Gene Symbol: wapl
Description: wings apart-like
Alias: C204, CG3707, Dmel\CG3707, EG:87B1.2, RNA D, RNAD, Wapl, l(1)2Dd, l(1)2Df, l(1)C204, l(1)N2, l(1)N5[72], l74, pasc, wap, wings apart-like, CG3707-PA, CG3707-PB, CG3707-PC, parallel sister chromatids protein, wapl-PA, wapl-PB, wapl-PC, wings-apart-like
Species: fruit fly

Top Publications

  1. Eichinger C, Kurze A, Oliveira R, Nasmyth K. Disengaging the Smc3/kleisin interface releases cohesin from Drosophila chromosomes during interphase and mitosis. EMBO J. 2013;32:656-65 pubmed publisher
    ..during prophase when most cohesin dissociates from chromosome arms in a process dependent on the regulatory subunit Wapl. We show here that Wapl-dependent release from salivary gland polytene chromosomes during interphase and from ..
  2. Verni F, Gandhi R, Goldberg M, Gatti M. Genetic and molecular analysis of wings apart-like (wapl), a gene controlling heterochromatin organization in Drosophila melanogaster. Genetics. 2000;154:1693-710 pubmed
    Mutations in the X-linked gene wings apart-like (wapl) result in late larval lethality associated with an unusual chromosome morphology...
  3. Gause M, Misulovin Z, Bilyeu A, Dorsett D. Dosage-sensitive regulation of cohesin chromosome binding and dynamics by Nipped-B, Pds5, and Wapl. Mol Cell Biol. 2010;30:4940-51 pubmed publisher
    ..We also found that Nipped-B, Pds5, and the Wapl protein that interacts with Pds5 all play unique roles in cohesin chromosome binding.
  4. Tolchkov E, Kramerova I, Lavrov S, Rasheva V, Bonaccorsi S, Alatortsev V, et al. Position-effect variegation in Drosophila melanogaster X chromosome inversion with a breakpoint in a satellite block and its suppression in a secondary rearrangement. Chromosoma. 1997;106:520-5 pubmed
    ..It is associated with position-effect variegation (PEV) of the pn, wapl, Pgd and other vital loci of the 2E region, which are relocated near the bulk of the X heterochromatin...
  5. Wang J, Lee C, Lin S, Lee T. Steroid hormone-dependent transformation of polyhomeotic mutant neurons in the Drosophila brain. Development. 2006;133:1231-40 pubmed
    ..Taken together, Drosophila Ph is essential for governing neuronal diversity, especially during steroid hormone signaling. ..
  6. Gatti M, Goldberg M. Mutations affecting cell division in Drosophila. Methods Cell Biol. 1991;35:543-86 pubmed
  7. Dorsett D, Kassis J. Checks and balances between cohesin and polycomb in gene silencing and transcription. Curr Biol. 2014;24:R535-9 pubmed publisher
  8. Perrimon N, Engstrom L, Mahowald A. Developmental genetics of the 2C-D region of the Drosophila X chromosome. Genetics. 1985;111:23-41 pubmed
    ..lethals has revealed three types of gene requirements: normal activity at two pupal lethal loci (corkscrew and C204) and one larval lethal locus (ultraspiracle) is required for normal embryogenesis; normal activity at three larval ..
  9. Thornton K, Jensen J. Controlling the false-positive rate in multilocus genome scans for selection. Genetics. 2007;175:737-50 pubmed
    ..5 kbp) in genome-scan studies leads to more power to detect recent selective sweeps. ..

More Information


  1. Tolchkov E, Rasheva V, Bonaccorsi S, Westphal T, Gvozdev V. The size and internal structure of a heterochromatic block determine its ability to induce position effect variegation in Drosophila melanogaster. Genetics. 2000;154:1611-26 pubmed
    ..These rearrangements demonstrate a positive correlation between the strength of PEV of the wapl locus and the sizes of the adjacent heterochromatic blocks carrying the centromere...
  2. Feng S, Huang J, Wang J. Loss of the Polycomb group gene polyhomeotic induces non-autonomous cell overproliferation. EMBO Rep. 2011;12:157-63 pubmed publisher
    ..We propose that PcG misregulation promotes tumorigenesis through several cellular mechanisms. ..
  3. Leemans R, Loop T, Egger B, He H, Kammermeier L, Hartmann B, et al. Identification of candidate downstream genes for the homeodomain transcription factor Labial in Drosophila through oligonucleotide-array transcript imaging. Genome Biol. 2001;2:RESEARCH0015 pubmed
    ..Our results identify a number of novel candidate downstream target genes for Labial, suggesting that this homeoprotein differentially regulates a limited and distinct set of embryonically expressed Drosophila genes. ..
  4. Dobie K, Kennedy C, Velasco V, McGrath T, Weko J, Patterson R, et al. Identification of chromosome inheritance modifiers in Drosophila melanogaster. Genetics. 2001;157:1623-37 pubmed
    ..P insertions within or close to genes with previously described inheritance functions, including wings apart-like (wapl), centrosomin (cnn), and pavarotti (pav)...
  5. Nishiyama T, Ladurner R, Schmitz J, Kreidl E, Schleiffer A, Bhaskara V, et al. Sororin mediates sister chromatid cohesion by antagonizing Wapl. Cell. 2010;143:737-49 pubmed publisher
    ..Cohesin-DNA interactions can be reversed by the cohesion-associated protein Wapl, whereas a stably DNA-bound form of cohesin is thought to mediate cohesion...
  6. Cirera S, Martin Campos J, Segarra C, Aguade M. Molecular characterization of the breakpoints of an inversion fixed between Drosophila melanogaster and D. subobscura. Genetics. 1995;139:321-6 pubmed
    ..Although alternating Pur-Pyr sequences were detected, these putative target sites for topoisomerase II were not differentially clustered in the breakpoints. ..
  7. Kusch T. Brca2-Pds5 complexes mobilize persistent meiotic recombination sites to the nuclear envelope. J Cell Sci. 2015;128:717-27 pubmed publisher
    ..The identification of Brca2-Pds5 complexes as key mediators of this process provides a first mechanistic explanation for the contribution of lamins and cohesins to meiotic recombination. ..
  8. Popkova A, Rasheva V, Tolchkov E, Alatortsev V. [Trans-effect of modifiers on position-effect variegation in a set of euchromatin-heterochromatin rearrangements in Drosophila melanogaster]. Genetika. 2001;37:1430-4 pubmed
    ..in a set of euchromatin-heterochromatin rearrangements of the X chromosome accompanied by inactivation of the gene wapl. The rearrangements differed from one another in the size of the heterochromatic block adjacent to euchromatin, ..
  9. Jensen J, Thornton K, Aquadro C. Inferring selection in partially sequenced regions. Mol Biol Evol. 2008;25:438-46 pubmed publisher
    ..Additionally, we examine the performance of a commonly used test of selection under a variety of recurrent and single sweep models. ..
  10. Beisswanger S, Stephan W, De Lorenzo D. Evidence for a selective sweep in the wapl region of Drosophila melanogaster. Genetics. 2006;172:265-74 pubmed
    ..We detect a 60.5-kb stretch of DNA encompassing the genes ph-d, ph-p, CG3835, bcn92, Pgd, wapl, and Cyp4d1, which almost completely lacks variation in the European sample...
  11. Gvozdev V, Gostimsky S, Gerasimova T, Dubrovskaya E, Braslavskaya O. Fine genetic structure of the 2D3-2F5 region of the X-chromosome of Drosophila melanogaster. Mol Gen Genet. 1975;141:269-75 pubmed
    ..The Pgd locus coding for 6-phosphogluconate dehydrogenase (6PGD) is mapped in the 2D3 (OR 2D4) band. Isolation of 11 lethal or semilethal point mutations with null or reduced 6PGD activity shows that the Pgd locus is a vital one. ..
  12. Cook K, Murphy T, Nguyen T, Karpen G. Identification of trans-acting genes necessary for centromere function in Drosophila melanogaster using centromere-defective minichromosomes. Genetics. 1997;145:737-47 pubmed
    ..The results presented in this study strongly suggest that dominant genetic interactions between mutations and centromere-defective minichromosomes could be used effectively to identify novel genes necessary for centromere function. ..
  13. Dura J, Randsholt N, Deatrick J, Erk I, Santamaria P, Freeman J, et al. A complex genetic locus, polyhomeotic, is required for segmental specification and epidermal development in D. melanogaster. Cell. 1987;51:829-39 pubmed
    ..We propose a model that may account for this unusual functional organization. ..
  14. Cunningham M, Gause M, Cheng Y, Noyes A, Dorsett D, Kennison J, et al. Wapl antagonizes cohesin binding and promotes Polycomb-group silencing in Drosophila. Development. 2012;139:4172-9 pubmed publisher
    b>Wapl protein regulates binding of the cohesin complex to chromosomes during interphase and helps remove cohesin from chromosomes at mitosis...
  15. Oliveira R, Kotadia S, Tavares A, Mirkovic M, Bowlin K, Eichinger C, et al. Centromere-independent accumulation of cohesin at ectopic heterochromatin sites induces chromosome stretching during anaphase. PLoS Biol. 2014;12:e1001962 pubmed publisher
  16. Gandhi R, Varak E, Goldberg M. Molecular analysis of a cytochrome P450 gene of family 4 on the Drosophila X chromosome. DNA Cell Biol. 1992;11:397-404 pubmed
    ..This transduced fragment does not rescue any of the lethal mutations that have been identified in this genetically well-characterized region of the Drosophila genome. ..