WASp

Summary

Gene Symbol: WASp
Description: WASp
Alias: CG1520, D-WASP, Dm WASP, DmWASP, Dmel\CG1520, WASP, WSP, Wasp, Wsp, dWASP, wasp, wsp, WASp, CG1520-PA, CG1520-PB, CG1520-PC, CG1520-PD, WASP, WASp-PA, WASp-PB, WASp-PC, WASp-PD, Wiscott-Aldrich syndrome protein, Wiskott-Aldrich syndrome protein
Species: fruit fly
Products:     WASp

Top Publications

  1. Georgiou M, Baum B. Polarity proteins and Rho GTPases cooperate to spatially organise epithelial actin-based protrusions. J Cell Sci. 2010;123:1089-98 pubmed publisher
  2. Fricke R, Gohl C, Dharmalingam E, Grevelhörster A, Zahedi B, Harden N, et al. Drosophila Cip4/Toca-1 integrates membrane trafficking and actin dynamics through WASP and SCAR/WAVE. Curr Biol. 2009;19:1429-37 pubmed publisher
    ..Cip4 is able to form a complex with WASP and SCAR/WAVE and recruits both actin-nucleation-promoting factors to invaginating membranes and endocytic vesicles...
  3. Berger S, Schäfer G, Kesper D, Holz A, Eriksson T, Palmer R, et al. WASP and SCAR have distinct roles in activating the Arp2/3 complex during myoblast fusion. J Cell Sci. 2008;121:1303-13 pubmed publisher
    ..Fusion relies on the HEM2 (NAP1) homolog Kette, as well as Blow and WASP, a member of the Wiskott-Aldrich-syndrome protein family...
  4. Ben Yaacov S, Le Borgne R, Abramson I, Schweisguth F, Schejter E. Wasp, the Drosophila Wiskott-Aldrich syndrome gene homologue, is required for cell fate decisions mediated by Notch signaling. J Cell Biol. 2001;152:1-13 pubmed
    ..Mutations in the Drosophila homologue, Wasp (Wsp), reveal an essential requirement for this gene in implementation of cell fate decisions during adult and ..
  5. Rodriguez Mesa E, Abreu Blanco M, Rosales Nieves A, Parkhurst S. Developmental expression of Drosophila Wiskott-Aldrich Syndrome family proteins. Dev Dyn. 2012;241:608-26 pubmed publisher
    Wiskott-Aldrich Syndrome (WASP) family proteins participate in many cellular processes involving rearrangements of the actin cytoskeleton...
  6. Jin P, Duan R, Luo F, Zhang G, Hong S, Chen E. Competition between Blown fuse and WASP for WIP binding regulates the dynamics of WASP-dependent actin polymerization in vivo. Dev Cell. 2011;20:623-38 pubmed publisher
    ..We demonstrate that Blow is an FCM-specific protein that colocalizes with WASP, WIP/Solitary, and the actin focus within the PLS...
  7. Nahm M, Kim S, Paik S, Lee M, Lee S, Lee Z, et al. dCIP4 (Drosophila Cdc42-interacting protein 4) restrains synaptic growth by inhibiting the secretion of the retrograde Glass bottom boat signal. J Neurosci. 2010;30:8138-50 pubmed publisher
    ..Biochemical and genetic analyses demonstrate that dCIP4 acts downstream of Cdc42 to activate the postsynaptic Wsp-Arp2/3 pathway...
  8. Leibfried A, Fricke R, Morgan M, Bogdan S, Bellaiche Y. Drosophila Cip4 and WASp define a branch of the Cdc42-Par6-aPKC pathway regulating E-cadherin endocytosis. Curr Biol. 2008;18:1639-48 pubmed publisher
    ..Cdc42-interacting protein 4 (Cip4) is a Cdc42 effector that interacts with Dynamin and the Arp2/3 activator WASp in Drosophila. Accordingly, Cip4, WASp, or Arp2/3 loss of function also results in defective E-Cadherin endocytosis...
  9. Schäfer G, Weber S, Holz A, Bogdan S, Schumacher S, Muller A, et al. The Wiskott-Aldrich syndrome protein (WASP) is essential for myoblast fusion in Drosophila. Dev Biol. 2007;304:664-74 pubmed
    ..By screening an EMS mutagenesis collection, we discovered a new wasp allele that does not complete fusion during myogenesis...

More Information

Publications79

  1. Linardopoulou E, Parghi S, Friedman C, Osborn G, Parkhurst S, Trask B. Human subtelomeric WASH genes encode a new subclass of the WASP family. PLoS Genet. 2007;3:e237 pubmed
    ..Thus, human subtelomeres are not genetic junkyards, and WASH's location in these dynamic regions could have advantageous as well as pathologic consequences...
  2. Sens K, Zhang S, Jin P, Duan R, Zhang G, Luo F, et al. An invasive podosome-like structure promotes fusion pore formation during myoblast fusion. J Cell Biol. 2010;191:1013-27 pubmed publisher
    ..Two actin nucleation-promoting factors of the Arp2/3 complex, WASP and Scar, are required for the formation of the F-actin foci, whereas WASP but not Scar promotes efficient foci ..
  3. Biyasheva A, Svitkina T, Kunda P, Baum B, Borisy G. Cascade pathway of filopodia formation downstream of SCAR. J Cell Sci. 2004;117:837-48 pubmed
    ..to be regulated by two parallel pathways: from Rac1 through Scar/WAVEs to lamellipodia, and from Cdc42 through N-WASP to filopodia...
  4. Coyle I, Koh Y, Lee W, Slind J, Fergestad T, Littleton J, et al. Nervous wreck, an SH3 adaptor protein that interacts with Wsp, regulates synaptic growth in Drosophila. Neuron. 2004;41:521-34 pubmed
    ..protein that localizes to the periactive zone of presynaptic terminals and binds to the Drosophila ortholog of Wasp (Wsp), a key regulator of actin polymerization...
  5. Gildor B, Massarwa R, Shilo B, Schejter E. The SCAR and WASp nucleation-promoting factors act sequentially to mediate Drosophila myoblast fusion. EMBO Rep. 2009;10:1043-50 pubmed publisher
    The actin nucleation-promoting factors SCAR/WAVE and WASp, together with associated elements, mediate the formation of muscle fibres through myoblast fusion during Drosophila embryogenesis...
  6. Liu R, Abreu Blanco M, Barry K, Linardopoulou E, Osborn G, Parkhurst S. Wash functions downstream of Rho and links linear and branched actin nucleation factors. Development. 2009;136:2849-60 pubmed publisher
    ..b>Wasp and Scar/WAVE, the two founding members of the family, are regulated by the GTPases Cdc42 and Rac, respectively...
  7. Koch N, Dharmalingam E, Westermann M, Qualmann B, Thomas U, Kessels M. Abp1 utilizes the Arp2/3 complex activator Scar/WAVE in bristle development. J Cell Sci. 2012;125:3578-89 pubmed
    ..This phenotype was dependent on Scar but not on WASP and required the Scar-interacting SH3 domain of Abp1...
  8. Tal T, Vaizel Ohayon D, Schejter E. Conserved interactions with cytoskeletal but not signaling elements are an essential aspect of Drosophila WASp function. Dev Biol. 2002;243:260-71 pubmed
    Wiskott-Aldrich Syndrome proteins (WASp) serve as important regulators of cytoskeletal organization and function...
  9. Frank D, Hopmann R, Lenartowska M, Miller K. Capping protein and the Arp2/3 complex regulate nonbundle actin filament assembly to indirectly control actin bundle positioning during Drosophila melanogaster bristle development. Mol Biol Cell. 2006;17:3930-9 pubmed
    ..In addition, our results suggest that the Arpc1 subunit may have an additional function, independent of the rest of the Arp2/3 complex. ..
  10. Kamiyama D, Chiba A. Endogenous activation patterns of Cdc42 GTPase within Drosophila embryos. Science. 2009;324:1338-40 pubmed publisher
    ..Thus, bioprobe-assisted analysis uncovers how ubiquitously expressed signaling proteins control cellular events through continual regulation of their activities within animals. ..
  11. Stephan R, Grevelhörster A, Wenderdel S, Klämbt C, Bogdan S. Abi induces ectopic sensory organ formation by stimulating EGFR signaling. Mech Dev. 2008;125:183-95 pubmed publisher
    ..Its activity regulates WASP-/WAVE mediated F-actin formation and in addition modulates the activity of the Abelson tyrosine kinase (Abl)...
  12. Bothe I, Deng S, Baylies M. PI(4,5)P2 regulates myoblast fusion through Arp2/3 regulator localization at the fusion site. Development. 2014;141:2289-301 pubmed publisher
    ..Thus, PI(4,5)P2 enrichment at the fusion site encodes spatial and temporal information that regulates fusion progression through the localization of activators of actin polymerization. ..
  13. Khuong T, Habets R, Slabbaert J, Verstreken P. WASP is activated by phosphatidylinositol-4,5-bisphosphate to restrict synapse growth in a pathway parallel to bone morphogenetic protein signaling. Proc Natl Acad Sci U S A. 2010;107:17379-84 pubmed publisher
    ..critical in restricting synaptic growth by localizing and activating presynaptic Wiscott-Aldrich syndrome protein/WASP (WSP)...
  14. Georgiou M, Marinari E, Burden J, Baum B. Cdc42, Par6, and aPKC regulate Arp2/3-mediated endocytosis to control local adherens junction stability. Curr Biol. 2008;18:1631-8 pubmed publisher
    ..However, similar AJ defects are observed in wasp, arp2/3, and dynamin mutant cells, suggesting a requirement for actin-mediated endocytosis in the maintenance of ..
  15. Zallen J, Cohen Y, Hudson A, Cooley L, Wieschaus E, Schejter E. SCAR is a primary regulator of Arp2/3-dependent morphological events in Drosophila. J Cell Biol. 2002;156:689-701 pubmed
    The Arp2/3 complex and its activators, Scar/WAVE and Wiskott-Aldrich Syndrome protein (WASp), promote actin polymerization in vitro and have been proposed to influence cell shape and motility in vivo...
  16. Kaipa B, Shao H, Schäfer G, Trinkewitz T, Groth V, Liu J, et al. Dock mediates Scar- and WASp-dependent actin polymerization through interaction with cell adhesion molecules in founder cells and fusion-competent myoblasts. J Cell Sci. 2013;126:360-72 pubmed publisher
    ..Additionally, we show that Dock interacts biochemically and genetically with Drosophila Scar, Vrp1 and WASp. Based on these data, we propose that Dock links cell adhesion in FCs and FCMs with either Scar- or Vrp1-WASp-..
  17. Eriksson T, Varshney G, Aspenstrom P, Palmer R. Characterisation of the role of Vrp1 in cell fusion during the development of visceral muscle of Drosophila melanogaster. BMC Dev Biol. 2010;10:86 pubmed publisher
    ..The actin cytoskeleton regulator Verprolin acts by binding to WASP, which in turn binds to the Arp2/3 complex and thus activates actin polymerization...
  18. Kim S, Shilagardi K, Zhang S, Hong S, Sens K, Bo J, et al. A critical function for the actin cytoskeleton in targeted exocytosis of prefusion vesicles during myoblast fusion. Dev Cell. 2007;12:571-86 pubmed
    ..sltr encodes the Drosophila ortholog of the mammalian WASP-interacting protein...
  19. Massarwa R, Carmon S, Shilo B, Schejter E. WIP/WASp-based actin-polymerization machinery is essential for myoblast fusion in Drosophila. Dev Cell. 2007;12:557-69 pubmed
    ..We have established that Wsp, the Drosophila homolog of the WASp family of microfilament nucleation-promoting factors, is an essential facilitator of myoblast fusion in Drosophila ..
  20. Duan R, Jin P, Luo F, Zhang G, Anderson N, Chen E. Group I PAKs function downstream of Rac to promote podosome invasion during myoblast fusion in vivo. J Cell Biol. 2012;199:169-85 pubmed publisher
    ..We propose a model whereby group I PAKs act downstream of Rac to organize the actin filaments within the PLS into a dense focus, which in turn promotes PLS invasion and fusion pore initiation during myoblast fusion. ..
  21. Li W, Baker N. Engulfment is required for cell competition. Cell. 2007;129:1215-25 pubmed
    ..The engulfment genes draper, wasp, the phosphatidylserine receptor, mbc/dock180, and rac1 are needed in wild-type cells for the death of Minute ..
  22. Paunola E, Mattila P, Lappalainen P. WH2 domain: a small, versatile adapter for actin monomers. FEBS Lett. 2002;513:92-7 pubmed
    ..in many different regulators of the actin cytoskeleton, including the beta-thymosins, ciboulot, WASP (Wiskott Aldrich syndrome protein), verprolin/WIP (WASP-interacting protein), Srv2/CAP (adenylyl cyclase-associated protein) and ..
  23. Bogdan S, Stephan R, Löbke C, Mertens A, Klämbt C. Abi activates WASP to promote sensory organ development. Nat Cell Biol. 2005;7:977-84 pubmed
    ..To a large extent, the formation of filamentous actin is controlled by the WASP and WAVE proteins that activate the Arp2/3 complex in different developmental processes...
  24. Kumar V, Fricke R, Bhar D, Reddy Alla S, Krishnan K, Bogdan S, et al. Syndapin promotes formation of a postsynaptic membrane system in Drosophila. Mol Biol Cell. 2009;20:2254-64 pubmed publisher
  25. Bogdan S, Grewe O, Strunk M, Mertens A, Klämbt C. Sra-1 interacts with Kette and Wasp and is required for neuronal and bristle development in Drosophila. Development. 2004;131:3981-9 pubmed
    ..An important regulator of F-actin formation is the Arp2/3 complex, which in turn is activated by Wasp and Wave...
  26. Vartiainen M, Machesky L. The WASP-Arp2/3 pathway: genetic insights. Curr Opin Cell Biol. 2004;16:174-81 pubmed
    ..b>WASP/Scar family proteins regulate the activity of the Arp2/3 complex, and also link it to several signaling pathways...
  27. Kunda P, Craig G, Dominguez V, Baum B. Abi, Sra1, and Kette control the stability and localization of SCAR/WAVE to regulate the formation of actin-based protrusions. Curr Biol. 2003;13:1867-75 pubmed
    ..to promote the activation of SCAR/WAVE, whereas Cdc42 is thought to initiate the formation of filopodia through WASP. SCAR and WASP then activate the Arp2/3 complex to nucleate the formation of new actin filaments, which through ..
  28. Gildor B, Schejter E, Shilo B. Bidirectional Notch activation represses fusion competence in swarming adult Drosophila myoblasts. Development. 2012;139:4040-50 pubmed publisher
    ..The ensuing induction of proteins required for fusion enables myoblasts to fuse with the myotubes and give rise to subsequent muscle fiber growth...
  29. Ratnaparkhi A. Signaling by Folded gastrulation is modulated by mitochondrial fusion and fission. J Cell Sci. 2013;126:5369-76 pubmed publisher
    ..The findings presented here show that mitochondria, through regulation of fusion and fission, function as downstream effectors and modulators of Fog signaling and Fog-dependent cell shape change. ..
  30. Rojas Ríos P, Guerrero I, González Reyes A. Cytoneme-mediated delivery of hedgehog regulates the expression of bone morphogenetic proteins to maintain germline stem cells in Drosophila. PLoS Biol. 2012;10:e1001298 pubmed publisher
  31. Kumar V, Alla S, Krishnan K, Ramaswami M. Syndapin is dispensable for synaptic vesicle endocytosis at the Drosophila larval neuromuscular junction. Mol Cell Neurosci. 2009;40:234-41 pubmed publisher
    ..Our work in Drosophila leads to the suggestion that syndapin may not be a general or essential component in dynamin-dependent synaptic-vesicle endocytosis. ..
  32. Brinkmann K, Winterhoff M, Önel S, Schultz J, Faix J, Bogdan S. WHAMY is a novel actin polymerase promoting myoblast fusion, macrophage cell motility and sensory organ development in Drosophila. J Cell Sci. 2016;129:604-20 pubmed publisher
    ..In Drosophila, three different family members, SCAR (also known as WAVE), WASP and WASH (also known as CG13176), have been analyzed so far...
  33. Dhanyasi N, Segal D, Shimoni E, Shinder V, Shilo B, Vijayraghavan K, et al. Surface apposition and multiple cell contacts promote myoblast fusion in Drosophila flight muscles. J Cell Biol. 2015;211:191-203 pubmed publisher
  34. Rudolf A, Buttgereit D, Jacobs M, Wolfstetter G, Kesper D, Pütz M, et al. Distinct genetic programs guide Drosophila circular and longitudinal visceral myoblast fusion. BMC Cell Biol. 2014;15:27 pubmed publisher
    ..Longitudinal fusion was disturbed in rols and blow single, and scar wip double mutants. Mutants of wasp or its interaction partner wip had no defects in longitudinal fusion...
  35. Zhu Z, Bhat K. The Hem protein mediates neuronal migration by inhibiting WAVE degradation and functions opposite of Abelson tyrosine kinase. Dev Biol. 2011;357:283-94 pubmed publisher
    ..Our results also show that during the degradation of WAVE, Hem function is opposite to that of and downstream of Abl. ..
  36. Haralalka S, Shelton C, Cartwright H, Guo F, Trimble R, Kumar R, et al. Live imaging provides new insights on dynamic F-actin filopodia and differential endocytosis during myoblast fusion in Drosophila. PLoS ONE. 2014;9:e114126 pubmed publisher
    ..to provide the driving force for fusion, via the assembly of protrusions associated with branched F-actin and the WASp, SCAR and Arp2/3 pathways...
  37. Bertet C, Rauzi M, Lecuit T. Repression of Wasp by JAK/STAT signalling inhibits medial actomyosin network assembly and apical cell constriction in intercalating epithelial cells. Development. 2009;136:4199-212 pubmed publisher
    ..We show that regulation of actin polymerization by Wasp, but not by Dia, is important in this process...
  38. Benhra N, Lallet S, Cotton M, Le Bras S, Dussert A, Le Borgne R. AP-1 controls the trafficking of Notch and Sanpodo toward E-cadherin junctions in sensory organ precursors. Curr Biol. 2011;21:87-95 pubmed publisher
    ..Because AP-1 does not prevent endocytosis and recycling of the Notch ligand Delta, our data indicate that the DE-cadherin junctional domain may act as a launching pad through which endocytosed Notch ligand is trafficked for signaling. ..
  39. Martin P, Wood W. Epithelial fusions in the embryo. Curr Opin Cell Biol. 2002;14:569-74 pubmed
    ..It is now clear that there are intriguing parallels with more complex morphogenetic tissue movements in vertebrates. ..
  40. Hamp J, Löwer A, Dottermusch Heidel C, Beck L, Moussian B, Flötenmeyer M, et al. Drosophila Kette coordinates myoblast junction dissolution and the ratio of Scar-to-WASp during myoblast fusion. J Cell Sci. 2016;129:3426-36 pubmed publisher
    ..Furthermore, analysis of double mutants and attempts to rescue the kette mutant phenotype with N-cadherin, wasp and genes of members of the regulatory Scar complex revealed that Kette has two functions during myoblast fusion...
  41. Johnson R, Seppa M, Cagan R. The Drosophila CD2AP/CIN85 orthologue Cindr regulates junctions and cytoskeleton dynamics during tissue patterning. J Cell Biol. 2008;180:1191-204 pubmed publisher
    ..Together, these data demonstrate that Cindr is involved in dynamic cell rearrangement in an emerging epithelium. ..
  42. Matsubayashi Y, Coulson Gilmer C, Millard T. Endocytosis-dependent coordination of multiple actin regulators is required for wound healing. J Cell Biol. 2015;210:419-33 pubmed publisher
    ..In this paper, using Drosophila melanogaster embryos, we demonstrate that Diaphanous, SCAR, and WASp play distinct but overlapping roles in regulating actin assembly during wound healing...
  43. Verboon J, Sugumar B, Parkhurst S. Wiskott-Aldrich syndrome proteins in the nucleus: aWASH with possibilities. Nucleus. 2015;6:349-59 pubmed publisher
    ..The Wiskott Aldrich Syndrome (WAS) family of proteins, comprising the WASP/N-WASP, SCAR/WAVE, WHAMM/JMY/WHAMY, and WASH subfamilies, function in the cytoplasm where they activate the Arp2/3 ..
  44. Rosa A, Vlassaks E, Pichaud F, Baum B. Ect2/Pbl acts via Rho and polarity proteins to direct the assembly of an isotropic actomyosin cortex upon mitotic entry. Dev Cell. 2015;32:604-16 pubmed publisher
  45. Uytterhoeven V, Lauwers E, Maes I, Miskiewicz K, Melo M, Swerts J, et al. Hsc70-4 Deforms Membranes to Promote Synaptic Protein Turnover by Endosomal Microautophagy. Neuron. 2015;88:735-48 pubmed publisher
  46. Külshammer E, Uhlirova M. The actin cross-linker Filamin/Cheerio mediates tumor malignancy downstream of JNK signaling. J Cell Sci. 2013;126:927-38 pubmed publisher
    ..Our study identifies Cher as a new target of JNK signaling that links cytoskeleton dynamics to tumor progression. ..
  47. Stanishneva Konovalova T, Kelley C, Eskin T, Messelaar E, Wasserman S, Sokolova O, et al. Coordinated autoinhibition of F-BAR domain membrane binding and WASp activation by Nervous Wreck. Proc Natl Acad Sci U S A. 2016;113:E5552-61 pubmed publisher
    ..these autoregulatory interactions inhibit the ability of Nwk-SH3a to activate Wiskott-Aldrich syndrome protein (WASp)/actin related protein (Arp) 2/3-dependent actin filament assembly...
  48. Levayer R, Pelissier Monier A, Lecuit T. Spatial regulation of Dia and Myosin-II by RhoGEF2 controls initiation of E-cadherin endocytosis during epithelial morphogenesis. Nat Cell Biol. 2011;13:529-40 pubmed publisher
    ..Finally, we provide evidence that Dia and Myo-II control the initiation of E-cadherin endocytosis by regulating the lateral clustering of E-cadherin...
  49. Evans I, Ghai P, Urbančič V, Tan K, Wood W. SCAR/WAVE-mediated processing of engulfed apoptotic corpses is essential for effective macrophage migration in Drosophila. Cell Death Differ. 2013;20:709-20 pubmed publisher
  50. Renfranz P, Beckerle M. Doing (F/L)PPPPs: EVH1 domains and their proline-rich partners in cell polarity and migration. Curr Opin Cell Biol. 2002;14:88-103 pubmed
  51. Kim J, Cho A, Yin H, Schafer D, Mouneimne G, Simpson K, et al. Psidin, a conserved protein that regulates protrusion dynamics and cell migration. Genes Dev. 2011;25:730-41 pubmed publisher
    ..These results indicate that Psid is an actin regulatory protein that plays a conserved role in protrusion dynamics and cell migration. ..
  52. Cavey M, Rauzi M, Lenne P, Lecuit T. A two-tiered mechanism for stabilization and immobilization of E-cadherin. Nature. 2008;453:751-6 pubmed publisher
    ..Uncoupling stability and mobility of E-cadherin complexes suggests that stable epithelia may remodel through the regulated mobility of very stable adhesive foci. ..
  53. Mack N, Georgiou M. The interdependence of the Rho GTPases and apicobasal cell polarity. Small Gtpases. 2014;5:10 pubmed publisher
    ..Regarding this latter theme, we provide further discussion of the potential plasticity of the cell polarity machinery and as a result the possible implications for human disease. ..
  54. Gates J, Mahaffey J, Rogers S, Emerson M, Rogers E, Sottile S, et al. Enabled plays key roles in embryonic epithelial morphogenesis in Drosophila. Development. 2007;134:2027-39 pubmed
    ..We also explored filopodial regulation in cultured Drosophila cells and embryos. These data provide new insights into developmental and mechanistic roles of this important actin regulator. ..
  55. Pirone D, Carter D, Burbelo P. Evolutionary expansion of CRIB-containing Cdc42 effector proteins. Trends Genet. 2001;17:370-3 pubmed
    ..These evolutionary changes correlate with the development of the more complex signaling pathways present in higher organisms. ..
  56. Worby C, Simonson Leff N, Clemens J, Huddler D, Muda M, Dixon J. Drosophila Ack targets its substrate, the sorting nexin DSH3PX1, to a protein complex involved in axonal guidance. J Biol Chem. 2002;277:9422-8 pubmed
    ..These results suggest that the phosphorylation of DSH3PX1 by DAck targets this sorting nexin to a protein complex that includes Dock, an adaptor protein important for axonal guidance. ..
  57. Natarajan R, Barber K, Buckley A, Cho P, Egbejimi A, Wairkar Y. Tricornered Kinase Regulates Synapse Development by Regulating the Levels of Wiskott-Aldrich Syndrome Protein. PLoS ONE. 2015;10:e0138188 pubmed publisher
    ..In addition, Tsc2 and trc mutants exhibit a dramatic reduction in synaptic levels of WASP, an important regulator of actin polymerization...
  58. Pearson A, Baksa K, Ramet M, Protas M, McKee M, Brown D, et al. Identification of cytoskeletal regulatory proteins required for efficient phagocytosis in Drosophila. Microbes Infect. 2003;5:815-24 pubmed
    ..Finally, RNA interference studies in S2 cells indicated that the D-SCAR homolog D-WASp also participates in phagocytosis...
  59. Lolo F, Casas Tinto S, Moreno E. Cell competition time line: winners kill losers, which are extruded and engulfed by hemocytes. Cell Rep. 2012;2:526-39 pubmed publisher
    ..It is believed that the genes wasp, psr, and draper are active in the cells that win the competition ("winner cells") and that they are ..
  60. Koch N, Kobler O, Thomas U, Qualmann B, Kessels M. Terminal axonal arborization and synaptic bouton formation critically rely on abp1 and the arp2/3 complex. PLoS ONE. 2014;9:e97692 pubmed publisher
    ..Abp1 is able to indirectly trigger Arp2/3 complex-mediated actin nucleation and interacts with both WASP and Scar...
  61. Galy A, Schenck A, Sahin H, Qurashi A, Sahel J, Diebold C, et al. CYFIP dependent actin remodeling controls specific aspects of Drosophila eye morphogenesis. Dev Biol. 2011;359:37-46 pubmed publisher
    ..Mutations in WAVE/SCAR and in ARP2/3 complex subunits but not in WASP, another major regulator of Actin nucleation, phenocopy CYFIP defects...
  62. Menon K, Carrillo R, Zinn K. The translational regulator Cup controls NMJ presynaptic terminal morphology. Mol Cell Neurosci. 2015;67:126-36 pubmed publisher
    ..Our results are consistent with a model in which Cup and eIF4E work together to ensure efficient localization and translation of endocytosis proteins in motor neurons and control the strength of the retrograde BMP signal. ..
  63. Zelhof A, Hardy R. WASp is required for the correct temporal morphogenesis of rhabdomere microvilli. J Cell Biol. 2004;164:417-26 pubmed
    ..Here, we report that the Wiskott-Aldrich syndrome protein (WASp) is necessary for rhabdomere microvillus morphogenesis...
  64. Zobel T, Brinkmann K, Koch N, Schneider K, Seemann E, Fleige A, et al. Cooperative functions of the two F-BAR proteins Cip4 and Nostrin in the regulation of E-cadherin in epithelial morphogenesis. J Cell Sci. 2015;128:499-515 pubmed
  65. Miller K. Extending the Arp2/3 complex and its regulation beyond the leading edge. J Cell Biol. 2002;156:591-3 pubmed
    ..These studies also show that assembly of other actin structures is independent of these proteins, suggesting that alternative mechanisms also exist. ..
  66. Segal D, Dhanyasi N, Schejter E, Shilo B. Adhesion and Fusion of Muscle Cells Are Promoted by Filopodia. Dev Cell. 2016;38:291-304 pubmed publisher
    ..We therefore propose that the filopodia are necessary to prime the heterotypic adhesion process between the two cell types, possibly by recruiting the cell-adhesion molecule Sns to discrete patches on the myoblast cell surface. ..
  67. Ng J, Luo L. Rho GTPases regulate axon growth through convergent and divergent signaling pathways. Neuron. 2004;44:779-93 pubmed
    ..These genetic analyses reveal convergent and divergent pathways from Rho GTPases to the cytoskeleton during axon growth in vivo and suggest that different developmental outcomes could be achieved by biases in pathway selection...
  68. Worby C, Simonson Leff N, Clemens J, Kruger R, Muda M, Dixon J. The sorting nexin, DSH3PX1, connects the axonal guidance receptor, Dscam, to the actin cytoskeleton. J Biol Chem. 2001;276:41782-9 pubmed
    ..We further show that DSH3PX1 interacts with the Drosophila orthologue of Wasp, a protein component of actin polymerization machinery, and that DSH3PX1 co-immunoprecipitates with AP-50, the ..
  69. Förster D, Luschnig S. Src42A-dependent polarized cell shape changes mediate epithelial tube elongation in Drosophila. Nat Cell Biol. 2012;14:526-34 pubmed publisher
    ..Whereas exocytosis-dependent membrane growth drives circumferential tube expansion, Src42A is required to orient membrane growth in the axial dimension of the tube. ..
  70. Han C, Song Y, Xiao H, Wang D, Franc N, Jan L, et al. Epidermal cells are the primary phagocytes in the fragmentation and clearance of degenerating dendrites in Drosophila. Neuron. 2014;81:544-560 pubmed publisher
    ..Our finding reveals the physiological importance of coordination between neurons and their surrounding epidermis, for both dendrite fragmentation and clearance. ..