Vps4

Summary

Gene Symbol: Vps4
Description: Vacuolar protein sorting 4
Alias: 3B1, BcDNA:GH02678, CG6842, DmBcDNA.GH02678, Dmel\CG6842, Dvps4, Vps4B, bcDNA:GH02678, dvps4, vps4, vacuolar protein sorting 4, CG6842-PA, CG6842-PB, Vps4-PA, Vps4-PB
Species: fruit fly

Top Publications

  1. Rusten T, Vaccari T, Lindmo K, Rodahl L, Nezis I, Sem Jacobsen C, et al. ESCRTs and Fab1 regulate distinct steps of autophagy. Curr Biol. 2007;17:1817-25 pubmed
    ..of endosomal sorting complex required for transport (ESCRT)-I, -II and -III, as well as their regulatory ATPase Vps4 and the endosomal PtdIns(3)P 5-kinase Fab1, all are required for autophagy...
  2. Michelet X, Djeddi A, Legouis R. Developmental and cellular functions of the ESCRT machinery in pluricellular organisms. Biol Cell. 2010;102:191-202 pubmed publisher
    ..The present review summarizes recent research on the developmental and cellular functions of the ESCRT in Caenorhabditis elegans, Drosophila melanogaster, Mus musculus or Arabidopsis thaliana. ..
  3. Rodahl L, Haglund K, Sem Jacobsen C, Wendler F, Vincent J, Lindmo K, et al. Disruption of Vps4 and JNK function in Drosophila causes tumour growth. PLoS ONE. 2009;4:e4354 pubmed publisher
    ..Here we report that disruption of the ATPase dVps4, the most downstream component of the ESCRT machinery, causes the same array of cellular phenotypes...
  4. Hilger M, Bonaldi T, Gnad F, Mann M. Systems-wide analysis of a phosphatase knock-down by quantitative proteomics and phosphoproteomics. Mol Cell Proteomics. 2009;8:1908-20 pubmed publisher
    ..Our analysis highlights a connection of Ptp61F to cytoskeletal regulation through GTPase regulating proteins and focal adhesion components. ..
  5. Parchure A, Vyas N, Ferguson C, Parton R, Mayor S. Oligomerization and endocytosis of Hedgehog is necessary for its efficient exovesicular secretion. Mol Biol Cell. 2015;26:4700-17 pubmed publisher
    ..These results provide evidence that nanoscale organization of Hh regulates the secretion of Hh on ESCRT-derived exovesicles, which in turn act as a vehicle for long-range signaling. ..
  6. Kammermeier L, Spring J, Stierwald M, Burgunder J, Reichert H. Identification of the Drosophila melanogaster homolog of the human spastin gene. Dev Genes Evol. 2003;213:412-5 pubmed
    ..Given this nervous system-specific expression, it will be important to determine if Drosophila spastin loss-of-function mutations also lead to neurodegeneration. ..
  7. Hori K, Sen A, Kirchhausen T, Artavanis Tsakonas S. Synergy between the ESCRT-III complex and Deltex defines a ligand-independent Notch signal. J Cell Biol. 2011;195:1005-15 pubmed publisher
    ..This activation mode of the receptor emphasizes the complexity of Notch signal modulation in a cell and has significant implications for both development and disease. ..
  8. Loncle N, Agromayor M, Martin Serrano J, Williams D. An ESCRT module is required for neuron pruning. Sci Rep. 2015;5:8461 pubmed publisher
    ..Furthermore we show that this ESCRT module requires a direct, in vivo, interaction between Shrub/CHMP4B and the accessory protein Myopic/HD-PTP. ..
  9. Legent K, Liu H, Treisman J. Drosophila Vps4 promotes Epidermal growth factor receptor signaling independently of its role in receptor degradation. Development. 2015;142:1480-91 pubmed publisher
    ..In a genetic screen for mutations that affect Drosophila eye development, we identified an allele of Vacuolar protein sorting 4 (Vps4), which encodes an AAA ATPase that interacts with the ESCRT-III complex to drive the final step of ..

More Information

Publications16

  1. Philips J, Porto M, Wang H, Rubin E, Perrimon N. ESCRT factors restrict mycobacterial growth. Proc Natl Acad Sci U S A. 2008;105:3070-5 pubmed publisher
    ..Furthermore, we demonstrate that, in mammalian cells, the ESCRT machinery plays a conserved role in restricting bacterial growth. ..
  2. Troost T, Jaeckel S, Ohlenhard N, Klein T. The tumour suppressor Lethal (2) giant discs is required for the function of the ESCRT-III component Shrub/CHMP4. J Cell Sci. 2012;125:763-76 pubmed publisher
  3. Matusek T, Wendler F, Polès S, Pizette S, D Angelo G, Fürthauer M, et al. The ESCRT machinery regulates the secretion and long-range activity of Hedgehog. Nature. 2014;516:99-103 pubmed publisher
  4. Gradilla A, González E, Seijo I, Andrés G, Bischoff M, González Mendez L, et al. Exosomes as Hedgehog carriers in cytoneme-mediated transport and secretion. Nat Commun. 2014;5:5649 pubmed publisher
    ..We propose Hh transport via exosomes along cytonemes as a significant mechanism for the restricted distribution of a lipid-modified morphogen. ..
  5. Jia T, Macare C, Desrivières S, Gonzalez D, Tao C, Ji X, et al. Neural basis of reward anticipation and its genetic determinants. Proc Natl Acad Sci U S A. 2016;113:3879-84 pubmed publisher
    ..and the vacuolar protein sorting-associated protein 4A (VPS4A) gene in humans, and the causal role of Vps4 for hyperactivity was validated in Drosophila Our data provide a neurobehavioral model explaining the heterogeneity ..
  6. Bischoff M, Gradilla A, Seijo I, Andrés G, Rodríguez Navas C, González Méndez L, et al. Cytonemes are required for the establishment of a normal Hedgehog morphogen gradient in Drosophila epithelia. Nat Cell Biol. 2013;15:1269-81 pubmed publisher
    ..Indeed, mutant conditions that affect cytoneme formation reduce both cytoneme length and Hh gradient length. Our results suggest that cytoneme-mediated Hh transport is the mechanistic basis for Hh gradient formation. ..
  7. Mattissek C, Teis D. The role of the endosomal sorting complexes required for transport (ESCRT) in tumorigenesis. Mol Membr Biol. 2014;31:111-9 pubmed publisher
    ..Therefore the aim of this review is to provide an overview on different model systems used to study the role of the ESCRT machinery in cancer development, to highlight common grounds and present certain controversies in the field. ..