vig

Summary

Gene Symbol: vig
Description: vasa intronic gene
Alias: BG:DS00929.13, CG4170, Dmel\CG4170, EP(2)0812, VIG, Vig, vasa intronic gene, CG4170-PA, CG4170-PB, CG4170-PC, CG4170-PD, vig-PA, vig-PB, vig-PC, vig-PD
Species: fruit fly

Top Publications

  1. Shpiz S, Kwon D, Uneva A, Kim M, Klenov M, Rozovsky Y, et al. Characterization of Drosophila telomeric retroelement TAHRE: transcription, transpositions, and RNAi-based regulation of expression. Mol Biol Evol. 2007;24:2535-45 pubmed
    ..Taking into account a common pattern of HeT-A and TAHRE expression, one may consider TAHRE as a source of reverse transcriptase enzymatic activity for HeT-A transpositions in ovaries. ..
  2. Caudy A, Myers M, Hannon G, Hammond S. Fragile X-related protein and VIG associate with the RNA interference machinery. Genes Dev. 2002;16:2491-6 pubmed
    ..proteins, the Drosophila homolog of the fragile X mental retardation protein (FMRP), dFXR, and VIG (Vasa intronic gene), through their association with RISC...
  3. Caudy A, Ketting R, Hammond S, Denli A, Bathoorn A, Tops B, et al. A micrococcal nuclease homologue in RNAi effector complexes. Nature. 2003;425:411-4 pubmed
    ..We have previously identified four Drosophila components (short interfering RNAs, Argonaute 2 (ref. 2), VIG and FXR) of a RISC enzyme that degrades specific mRNAs in response to a double-stranded-RNA trigger...
  4. Gracheva E, Dus M, Elgin S. Drosophila RISC component VIG and its homolog Vig2 impact heterochromatin formation. PLoS ONE. 2009;4:e6182 pubmed publisher
    ..Here we present results from a study of the D. melanogaster gene vig, encoding an RNAi complex component and its homolog vig2 (CG11844) that support their involvement in ..
  5. Shpiz S, Kwon D, Rozovsky Y, Kalmykova A. rasiRNA pathway controls antisense expression of Drosophila telomeric retrotransposons in the nucleus. Nucleic Acids Res. 2009;37:268-78 pubmed publisher
    ..Finally, this regulation occurs in the nucleus since disruption of the rasiRNA pathway leads to an accumulation of TART and HeT-A transcripts in germ cell nuclei. ..
  6. Kavi H, Fernandez H, Xie W, Birchler J. RNA silencing in Drosophila. FEBS Lett. 2005;579:5940-9 pubmed
    ..RNA silencing processes in Drosophila are described. ..
  7. Du T, Zamore P. microPrimer: the biogenesis and function of microRNA. Development. 2005;132:4645-52 pubmed
    ..miRNAs function very much like siRNAs, but these two types of small RNAs can be distinguished by their distinct pathways for maturation and by the logic by which they regulate gene expression. ..
  8. Olivieri D, Sykora M, Sachidanandam R, Mechtler K, Brennecke J. An in vivo RNAi assay identifies major genetic and cellular requirements for primary piRNA biogenesis in Drosophila. EMBO J. 2010;29:3301-17 pubmed publisher
    ..Loss of Zucchini leads to an accumulation of Piwi and Armitage in Yb bodies, indicating that Yb bodies are sites of primary piRNA biogenesis. ..
  9. He L, Hannon G. MicroRNAs: small RNAs with a big role in gene regulation. Nat Rev Genet. 2004;5:522-31 pubmed

More Information

Publications22

  1. Cai Y, Chia W, Yang X. A family of snail-related zinc finger proteins regulates two distinct and parallel mechanisms that mediate Drosophila neuroblast asymmetric divisions. EMBO J. 2001;20:1704-14 pubmed
  2. Obbard D, Gordon K, Buck A, Jiggins F. The evolution of RNAi as a defence against viruses and transposable elements. Philos Trans R Soc Lond B Biol Sci. 2009;364:99-115 pubmed publisher
    ..Over longer time scales, key RNAi genes are repeatedly duplicated or lost across the metazoan phylogeny, with important implications for RNAi as an immune defence. ..
  3. Kolaczkowski B, Hupalo D, Kern A. Recurrent adaptation in RNA interference genes across the Drosophila phylogeny. Mol Biol Evol. 2011;28:1033-42 pubmed publisher
    ..Our observations suggest a predictive model of how selective pressures generated by evolutionary arms race scenarios may affect multiple genes across protein interaction networks and other biochemical pathways. ..
  4. Murchison E, Hannon G. miRNAs on the move: miRNA biogenesis and the RNAi machinery. Curr Opin Cell Biol. 2004;16:223-9 pubmed
    ..MicroRNA functional analyses and genetic and biochemical interrogation of components of the pathway are starting to provide a glimpse at the range of biological processes and phenomena regulated by RNA interference. ..
  5. Tinker R, Silver D, Montell D. Requirement for the vasa RNA helicase in gurken mRNA localization. Dev Biol. 1998;199:1-10 pubmed
  6. Shpiz S, Olovnikov I, Sergeeva A, Lavrov S, Abramov Y, Savitsky M, et al. Mechanism of the piRNA-mediated silencing of Drosophila telomeric retrotransposons. Nucleic Acids Res. 2011;39:8703-11 pubmed publisher
    ..Therefore piRNA-mediated transcriptional mode of silencing is involved in the control of retrotransposon expression in the Drosophila germline. ..
  7. Kibanov M, Egorova K, Ryazansky S, Sokolova O, Kotov A, Olenkina O, et al. A novel organelle, the piNG-body, in the nuage of Drosophila male germ cells is associated with piRNA-mediated gene silencing. Mol Biol Cell. 2011;22:3410-9 pubmed publisher
  8. Zhang F, Wang J, Xu J, Zhang Z, Koppetsch B, Schultz N, et al. UAP56 couples piRNA clusters to the perinuclear transposon silencing machinery. Cell. 2012;151:871-884 pubmed publisher
    ..We therefore propose that UAP56 and Vasa function in a piRNA-processing compartment that spans the nuclear envelope. ..
  9. Tomari Y, Zamore P. Perspective: machines for RNAi. Genes Dev. 2005;19:517-29 pubmed
    ..Here, we review our current understanding of how small RNAs are produced, how they are loaded into protein complexes, and how they repress gene expression. ..
  10. Thomsen S, Anders S, Janga S, Huber W, Alonso C. Genome-wide analysis of mRNA decay patterns during early Drosophila development. Genome Biol. 2010;11:R93 pubmed publisher
    ..Our data also provide a valuable resource for further experimental and computational studies investigating the process of mRNA decay. ..
  11. Kim K, Lee Y, Carthew R. Conversion of pre-RISC to holo-RISC by Ago2 during assembly of RNAi complexes. RNA. 2007;13:22-9 pubmed
    ..We have also identified a new intermediate complex in the RISC assembly pathway, pre-RISC, in which Ago2 is stably bound to double-stranded siRNA. ..
  12. de Wit E, Greil F, van Steensel B. Genome-wide HP1 binding in Drosophila: developmental plasticity and genomic targeting signals. Genome Res. 2005;15:1265-73 pubmed
    ..These results provide insights into the mechanisms of HP1 targeting in the natural genomic context. ..
  13. Pham J, Pellino J, Lee Y, Carthew R, Sontheimer E. A Dicer-2-dependent 80s complex cleaves targeted mRNAs during RNAi in Drosophila. Cell. 2004;117:83-94 pubmed
    ..Dcr-2 does not simply transfer siRNAs to a distinct effector complex, but rather assembles into RISC along with the siRNAs, indicating that its role extends beyond the initiation phase of RNAi. ..