Gene Symbol: Vps16A
Description: Vacuolar protein sorting 16A
Alias: CG8454, DmVps16, Dmel\CG8454, V16, Vps16, dVps16A, vps16A, vacuolar protein sorting 16A, CG8454-PA, Vps16, Vps16A-PA
Species: fruit fly

Top Publications

  1. Kim S, Wairkar Y, Daniels R, DiAntonio A. The novel endosomal membrane protein Ema interacts with the class C Vps-HOPS complex to promote endosomal maturation. J Cell Biol. 2010;188:717-34 pubmed publisher
    ..Ema binds to and genetically interacts with Vps16A, a component of the class C Vps-HOPS complex that promotes endosomal maturation...
  2. Pulipparacharuvil S, Akbar M, Ray S, Sevrioukov E, Haberman A, Rohrer J, et al. Drosophila Vps16A is required for trafficking to lysosomes and biogenesis of pigment granules. J Cell Sci. 2005;118:3663-73 pubmed publisher
    ..Here we demonstrate that dVps16A (CG8454) encodes another Vps-C subunit...
  3. Akbar M, Ray S, KRAMER H. The SM protein Car/Vps33A regulates SNARE-mediated trafficking to lysosomes and lysosome-related organelles. Mol Biol Cell. 2009;20:1705-14 pubmed publisher
    ..Consistent with a role in Car-mediated fusion, dSyntaxin16 is not restricted to Golgi membranes but also present on lysosomes. ..
  4. Solinger J, Spang A. Tethering complexes in the endocytic pathway: CORVET and HOPS. FEBS J. 2013;280:2743-57 pubmed publisher
    ..Accumulating evidence supports the view that endosomal tethering complexes implement a regulatory logic that governs endomembrane identity and dynamics. ..
  5. Akbar M, Tracy C, Kahr W, KRAMER H. The full-of-bacteria gene is required for phagosome maturation during immune defense in Drosophila. J Cell Biol. 2011;192:383-90 pubmed publisher
    ..These findings suggest that defects in phagosome maturation may contribute to symptoms of ARC patients including recurring infections. ..
  6. Takáts S, Pircs K, Nagy P, Varga Ã, Kárpáti M, Hegedűs K, et al. Interaction of the HOPS complex with Syntaxin 17 mediates autophagosome clearance in Drosophila. Mol Biol Cell. 2014;25:1338-54 pubmed publisher
    ..We show that all six HOPS subunits (Vps11 [vacuolar protein sorting 11]/CG32350, Vps18/Dor, Vps16A, Vps33A/Car, Vps39/CG7146, and Vps41/Lt) are required for fusion of autophagosomes with lysosomes in Drosophila...
  7. Takáts S, Varga Ã, Pircs K, Juhász G. Loss of Drosophila Vps16A enhances autophagosome formation through reduced Tor activity. Autophagy. 2015;11:1209-15 pubmed publisher
    ..Here we show that loss of the core HOPS complex subunit Vps16A enhances autophagosome formation and slows down Drosophila development...
  8. Tjota M, Lee S, Wu J, Williams J, Khanna M, Thomas G. Annexin B9 binds to ?(H)-spectrin and is required for multivesicular body function in Drosophila. J Cell Sci. 2011;124:2914-26 pubmed publisher
    ..an increase in basolateral ?(H) and its appearance on cytoplasmic vesicles that overlap with the MVB markers Hrs, Vps16 and EPS15...
  9. LÅ‘rincz P, Lakatos Z, Varga Ã, Maruzs T, Simon Vecsei Z, Darula Z, et al. MiniCORVET is a Vps8-containing early endosomal tether in Drosophila. elife. 2016;5: pubmed publisher
    ..We find that Vps8 forms a complex and acts together with Vps16A, Dor/Vps18 and Car/Vps33A, and loss of any of these proteins leads to fragmentation of endosomes...

More Information


  1. Lotti F, Imlach W, Saieva L, Beck E, Hao L, Li D, et al. An SMN-dependent U12 splicing event essential for motor circuit function. Cell. 2012;151:440-54 pubmed publisher
    ..These findings directly link defective splicing of critical neuronal genes induced by SMN deficiency to motor circuit dysfunction, establishing a molecular framework for the selective pathology of SMA. ..
  2. Williamson W, Wang D, Haberman A, Hiesinger P. A dual function of V0-ATPase a1 provides an endolysosomal degradation mechanism in Drosophila melanogaster photoreceptors. J Cell Biol. 2010;189:885-99 pubmed publisher
    ..We propose that V100 exerts a temporally integrated dual function that increases neuronal degradative capacity. ..
  3. Haberman A, Akbar M, Ray S, KRAMER H. Drosophila acinus encodes a novel regulator of endocytic and autophagic trafficking. Development. 2010;137:2157-66 pubmed publisher
    ..Taken together, our data show that dacn encodes a regulator of endosomal and autophagosomal dynamics, modulating developmental signaling and the cellular response to starvation. ..
  4. Chi C, Zhu H, Han M, Zhuang Y, Wu X, Xu T. Disruption of lysosome function promotes tumor growth and metastasis in Drosophila. J Biol Chem. 2010;285:21817-23 pubmed publisher
    ..Knocking down either of the two other components of the Class C VPS complex, carnation (car) and vps16A, also renders Ras(V12) cells capable for uncontrolled growth and metastatic behavior...
  5. Nagy P, Varga Ã, Kovács A, Takáts S, Juhász G. How and why to study autophagy in Drosophila: it's more than just a garbage chute. Methods. 2015;75:151-61 pubmed publisher
    ..We show examples for results obtained in different assays, explain how to interpret these with regard to autophagic activity, and how to find out which step of autophagy a given gene product is involved in. ..
  6. Ismat A, Cheshire A, Andrew D. The secreted AdamTS-A metalloprotease is required for collective cell migration. Development. 2013;140:1981-93 pubmed publisher
    ..Our analysis of AdamTS-A function in the SG suggests a novel role for ADAMTS proteins in detaching cells from the apical ECM, facilitating tube elongation during collective cell migration. ..
  7. Han C, Song Y, Xiao H, Wang D, Franc N, Jan L, et al. Epidermal cells are the primary phagocytes in the fragmentation and clearance of degenerating dendrites in Drosophila. Neuron. 2014;81:544-560 pubmed publisher
    ..Our finding reveals the physiological importance of coordination between neurons and their surrounding epidermis, for both dendrite fragmentation and clearance. ..
  8. Falcon Perez J, Romero Calderon R, Brooks E, Krantz D, Dell Angelica E. The Drosophila pigmentation gene pink (p) encodes a homologue of human Hermansky-Pudlak syndrome 5 (HPS5). Traffic. 2007;8:154-68 pubmed
    ..The phenotype of pink mutants was exacerbated by mutations in AP-3 subunits or in the orthologs of VPS33A and Rab38. These results validate D. melanogaster as a genetic model to study the function of the BLOCs. ..