Gene Symbol: wg
Description: wingless
Alias: CG4889, DWint-1, DWnt-1, Dint-1, Dm Wg, Dm-1, Dmel\CG4889, Gla, WNT, Wnt, Wnt-1, Wnt/Wg, Wnt1, beta-catenin, dWnt, int-1, l(2)02657, l(2)SH1281, l(2)SH2 1281, l(2)rO727, l(2)wg, spd, wgl, wnt, wnt1, wingless, CG4889-PA, Wnt-1, bristled, complementation group I, flag, glazed, lethal (2) SH1281, spade, sternopleural, wg-PA
Species: fruit fly
Products:     wg

Top Publications

  1. Wang W, Kidd B, Carroll S, Yoder J. Sexually dimorphic regulation of the Wingless morphogen controls sex-specific segment number in Drosophila. Proc Natl Acad Sci U S A. 2011;108:11139-44 pubmed publisher
    ..Here we show that sex-specific and segment-specific regulation of the Wingless (Wg) morphogen underlies the development of sexually dimorphic adult segment number in Drosophila...
  2. Pepperl J, Reim G, Lüthi U, Kaech A, Hausmann G, Basler K. Sphingolipid depletion impairs endocytic traffic and inhibits Wingless signaling. Mech Dev. 2013;130:493-505 pubmed publisher
    ..One of the affected proteins is the Wnt ligand Wingless (Wg) that accumulated...
  3. Widmann T, Dahmann C. Dpp signaling promotes the cuboidal-to-columnar shape transition of Drosophila wing disc epithelia by regulating Rho1. J Cell Sci. 2009;122:1362-73 pubmed publisher
    ..Our results identify a cell-autonomous role for Dpp signaling in promoting and maintaining the elongated columnar shape of wing disc cells and suggest that Dpp signaling acts by regulating Rho1 and MRLC. ..
  4. Suzanne M, Steller H. Shaping organisms with apoptosis. Cell Death Differ. 2013;20:669-75 pubmed publisher
    ..In this review, we will focus exclusively on developmental cell death by apoptosis and its role in tissue remodeling. ..
  5. Somorjai I, Martinez Arias A. Wingless signalling alters the levels, subcellular distribution and dynamics of Armadillo and E-cadherin in third instar larval wing imaginal discs. PLoS ONE. 2008;3:e2893 pubmed publisher
    Armadillo, the Drosophila orthologue of vertebrate ss-catenin, plays a dual role as the key effector of Wingless/Wnt1 signalling, and as a bridge between E-Cadherin and the actin cytoskeleton...
  6. Pennetier D, Oyallon J, Morin Poulard I, Dejean S, Vincent A, Crozatier M. Size control of the Drosophila hematopoietic niche by bone morphogenetic protein signaling reveals parallels with mammals. Proc Natl Acad Sci U S A. 2012;109:3389-94 pubmed publisher
    ..Dpp antagonizes activity of wingless (Wg)/Wnt signaling, which positively regulates the number of PSC cells via the control of Dmyc expression...
  7. Mitchell N, Cranna N, Richardson H, Quinn L. The Ecdysone-inducible zinc-finger transcription factor Crol regulates Wg transcription and cell cycle progression in Drosophila. Development. 2008;135:2707-16 pubmed publisher
    ..transcription factor Crol provides a crucial link between the Ecdysone steroid hormone pathway and the Wingless (Wg) signalling pathway in Drosophila...
  8. Vincent S, Perrimon N, Axelrod J. Hedgehog and Wingless stabilize but do not induce cell fate during Drosophila dorsal embryonic epidermal patterning. Development. 2008;135:2767-75 pubmed publisher
    A fundamental concept in development is that secreted molecules such as Wingless (Wg) and Hedgehog (Hh) generate pattern by inducing cell fate...
  9. Lebreton G, Faucher C, Cribbs D, Benassayag C. Timing of Wingless signalling distinguishes maxillary and antennal identities in Drosophila melanogaster. Development. 2008;135:2301-9 pubmed publisher
    ..to the antennal one, but is distinguished primarily by delayed prepupal expression of the ventral morphogen Wingless (Wg)...

More Information


  1. San Juán B, Andrade Zapata I, Baonza A. The bHLH factors Dpn and members of the E(spl) complex mediate the function of Notch signalling regulating cell proliferation during wing disc development. Biol Open. 2012;1:667-76 pubmed publisher
  2. Wells B, Johnston L. Maintenance of imaginal disc plasticity and regenerative potential in Drosophila by p53. Dev Biol. 2012;361:263-76 pubmed publisher
    ..These findings place p53 in a role as master coordinator of DNA and tissue repair following IR. ..
  3. Merabet S, Litim Mecheri I, Karlsson D, Dixit R, Saadaoui M, Monier B, et al. Insights into Hox protein function from a large scale combinatorial analysis of protein domains. PLoS Genet. 2011;7:e1002302 pubmed publisher
  4. Lin G, Xi R. Intestinal stem cell, muscular niche and Wingless signaling. Fly (Austin). 2008;2:310-2 pubmed
    ..Recently, we have obtained evidence to show that Wingless signaling is critical for ISC self-renewal...
  5. Fox D, Spradling A. The Drosophila hindgut lacks constitutively active adult stem cells but proliferates in response to tissue damage. Cell Stem Cell. 2009;5:290-7 pubmed publisher
    ..Thus, the hindgut does not provide a model of tissue maintenance by constitutively active stem cells, but has great potential to illuminate mechanisms of stress-induced tissue repair. ..
  6. Smith Bolton R, Worley M, Kanda H, Hariharan I. Regenerative growth in Drosophila imaginal discs is regulated by Wingless and Myc. Dev Cell. 2009;16:797-809 pubmed publisher
    ..b>Wingless and Myc are induced by tissue damage and are important for regenerative growth...
  7. Rhiner C, López Gay J, Soldini D, Casas Tinto S, Martín F, Lombardia L, et al. Flower forms an extracellular code that reveals the fitness of a cell to its neighbors in Drosophila. Dev Cell. 2010;18:985-98 pubmed publisher
    ..Cell-cell comparison of relative fwe(Lose) and fwe(ubi) levels ultimately determines which cell undergoes apoptosis. This "extracellular code" may constitute an ancient mechanism to terminate competitive conflicts among cells. ..
  8. Herr P, Basler K. Porcupine-mediated lipidation is required for Wnt recognition by Wls. Dev Biol. 2012;361:392-402 pubmed publisher
    b>Wnt proteins are members of a conserved family of secreted signaling ligands and play crucial roles during development and in tissue homeostasis...
  9. Pfleger C, Harvey K, Yan H, Hariharan I. Mutation of the gene encoding the ubiquitin activating enzyme ubal causes tissue overgrowth in Drosophila. Fly (Austin). 2007;1:95-105 pubmed
    ..Our studies show that a reduction in E1 activity can promote tissue growth in a multicellular organism and raise the possibility that changes in E1 activity may occur during normal development or in cancer. ..
  10. Yang M, Hatton Ellis E, Simpson P. The kinase Sgg modulates temporal development of macrochaetes in Drosophila by phosphorylation of Scute and Pannier. Development. 2012;139:325-34 pubmed publisher
    ..required for ac-sc expression, the expression of which coincides temporally with that of ac-sc in the notum, is Wingless (Wg; also known as Wnt)...
  11. Purvanov V, Koval A, Katanaev V. A direct and functional interaction between Go and Rab5 during G protein-coupled receptor signaling. Sci Signal. 2010;3:ra65 pubmed publisher
    ..We further showed that the G(o)-Rab5 interaction functioned in Drosophila planar cell polarity and Wingless signal transduction, pathways initiated by GPCRs of the Frizzled (Fz) family...
  12. Kagey J, Brown J, Moberg K. Regulation of Yorkie activity in Drosophila imaginal discs by the Hedgehog receptor gene patched. Mech Dev. 2012;129:339-49 pubmed publisher
  13. Colombani J, Andersen D, Leopold P. Secreted peptide Dilp8 coordinates Drosophila tissue growth with developmental timing. Science. 2012;336:582-5 pubmed publisher
    ..We propose that Dilp8 peptide is a secreted signal that coordinates the growth status of tissues with developmental timing. ..
  14. Liu Y, Chang M, Li H, Barolo S, Chang J, Blauwkamp T, et al. The chromatin remodelers ISWI and ACF1 directly repress Wingless transcriptional targets. Dev Biol. 2008;323:41-52 pubmed publisher
    The highly conserved Wingless/Wnt signaling pathway controls many developmental processes by regulating the expression of target genes, most often through members of the TCF family of DNA-binding proteins...
  15. Zimmerman S, Thorpe L, Medrano V, Mallozzi C, McCartney B. Apical constriction and invagination downstream of the canonical Wnt signaling pathway require Rho1 and Myosin II. Dev Biol. 2010;340:54-66 pubmed publisher
    The tumor suppressor Adenomatous polyposis coli (APC) is a negative regulator of Wnt signaling and functions in cytoskeletal organization...
  16. Baena Lopez L, Alexandre C, Mitchell A, Pasakarnis L, Vincent J. Accelerated homologous recombination and subsequent genome modification in Drosophila. Development. 2013;140:4818-25 pubmed publisher
    ..Therefore, our method retains the advantages of homologous recombination while capitalising on the mutagenic power of CRISPR...
  17. Herrera S, Martin R, Morata G. Tissue homeostasis in the wing disc of Drosophila melanogaster: immediate response to massive damage during development. PLoS Genet. 2013;9:e1003446 pubmed publisher
    ..Furthermore, our results indicate that the Dpp and Wg pathways are not specifically involved in the regenerative response, but that activity of the JNK pathway is ..
  18. Korkut C, Ataman B, Ramachandran P, Ashley J, Barria R, Gherbesi N, et al. Trans-synaptic transmission of vesicular Wnt signals through Evi/Wntless. Cell. 2009;139:393-404 pubmed publisher
    ..neuromuscular junction (NMJ), presynaptic vesicular release of Evi is required for the secretion of the Wnt, Wingless (Wg)...
  19. McClure K, Sustar A, Schubiger G. Three genes control the timing, the site and the size of blastema formation in Drosophila. Dev Biol. 2008;319:68-77 pubmed publisher
    ..regeneration can be induced either by fragmentation and in vivo culture or in situ by ubiquitous expression of wingless (wg/wnt1)...
  20. Chang J, Chang M, Barolo S, Cadigan K. Regulation of the feedback antagonist naked cuticle by Wingless signaling. Dev Biol. 2008;321:446-54 pubmed publisher
    ..For example, the Wnt ligand Wingless (Wg) activates the naked cuticle (nkd) gene in all tissues examined throughout Drosophila development...
  21. Zeng Y, Rahnama M, Wang S, Lee W, Verheyen E. Inhibition of Drosophila Wg signaling involves competition between Mad and Armadillo/beta-catenin for dTcf binding. PLoS ONE. 2008;3:e3893 pubmed publisher
    ..Both the Transforming Growth Factor beta (TGFbeta)/Bone morphogenetic protein (BMP) and Wnt/Wingless (Wg) pathways play essential roles in organismal patterning and growth, and their deregulation can lead to ..
  22. Gross J, Chaudhary V, Bartscherer K, Boutros M. Active Wnt proteins are secreted on exosomes. Nat Cell Biol. 2012;14:1036-45 pubmed publisher
    b>Wnt signalling has important roles during development and in many diseases. As morphogens, hydrophobic Wnt proteins exert their function over a distance to induce patterning and cell differentiation decisions...
  23. Mohan M, Herz H, Takahashi Y, Lin C, Lai K, Zhang Y, et al. Linking H3K79 trimethylation to Wnt signaling through a novel Dot1-containing complex (DotCom). Genes Dev. 2010;24:574-89 pubmed publisher
    ..and, given the association of beta-catenin, Skp1, and TRRAP, we investigated, and found, a role for Dot1 in Wnt/Wingless signaling in an in vivo model system...
  24. Schwank G, Restrepo S, Basler K. Growth regulation by Dpp: an essential role for Brinker and a non-essential role for graded signaling levels. Development. 2008;135:4003-13 pubmed publisher
    ..The Dpp-Brk system converts an inherently uneven growth program, with excessive cell proliferation in lateral regions and low proliferation in medial regions, into a spatially homogeneous profile of cell divisions throughout the disc. ..
  25. Karim M, Moore A. Convergent local identity and topographic projection of sensory neurons. J Neurosci. 2011;31:17017-27 pubmed publisher
    ..These findings indicate that convergent sensory neuron specification, local differentiation, and topographic wiring are mediated by Mirror, and they suggest an integrated paradigm for position-sensitive neural development. ..
  26. Gutierrez Aviño F, Ferres Marco D, Dominguez M. The position and function of the Notch-mediated eye growth organizer: the roles of JAK/STAT and four-jointed. EMBO Rep. 2009;10:1051-8 pubmed publisher
    ..These findings redefine the process of organizer formation and function, and they identify four-jointed as a regulatory node, integrating multiple growth-control pathways. ..
  27. Perea D, Molohon K, Edwards K, Diaz Benjumea F. Multiple roles of the gene zinc finger homeodomain-2 in the development of the Drosophila wing. Mech Dev. 2013;130:467-81 pubmed publisher
  28. Biehs B, Kechris K, Liu S, Kornberg T. Hedgehog targets in the Drosophila embryo and the mechanisms that generate tissue-specific outputs of Hedgehog signaling. Development. 2010;137:3887-98 pubmed publisher
  29. Widmann T, Dahmann C. Wingless signaling and the control of cell shape in Drosophila wing imaginal discs. Dev Biol. 2009;334:161-73 pubmed publisher
    ..Here we address the role of the Wnt/Wingless signal transduction pathway and two of its target genes, vestigial and shotgun (encoding E-cadherin), in ..
  30. Liu M, Lim T, Cai Y. The Drosophila female germline stem cell lineage acts to spatially restrict DPP function within the niche. Sci Signal. 2010;3:ra57 pubmed publisher
    ..Thus, our data reveal that the reciprocal crosstalk between the GSCs and the somatic cells defines the spatial limits of DPP action and therefore the extent of the GSC niche. ..
  31. Fiuza U, Klein T, Martinez Arias A, Hayward P. Mechanisms of ligand-mediated inhibition in Notch signaling activity in Drosophila. Dev Dyn. 2010;239:798-805 pubmed publisher
  32. Lin G, Xu N, Xi R. Paracrine Wingless signalling controls self-renewal of Drosophila intestinal stem cells. Nature. 2008;455:1119-23 pubmed publisher
    ..Here we show that a canonical Wnt signalling pathway controls ISC self-renewal. The ligand Wingless (Wg) is specifically expressed in the circular muscles next to ISCs, separated by a thin layer of basement ..
  33. Deshpande G, Godishala A, Schedl P. Ggamma1, a downstream target for the hmgcr-isoprenoid biosynthetic pathway, is required for releasing the Hedgehog ligand and directing germ cell migration. PLoS Genet. 2009;5:e1000333 pubmed publisher
  34. Cordero J, Stefanatos R, Scopelliti A, Vidal M, Sansom O. Inducible progenitor-derived Wingless regulates adult midgut regeneration in Drosophila. EMBO J. 2012;31:3901-17 pubmed publisher
    ..Here, we study the role and regulation of Wingless (Wg)/Wnt signalling during intestinal regeneration using the Drosophila adult midgut...
  35. Rendic D, Sharrow M, Katoh T, Overcarsh B, Nguyen K, Kapurch J, et al. Neural-specific ?3-fucosylation of N-linked glycans in the Drosophila embryo requires fucosyltransferase A and influences developmental signaling associated with O-glycosylation. Glycobiology. 2010;20:1353-65 pubmed publisher
  36. Beckett K, Monier S, Palmer L, Alexandre C, Green H, Bonneil E, et al. Drosophila S2 cells secrete wingless on exosome-like vesicles but the wingless gradient forms independently of exosomes. Traffic. 2013;14:82-96 pubmed publisher
    b>Wingless acts as a morphogen in Drosophila wing discs, where it specifies cell fates and controls growth several cell diameters away from its site of expression...
  37. Ramos A, Barolo S. Low-affinity transcription factor binding sites shape morphogen responses and enhancer evolution. Philos Trans R Soc Lond B Biol Sci. 2013;368:20130018 pubmed publisher
    ..Contrary to our initial hypothesis, improving the affinity of Ci/Gli sites in enhancers of dpp, wingless and stripe, by transplanting optimal sites from the patched gene, did not result in ectopic responses to Hh ..
  38. Sahai Hernandez P, Nystul T. A dynamic population of stromal cells contributes to the follicle stem cell niche in the Drosophila ovary. Development. 2013;140:4490-8 pubmed publisher
    ..We show that escort cells produce both Wingless and Hedgehog ligands for the FSC lineage, and that Wingless signaling is specific for the FSC niche whereas ..
  39. Pérez Garijo A, Shlevkov E, Morata G. The role of Dpp and Wg in compensatory proliferation and in the formation of hyperplastic overgrowths caused by apoptotic cells in the Drosophila wing disc. Development. 2009;136:1169-77 pubmed publisher
    ..The finding that apoptotic cells ectopically express dpp and wg suggested that ectopic Dpp/Wg signalling might be responsible for compensatory proliferation...
  40. Zhang P, Wu Y, Belenkaya T, Lin X. SNX3 controls Wingless/Wnt secretion through regulating retromer-dependent recycling of Wntless. Cell Res. 2011;21:1677-90 pubmed publisher
    Drosophila Wingless (Wg) acts as a morphogen during development. Wg secretion is controlled by a seven-pass transmembrane cargo Wntless (Wls). We have recently identified retromer as a key regulator involved in Wls trafficking...
  41. Suissa Y, Ziv O, Dinur T, Arama E, Gerlitz O. The NAB-Brk signal bifurcates at JNK to independently induce apoptosis and compensatory proliferation. J Biol Chem. 2011;286:15556-64 pubmed publisher
    ..Once induced, the apoptotic pathway further activates a CP response. Our data suggest that JNK is the candidate factor that differentiates between apoptosis that involves CP and apoptosis that does not. ..
  42. Fiedler M, Mendoza Topaz C, Rutherford T, Mieszczanek J, Bienz M. Dishevelled interacts with the DIX domain polymerization interface of Axin to interfere with its function in down-regulating ?-catenin. Proc Natl Acad Sci U S A. 2011;108:1937-42 pubmed publisher
    b>Wnt/?-catenin signaling controls numerous steps in normal animal development and can also cause cancer if inappropriately activated...
  43. Agelopoulos M, Mckay D, Mann R. Developmental regulation of chromatin conformation by Hox proteins in Drosophila. Cell Rep. 2012;1:350-9 pubmed
    ..The pattern of binding by GAGA factor and the variant histone H2Av suggest that they play a role in the regulation of Dll chromatin conformation in expressing and nonexpressing cell types, respectively. ..
  44. Heckscher E, Lockery S, Doe C. Characterization of Drosophila larval crawling at the level of organism, segment, and somatic body wall musculature. J Neurosci. 2012;32:12460-71 pubmed publisher
    ..This work lays a foundation for use of Drosophila larva as a model system for studying the genetics and development of rhythmic behavior. ..
  45. Dani N, Nahm M, Lee S, Broadie K. A targeted glycan-related gene screen reveals heparan sulfate proteoglycan sulfation regulates WNT and BMP trans-synaptic signaling. PLoS Genet. 2012;8:e1003031 pubmed publisher
    ..Consistently, hs6st and sulf1 nulls differentially elevate both WNT (Wingless; Wg) and BMP (Glass Bottom Boat; Gbb) ligand abundance in the synaptomatrix...
  46. Takashima S, Mkrtchyan M, Younossi Hartenstein A, Merriam J, Hartenstein V. The behaviour of Drosophila adult hindgut stem cells is controlled by Wnt and Hh signalling. Nature. 2008;454:651-5 pubmed publisher
    ..as well as subsequent proliferation and differentiation of ISC descendants, are controlled by locally emanating Wingless (Wg, a Drosophila Wnt homologue) and Hh signals...
  47. Solis G, Lüchtenborg A, Katanaev V. Wnt secretion and gradient formation. Int J Mol Sci. 2013;14:5130-45 pubmed publisher
    Concentration gradients formed by the lipid-modified morphogens of the Wnt family are known for their pivotal roles during embryogenesis and adult tissue homeostasis...
  48. Terriente J, Perea D, Suzanne M, Diaz Benjumea F. The Drosophila gene zfh2 is required to establish proximal-distal domains in the wing disc. Dev Biol. 2008;320:102-12 pubmed publisher
    ..generation of nested circular domains defined by different combinations of gene expression; second, activation of wingless (wg) gene expression in a ring of cells; and third, an increase of cell number in each domain in response to Wg...
  49. Apidianakis Y, Rahme L. Drosophila melanogaster as a model for human intestinal infection and pathology. Dis Model Mech. 2011;4:21-30 pubmed publisher
    ..In this Perspective, we discuss recent advances in the study of Drosophila intestinal infection and pathology, and briefly review the parallels and differences between human and Drosophila intestinal regeneration and disease. ..
  50. White M, Parker D, Barolo S, Cohen B. A model of spatially restricted transcription in opposing gradients of activators and repressors. Mol Syst Biol. 2012;8:614 pubmed publisher
    ..Because our model is general, it may explain the role of low-affinity binding sites in many contexts, including mammalian Hedgehog gradients. ..
  51. Martín F, Pérez Garijo A, Morata G. Apoptosis in Drosophila: compensatory proliferation and undead cells. Int J Dev Biol. 2009;53:1341-7 pubmed publisher
    ..These "undead" cells acquire special features, such as the emission of the growth signals Dpp and Wg, changes in cellular morphology and induction of proliferation in neighbouring cells...
  52. Marie B, Pym E, Bergquist S, Davis G. Synaptic homeostasis is consolidated by the cell fate gene gooseberry, a Drosophila pax3/7 homolog. J Neurosci. 2010;30:8071-82 pubmed publisher
    ..Finally, Gsb has been shown to antagonize Wingless signaling during embryonic fate specification, and we present initial evidence that this activity is conserved ..
  53. Miech C, Pauer H, He X, Schwarz T. Presynaptic local signaling by a canonical wingless pathway regulates development of the Drosophila neuromuscular junction. J Neurosci. 2008;28:10875-84 pubmed publisher
    Wnt/wingless signaling contributes to the development of neuronal synapses, including the Drosophila neuromuscular junction. Loss of wg (wingless) function alters the number and structure of boutons at this model synapse...
  54. Lin G, Xu N, Xi R. Paracrine unpaired signaling through the JAK/STAT pathway controls self-renewal and lineage differentiation of drosophila intestinal stem cells. J Mol Cell Biol. 2010;2:37-49 pubmed publisher
    ..and mammalian intestinal stem cells (ISCs) share similarities in their regulatory mechanisms, with both requiring Wingless (Wg)/Wnt signaling for their self-renewal, although additional regulatory mechanisms are largely unknown...
  55. Alexandre C, Baena Lopez A, Vincent J. Patterning and growth control by membrane-tethered Wingless. Nature. 2014;505:180-5 pubmed publisher
    ..Here we used genome engineering to replace the endogenous wingless gene, which encodes the main Drosophila Wnt, with one that expresses a membrane-tethered form of the protein...
  56. Mulligan K, Fuerer C, Ching W, Fish M, Willert K, Nusse R. Secreted Wingless-interacting molecule (Swim) promotes long-range signaling by maintaining Wingless solubility. Proc Natl Acad Sci U S A. 2012;109:370-7 pubmed publisher
    Lipid-modified Wnt/Wingless (Wg) proteins can signal to their target cells in a short- or long-range manner. How these hydrophobic proteins travel through the extracellular environment remains an outstanding question...
  57. Piddini E, Vincent J. Interpretation of the wingless gradient requires signaling-induced self-inhibition. Cell. 2009;136:296-307 pubmed publisher
    ..Accordingly, in Drosophila, the morphogen Wingless produced in the wing's prospective distal region activates target genes in a dose-dependent fashion to organize ..
  58. Martín F, Herrera S, Morata G. Cell competition, growth and size control in the Drosophila wing imaginal disc. Development. 2009;136:3747-56 pubmed publisher
    ..The values predicted by the simulation are very close to those obtained experimentally. ..
  59. Roignant J, Legent K, Janody F, Treisman J. The transcriptional co-factor Chip acts with LIM-homeodomain proteins to set the boundary of the eye field in Drosophila. Development. 2010;137:273-81 pubmed publisher
    ..Loss-of-function studies support the model that Arrowhead and Lim1 act redundantly, using Chip as a co-factor, to prevent retinal differentiation in regions of the eye disc destined to become ventral head tissue. ..
  60. Vallejo D, Caparros E, Dominguez M. Targeting Notch signalling by the conserved miR-8/200 microRNA family in development and cancer cells. EMBO J. 2011;30:756-69 pubmed publisher
    ..Together, these data define a new way to attenuate or boost Notch signalling that may have clinical interest. ..
  61. Speese S, Ashley J, Jokhi V, Nunnari J, Barria R, Li Y, et al. Nuclear envelope budding enables large ribonucleoprotein particle export during synaptic Wnt signaling. Cell. 2012;149:832-46 pubmed publisher
    ..We previously reported that during synapse development, a fragment of the Wnt-1 receptor, DFrizzled2, enters postsynaptic nuclei where it forms prominent foci...
  62. Sagner A, Merkel M, Aigouy B, Gaebel J, Brankatschk M, Jülicher F, et al. Establishment of global patterns of planar polarity during growth of the Drosophila wing epithelium. Curr Biol. 2012;22:1296-301 pubmed publisher
    ..Thus, PCP may be guided by morphogenesis rather than morphogen gradients. ..
  63. Rodrigues A, Zoranovic T, Ayala Camargo A, Grewal S, Reyes Robles T, Krasny M, et al. Activated STAT regulates growth and induces competitive interactions independently of Myc, Yorkie, Wingless and ribosome biogenesis. Development. 2012;139:4051-61 pubmed publisher
    ..that kill losers located at a distance in a manner that is dependent on hid but independent of Myc, Yorkie, Wingless signaling, and of ribosome biogenesis...
  64. Olson E, Pancratov R, Chatterjee S, Changkakoty B, Pervaiz Z, DasGupta R. Yan, an ETS-domain transcription factor, negatively modulates the Wingless pathway in the Drosophila eye. EMBO Rep. 2011;12:1047-54 pubmed publisher
    ..factor belonging to the Drosophila epidermal growth factor receptor (DER) pathway, as an antagonist of the Wingless signalling pathway...
  65. Martinez A, Schuettengruber B, Sakr S, Janic A, Gonzalez C, Cavalli G. Polyhomeotic has a tumor suppressor activity mediated by repression of Notch signaling. Nat Genet. 2009;41:1076-82 pubmed publisher
    ..These data show that ph is a tumor suppressor locus that controls cellular proliferation by silencing multiple Notch signaling components. ..
  66. Kleinschmit A, Koyama T, Dejima K, Hayashi Y, Kamimura K, Nakato H. Drosophila heparan sulfate 6-O endosulfatase regulates Wingless morphogen gradient formation. Dev Biol. 2010;345:204-14 pubmed publisher
    ..Our genetic and biochemical analyses show that Sulf1 acts as a novel regulator of the Wg morphogen gradient by modulating the sulfation status of HS on the cell surface in the developing wing...
  67. Perea D, Terriente J, Diaz Benjumea F. Temporal and spatial windows delimit activation of the outer ring of wingless in the Drosophila wing. Dev Biol. 2009;328:445-55 pubmed publisher
    ..The pattern of expression of the signalling molecule Wingless/WNT in Drosophila is extraordinarily complex...
  68. Salvany L, Requena D, Azpiazu N. Functional association between eyegone and HP1a mediates wingless transcriptional repression during development. Mol Cell Biol. 2012;32:2407-15 pubmed publisher
    ..In addition, Eyg binds to a wingless (wg) enhancer region, recruiting HP1a to assemble a closed, heterochromatin-like conformation that represses ..
  69. You J, Belenkaya T, Lin X. Sulfated is a negative feedback regulator of wingless in Drosophila. Dev Dyn. 2011;240:640-8 pubmed publisher
    Drosophila Wingless (Wg) acts as a morphogen to control pattern formation in a concentration dependent manner...
  70. Mirth C, Truman J, Riddiford L. The ecdysone receptor controls the post-critical weight switch to nutrition-independent differentiation in Drosophila wing imaginal discs. Development. 2009;136:2345-53 pubmed publisher
    ..pre-critical weight larvae [5 hours after third instar ecdysis (AL3E)] fed on sucrose alone showed suppressed Wingless (WG), Cut (CT) and Senseless (SENS) expression...
  71. Franch Marro X, Wendler F, Griffith J, Maurice M, Vincent J. In vivo role of lipid adducts on Wingless. J Cell Sci. 2008;121:1587-92 pubmed publisher
    ..amino acids, we have investigated how these adducts contribute to the secretion and signalling activity of Wingless, the main Drosophila member of the Wnt family...
  72. Schubiger M, Sustar A, Schubiger G. Regeneration and transdetermination: the role of wingless and its regulation. Dev Biol. 2010;347:315-24 pubmed publisher
    ..After fragmentation wound healing occurs, ectopic wg is induced and a blastema is formed...
  73. Dichtel Danjoy M, Ma D, Dourlen P, Chatelain G, Napoletano F, Robin M, et al. Drosophila p53 isoforms differentially regulate apoptosis and apoptosis-induced proliferation. Cell Death Differ. 2013;20:108-16 pubmed publisher
    ..Expression of D?Np53 induced Wingless (Wg) expression and enhanced proliferation in both 'undead cells' and in 'genuine' apoptotic cells...
  74. Zecca M, Struhl G. A feed-forward circuit linking wingless, fat-dachsous signaling, and the warts-hippo pathway to Drosophila wing growth. PLoS Biol. 2010;8:e1000386 pubmed publisher
    ..primordium undergoes a dramatic increase in cell number and mass under the control of the long-range morphogens Wingless (Wg, a Wnt) and Decapentaplegic (Dpp, a BMP)...
  75. Formaz Preston A, Ryu J, Svendsen P, Brook W. The Tbx20 homolog Midline represses wingless in conjunction with Groucho during the maintenance of segment polarity. Dev Biol. 2012;369:319-29 pubmed publisher
    The regulation of the segment polarity gene wingless is essential for the correct patterning of the Drosophila ectoderm...
  76. Yan D, Wu Y, Feng Y, Lin S, Lin X. The core protein of glypican Dally-like determines its biphasic activity in wingless morphogen signaling. Dev Cell. 2009;17:470-81 pubmed publisher
    ..In Drosophila wing discs, Dlp represses short-range Wingless (Wg) signaling, but activates long-range Wg signaling...
  77. Estacio Gómez A, Moris Sanz M, Schäfer A, Perea D, Herrero P, Diaz Benjumea F. Bithorax-complex genes sculpt the pattern of leucokinergic neurons in the Drosophila central nervous system. Development. 2013;140:2139-48 pubmed publisher
    ..We show that genes of the Bx-C acted in postmitotic cells to specify the segment-specific appearance of leucokinergic cells in the larval and adult ventral nerve cord. ..
  78. Cruz C, Glavic A, Casado M, de Celis J. A gain-of-function screen identifying genes required for growth and pattern formation of the Drosophila melanogaster wing. Genetics. 2009;183:1005-26 pubmed publisher
    ..Finally, we present a preliminary characterization of a gene identified in the screen, the function of which is required for the development of the L5 longitudinal vein. ..
  79. Yan D, Wu Y, Yang Y, Belenkaya T, Tang X, Lin X. The cell-surface proteins Dally-like and Ihog differentially regulate Hedgehog signaling strength and range during development. Development. 2010;137:2033-44 pubmed publisher
    ..However, Ihog might not act as a classic co-receptor; rather, it may act as an exchange factor by retaining Hh on the cell surface, but also compete with the receptor for Hh binding. ..
  80. Rogulja D, Rauskolb C, Irvine K. Morphogen control of wing growth through the Fat signaling pathway. Dev Cell. 2008;15:309-21 pubmed publisher
    ..These observations identify Fat as a signaling pathway that links the morphogen-mediated establishment of gradients of positional values across developing organs to the regulation of organ growth. ..
  81. Foronda D, Martin P, Sánchez Herrero E. Drosophila Hox and sex-determination genes control segment elimination through EGFR and extramacrochetae activity. PLoS Genet. 2012;8:e1002874 pubmed publisher
    ..Our results show the complex orchestration of cellular and genetic events that lead to this important sexually dimorphic character change. ..
  82. Wong C, Li R, Montell C, Venkatachalam K. Drosophila TRPML is required for TORC1 activation. Curr Biol. 2012;22:1616-21 pubmed publisher
    ..Our findings delineate the interrelationship between the TRPML and TORC1 pathways and raise the intriguing possibility that a high-protein diet might reduce the severity of MLIV. ..
  83. Wilkin M, Tongngok P, Gensch N, Clemence S, Motoki M, Yamada K, et al. Drosophila HOPS and AP-3 complex genes are required for a Deltex-regulated activation of notch in the endosomal trafficking pathway. Dev Cell. 2008;15:762-72 pubmed publisher
    ..We discuss ways in which these endocytic pathways may modulate ligand-dependent and -independent events, as a mechanism that can potentiate Notch signaling or dampen noise in the signaling network. ..
  84. Sinenko S, Mandal L, Martinez Agosto J, Banerjee U. Dual role of wingless signaling in stem-like hematopoietic precursor maintenance in Drosophila. Dev Cell. 2009;16:756-63 pubmed publisher
    ..Here we show that components of the Wingless (Wg) signaling pathway are expressed in prohemocytes...
  85. Avanesov A, Honeyager S, Malicki J, Blair S. The role of glypicans in Wnt inhibitory factor-1 activity and the structural basis of Wif1's effects on Wnt and Hedgehog signaling. PLoS Genet. 2012;8:e1002503 pubmed publisher
    Proper assignment of cellular fates relies on correct interpretation of Wnt and Hedgehog (Hh) signals. Members of the Wnt Inhibitory Factor-1 (WIF1) family are secreted modulators of these extracellular signaling pathways...