Gene Symbol: vn
Description: vein
Alias: CG10491, CT29452, Dm vn, Dmel\CG10491, P1749, Vein, ddd, l(3)10567, l(3)10568, l(3)L6A, l(3)ddd, l(3)rF264, l(3)vn10567, wvn, vein, CG10491-PA, CG10491-PC, Dm vein, defective dorsal discs, vn-PA, vn-PC
Species: fruit fly

Top Publications

  1. Klein T. Wing disc development in the fly: the early stages. Curr Opin Genet Dev. 2001;11:470-5 pubmed
    ..Recent data have now started to provide some insight in the molecular processes required for the definition of the major boundaries and subdivision of the wing anlage into the hinge and blade region. ..
  2. Wang W, Kidd B, Carroll S, Yoder J. Sexually dimorphic regulation of the Wingless morphogen controls sex-specific segment number in Drosophila. Proc Natl Acad Sci U S A. 2011;108:11139-44 pubmed publisher
    ..We propose that dimorphic Wg regulation, in concert with monomorphic segment-specific programmed cell death, are the principal mechanisms of sculpting the sexually dimorphic abdomen of Drosophila. ..
  3. Yang L, Baker N. Cell cycle withdrawal, progression, and cell survival regulation by EGFR and its effectors in the differentiating Drosophila eye. Dev Cell. 2003;4:359-69 pubmed
    ..Our results suggest that, rather than triggering all or none responses, EGFR coordinates partially independent processes as the eye differentiates. ..
  4. Spencer S, Powell P, Miller D, Cagan R. Regulation of EGF receptor signaling establishes pattern across the developing Drosophila retina. Development. 1998;125:4777-90 pubmed
    ..R8s in turn appear to signal through Rhomboid and Vein to create a patterned array of 'proneural clusters' which contain high levels of phosphorylated ERKA and the bHLH ..
  5. Schweitzer R, Shilo B. A thousand and one roles for the Drosophila EGF receptor. Trends Genet. 1997;13:191-6 pubmed
    ..The cellular mechanisms that translate EGFR activation to discrete cell fates are now the focus of intense studies. ..
  6. Jiang H, Edgar B. EGFR signaling regulates the proliferation of Drosophila adult midgut progenitors. Development. 2009;136:483-93 pubmed publisher
    ..Midgut visceral muscle produces a weak EGFR ligand, Vein, which is required for early AMP proliferation...
  7. McDonald J, Pinheiro E, Kadlec L, Schupbach T, Montell D. Multiple EGFR ligands participate in guiding migrating border cells. Dev Biol. 2006;296:94-103 pubmed
    ..Two ligands, Keren and Spitz, guided border cells whereas the other ligands, Gurken and Vein, did not...
  8. Lesokhin A, Yu S, Katz J, Baker N. Several levels of EGF receptor signaling during photoreceptor specification in wild-type, Ellipse, and null mutant Drosophila. Dev Biol. 1999;205:129-44 pubmed
    ..Drosophila EGF receptor homologue (DER) dramatically suppress ommatidium development in the eye and induce ectopic vein development in the wing...
  9. Sepp K, Auld V. Reciprocal interactions between neurons and glia are required for Drosophila peripheral nervous system development. J Neurosci. 2003;23:8221-30 pubmed
    ..Mutant analysis also suggested that the EGFR ligands Spitz and Vein play roles in peripheral glial development...

More Information


  1. de Celis J. Expression and function of decapentaplegic and thick veins during the differentiation of the veins in the Drosophila wing. Development. 1997;124:1007-18 pubmed
    ..In this report, the role of the signalling molecule Decapentaplegic during vein differentiation has been analysed...
  2. Schnepp B, Donaldson T, Grumbling G, Ostrowski S, Schweitzer R, Shilo B, et al. EGF domain swap converts a drosophila EGF receptor activator into an inhibitor. Genes Dev. 1998;12:908-13 pubmed
    ..EGF) receptor is modulated zygotically by three EGF-like proteins: Spitz (Spi), which is a potent activator; Vein (Vn), which is a moderate activator; and Argos (Aos), which is an inhibitor...
  3. Crocker J, Tamori Y, Erives A. Evolution acts on enhancer organization to fine-tune gradient threshold readouts. PLoS Biol. 2008;6:e263 pubmed publisher
    ..Our study demonstrates that equivalence classes of CRMs are powerful tools for detecting lineage-specific adaptations by gene regulatory sequences. ..
  4. Ren F, Wang B, Yue T, Yun E, Ip Y, Jiang J. Hippo signaling regulates Drosophila intestine stem cell proliferation through multiple pathways. Proc Natl Acad Sci U S A. 2010;107:21064-9 pubmed publisher
    ..Finally, we show that the Hpo pathway mediator Yorkie (Yki) is also required in precursor cells for injury-induced ISC proliferation in response to tissue-damaging reagent DSS. ..
  5. Schlesinger A, Kiger A, Perrimon N, Shilo B. Small wing PLCgamma is required for ER retention of cleaved Spitz during eye development in Drosophila. Dev Cell. 2004;7:535-45 pubmed
    ..Retention of cSpi in the ER provides a novel mechanism for restricting active ligand levels and hence the range of EGFR activation in the developing eye. ..
  6. Li Z, Zhang Y, Han L, Shi L, Lin X. Trachea-derived dpp controls adult midgut homeostasis in Drosophila. Dev Cell. 2013;24:133-43 pubmed publisher
    ..This work will provide important insights into the mechanisms of tissue homeostasis control by interorgan communication...
  7. Zhou F, Rasmussen A, Lee S, Agaisse H. The UPD3 cytokine couples environmental challenge and intestinal stem cell division through modulation of JAK/STAT signaling in the stem cell microenvironment. Dev Biol. 2013;373:383-93 pubmed publisher
    ..modulate the rate of the EGFR-dependent ISC division through upd3-dependent production of the EGF ligands Spitz and Vein, respectively...
  8. Poernbacher I, Baumgartner R, Marada S, Edwards K, Stocker H. Drosophila Pez acts in Hippo signaling to restrict intestinal stem cell proliferation. Curr Biol. 2012;22:389-96 pubmed publisher
    ..Thus, Pez displays a tissue-specific requirement and functions as a negative upstream regulator of Yki in the regulation of ISC proliferation. ..
  9. Simcox A, Grumbling G, Schnepp B, Bennington Mathias C, Hersperger E, Shearn A. Molecular, phenotypic, and expression analysis of vein, a gene required for growth of the Drosophila wing disc. Dev Biol. 1996;177:475-89 pubmed
    ..Stronger alleles, originally called defective dorsal discs, show vn is also required for the growth of the wing and haltere discs, as mutants for these alleles have ..
  10. Buchon N, Broderick N, Kuraishi T, Lemaitre B. Drosophila EGFR pathway coordinates stem cell proliferation and gut remodeling following infection. BMC Biol. 2010;8:152 pubmed publisher
    ..The EGFR pathway is activated by the EGF ligands, Spitz, Keren and Vein, the latter being induced in the surrounding visceral muscles in part under the control of the Janus kinase/signal ..
  11. Lanoue B, Gordon M, Battye R, Jacobs J. Genetic analysis of vein function in the Drosophila embryonic nervous system. Genome. 2000;43:564-73 pubmed
    ..growth factor receptor (EGFR) may be activated by two ligands expressed in the embryonic nervous system, Spitz and Vein. Previous studies have established Spitz as an essential activator of EGFR signaling in nervous system development...
  12. Erives A, Levine M. Coordinate enhancers share common organizational features in the Drosophila genome. Proc Natl Acad Sci U S A. 2004;101:3851-6 pubmed
    ..Organized binding sites should facilitate the identification of regulatory codes that link primary DNA sequence information with predicted patterns of gene activity. ..
  13. Schnepp B, Grumbling G, Donaldson T, Simcox A. Vein is a novel component in the Drosophila epidermal growth factor receptor pathway with similarity to the neuregulins. Genes Dev. 1996;10:2302-13 pubmed
    ..Here we show molecular and genetic evidence that Drosophila vein (vn) encodes a candidate EGFR ligand and that vn expression is spatially restricted...
  14. Biteau B, Jasper H. EGF signaling regulates the proliferation of intestinal stem cells in Drosophila. Development. 2011;138:1045-55 pubmed publisher
    ..The EGF ligand Vein is expressed in the muscle surrounding the intestinal epithelium, providing a permissive signal for ISC ..
  15. Xu N, Wang S, Tan D, Gao Y, Lin G, Xi R. EGFR, Wingless and JAK/STAT signaling cooperatively maintain Drosophila intestinal stem cells. Dev Biol. 2011;354:31-43 pubmed publisher
    ..The EGFR ligand Vein is specifically expressed in muscle cells and is important for ISC maintenance and proliferation...
  16. Yarnitzky T, Min L, Volk T. The Drosophila neuregulin homolog Vein mediates inductive interactions between myotubes and their epidermal attachment cells. Genes Dev. 1997;11:2691-700 pubmed
    ..signal for terminal differentiation of tendon cells is the secreted Drosophila neuregulin-like growth factor Vein produced by the myotubes...
  17. Li Q, Li S, Mana Capelli S, Roth Flach R, Danai L, Amcheslavsky A, et al. The conserved misshapen-warts-Yorkie pathway acts in enteroblasts to regulate intestinal stem cells in Drosophila. Dev Cell. 2014;31:291-304 pubmed publisher
    ..These findings also provide a model in which to study requirements for MAP4K4-related kinases in MST1/2-independent regulation of LATS and YAP. ..
  18. Maeng O, Son W, Chung J, Lee K, Lee Y, Yoo O, et al. The BTB/POZ-ZF transcription factor dPLZF is involved in Ras/ERK signaling during Drosophila wing development. Mol Cells. 2012;33:457-63 pubmed publisher
    ..Ectopic expression of dPLZF in the wing induced extra vein formation during wing development in Drosophila...
  19. Zehavi Y, Kuznetsov O, Ovadia Shochat A, Juven Gershon T. Core promoter functions in the regulation of gene expression of Drosophila dorsal target genes. J Biol Chem. 2014;289:11993-2004 pubmed publisher
    ..Taken together, our results provide evidence for the importance of core promoter composition in the regulation of Dorsal target genes. ..
  20. Inbal A, Volk T, Salzberg A. Recruitment of ectodermal attachment cells via an EGFR-dependent mechanism during the organogenesis of Drosophila proprioceptors. Dev Cell. 2004;7:241-50 pubmed
    ..Molecular characterization of lch5 attachment cells demonstrated that they share significant properties with Drosophila tendon cells and with mammalian proprioceptive organs. ..
  21. de Celis J, Bray S, Garcia Bellido A. Notch signalling regulates veinlet expression and establishes boundaries between veins and interveins in the Drosophila wing. Development. 1997;124:1919-28 pubmed
    ..find that this asymmetrical distribution of ligand and receptor leads to activation of Notch on both sides of each vein within a territory of Delta-expressing cells, and to the establishment of boundary cells that separate the vein ..
  22. Shearn A, Rice T, Garen A, Gehring W. Imaginal disc abnormalities in lethal mutants of Drosophila. Proc Natl Acad Sci U S A. 1971;68:2594-8 pubmed
    ..The late lethals are therefore a major source of mutants for studying the genetic control of disc formation. ..
  23. Guo Y, Li Z, Lin X. Hs3st-A and Hs3st-B regulate intestinal homeostasis in Drosophila adult midgut. Cell Signal. 2014;26:2317-25 pubmed publisher
    ..Together, our data suggest that Drosophila Hs3st-A and Hs3st-B are involved in the regulation of ISC proliferation and midgut homeostasis maintenance. ..
  24. García Bellido A, Garcia Bellido A. Cell proliferation in the attainment of constant sizes and shapes: the Entelechia model. Int J Dev Biol. 1998;42:353-62 pubmed
  25. Urban S, Brown G, Freeman M. EGF receptor signalling protects smooth-cuticle cells from apoptosis during Drosophila ventral epidermis development. Development. 2004;131:1835-45 pubmed addition to the spitz group genes, Rhomboid-3/roughoid, but not Rhomboid-2 or -4, and the neuregulin-like ligand Vein also function in survival signalling...
  26. Chang J, Kim I, Ahn J, Kim S. The CNS midline cells control the spitz class and Egfr signaling genes to establish the proper cell fate of the Drosophila ventral neuroectoderm. Int J Dev Biol. 2001;45:715-24 pubmed
    ..the Drosophila epidermal growth factor receptor (Egfr) signaling genes, argos (aos), Egfr, orthodenticle (otd) and vein (vn), are required for the proper establishment of ventral neuroectodermal cell fate...
  27. Nagel A, Szawinski J, Zimmermann M, Preiss A. Drosophila Cyclin G Is a Regulator of the Notch Signalling Pathway during Wing Development. PLoS ONE. 2016;11:e0151477 pubmed publisher
    ..For example, Notch activity is required for proper wing vein differentiation which is hampered in mutants of either the receptor Notch, the ligand Delta or the antagonist ..
  28. Guichard A, Park J, Cruz Moreno B, Karin M, Bier E. Anthrax lethal factor and edema factor act on conserved targets in Drosophila. Proc Natl Acad Sci U S A. 2006;103:3244-9 pubmed
  29. Scopelliti A, Cordero J, Diao F, Strathdee K, White B, Sansom O, et al. Local control of intestinal stem cell homeostasis by enteroendocrine cells in the adult Drosophila midgut. Curr Biol. 2014;24:1199-211 pubmed publisher
    ..G protein-coupled receptors (LGR4-6), represses the production of the VM-derived EGF-like growth factor Vein through activation of cAMP...
  30. Szuts D, Eresh S, Bienz M. Functional intertwining of Dpp and EGFR signaling during Drosophila endoderm induction. Genes Dev. 1998;12:2022-35 pubmed
    ..We discovered a secondary signal with a permissive role in this process, namely Vein, a neuregulin-like ligand that stimulates the epidermal growth factor receptor (EGFR) and Ras signaling...
  31. Bier E. Drawing lines in the Drosophila wing: initiation of wing vein development. Curr Opin Genet Dev. 2000;10:393-8 pubmed
    ..Recently, analysis of events underlying initiation of vein formation suggests that there is a general developmental mechanism for drawing lines between adjacent domains of ..
  32. Wang S, Simcox A, Campbell G. Dual role for Drosophila epidermal growth factor receptor signaling in early wing disc development. Genes Dev. 2000;14:2271-6 pubmed
    ..Here we show that EGF-receptor (EGFR) signaling stimulated by its ligand, Vein, has a fundamental role in regulating two of these cell fate choices: (1) Vn/EGFR signaling directs cells to become ..
  33. Duchek P, Somogyi K, Jekely G, Beccari S, Rørth P. Guidance of cell migration by the Drosophila PDGF/VEGF receptor. Cell. 2001;107:17-26 pubmed
    ..Intriguingly, the guidance function of PVR is largely redundant with that of EGFR. We present evidence implicating Rac and the Rac activator Mbc/DOCK180/CED-5 as mediators of the guidance signal. ..
  34. Baker D, Mille Baker B, Wainwright S, Ish Horowicz D, Dibb N. Mae mediates MAP kinase phosphorylation of Ets transcription factors in Drosophila. Nature. 2001;411:330-4 pubmed
    ..Our study indicates that MAPK signalling specificity may depend on proteins that couple specific substrates to the kinase. ..
  35. Rafel N, Milan M. Notch signalling coordinates tissue growth and wing fate specification in Drosophila. Development. 2008;135:3995-4001 pubmed publisher defined by the opposing activities of two secreted signalling molecules, Wingless and the EGF receptor ligand Vein. Notch signalling is involved in the determination of a variety of cell fates, including growth and cell survival...
  36. Martin Bermudo M. Integrins modulate the Egfr signaling pathway to regulate tendon cell differentiation in the Drosophila embryo. Development. 2000;127:2607-15 pubmed
    ..Furthermore, the levels of the Egfr ligand Vein at the muscle attachment sites are reduced in PS mutant embryos...
  37. Charroux B, Freeman M, Kerridge S, Baonza A. Atrophin contributes to the negative regulation of epidermal growth factor receptor signaling in Drosophila. Dev Biol. 2006;291:278-90 pubmed
    ..of function clones induces cell autonomous expression of the EGFR target gene Delta, and the formation of extra vein tissue, while overexpression of Atrophin inhibits EGFR-dependent vein formation...
  38. Roch F, Baonza A, Martin Blanco E, Garcia Bellido A. Genetic interactions and cell behaviour in blistered mutants during proliferation and differentiation of the Drosophila wing. Development. 1998;125:1823-32 pubmed
    In this work, we analyse the blistered function in wing vein development by studying genetic mosaics of mutant cells, genetic interactions with other genes affecting vein development and blistered expression in several mutant backgrounds...
  39. Inaki M, Vishnu S, Cliffe A, Rørth P. Effective guidance of collective migration based on differences in cell states. Proc Natl Acad Sci U S A. 2012;109:2027-32 pubmed publisher
    ..Cell signaling states could manifest as differences in gene expression or metabolite levels and thus differ substantially from factors normally considered when analyzing eukaryotic cell guidance. ..
  40. Rendina R, Strangi A, Avallone B, Giordano E. Bap170, a subunit of the Drosophila PBAP chromatin remodeling complex, negatively regulates the EGFR signaling. Genetics. 2010;186:167-81 pubmed publisher
    ..Interestingly, genetic evidence also indicates that Bap170-mediated repression of rho is inhibited by EGFR signaling, suggesting a scenario of mutual antagonism between EGFR signaling and PBAP function. ..
  41. Guichard A, Biehs B, Sturtevant M, Wickline L, Chacko J, Howard K, et al. rhomboid and Star interact synergistically to promote EGFR/MAPK signaling during Drosophila wing vein development. Development. 1999;126:2663-76 pubmed Drosophila are dedicated to developmental regulation of Egfr signaling in multiple processes including wing vein development...
  42. Austin C, Manivannan S, Simcox A. TGF-α ligands can substitute for the neuregulin Vein in Drosophila development. Development. 2014;141:4110-4 pubmed publisher
    ..The single Drosophila Egfr has four ligands: three of the TGF-α-type and a single neuregulin-like called vein (vn)...
  43. Okumura T, Takeda K, Taniguchi K, Adachi Yamada T. ?? integrin inhibits chronic and high level activation of JNK to repress senescence phenotypes in Drosophila adult midgut. PLoS ONE. 2014;9:e89387 pubmed publisher
  44. Kux K, Pitsouli C. Tissue communication in regenerative inflammatory signaling: lessons from the fly gut. Front Cell Infect Microbiol. 2014;4:49 pubmed publisher
    ..Here we review tissue communication during homeostasis and regenerative inflammatory signaling in Drosophila focusing on the signals that emanate from non-intestinal epithelial tissues to ensure intestinal integrity. ..
  45. Beck G, Fainzilber M. Genetic models meet trophic mechanisms: EGF family members are gliatrophins in Drosophila. Neuron. 2002;33:673-5 pubmed
    ..Fly genetics thus promises new insights on trophic signaling mechanisms and confirms that trophic regulation of cell survival is an evolutionarily ancient mechanism for building the nervous system. ..
  46. Hartl T, Scott M. Wing tips: The wing disc as a platform for studying Hedgehog signaling. Methods. 2014;68:199-206 pubmed publisher
    ..The tools and approaches we highlight form the cornerstone of research efforts in many laboratories that use Drosophila to study Hh signaling, and are essential for ongoing discoveries. ..
  47. Sen A, Kuruvilla D, Pinto L, Sarin A, Rodrigues V. Programmed cell death and context dependent activation of the EGF pathway regulate gliogenesis in the Drosophila olfactory system. Mech Dev. 2004;121:65-78 pubmed
    ..These results underscore the importance of developmental context of cell lineages in their responses to non-autonomous signaling in the choice between survival and death. ..
  48. Wolfgang W, Roberts I, Quan F, O Kane C, Forte M. Activation of protein kinase A-independent pathways by Gs alpha in Drosophila. Proc Natl Acad Sci U S A. 1996;93:14542-7 pubmed
    ..This novel pathway may in part be responsible for some of the complex, cell-specific responses observed following activation of this pathway in different cell types. ..
  49. Ozdemir A, Fisher Aylor K, Pepke S, Samanta M, Dunipace L, McCue K, et al. High resolution mapping of Twist to DNA in Drosophila embryos: Efficient functional analysis and evolutionary conservation. Genome Res. 2011;21:566-77 pubmed publisher
    ..Our results show that high resolution in vivo occupancy data can be used to drive efficient discovery and dissection of global and local cis-regulatory logic. ..
  50. Yarnitzky T, Min L, Volk T. An interplay between two EGF-receptor ligands, Vein and Spitz, is required for the formation of a subset of muscle precursors in Drosophila. Mech Dev. 1998;79:73-82 pubmed
    ..We show that a second DER ligand, Vein, complements the activity of Spitz in the development of various somatic muscle precursors...
  51. Matsuoka S, Hiromi Y, Asaoka M. Egfr signaling controls the size of the stem cell precursor pool in the Drosophila ovary. Mech Dev. 2013;130:241-53 pubmed publisher
    ..While excess GSC formation is compensated by the adult stage, insufficient GSC formation can lead to adult ovarioles that completely lack GSCs, suggesting that ensuring an absolute size of the PGC pool is crucial for the GSC system...
  52. King I, Eddison M, Kaun K, Heberlein U. EGFR and FGFR pathways have distinct roles in Drosophila mushroom body development and ethanol-induced behavior. PLoS ONE. 2014;9:e87714 pubmed publisher
    ..We find, however, that FGFR signaling most likely affects ethanol-induced behavior through a different mechanism, possibly through acute action in adult neurons. ..
  53. Foronda D, Pérez Garijo A, Martín F. Dpp of posterior origin patterns the proximal region of the wing. Mech Dev. 2009;126:99-106 pubmed publisher
    ..Since there is a similar expression in the haltere disc, we suggest that this late appearing posterior Dpp activity may be an attribute of dorsal thoracic discs. ..
  54. Duchek P, Rørth P. Guidance of cell migration by EGF receptor signaling during Drosophila oogenesis. Science. 2001;291:131-3 pubmed
    ..The transforming growth factor-alpha (TGF-alpha)-like ligand Gurken appears to serve as the guidance cue. To mediate this guidance function, EGFR signals via a pathway that is independent of Raf-MAP kinase and receptor-specific. ..
  55. Eggert H, Bergemann K, Saumweber H. Molecular screening for P-element insertions in a large genomic region of Drosophila melanogaster using polymerase chain reaction mediated by the vectorette. Genetics. 1998;149:1427-34 pubmed
    ..We detected a single transposition to a 13-kb region close to the BJ1 gene among 6650 progeny that were analyzed. Southern analysis of the homozygous line confirmed the integration 3 kb downstream of BJ1. ..
  56. Angulo M, Corominas M, Serras F. Activation and repression activities of ash2 in Drosophila wing imaginal discs. Development. 2004;131:4943-53 pubmed
    ..Our results also show that ash2 acts as a repressor of the vein L2-organising gene knirps (kni), whose expression is upregulated throughout the whole wing imaginal disc in ash2 ..
  57. Lunde K, Trimble J, Guichard A, Guss K, Nauber U, Bier E. Activation of the knirps locus links patterning to morphogenesis of the second wing vein in Drosophila. Development. 2003;130:235-48 pubmed
    ..related zinc finger transcription factors that collaborate to initiate development of the second longitudinal wing vein (L2)...
  58. Skeath J. The Drosophila EGF receptor controls the formation and specification of neuroblasts along the dorsal-ventral axis of the Drosophila embryo. Development. 1998;125:3301-12 pubmed
    ..In addition, I demonstrate that the concomitant loss of rhomboid and vein yield CNS phenotypes indistinguishable from DER mutant embryos, even though loss of either gene alone yields minor ..
  59. de Celis J, Garcia Bellido A. Roles of the Notch gene in Drosophila wing morphogenesis. Mech Dev. 1994;46:109-22 pubmed
    ..We study here the Notch function in wing morphogenesis and vein patterning in genetic mosaics of both Notch null and Notch gain-of-function alleles...
  60. Alvarez A, Shi W, Wilson B, Skeath J. pannier and pointedP2 act sequentially to regulate Drosophila heart development. Development. 2003;130:3015-26 pubmed
  61. Baena Lopez L, Pastor Pareja J, Resino J. Wg and Egfr signalling antagonise the development of the peripodial epithelium in Drosophila wing discs. Development. 2003;130:6497-506 pubmed
    ..These findings suggest that suppression of Wg and Egfr activities is an early step in the development of the peripodial epithelium of the wing discs. ..
  62. Pallavi S, Kannan R, Shashidhara L. Negative regulation of Egfr/Ras pathway by Ultrabithorax during haltere development in Drosophila. Dev Biol. 2006;296:340-52 pubmed
    ..and epistasis genetic experiments suggest that Ubx negatively regulates the expression of the ligand vein as well as the receptor Egf-r to down-regulate the signaling pathway...
  63. Leevers S. What goes up must come down. Nat Cell Biol. 1999;1:E10-1 pubmed
  64. Stevens L. Twin peaks: Spitz and Argos star in patterning of the Drosophila egg. Cell. 1998;95:291-4 pubmed
  65. Hidalgo A, Griffiths R. Coupling glial numbers and axonal patterns. Cell Cycle. 2004;3:1118-20 pubmed
    ..It is compelling to investigate whether the vertebrate homologue Prox1 may enable the repair response of vertebrate glia. ..
  66. Cavodeassi F, Rodriguez I, Modolell J. Dpp signalling is a key effector of the wing-body wall subdivision of the Drosophila mesothorax. Development. 2002;129:3815-23 pubmed
    ..Neither Wingless signalling, which is essential for wing development, nor Vein-dependent EGFR signalling, which is needed to activate Iro-C, appear to delimit Iro-C expression...
  67. Garcia Bellido A, Cortes F, Milan M. Cell interactions in the control of size in Drosophila wings. Proc Natl Acad Sci U S A. 1994;91:10222-6 pubmed
    The vein locus (vn) includes lethal alleles (designated also defective dorsal discs) that prevent growth of dorsal discs and in viable genetic combinations reduce the number of cells of the adult wing...
  68. Gabay L, Seger R, Shilo B. In situ activation pattern of Drosophila EGF receptor pathway during development. Science. 1997;277:1103-6 pubmed
    ..This in situ approach can be used to monitor other receptor-triggered pathways in a wide range of organisms. ..
  69. Price J, Savenye E, Lum D, Breitkreutz A. Dominant enhancers of Egfr in Drosophila melanogaster: genetic links between the Notch and Egfr signaling pathways. Genetics. 1997;147:1139-53 pubmed
    ..We have performed an F1 screen for mutations that cause dominant enhancement of wing vein phenotypes associated with mutations in Egfr...
  70. Foronda D, Martin P, Sánchez Herrero E. Drosophila Hox and sex-determination genes control segment elimination through EGFR and extramacrochetae activity. PLoS Genet. 2012;8:e1002874 pubmed publisher
    ..Our results show the complex orchestration of cellular and genetic events that lead to this important sexually dimorphic character change. ..
  71. Kim H, Ahn H, Lee S, Kim J, Park J, Jeon S, et al. Intrinsic dorsoventral patterning and extrinsic EGFR signaling genes control glial cell development in the Drosophila nervous system. Neuroscience. 2015;307:242-52 pubmed publisher
    ..Therefore, the dorsoventral patterning and EGFR signaling genes play essential roles in correct identity determination and differentiation of lateral glia in the Drosophila nervous system. ..
  72. Griffiths R, Hidalgo A. Prospero maintains the mitotic potential of glial precursors enabling them to respond to neurons. EMBO J. 2004;23:2440-50 pubmed
    ..During growth cone guidance, Prospero positively regulates cycE promoting cell proliferation. Neuronal Vein activates the MAPKinase signalling pathway in the glia with highest Prospero levels, coupling axon extension with ..
  73. Lawlor K, O Keefe L, Samaraweera S, van Eyk C, McLeod C, Maloney C, et al. Double-stranded RNA is pathogenic in Drosophila models of expanded repeat neurodegenerative diseases. Hum Mol Genet. 2011;20:3757-68 pubmed publisher
    ..These data identify a novel pathway through which double-stranded repeat RNA is toxic and capable of eliciting symptoms common to neurodegenerative human diseases resulting from dominantly inherited expanded repeats. ..
  74. Montagne J, Groppe J, Guillemin K, Krasnow M, Gehring W, Affolter M. The Drosophila Serum Response Factor gene is required for the formation of intervein tissue of the wing and is allelic to blistered. Development. 1996;122:2589-97 pubmed
    The adult Drosophila wing is formed by an epithelial sheet, which differentiates into two non-neural tissues, vein or intervein...
  75. Lim B, Dsilva C, Levario T, Lu H, Schüpbach T, Kevrekidis I, et al. Dynamics of Inductive ERK Signaling in the Drosophila Embryo. Curr Biol. 2015;25:1784-90 pubmed publisher
    ..The quantitative approach that led to this model, based on the integration of data from fixed embryos and live imaging, can be extended to other developmental systems patterned by transient inductive signals. ..
  76. Galindo M, Bishop S, Couso J. Dynamic EGFR-Ras signalling in Drosophila leg development. Dev Dyn. 2005;233:1496-508 pubmed
    ..Early, the EGFR ligand Vein is the main player in distal leg patterning, possibly supported later by another ligand activated by Rhomboid...
  77. Cavodeassi F, Modolell J, Gomez Skarmeta J. The Iroquois family of genes: from body building to neural patterning. Development. 2001;128:2847-55 pubmed
    ..Later in development in both Drosophila and vertebrates, the Iro genes function again to subdivide those territories into smaller domains...
  78. Casso D, Biehs B, Kornberg T. A novel interaction between hedgehog and Notch promotes proliferation at the anterior-posterior organizer of the Drosophila wing. Genetics. 2011;187:485-99 pubmed publisher
    ..This work thus reveals a novel collaboration by the Hedgehog and Notch pathways that regulates proliferation in the 3-4 intervein region independently of Decapentaplegic. ..
  79. Vasil eva L, Ratner V. [Effect of genotypic environment on phenotypic manifestation of radius incompletus mutation in Drosophila melanogaster]. Genetika. 2000;36:182-90 pubmed
    ..of the marked regions of chromosome 3 to the expression of the proximal and distal fragments of the wing radial vein were estimated...
  80. Page D. A function for Egf receptor signaling in expanding the developing brain in Drosophila. Curr Biol. 2003;13:474-82 pubmed
  81. Ralston A, Blair S. Long-range Dpp signaling is regulated to restrict BMP signaling to a crossvein competent zone. Dev Biol. 2005;280:187-200 pubmed
    ..However, this requirement can be overridden by co-misexpression of the BMP agonist Cv-2, indicating the presence of as yet unknown cues; we discuss possible candidates. ..
  82. Hwang H, Rulifson E. Serial specification of diverse neuroblast identities from a neurogenic placode by Notch and Egfr signaling. Development. 2011;138:2883-93 pubmed publisher
    ..We discuss the surprising parallels between the serial specification of neural fates from this neurogenic placode and the fly retina. ..