 1999;126:4421-30 pubmed
    ..Wingless signaling may thus be attenuated by Dfrizzled-3 at least in wingless hypomorphic mutants. ..
  6. Peradziryi H, Kaplan N, Podleschny M, Liu X, Wehner P, Borchers A, et al. PTK7/Otk interacts with Wnts and inhibits canonical Wnt signalling. EMBO J. 2011;30:3729-40 pubmed publisher
    ..In Drosophila, Otk interacts with Wnt4 and opposes canonical Wnt signalling in embryonic patterning...
  7. Veeman M, Axelrod J, Moon R. A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling. Dev Cell. 2003;5:367-77 pubmed
    More is becoming known about so-called noncanonical Wnt pathways that signal independently of beta-catenin. Here we review recent developments in both the functions and mechanisms of noncanonical Wnt signaling...
  8. Port F, Kuster M, Herr P, Furger E, Bänziger C, Hausmann G, et al. Wingless secretion promotes and requires retromer-dependent cycling of Wntless. Nat Cell Biol. 2008;10:178-85 pubmed publisher
    b>Wnt ligands are lipid-modified, secreted glycoproteins that control multiple steps during embryogenesis and adult-tissue homeostasis. Little is known about the mechanisms underlying Wnt secretion...
  9. Carvajal Gonzalez J, Mlodzik M. Mechanisms of planar cell polarity establishment in Drosophila. F1000Prime Rep. 2014;6:98 pubmed publisher
    ..Here, we discuss the current models based on Drosophila studies and incorporate recent insights into this long-standing cell and developmental biology problem. ..
  10. Taylor M. A novel Drosophila, mef2-regulated muscle gene isolated in a subtractive hybridization-based molecular screen using small amounts of zygotic mutant RNA. Dev Biol. 2000;220:37-52 pubmed
    ..The tin-independent and Dmef2-independent expression of Dmeso18E indicates that it either occupies a link between twi and genes like tin and Dmef2 or it lies in a parallel pathway of gene activation. ..
  11. Harris R, Setiawan L, Saul J, Hariharan I. Localized epigenetic silencing of a damage-activated WNT enhancer limits regeneration in mature Drosophila imaginal discs. elife. 2016;5: pubmed publisher
    ..This correlates with reduced damage-responsive expression of multiple genes, including the WNT genes wingless (wg) and Wnt6...
  12. Bajpai R, Sambrani N, Stadelmayer B, Shashidhara L. Identification of a novel target of D/V signaling in Drosophila wing disc: Wg-independent function of the organizer. Gene Expr Patterns. 2004;5:113-21 pubmed
    ..The non-cell autonomous nature of Ubx-mediated repression of CG32062 expression suggests that the novel component of D/V signaling is also negatively regulated during haltere specification...
  13. Peifer M, McEwen D. The ballet of morphogenesis: unveiling the hidden choreographers. Cell. 2002;109:271-4 pubmed
    Several recent papers reveal new insights into the mechanisms by which cells turn their perceptions about fate into action, focusing on the role of Wnt signal transduction in cell polarization and migration.
  14. Sato M, Umetsu D, Murakami S, Yasugi T, Tabata T. DWnt4 regulates the dorsoventral specificity of retinal projections in the Drosophila melanogaster visual system. Nat Neurosci. 2006;9:67-75 pubmed
    ..Here we show that DWnt4, a secreted protein of the Wnt family, is the ventral cue for the lamina...
  15. Hamada Kawaguchi N, Nore B, Kuwada Y, Smith C, Yamamoto D. Btk29A promotes Wnt4 signaling in the niche to terminate germ cell proliferation in Drosophila. Science. 2014;343:294-7 pubmed publisher
    ..This phenotype was rescued by overexpression of wild-type Btk29A and phenocopied by the interference of Wnt4-?-catenin signaling or its putative downstream nuclear protein Piwi in somatic escort cells...
  16. Charron F, Tessier Lavigne M. Novel brain wiring functions for classical morphogens: a role as graded positional cues in axon guidance. Development. 2005;132:2251-62 pubmed
    ..This review presents the roles identified for members of three prominent morphogen families--the Hedgehog, Wnt and TGFbeta/BMP families--in axon guidance, and discusses potential implications for the molecular mechanisms ..
  17. Wu J, Roman A, Carvajal Gonzalez J, Mlodzik M. Wg and Wnt4 provide long-range directional input to planar cell polarity orientation in Drosophila. Nat Cell Biol. 2013;15:1045-55 pubmed publisher
    ..We demonstrate in Drosophila melanogaster wings that Wg (Wingless) and dWnt4 (Drosophila Wnt homologue) provide instructive regulatory input for PCP axis determination, establishing polarity ..
  18. Linnemannstöns K, Ripp C, Honemann Capito M, Brechtel Curth K, Hedderich M, Wodarz A. The PTK7-related transmembrane proteins off-track and off-track 2 are co-receptors for Drosophila Wnt2 required for male fertility. PLoS Genet. 2014;10:e1004443 pubmed publisher
    b>Wnt proteins regulate many developmental processes and are required for tissue homeostasis in adult animals...
  19. Gupta T, Schupbach T. Cct1, a phosphatidylcholine biosynthesis enzyme, is required for Drosophila oogenesis and ovarian morphogenesis. Development. 2003;130:6075-87 pubmed
    ..These data provide the first evidence for a specific role for CCT, and thus for phosphatidylcholine, in patterning during development. ..
  20. Cadigan K, Jou A, Nusse R. Wingless blocks bristle formation and morphogenetic furrow progression in the eye through repression of Daughterless. Development. 2002;129:3393-402 pubmed
    ..These results are summarized in a model where daughterless is a major, but probably not the only, target of wingless action in the eye. ..
  21. Inaki M, Shinza Kameda M, Ismat A, Frasch M, Nose A. Drosophila Tey represses transcription of the repulsive cue Toll and generates neuromuscular target specificity. Development. 2010;137:2139-46 pubmed publisher
    ..These results suggest that Tey determines target specificity by repressing the expression of Toll. These results reveal a mechanism for generating synaptic specificity that relies on the negative regulation of a repulsive target cue. ..
  22. Nose A, Inaki M, Shinza Kameda M. [Molecular mechanism of neural connectivity: target determination by a negative signal]. Tanpakushitsu Kakusan Koso. 2008;53:531-6 pubmed
  23. Herr P, Basler K. Porcupine-mediated lipidation is required for Wnt recognition by Wls. Dev Biol. 2012;361:392-402 pubmed publisher
    b>Wnt proteins are members of a conserved family of secreted signaling ligands and play crucial roles during development and in tissue homeostasis...
  24. Graba Y, Gieseler K, Aragnol D, Laurenti P, Mariol M, Berenger H, et al. DWnt-4, a novel Drosophila Wnt gene acts downstream of homeotic complex genes in the visceral mesoderm. Development. 1995;121:209-18 pubmed
    b>Wnt genes encode putative cell signalling proteins which play crucial roles during development. From a library of DNA fragments associated, in vivo, with Ultrabithorax proteins, we isolated a novel Drosophila Wnt gene, DWnt-4...
  25. Wodarz A, Nusse R. Mechanisms of Wnt signaling in development. Annu Rev Cell Dev Biol. 1998;14:59-88 pubmed
    b>Wnt genes encode a large family of secreted, cysteine-rich proteins that play key roles as intercellular signaling molecules in development...
  26. Upadhyay M, Martino Cortez Y, Wong Deyrup S, Tavares L, Schowalter S, Flora P, et al. Transposon Dysregulation Modulates dWnt4 Signaling to Control Germline Stem Cell Differentiation in Drosophila. PLoS Genet. 2016;12:e1005918 pubmed publisher
    ..for the expression of a Wnt ligand, Drosophila Wingless type mouse mammary virus integration site number 4 (dWnt4) in the somatic niche...
  27. Tauc H, Mann T, Werner K, Pandur P. A role for Drosophila Wnt-4 in heart development. Genesis. 2012;50:466-81 pubmed publisher
    ..In Drosophila, wingless holds an essential role in heart development. Among the known Drosophila Wnts is DWnt4, the function of which has been studied in various developmental processes except for heart development...
  28. Hosono C, Takaira K, Matsuda R, Saigo K. Functional subdivision of trunk visceral mesoderm parasegments in Drosophila is required for gut and trachea development. Development. 2003;130:439-49 pubmed
  29. Buratovich M, Anderson S, Gieseler K, Pradel J, Wilder E. DWnt-4 and Wingless have distinct activities in the Drosophila dorsal epidermis. Dev Genes Evol. 2000;210:111-9 pubmed
    b>Wnt genes are often expressed in overlapping patterns, where they affect a wide array of developmental processes...
  30. Chen Z, Zhu J, Fu Y, Richman A, Han Z. Wnt4 is required for ostia development in the Drosophila heart. Dev Biol. 2016;413:188-98 pubmed publisher
    ..We observed high levels of Wnt4 gene expression in Drosophila ostia progenitor cells, immediately prior to morphological differentiation of these ..
  31. Schubert M, Holland L, Holland N, Jacobs D. A phylogenetic tree of the Wnt genes based on all available full-length sequences, including five from the cephalochordate amphioxus. Mol Biol Evol. 2000;17:1896-903 pubmed
    The WNT: gene family is large, and new members are still being discovered. We constructed a parsimony tree for the WNT: family based on all 82 of the full-length sequences currently available...
  32. Bhat K. Segment polarity genes in neuroblast formation and identity specification during Drosophila neurogenesis. Bioessays. 1999;21:472-85 pubmed
  33. Kuroda J, Nakamura M, Yoshida M, Yamamoto H, Maeda T, Taniguchi K, et al. Canonical Wnt signaling in the visceral muscle is required for left-right asymmetric development of the Drosophila midgut. Mech Dev. 2012;128:625-39 pubmed publisher
    ..frizzled 2 (fz2) and Wnt4, which encode a receptor and ligand of Wnt signaling, respectively, were required for the LR asymmetric development ..
  34. Cadigan K. Wnt signaling--20 years and counting. Trends Genet. 2002;18:340-2 pubmed
  35. Mottier Pavie V, Palacios V, Eliazer S, Scoggin S, Buszczak M. The Wnt pathway limits BMP signaling outside of the germline stem cell niche in Drosophila ovaries. Dev Biol. 2016;417:50-62 pubmed publisher
    ..Through these efforts, we found that disruption of Wnt4 and components of the canonical Wnt pathway results in a complex germ cell phenotype marked by an expansion of GSC-..
  36. Srahna M, Leyssen M, Choi C, Fradkin L, Noordermeer J, Hassan B. A signaling network for patterning of neuronal connectivity in the Drosophila brain. PLoS Biol. 2006;4:e348 pubmed
    ..this question in the developing adult brain of Drosophila and find that it is regulated by crosstalk between Wnt, fibroblast growth factor (FGF) receptor, and Jun N-terminal kinase (JNK) signaling, but independent of neuronal ..
  37. Huang H, Klein P. The Frizzled family: receptors for multiple signal transduction pathways. Genome Biol. 2004;5:234 pubmed
    ..Frizzled proteins are receptors for secreted Wnt proteins, as well as other ligands, and also play a critical role in the regulation of cell polarity...
  38. Gieseler K, Mariol M, Sagnier T, Graba Y, Pradel J. wingless and DWnt4, 2 Drosophila Wnt genes, have related expression, regulation and function during the embryonic development. C R Acad Sci III. 1995;318:1101-10 pubmed
    ..that exist between the Drosophila genes wingless, the orthologue of the mammalian Wnt1 proto-oncogene, and DWnt4, a new member of the Wnt family...
  39. Lahaye L, Wouda R, de Jong A, Fradkin L, Noordermeer J. WNT5 interacts with the Ryk receptors doughnut and derailed to mediate muscle attachment site selection in Drosophila melanogaster. PLoS ONE. 2012;7:e32297 pubmed publisher
    ..These results extend previous findings that at least some of the molecular pathways that guide axons towards their targets are also employed for guidance of muscle fibers to their appropriate attachment sites. ..
  40. Pandur P, Maurus D, Kuhl M. Increasingly complex: new players enter the Wnt signaling network. Bioessays. 2002;24:881-4 pubmed
    b>Wnt proteins can activate different intracellular signaling cascades in various organisms by interacting with receptors of the Frizzled family...
  41. Jockusch E, Ober K. Phylogenetic analysis of the Wnt gene family and discovery of an arthropod wnt-10 orthologue. J Exp Zool. 2000;288:105-19 pubmed
    b>Wnt genes encode a conserved family of secreted signaling proteins that play many roles in arthropod and vertebrate development. We have investigated both the phylogenetic history and molecular evolution of this gene family...
  42. Wang S, Gao Y, Song X, Ma X, Zhu X, Mao Y, et al. Wnt signaling-mediated redox regulation maintains the germ line stem cell differentiation niche. elife. 2015;4:e08174 pubmed publisher
    ..Finally, Wnt2 and Wnt4 function redundantly to maintain active Wnt signaling in the differentiation niche...
  43. Blair S. Eye development: Notch lends a handedness. Curr Biol. 1999;9:R356-60 pubmed
    ..Notch signalling helps determine this handedness, first by establishing a signalling center at the eye equator, and second by mediating a choice between two photoreceptor fates ..
  44. Wehrli M, Tomlinson A. Independent regulation of anterior/posterior and equatorial/polar polarity in the Drosophila eye; evidence for the involvement of Wnt signaling in the equatorial/polar axis. Development. 1998;125:1421-32 pubmed
    ..Further, we show that the polarizing information acting in this equatorial/polar axis (Eq/Pl) is established in at least two steps - the activity of one signaling molecule functions to establish the graded activity of a second signal. ..
  45. Bhat K. Cell-cell signaling during neurogenesis: some answers and many questions. Int J Dev Biol. 1998;42:127-39 pubmed