Gene Symbol: Vps2
Description: Vacuolar protein sorting 2
Alias: CG14542, Did4, DmVPS2, Dmel\CG14542, Dvps2, NEST:bs02f06, dvps2, vps2, vacuolar protein sorting 2, CG14542-PA, Vps2-PA, vps2
Species: fruit fly
Vaccari T, Rusten T, Menut L, Nezis I, Brech A, Stenmark H, et al
. Comparative analysis of ESCRT-I, ESCRT-II and ESCRT-III function in Drosophila by efficient isolation of ESCRT mutants. J Cell Sci. 2009;122:2413-23 pubmed publisher
Michelet X, Djeddi A, Legouis R. Developmental and cellular functions of the ESCRT machinery in pluricellular organisms. Biol Cell. 2010;102:191-202 pubmed publisher
..The present review summarizes recent research on the developmental and cellular functions of the ESCRT in Caenorhabditis elegans, Drosophila melanogaster, Mus musculus or Arabidopsis thaliana. ..
Philips J, Porto M, Wang H, Rubin E, Perrimon N. ESCRT factors restrict mycobacterial growth. Proc Natl Acad Sci U S A. 2008;105:3070-5 pubmed publisher
..Furthermore, we demonstrate that, in mammalian cells, the ESCRT machinery plays a conserved role in restricting bacterial growth. ..
Hori K, Sen A, Kirchhausen T, Artavanis Tsakonas S. Synergy between the ESCRT-III complex and Deltex defines a ligand-independent Notch signal. J Cell Biol. 2011;195:1005-15 pubmed publisher
..This activation mode of the receptor emphasizes the complexity of Notch signal modulation in a cell and has significant implications for both development and disease. ..
Aoyama N, Yamakawa T, Sasamura T, Yoshida Y, Ohori M, Okubo H, et al
. Loss- and gain-of-function analyses of vacuolar protein sorting 2 in Notch signaling of Drosophila melanogaster. Genes Genet Syst. 2013;88:45-57 pubmed
..A loss-of-function allele of vacuolar protein sorting 2 (vps2), which encodes a component of ESCRT-III, has been reported...
Loncle N, Agromayor M, Martin Serrano J, Williams D. An ESCRT module is required for neuron pruning. Sci Rep. 2015;5:8461 pubmed publisher
..Furthermore we show that this ESCRT module requires a direct, in vivo, interaction between Shrub/CHMP4B and the accessory protein Myopic/HD-PTP. ..
Ahmad S, Sweeney S, Lee J, Sweeney N, Gao F. Genetic screen identifies serpin5 as a regulator of the toll pathway and CHMP2B toxicity associated with frontotemporal dementia. Proc Natl Acad Sci U S A. 2009;106:12168-73 pubmed publisher
..This fly model will be useful to further dissect genetic pathways that are potentially relevant to the pathogenesis and treatment of FTD. ..
Zhang J, Du J, Lei C, Liu M, Zhu A. Ubpy controls the stability of the ESCRT-0 subunit Hrs in development. Development. 2014;141:1473-9 pubmed publisher
..Together, our data support a model in which Ubpy plays a dual role in both cargo deubiquitylation and the ESCRT-0 stability during development. ..
Mattissek C, Teis D. The role of the endosomal sorting complexes required for transport (ESCRT) in tumorigenesis. Mol Membr Biol. 2014;31:111-9 pubmed publisher
..Therefore the aim of this review is to provide an overview on different model systems used to study the role of the ESCRT machinery in cancer development, to highlight common grounds and present certain controversies in the field. ..