Gene Symbol: VhaPPA1-1
Description: Vacuolar H[+] ATPase PPA1 subunit 1
Alias: CG7007, Dmel\CG7007, V0c'', Vha26, VhaPPA1, vhaPPA1-1, vacuolar H[+] ATPase PPA1 subunit 1, CG7007-PA, CG7007-PB, V-ATPase proton pump, VhaPPA1-1-PA, VhaPPA1-1-PB, vacuolar H[+] ATPase subunit PPA1-1
Species: fruit fly
Sessions O, Barrows N, Souza Neto J, Robinson T, Hershey C, Rodgers M, et al
. Discovery of insect and human dengue virus host factors. Nature. 2009;458:1047-50 pubmed publisher
..This indicates notable conservation of required factors between dipteran and human hosts. This work suggests new approaches to control infection in the insect vector and the mammalian host. ..
Wang J, Binks T, Warr C, Burke R. Vacuolar-type H(+)-ATPase subunits and the neurogenic protein big brain are required for optimal copper and zinc uptake. Metallomics. 2014;6:2100-8 pubmed publisher
..We have identified a subunit of the vacuolar-type H(+)-ATPase (V-ATPase) complex, vhaPPA1-2, and the Drosophila aquaporin homolog big brain (bib), as being required for the correct localization of the ..
Francis D, Ghabrial A. Compensatory branching morphogenesis of stalk cells in the Drosophila trachea. Development. 2015;142:2048-57 pubmed publisher
..This compensatory branching also occurs in response to injury, with damaged terminal cells being rapidly invaded by their stalk cell neighbor. ..
Dow J. The multifunctional Drosophila melanogaster V-ATPase is encoded by a multigene family. J Bioenerg Biomembr. 1999;31:75-83 pubmed
..gene family size and the new Drosophila genes vhaSFD, vha100-1, vha100-2, vha100-3, vha16-2, vha16-3, vha16-4, vhaPPA1, vhaPPA2, vhaM9.7.1, and vhaM9.7.2 are described...
Lim D, Lee L, Oh C, Kim N, Hwang S, Han S, et al
. Microarray analysis of Drosophila dicer-2 mutants reveals potential regulation of mitochondrial metabolism by endogenous siRNAs. J Cell Biochem. 2013;114:418-27 pubmed publisher
..Our data support a potential role for the endo-siRNA pathway in energy homeostasis through regulation of mitochondrial metabolism. ..
Mauvezin C, Nagy P, JuhÃ¡sz G, Neufeld T. Autophagosome-lysosome fusion is independent of V-ATPase-mediated acidification. Nat Commun. 2015;6:7007 pubmed publisher
..Collectively, our results indicate that lysosomal acidification is not a prerequisite for fusion, and that BafilomycinA1 inhibits fusion independent of its effect on lysosomal pH. ..
Overend G, Luo Y, Henderson L, Douglas A, Davies S, Dow J. Molecular mechanism and functional significance of acid generation in the Drosophila midgut. Sci Rep. 2016;6:27242 pubmed publisher
..These results demonstrate that the acidic gut region protects the insect and gut microbiome from pathological disruption, and shed light on the mechanisms by which low pH can be maintained in the absence of H(+), K(+) ATPase. ..
Ostrin E, Li Y, Hoffman K, Liu J, Wang K, Zhang L, et al
. Genome-wide identification of direct targets of the Drosophila retinal determination protein Eyeless. Genome Res. 2006;16:466-76 pubmed
..These results suggest that the integrated strategy of computational biology, genomics, and genetics is a powerful approach to identify direct downstream targets for any transcription factor genome-wide. ..