Gene Symbol: Wnt2
Description: Wnt oncogene analog 2
Alias: CG1916, D-wnt-2, DWnt-2, DWnt2, Dm DWnt2, Dm-2, Dmel\CG1916, Dwnt-2, Dwnt2, Wnt, Wnt-2, dWnt2, wnt-2, wnt2, Wnt oncogene analog 2, CG1916-PA, CG1916-PB, Wnt2-PA, Wnt2-PB
Species: fruit fly

Top Publications

  1. Wehrli M, Tomlinson A. Independent regulation of anterior/posterior and equatorial/polar polarity in the Drosophila eye; evidence for the involvement of Wnt signaling in the equatorial/polar axis. Development. 1998;125:1421-32 pubmed
    ..Further, we show that the polarizing information acting in this equatorial/polar axis (Eq/Pl) is established in at least two steps - the activity of one signaling molecule functions to establish the graded activity of a second signal. ..
  2. Willert K, Logan C, Arora A, Fish M, Nusse R. A Drosophila Axin homolog, Daxin, inhibits Wnt signaling. Development. 1999;126:4165-73 pubmed
    The vertebrate Axin protein, the product of the mouse fused gene, binds to beta-catenin to inhibit Wnt signaling. We have identified a homolog of Axin in Drosophila, Daxin...
  3. Fouquet W, Owald D, Wichmann C, Mertel S, Depner H, Dyba M, et al. Maturation of active zone assembly by Drosophila Bruchpilot. J Cell Biol. 2009;186:129-45 pubmed publisher
    ..BRP seems responsible for effectively clustering Ca(2+) channels beneath the T-bar density late in a protracted AZ formation process, potentially through a direct molecular interaction with intracellular Ca(2+) channel domains. ..
  4. Wu C, Nusse R. Ligand receptor interactions in the Wnt signaling pathway in Drosophila. J Biol Chem. 2002;277:41762-9 pubmed
    Secreted Wnt proteins have numerous signaling functions during development, mediated by Frizzled molecules that act as Wnt receptors on the cell surface...
  5. Kozopas K, Samos C, Nusse R. DWnt-2, a Drosophila Wnt gene required for the development of the male reproductive tract, specifies a sexually dimorphic cell fate. Genes Dev. 1998;12:1155-65 pubmed
  6. Russell J, Gennissen A, Nusse R. Isolation and expression of two novel Wnt/wingless gene homologues in Drosophila. Development. 1992;115:475-85 pubmed
    Wingless (wg), the Drosophila homologue of the mouse Wnt-1 proto-oncogene, is a segment polarity gene essential in each segment for normal Drosophila development...
  7. Harris K, Beckendorf S. Different Wnt signals act through the Frizzled and RYK receptors during Drosophila salivary gland migration. Development. 2007;134:2017-25 pubmed
    ..Here we show that two distinct Wnt signaling pathways regulate salivary gland migration...
  8. Kozopas K, Nusse R. Direct flight muscles in Drosophila develop from cells with characteristics of founders and depend on DWnt-2 for their correct patterning. Dev Biol. 2002;243:312-25 pubmed
    ..We conclude that DWnt-2 promotes the correct patterning of DFMs through a mechanism that is independent of the attachment site differentiation initiated by stripe. ..
  9. Taylor J, Abramova N, Charlton J, Adler P. Van Gogh: a new Drosophila tissue polarity gene. Genetics. 1998;150:199-210 pubmed
    ..In both cases the domineering nonautonomy was suppressed consistent with Van Gogh being essential for frizzled signaling. ..

More Information


  1. Llimargas M, Lawrence P. Seven Wnt homologues in Drosophila: a case study of the developing tracheae. Proc Natl Acad Sci U S A. 2001;98:14487-92 pubmed
    ..We test each one of the seven DWnts in several ways and find evidence that wg and DWnt2 can function in the developing trachea: when both genes are removed together, the phenotype is identical or very ..
  2. Dupont P, Besson M, Devaux J, Liévens J. Reducing canonical Wingless/Wnt signaling pathway confers protection against mutant Huntingtin toxicity in Drosophila. Neurobiol Dis. 2012;47:237-47 pubmed publisher
    ..the stability and levels of ?-Catenin, a key molecule in cell adhesion and signal transduction in Wingless (Wg)/Wnt pathway. However it remains to establish whether manipulation of Wg/Wnt signaling can impact HD pathology...
  3. Srahna M, Leyssen M, Choi C, Fradkin L, Noordermeer J, Hassan B. A signaling network for patterning of neuronal connectivity in the Drosophila brain. PLoS Biol. 2006;4:e348 pubmed
    ..this question in the developing adult brain of Drosophila and find that it is regulated by crosstalk between Wnt, fibroblast growth factor (FGF) receptor, and Jun N-terminal kinase (JNK) signaling, but independent of neuronal ..
  4. Biemar F, Nix D, Piel J, Peterson B, Ronshaugen M, Sementchenko V, et al. Comprehensive identification of Drosophila dorsal-ventral patterning genes using a whole-genome tiling array. Proc Natl Acad Sci U S A. 2006;103:12763-8 pubmed
    ..to the identification of another 30 protein-coding genes, including the Drosophila homolog of Idax, an inhibitor of Wnt signaling...
  5. Hendrix D, Hong J, Zeitlinger J, Rokhsar D, Levine M. Promoter elements associated with RNA Pol II stalling in the Drosophila embryo. Proc Natl Acad Sci U S A. 2008;105:7762-7 pubmed publisher
    ..We discuss different models for Pol II binding and gene activation in the early embryo. ..
  6. Hamada Kawaguchi N, Nore B, Kuwada Y, Smith C, Yamamoto D. Btk29A promotes Wnt4 signaling in the niche to terminate germ cell proliferation in Drosophila. Science. 2014;343:294-7 pubmed publisher
    ..This signaling mechanism likely represents a versatile developmental switch. ..
  7. Georgiev P, Toscano S, Nair A, Hardie R, Raghu P. Identification of a suppressor of retinal degeneration in Drosophila photoreceptors. J Neurogenet. 2012;26:338-47 pubmed publisher
    ..Studies of su(40) as well as these new alleles should facilitate the understanding of the mechanisms by which excessive Ca(2+) influx results in retinal degeneration. ..
  8. Siegfried E, Perrimon N. Drosophila wingless: a paradigm for the function and mechanism of Wnt signaling. Bioessays. 1994;16:395-404 pubmed
    The link between oncogenesis and normal development is well illustrated by the study of the Wnt family of proteins...
  9. DeFalco T, Verney G, Jenkins A, McCaffery J, Russell S, Van Doren M. Sex-specific apoptosis regulates sexual dimorphism in the Drosophila embryonic gonad. Dev Cell. 2003;5:205-16 pubmed
    ..Our work furthers the hypotheses that a conserved pathway controls gonad sexual dimorphism in diverse species and that sex-specific cell recruitment and programmed cell death are common mechanisms for creating sexual dimorphism. ..
  10. Wang S, Gao Y, Song X, Ma X, Zhu X, Mao Y, et al. Wnt signaling-mediated redox regulation maintains the germ line stem cell differentiation niche. elife. 2015;4:e08174 pubmed publisher
    ..Finally, Wnt2 and Wnt4 function redundantly to maintain active Wnt signaling in the differentiation niche...
  11. Chen W, Antic D, Matis M, Logan C, Povelones M, Anderson G, et al. Asymmetric homotypic interactions of the atypical cadherin flamingo mediate intercellular polarity signaling. Cell. 2008;133:1093-105 pubmed publisher
  12. Boyle M, Bonini N, DiNardo S. Expression and function of clift in the development of somatic gonadal precursors within the Drosophila mesoderm. Development. 1997;124:971-82 pubmed
    ..Thus, these studies identify essential regulators of gonadal precursor specification and differentiation and reveal novel aspects of the general mechanism whereby distinct fates are allocated within the mesoderm. ..
  13. Lahaye L, Wouda R, de Jong A, Fradkin L, Noordermeer J. WNT5 interacts with the Ryk receptors doughnut and derailed to mediate muscle attachment site selection in Drosophila melanogaster. PLoS ONE. 2012;7:e32297 pubmed publisher
    ..These results extend previous findings that at least some of the molecular pathways that guide axons towards their targets are also employed for guidance of muscle fibers to their appropriate attachment sites. ..
  14. DeFalco T, Camara N, Le Bras S, Van Doren M. Nonautonomous sex determination controls sexually dimorphic development of the Drosophila gonad. Dev Cell. 2008;14:275-86 pubmed publisher
    ..Male-specific expression of Wnt2 within the somatic gonad triggers pigment cell precursor formation from surrounding cells...
  15. Liebl F, McKeown C, Yao Y, HING H. Mutations in Wnt2 alter presynaptic motor neuron morphology and presynaptic protein localization at the Drosophila neuromuscular junction. PLoS ONE. 2010;5:e12778 pubmed publisher
    ..We sought to determine the role of the Drosophila Wnt7b ortholog, Wnt2, using the neuromuscular junction (NMJ)...
  16. McNeil C, Bain C, Macdonald S. Multiple Quantitative Trait Loci Influence the Shape of a Male-Specific Genital Structure in Drosophila melanogaster. G3 (Bethesda). 2011;1:343-51 pubmed publisher
    ..These genes are good candidates to harbor naturally segregating polymorphisms contributing to posterior lobe shape. ..
  17. Sidow A. Diversification of the Wnt gene family on the ancestral lineage of vertebrates. Proc Natl Acad Sci U S A. 1992;89:5098-102 pubmed
    Diversification of the Wnt genes, a family of powerful developmental regulator molecules, is inferred by molecular evolutionary analyses...
  18. Boyle M, DiNardo S. Specification, migration and assembly of the somatic cells of the Drosophila gonad. Development. 1995;121:1815-25 pubmed
    ..Mutations in iab-4 abolish expression of abd A within these cells, and as a result block the coalescence of the gonad. ..
  19. Deshpande G, Nouri A, Schedl P. Wnt Signaling in Sexual Dimorphism. Genetics. 2016;202:661-73 pubmed publisher
    ..Here we demonstrate the involvement of a wnt family ligand, wnt-2, in the induction of these sex-specific differences...
  20. Chan C, Zhang S, Rousset R, Wharton K. Drosophila Naked cuticle (Nkd) engages the nuclear import adaptor Importin-alpha3 to antagonize Wnt/beta-catenin signaling. Dev Biol. 2008;318:17-28 pubmed publisher
    Precise control of Wnt/beta-catenin signaling is critical for animal development, stem cell renewal, and prevention of disease...
  21. Bajpai R, Sambrani N, Stadelmayer B, Shashidhara L. Identification of a novel target of D/V signaling in Drosophila wing disc: Wg-independent function of the organizer. Gene Expr Patterns. 2004;5:113-21 pubmed
    ..The non-cell autonomous nature of Ubx-mediated repression of CG32062 expression suggests that the novel component of D/V signaling is also negatively regulated during haltere specification...
  22. Wodarz A, Nusse R. Mechanisms of Wnt signaling in development. Annu Rev Cell Dev Biol. 1998;14:59-88 pubmed
    b>Wnt genes encode a large family of secreted, cysteine-rich proteins that play key roles as intercellular signaling molecules in development...
  23. Linnemannstöns K, Ripp C, Honemann Capito M, Brechtel Curth K, Hedderich M, Wodarz A. The PTK7-related transmembrane proteins off-track and off-track 2 are co-receptors for Drosophila Wnt2 required for male fertility. PLoS Genet. 2014;10:e1004443 pubmed publisher
    ..Otk and Otk2 bind to each other and form complexes with Frizzled, Frizzled2 and Wnt2, pointing to a function as Wnt co-receptors...
  24. Van Doren M, Mathews W, Samuels M, Moore L, Broihier H, Lehmann R. fear of intimacy encodes a novel transmembrane protein required for gonad morphogenesis in Drosophila. Development. 2003;130:2355-64 pubmed
    ..Our findings that FOI is a cell-surface protein required in the mesoderm for gonad morphogenesis shed light on the function of this new family of proteins and on the molecular mechanisms of organogenesis. ..
  25. Zhu F, Zhang X. The Wnt signaling pathway is involved in the regulation of phagocytosis of virus in Drosophila. Sci Rep. 2013;3:2069 pubmed publisher
    ..Gene expression profiles revealed that the dally-mediated Wnt signaling pathway was involved in S2 phagocytosis...
  26. Port F, Kuster M, Herr P, Furger E, Bänziger C, Hausmann G, et al. Wingless secretion promotes and requires retromer-dependent cycling of Wntless. Nat Cell Biol. 2008;10:178-85 pubmed publisher
    b>Wnt ligands are lipid-modified, secreted glycoproteins that control multiple steps during embryogenesis and adult-tissue homeostasis. Little is known about the mechanisms underlying Wnt secretion...
  27. Herr P, Basler K. Porcupine-mediated lipidation is required for Wnt recognition by Wls. Dev Biol. 2012;361:392-402 pubmed publisher
    b>Wnt proteins are members of a conserved family of secreted signaling ligands and play crucial roles during development and in tissue homeostasis...
  28. Graba Y, Gieseler K, Aragnol D, Laurenti P, Mariol M, Berenger H, et al. DWnt-4, a novel Drosophila Wnt gene acts downstream of homeotic complex genes in the visceral mesoderm. Development. 1995;121:209-18 pubmed
    b>Wnt genes encode putative cell signalling proteins which play crucial roles during development. From a library of DNA fragments associated, in vivo, with Ultrabithorax proteins, we isolated a novel Drosophila Wnt gene, DWnt-4...
  29. Chau J, Kulnane L, Salz H. Sex-lethal facilitates the transition from germline stem cell to committed daughter cell in the Drosophila ovary. Genetics. 2009;182:121-32 pubmed publisher
    ..Together these data demonstrate a novel role for Sxl in the lineage progression from stem cell to committed daughter cell and suggest a model in which Sxl partners with bam to facilitate this transition. ..
  30. Blair S. Eye development: Notch lends a handedness. Curr Biol. 1999;9:R356-60 pubmed
    ..Notch signalling helps determine this handedness, first by establishing a signalling center at the eye equator, and second by mediating a choice between two photoreceptor fates ..
  31. Jockusch E, Ober K. Phylogenetic analysis of the Wnt gene family and discovery of an arthropod wnt-10 orthologue. J Exp Zool. 2000;288:105-19 pubmed
    b>Wnt genes encode a conserved family of secreted signaling proteins that play many roles in arthropod and vertebrate development. We have investigated both the phylogenetic history and molecular evolution of this gene family...
  32. Schubert M, Holland L, Holland N, Jacobs D. A phylogenetic tree of the Wnt genes based on all available full-length sequences, including five from the cephalochordate amphioxus. Mol Biol Evol. 2000;17:1896-903 pubmed
    The WNT: gene family is large, and new members are still being discovered. We constructed a parsimony tree for the WNT: family based on all 82 of the full-length sequences currently available...
  33. Kikuchi A, Yamamoto H, Sato A. [Activation of the beta-catenin-independent pathway by Wnt and the diseases due to its abnormality]. Tanpakushitsu Kakusan Koso. 2009;54:1-10 pubmed
  34. Glise B, Miller C, Crozatier M, Halbisen M, Wise S, Olson D, et al. Shifted, the Drosophila ortholog of Wnt inhibitory factor-1, controls the distribution and movement of Hedgehog. Dev Cell. 2005;8:255-66 pubmed
    ..Surprisingly, shifted encodes the only Drosophila ortholog of the secreted vertebrate protein Wnt Inhibitory Factor-1 (WIF-1), whose known role is to bind to extracellular Wnts and inhibit their activity...
  35. Casal J, Lawrence P, Struhl G. Two separate molecular systems, Dachsous/Fat and Starry night/Frizzled, act independently to confer planar cell polarity. Development. 2006;133:4561-72 pubmed
    ..We consider how polarity may be propagated by Ds-Ft heterodimers acting as bridges between cells. ..