Gene Symbol: VhaM8.9
Description: Vacuolar H[+] ATPase M8.9 accessory subunit
Alias: ATP6AP2, CG8444, Dmel\CG8444, VhaM8-9, VhaPRR, dPRR, vhaM8.9, vacuolar H[+] ATPase M8.9 accessory subunit, CG8444-PA, VhaM8.9-PA
Species: fruit fly
Hermle T, Saltukoglu D, Grünewald J, Walz G, Simons M. Regulation of Frizzled-dependent planar polarity signaling by a V-ATPase subunit. Curr Biol. 2010;20:1269-76 pubmed publisher
..Here we describe that the transmembrane protein CG8444 (here termed VhaPRR) is needed for PCP signaling in Drosophila...
Buechling T, Bartscherer K, Ohkawara B, Chaudhary V, Spirohn K, Niehrs C, et al
. Wnt/Frizzled signaling requires dPRR, the Drosophila homolog of the prorenin receptor. Curr Biol. 2010;20:1263-8 pubmed publisher
..Here we identify the Drosophila homolog of the mammalian prorenin receptor (dPRR) as a conserved modulator of canonical Wnt/beta-cat and Fz/PCP signaling...
Hermle T, Guida M, Beck S, Helmstädter S, Simons M. Drosophila ATP6AP2/VhaPRR functions both as a novel planar cell polarity core protein and a regulator of endosomal trafficking. EMBO J. 2013;32:245-59 pubmed publisher
..These proteins form asymmetric PCP domains at apical junctions of epithelial cells. Here, we demonstrate that VhaPRR, an accessory subunit of the proton pump V-ATPase, directly interacts with the protocadherin Fmi through its ..
Rujano M, Cannata Serio M, Panasyuk G, Peanne R, Reunert J, Rymen D, et al
. Mutations in the X-linked ATP6AP2 cause a glycosylation disorder with autophagic defects. J Exp Med. 2017;214:3707-3729 pubmed publisher
..Here, we identify two hemizygous missense mutations in the extracellular domain of the accessory V-ATPase subunit ATP6AP2 (also known as the [pro]renin receptor) responsible for a glycosylation disorder with liver disease, ..
Cuartero S, Fresán U, Reina O, Planet E, Espinàs M. Ibf1 and Ibf2 are novel CP190-interacting proteins required for insulator function. EMBO J. 2014;33:637-47 pubmed publisher
..Taken together our data reveal a novel pathway of CP190 recruitment to chromatin that is required for insulator activity. ..
Carvajal Gonzalez J, Mlodzik M. Mechanisms of planar cell polarity establishment in Drosophila. F1000Prime Rep. 2014;6:98 pubmed publisher
..Here, we discuss the current models based on Drosophila studies and incorporate recent insights into this long-standing cell and developmental biology problem. ..
Gleixner E, Canaud G, Hermle T, Guida M, Kretz O, Helmstädter M, et al
. V-ATPase/mTOR signaling regulates megalin-mediated apical endocytosis. Cell Rep. 2014;8:10-9 pubmed publisher
..Thus, our findings unravel a homeostatic mechanism that allows epithelial cells to promote protein uptake under normal conditions and to prevent uptake in lysosomal stress conditions. ..
Mauvezin C, Nagy P, JuhÃ¡sz G, Neufeld T. Autophagosome-lysosome fusion is independent of V-ATPase-mediated acidification. Nat Commun. 2015;6:7007 pubmed publisher
..Collectively, our results indicate that lysosomal acidification is not a prerequisite for fusion, and that BafilomycinA1 inhibits fusion independent of its effect on lysosomal pH. ..
Dubos A, Castells Nobau A, Meziane H, Oortveld M, Houbaert X, Iacono G, et al
. Conditional depletion of intellectual disability and Parkinsonism candidate gene ATP6AP2 in fly and mouse induces cognitive impairment and neurodegeneration. Hum Mol Genet. 2015;24:6736-55 pubmed publisher
b>ATP6AP2, an essential accessory component of the vacuolar H+ ATPase (V-ATPase), has been associated with intellectual disability (ID) and Parkinsonism...