Gene Symbol: vib
Alias: 0450/02, 1104/16, CG5269, Dm-PITPalpha, Dmel\CG5269, PITP, PITP-DM, Vib, anon-WO0142479.3, anon-WO0172774.12, anon-WO0172774.16, anon-WO0172774.28, gio, l(3)S045002, l(3)S045002c, l(3)S110416, l(3)j4A3, l(3)j5A6, l(3)j7A3, l(3)j7C8, vibrator, CG5269-PA, CG5269-PB, CG5269-PC, PITP, giotto, lethal (3) S045002c, lethal (3) S110416, lethal (3) j5A6, vib-PA, vib-PB, vib-PC
Species: fruit fly
Fullwood Y, dos Santos M, Hsuan J. Cloning and characterization of a novel human phosphatidylinositol transfer protein, rdgBbeta. J Biol Chem. 1999;274:31553-8 pubmed
The various PITP, retinal degeneration B (rdgB), and amino-terminal domain interacting receptor (Nir) phosphatidylinositol transfer proteins can be divided into two structural families...
Giansanti M, Bonaccorsi S, Kurek R, Farkas R, Dimitri P, Fuller M, et al
. The class I PITP giotto is required for Drosophila cytokinesis. Curr Biol. 2006;16:195-201 pubmed
..Here we show for the first time that a class I PITP is involved in cytokinesis. We found that giotto (gio), a Drosophila gene that encodes a class I PITP, serves an essential function required for both mitotic and ..
Sechi S, Frappaolo A, Belloni G, Giansanti M. The roles of the oncoprotein GOLPH3 in contractile ring assembly and membrane trafficking during cytokinesis. Biochem Soc Trans. 2015;43:117-21 pubmed publisher
..Because cytokinesis failures have been linked with pre-malignant disease and cancer, the novel connection between GOLPH3 and cytokinesis imposes new fields of investigation in cancer biology and therapy. ..
Giansanti M, Belloni G, Gatti M. Rab11 is required for membrane trafficking and actomyosin ring constriction in meiotic cytokinesis of Drosophila males. Mol Biol Cell. 2007;18:5034-47 pubmed
..These cytokinesis phenotypes are identical to those elicited by mutations in giotto (gio) and four wheel drive (fwd) that encode a phosphatidylinositol transfer protein and a phosphatidylinositol 4-..
Yadav S, Garner K, Georgiev P, Li M, Gomez Espinosa E, Panda A, et al
. RDGBα, a PtdIns-PtdOH transfer protein, regulates G-protein-coupled PtdIns(4,5)P2 signalling during Drosophila phototransduction. J Cell Sci. 2015;128:3330-44 pubmed publisher
..RDGBα (hereafter RDGB) is a multi-domain protein with a PtdIns transfer protein (PITP) domain (RDGB-PITPd). We find that, in vitro, the RDGB-PITPd binds and transfers both PtdOH and PtdIns...
Giansanti M, Farkas R, Bonaccorsi S, Lindsley D, Wakimoto B, Fuller M, et al
. Genetic dissection of meiotic cytokinesis in Drosophila males. Mol Biol Cell. 2004;15:2509-22 pubmed
Belloni G, Sechi S, Riparbelli M, Fuller M, Callaini G, Giansanti M. Mutations in Cog7 affect Golgi structure, meiotic cytokinesis and sperm development during Drosophila spermatogenesis. J Cell Sci. 2012;125:5441-52 pubmed publisher
..We show that the recruitment of the small GTPase Rab11 and the phosphatidylinositol transfer protein Giotto (Gio) to the cleavage site requires a functioning wild-type Cog7 gene...
Gatt M, Glover D. The Drosophila phosphatidylinositol transfer protein encoded by vibrator is essential to maintain cleavage-furrow ingression in cytokinesis. J Cell Sci. 2006;119:2225-35 pubmed
..Here, we show mutants of the gene vibrator, previously found to encode the Drosophila phosphatidylinositol transfer protein, produce multinucleate cells ..
Jiang K, Liu Y, Fan J, Zhang J, Li X, Evers B, et al
. PI(4)P Promotes Phosphorylation and Conformational Change of Smoothened through Interaction with Its C-terminal Tail. PLoS Biol. 2016;14:e1002375 pubmed publisher