VhaSFD

Summary

Gene Symbol: VhaSFD
Description: Vacuolar H[+]-ATPase SFD subunit
Alias: 144191_at, ATP6V1H, CG17332, Dmel\CG17332, V-ATPase, vhaSFD, vacuolar H[+]-ATPase SFD subunit, CG17332-PA, CG17332-PB, CG17332-PD, CG17332-PE, V-ATPase H-subunit, V-ATPase subunit H, V1 H subunit, VhaSFD-PA, VhaSFD-PB, VhaSFD-PD, VhaSFD-PE, vacuolar H+-ATPase SFD subunit
Species: fruit fly

Top Publications

  1. Dow J. The multifunctional Drosophila melanogaster V-ATPase is encoded by a multigene family. J Bioenerg Biomembr. 1999;31:75-83 pubmed
    ..project resources have accelerated our knowledge of the V-ATPase gene family size and the new Drosophila genes vhaSFD, vha100-1, vha100-2, vha100-3, vha16-2, vha16-3, vha16-4, vhaPPA1, vhaPPA2, vhaM9.7.1, and vhaM9.7.2 are described...
  2. Yan Y, Denef N, Schupbach T. The vacuolar proton pump, V-ATPase, is required for notch signaling and endosomal trafficking in Drosophila. Dev Cell. 2009;17:387-402 pubmed publisher
    ..Our results demonstrate that Rbcn-3 affects Notch signaling and trafficking through regulating V-ATPase function, which implies that the acidification of an intracellular compartment in the receiving cells is crucial for signaling. ..
  3. Vaccari T, Duchi S, Cortese K, Tacchetti C, Bilder D. The vacuolar ATPase is required for physiological as well as pathological activation of the Notch receptor. Development. 2010;137:1825-32 pubmed publisher
    ..The results also suggest that the ionic properties of the endosomal lumen might regulate Notch cleavage, providing a rationale for physiological as well as pathological endocytic control of Notch activity. ..
  4. Pyza E, Borycz J, Giebultowicz J, Meinertzhagen I. Involvement of V-ATPase in the regulation of cell size in the fly's visual system. J Insect Physiol. 2004;50:985-94 pubmed
    ..As a result bafilomycin abolished the day/night difference in axon size in L1 and L2, their sizes being similar during the day and night. ..
  5. Mauvezin C, Nagy P, Juhász G, Neufeld T. Autophagosome-lysosome fusion is independent of V-ATPase-mediated acidification. Nat Commun. 2015;6:7007 pubmed publisher
    ..Collectively, our results indicate that lysosomal acidification is not a prerequisite for fusion, and that BafilomycinA1 inhibits fusion independent of its effect on lysosomal pH. ..
  6. Landis G, Bhole D, Tower J. A search for doxycycline-dependent mutations that increase Drosophila melanogaster life span identifies the VhaSFD, Sugar baby, filamin, fwd and Cctl genes. Genome Biol. 2003;4:R8 pubmed
    ..Two genes did not have previously known phenotypes and are implicated in membrane transport: VhaSFD encodes a regulatory subunit of the vacuolar ATPase proton pump (H+-ATPase), whereas Sugar baby (Sug) is related ..
  7. McGettigan J, McLennan R, Broderick K, Kean L, Allan A, Cabrero P, et al. Insect renal tubules constitute a cell-autonomous immune system that protects the organism against bacterial infection. Insect Biochem Mol Biol. 2005;35:741-54 pubmed
    ..coli challenge. Thus, we describe a novel role of Malpighian tubules in immune sensing and insect survival. ..
  8. Terhzaz S, Southall T, Lilley K, Kean L, Allan A, Davies S, et al. Differential gel electrophoresis and transgenic mitochondrial calcium reporters demonstrate spatiotemporal filtering in calcium control of mitochondria. J Biol Chem. 2006;281:18849-58 pubmed
    ..The results highlight the dynamic nature and both spatial and temporal heterogeneity of calcium signaling possible in differentiated, organotypic cells and provide a new model for neuroendocrine control of V-ATPase. ..
  9. Wang J, Binks T, Warr C, Burke R. Vacuolar-type H(+)-ATPase subunits and the neurogenic protein big brain are required for optimal copper and zinc uptake. Metallomics. 2014;6:2100-8 pubmed publisher
    ..These results suggest that metal ion transport is particularly sensitive to disturbances in cellular protein localization processes. ..

More Information

Publications18

  1. Adamson A, Chohan K, Swenson J, Lajeunesse D. A Drosophila model for genetic analysis of influenza viral/host interactions. Genetics. 2011;189:495-506 pubmed publisher
  2. Chang Y, Tang H, Liang S, Pu T, Meng T, Khoo K, et al. Evaluation of Drosophila metabolic labeling strategies for in vivo quantitative proteomic analyses with applications to early pupa formation and amino acid starvation. J Proteome Res. 2013;12:2138-50 pubmed publisher
  3. Petzoldt A, Gleixner E, Fumagalli A, Vaccari T, Simons M. Elevated expression of the V-ATPase C subunit triggers JNK-dependent cell invasion and overgrowth in a Drosophila epithelium. Dis Model Mech. 2013;6:689-700 pubmed publisher
    ..In summary, our in vivo-findings demonstrate that increased levels of V-ATPase C subunit induce a Eiger/JNK-dependent cell transformation within an epithelial organ that recapitulates early carcinoma stages. ..
  4. Tognon E, Kobia F, Busi I, Fumagalli A, De Masi F, Vaccari T. Control of lysosomal biogenesis and Notch-dependent tissue patterning by components of the TFEB-V-ATPase axis in Drosophila melanogaster. Autophagy. 2016;12:499-514 pubmed publisher
    ..Our data suggest that lysosomal-associated functions regulated by the TFEB-V-ATPase axis might play a conserved role in shaping cell fate. ..
  5. Chung W, Agius P, Westholm J, Chen M, Okamura K, Robine N, et al. Computational and experimental identification of mirtrons in Drosophila melanogaster and Caenorhabditis elegans. Genome Res. 2011;21:286-300 pubmed publisher
    ..elegans harboring eight distinct mirtrons. Altogether, we demonstrate that discovery of functional mirtrons, unlike canonical miRNAs, is amenable to computational methods independent of evolutionary constraint. ..
  6. Cobbe N, Savvidou E, Heck M. Diverse mitotic and interphase functions of condensins in Drosophila. Genetics. 2006;172:991-1008 pubmed
    ..This suggests either that the role of condensin proteins in interphase differs from their expected role in mitosis or that the way we envision condensin's activity needs to be modified to accommodate alternative possibilities. ..
  7. Gailite I, Egger Adam D, Wodarz A. The phosphoinositide-associated protein Rush hour regulates endosomal trafficking in Drosophila. Mol Biol Cell. 2012;23:433-47 pubmed publisher
    ..These results indicate that Rush controls trafficking from early to late endosomes and from late endosomes to lysosomes by modulating the activity of Rab proteins. ..
  8. Kristensen T, Sørensen P, Pedersen K, Kruhøffer M, Loeschcke V. Inbreeding by environmental interactions affect gene expression in Drosophila melanogaster. Genetics. 2006;173:1329-36 pubmed
  9. Xia Q, Wang H, Hao Z, Fu C, Hu Q, Gao F, et al. TDP-43 loss of function increases TFEB activity and blocks autophagosome-lysosome fusion. EMBO J. 2016;35:121-42 pubmed publisher
    ..Taken together, our data indicate that impaired mTORC1 signaling and influenced ALP may contribute to TDP-43-mediated neurodegeneration. ..