Gene Symbol: Wnk
Description: Wnk kinase
Alias: CG7177, DWNK, Dmel\CG7177, WNK, cg7177, dWNK, wnk, Wnk kinase, CG7177-PL, CG7177-PM, CG7177-PN, CG7177-PO, WNK homolog, WNK kinase, Wnk-PL, Wnk-PM, Wnk-PN, Wnk-PO, with-no-lysine kinase
Species: fruit fly
Hirata T, Czapar A, Brin L, Haritonova A, Bondeson D, LINSER P, et al
. Ion and solute transport by Prestin in Drosophila and Anopheles. J Insect Physiol. 2012;58:563-9 pubmed publisher
..OSR1 kinase increases dPrestin ion transport, implying another set of physiological processes controlled by WNK/SPAK signaling in epithelia. All of these mRNAs are highly expressed in the gut and Malpighian tubules...
Sato A, Shibuya H. WNK signaling is involved in neural development via Lhx8/Awh expression. PLoS ONE. 2013;8:e55301 pubmed publisher
b>WNK kinase family is conserved among many species and regulates SPAK/OSR1 and ion co-transporters. Some mutations in human WNK1 or WNK4 are associated with Pseudohypoaldosteronism type II, a form of hypertension...
Park J, Al Ramahi I, Tan Q, Mollema N, Diaz Garcia J, Gallego Flores T, et al
. RAS-MAPK-MSK1 pathway modulates ataxin 1 protein levels and toxicity in SCA1. Nature. 2013;498:325-331 pubmed publisher
..Collectively, these data reveal new therapeutic entry points for SCA1 and provide a proof-of-principle for tackling other classes of intractable neurodegenerative diseases. ..
Wu Y, Schellinger J, Huang C, Rodan A. Hypotonicity stimulates potassium flux through the WNK-SPAK/OSR1 kinase cascade and the Ncc69 sodium-potassium-2-chloride cotransporter in the Drosophila renal tubule. J Biol Chem. 2014;289:26131-42 pubmed publisher
..Mammalian NKCCs are regulated by a kinase cascade consisting of the with-no-lysine (WNK) and Ste20-related proline/alanine-rich (SPAK)/oxidative stress response (OSR1) kinases...
Anamika K, Abhinandan K, Deshmukh K, Srinivasan N. Classification of nonenzymatic homologues of protein kinases. Comp Funct Genomics. 2009;:365637 pubmed publisher
..The current classification scheme hopes to provide a convenient framework to classify the PKLNKs from other eukaryotes which would be helpful in deciphering their roles in cellular processes. ..
Serysheva E, Berhane H, Grumolato L, Demir K, Balmer S, Bodak M, et al
. Wnk kinases are positive regulators of canonical Wnt/?-catenin signalling. EMBO Rep. 2013;14:718-25 pubmed publisher
..Using phosphorylation of Dishevelled as readout of pathway activation, we identified Drosophila Wnk kinase as a new regulator of canonical Wnt/?-catenin signalling...