Vps28

Summary

Gene Symbol: Vps28
Description: Vacuolar protein sorting 28
Alias: CG12770, DmVps28, Dmel\CG12770, Dvps28, ESCRT-I, ESCRT-II, dVps28, dvps28, l(2)k16503, vps28, vacuolar protein sorting 28, CG12770-PA, CG12770-PB, Vps28-PA, Vps28-PB
Species: fruit fly

Top Publications

  1. Rusten T, Vaccari T, Lindmo K, Rodahl L, Nezis I, Sem Jacobsen C, et al. ESCRTs and Fab1 regulate distinct steps of autophagy. Curr Biol. 2007;17:1817-25 pubmed
    ..Thus, this study links ESCRT function with autophagy and aggregate-induced neurodegeneration, thereby providing a plausible explanation for the fact that ESCRT mutations are involved in inherited neurodegenerative disease in humans [4]. ..
  2. Vaccari T, Rusten T, Menut L, Nezis I, Brech A, Stenmark H, et al. Comparative analysis of ESCRT-I, ESCRT-II and ESCRT-III function in Drosophila by efficient isolation of ESCRT mutants. J Cell Sci. 2009;122:2413-23 pubmed publisher
  3. Michelet X, Djeddi A, Legouis R. Developmental and cellular functions of the ESCRT machinery in pluricellular organisms. Biol Cell. 2010;102:191-202 pubmed publisher
    ..The present review summarizes recent research on the developmental and cellular functions of the ESCRT in Caenorhabditis elegans, Drosophila melanogaster, Mus musculus or Arabidopsis thaliana. ..
  4. Sevrioukov E, Moghrabi N, Kuhn M, KRAMER H. A mutation in dVps28 reveals a link between a subunit of the endosomal sorting complex required for transport-I complex and the actin cytoskeleton in Drosophila. Mol Biol Cell. 2005;16:2301-12 pubmed
    ..Here, we characterize a mutation in the Drosophila homolog of vps28. The dVps28 gene is essential: homozygous mutants die at the transition from the first to second instar...
  5. Parchure A, Vyas N, Ferguson C, Parton R, Mayor S. Oligomerization and endocytosis of Hedgehog is necessary for its efficient exovesicular secretion. Mol Biol Cell. 2015;26:4700-17 pubmed publisher
    ..These results provide evidence that nanoscale organization of Hh regulates the secretion of Hh on ESCRT-derived exovesicles, which in turn act as a vehicle for long-range signaling. ..
  6. Saja S, Buff H, Smith A, Williams T, Korey C. Identifying cellular pathways modulated by Drosophila palmitoyl-protein thioesterase 1 function. Neurobiol Dis. 2010;40:135-45 pubmed publisher
    ..This work lays the groundwork for further experimental exploration of these processes to better understand their contributions to the INCL disease process. ..
  7. Haberman A, Akbar M, Ray S, KRAMER H. Drosophila acinus encodes a novel regulator of endocytic and autophagic trafficking. Development. 2010;137:2157-66 pubmed publisher
    ..Taken together, our data show that dacn encodes a regulator of endosomal and autophagosomal dynamics, modulating developmental signaling and the cellular response to starvation. ..
  8. Matusek T, Wendler F, Polès S, Pizette S, D Angelo G, Fürthauer M, et al. The ESCRT machinery regulates the secretion and long-range activity of Hedgehog. Nature. 2014;516:99-103 pubmed publisher
  9. Yang X, Mao F, Lv X, Zhang Z, Fu L, Lu Y, et al. Drosophila Vps36 regulates Smo trafficking in Hedgehog signaling. J Cell Sci. 2013;126:4230-8 pubmed publisher

More Information

Publications18

  1. Juhasz G, Hill J, Yan Y, Sass M, Baehrecke E, Backer J, et al. The class III PI(3)K Vps34 promotes autophagy and endocytosis but not TOR signaling in Drosophila. J Cell Biol. 2008;181:655-66 pubmed publisher
    ..Our results suggest that Vps34 is regulated by TOR-dependent nutrient signals directly at sites of autophagosome formation. ..
  2. Beckett K, Monier S, Palmer L, Alexandre C, Green H, Bonneil E, et al. Drosophila S2 cells secrete wingless on exosome-like vesicles but the wingless gradient forms independently of exosomes. Traffic. 2013;14:82-96 pubmed publisher
    ..Consistent with this conclusion, extracellularly tagged Evi expressed from a Bacterial Artificial Chromosome is not released from imaginal disc Wingless-expressing cells. ..
  3. Tjota M, Lee S, Wu J, Williams J, Khanna M, Thomas G. Annexin B9 binds to ?(H)-spectrin and is required for multivesicular body function in Drosophila. J Cell Sci. 2011;124:2914-26 pubmed publisher
    ..These results indicate that AnxB9 and ?(H) are intimately involved in endosomal trafficking to the MVB and play a role in maintaining high-fidelity segregation of the apical and lateral domains. ..
  4. Irion U, St Johnston D. bicoid RNA localization requires specific binding of an endosomal sorting complex. Nature. 2007;445:554-8 pubmed
    ..This function of ESCRT-II as an RNA-binding complex is conserved in vertebrates and may clarify some of its roles that are independent of endosomal sorting. ..
  5. Loncle N, Agromayor M, Martin Serrano J, Williams D. An ESCRT module is required for neuron pruning. Sci Rep. 2015;5:8461 pubmed publisher
    ..Furthermore we show that this ESCRT module requires a direct, in vivo, interaction between Shrub/CHMP4B and the accessory protein Myopic/HD-PTP. ..
  6. Hori K, Sen A, Kirchhausen T, Artavanis Tsakonas S. Synergy between the ESCRT-III complex and Deltex defines a ligand-independent Notch signal. J Cell Biol. 2011;195:1005-15 pubmed publisher
    ..This activation mode of the receptor emphasizes the complexity of Notch signal modulation in a cell and has significant implications for both development and disease. ..
  7. Ahmad S, Sweeney S, Lee J, Sweeney N, Gao F. Genetic screen identifies serpin5 as a regulator of the toll pathway and CHMP2B toxicity associated with frontotemporal dementia. Proc Natl Acad Sci U S A. 2009;106:12168-73 pubmed publisher
    ..This fly model will be useful to further dissect genetic pathways that are potentially relevant to the pathogenesis and treatment of FTD. ..
  8. Philips J, Porto M, Wang H, Rubin E, Perrimon N. ESCRT factors restrict mycobacterial growth. Proc Natl Acad Sci U S A. 2008;105:3070-5 pubmed publisher
    ..Furthermore, we demonstrate that, in mammalian cells, the ESCRT machinery plays a conserved role in restricting bacterial growth. ..
  9. Sheng Z, Yu L, Zhang T, Pei X, Li X, Zhang Z, et al. ESCRT-0 complex modulates Rbf-mutant cell survival by regulating Rhomboid endosomal trafficking and EGFR signaling. J Cell Sci. 2016;129:2075-84 pubmed publisher
    ..Because ESCRT-0 also plays crucial roles in EGFR downregulation after ligand binding, this study provides new insights into how loss of ESCRT-0 function can either increase or decrease EGFR signaling. ..