Gene Symbol: VhaAC39-1
Description: Vacuolar H[+] ATPase AC39 subunit 1
Alias: ATP6V0D1, CG2934, Dmel\CG2934, V0d, VhaAC39, Vhaac39, anon-EST:GressD5, vhaAC39, vhaAC39-1, vacuolar H[+] ATPase AC39 subunit 1, CG2934-PA, V-ATPase V0 d subunit, VhaAC39, VhaAC39-1-PA, vacuolar ATPsintase subunit 1, vacuolar H[+] ATPase subunit AC39-1, vacuolar H[+]-ATPase C39 subunit
Species: fruit fly

Top Publications

  1. Dow J. The multifunctional Drosophila melanogaster V-ATPase is encoded by a multigene family. J Bioenerg Biomembr. 1999;31:75-83 pubmed
    ..7.1, and vhaM9.7.2 are described. The Drosophila V-ATPase model is thus well-suited to both forward and reverse genetic analysis of this complex multifunctional enzyme. ..
  2. Tio L, Pagani M, Atrian S. Drosophila proteins interacting with metallothioneins: a metal-dependent recognition. Proteomics. 2009;9:2568-77 pubmed publisher
    ..Furthermore, new perspectives to investigate the often hypothesized contribution of MTs to the redox physiological networks are open. ..
  3. Sepp K, Hong P, Lizarraga S, Liu J, Mejia L, Walsh C, et al. Identification of neural outgrowth genes using genome-wide RNAi. PLoS Genet. 2008;4:e1000111 pubmed publisher
    ..Collectively, our results showed that RNAi phenotypes in primary neural culture can parallel in vivo phenotypes, and the screening technique can be used to identify many new genes that have important functions in the nervous system. ..
  4. Yan Y, Denef N, Schupbach T. The vacuolar proton pump, V-ATPase, is required for notch signaling and endosomal trafficking in Drosophila. Dev Cell. 2009;17:387-402 pubmed publisher
    ..We found that, similarly, Rbcn-3A and B appear to regulate V-ATPase function. Moreover, we identified mutants in VhaAC39, a V-ATPase subunit, and showed that they phenocopy Rbcn-3A and Rbcn-3B mutants...
  5. Adamson A, Chohan K, Swenson J, Lajeunesse D. A Drosophila model for genetic analysis of influenza viral/host interactions. Genetics. 2011;189:495-506 pubmed publisher
  6. Chang Y, Tang H, Liang S, Pu T, Meng T, Khoo K, et al. Evaluation of Drosophila metabolic labeling strategies for in vivo quantitative proteomic analyses with applications to early pupa formation and amino acid starvation. J Proteome Res. 2013;12:2138-50 pubmed publisher
  7. Francis D, Ghabrial A. Compensatory branching morphogenesis of stalk cells in the Drosophila trachea. Development. 2015;142:2048-57 pubmed publisher
    ..This compensatory branching also occurs in response to injury, with damaged terminal cells being rapidly invaded by their stalk cell neighbor. ..
  8. Gress T, Hoheisel J, Lennon G, Zehetner G, Lehrach H. Hybridization fingerprinting of high-density cDNA-library arrays with cDNA pools derived from whole tissues. Mamm Genome. 1992;3:609-19 pubmed
    ..Data obtained by the technique described will ultimately be correlated with additional transcriptional and sequence information for the same library clones and with genomic mapping information in a relational database. ..
  9. Zoncu R, Bar Peled L, Efeyan A, Wang S, Sancak Y, Sabatini D. mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase. Science. 2011;334:678-83 pubmed publisher
    ..These results identify the v-ATPase as a component of the mTOR pathway and delineate a lysosome-associated machinery for amino acid sensing. ..

More Information


  1. Mauvezin C, Nagy P, Juhász G, Neufeld T. Autophagosome-lysosome fusion is independent of V-ATPase-mediated acidification. Nat Commun. 2015;6:7007 pubmed publisher
    ..Collectively, our results indicate that lysosomal acidification is not a prerequisite for fusion, and that BafilomycinA1 inhibits fusion independent of its effect on lysosomal pH. ..
  2. Nikolova L, Metzstein M. Intracellular lumen formation in Drosophila proceeds via a novel subcellular compartment. Development. 2015;142:3964-73 pubmed publisher
    ..In general, our ultrastructural analysis methods could be useful for a wide range of cellular investigations in Drosophila larvae. ..