Vha68-2

Summary

Gene Symbol: Vha68-2
Description: Vacuolar H[+] ATPase 68 kDa subunit 2
Alias: A subunit, ATP6V1A, CG3762, Dmel\CG3762, MENE-R6, RE30552p, Vha68, Vha68.2, l(2)01510, l(2)s4214, vha67-2, vha68-2, vacuolar H[+] ATPase 68 kDa subunit 2, CG3762-PA, CG3762-PB, CG3762-PC, CG3762-PD, CG3762-PE, CG3762-PF, V-ATPase 69 kDa subunit 2, Vha68-2-PA, Vha68-2-PB, Vha68-2-PC, Vha68-2-PD, Vha68-2-PE, Vha68-2-PF, vacuolar ATPase, vacuolar H[+] ATPase subunit 68-2
Species: fruit fly

Top Publications

  1. Guo Y, Gillan A, Torok T, Kiss I, Dow J, Kaiser K. Site-selected mutagenesis of the Drosophila second chromosome via plasmid rescue of lethal P-element insertions. Genome Res. 1996;6:972-9 pubmed
    ..The success rate was better than one in four. This rate would undoubtedly be improved by the use of genomic DNA probes. ..
  2. Sözen M, Armstrong J, Yang M, Kaiser K, Dow J. Functional domains are specified to single-cell resolution in a Drosophila epithelium. Proc Natl Acad Sci U S A. 1997;94:5207-12 pubmed
    ..Building upon recent advances in Drosophila Malpighian tubule physiology, the present study confirms this tissue as a singular model for integrative physiology...
  3. Nikolova L, Metzstein M. Intracellular lumen formation in Drosophila proceeds via a novel subcellular compartment. Development. 2015;142:3964-73 pubmed publisher
    ..Using this technique, we have found that Vacuolar ATPase (V-ATPase) and the V-ATPase regulator Rabconnectin-3 are required for subcellular tube formation, probably in ..
  4. Farkaš R, Beňová Liszeková D, Mentelová L, Mahmood S, Ďatková Z, Beňo M, et al. Vacuole dynamics in the salivary glands of Drosophila melanogaster during prepupal development. Dev Growth Differ. 2015;57:74-96 pubmed publisher
    ..specific metabolic inhibitors and genetic tools, including mutations or transgenes for shi, Rab5, Rab11, vha55, vha68-2, vha36-1, syx1A, syx4, and Vps35 to characterize the dramatic series of cellular changes occurring in the SG ..
  5. Menut L, Vaccari T, Dionne H, Hill J, Wu G, Bilder D. A mosaic genetic screen for Drosophila neoplastic tumor suppressor genes based on defective pupation. Genetics. 2007;177:1667-77 pubmed
    ..The isolation of additional loci that affect hyperplastic as well as neoplastic growth indicates the utility of this screening strategy for studying epithelial growth control. ..
  6. Pathak R, Srinivasan A, Mishra R. Genome-wide mapping of matrix attachment regions in Drosophila melanogaster. BMC Genomics. 2014;15:1022 pubmed publisher
    ..We also identified sequence motifs and repeats that constitute MARs. Our data reveal the contact points of genome to the nuclear architecture and provide a link between nuclear functions and genomic packaging. ..
  7. Chang Y, Tang H, Liang S, Pu T, Meng T, Khoo K, et al. Evaluation of Drosophila metabolic labeling strategies for in vivo quantitative proteomic analyses with applications to early pupa formation and amino acid starvation. J Proteome Res. 2013;12:2138-50 pubmed publisher
  8. Hermle T, Guida M, Beck S, Helmstädter S, Simons M. Drosophila ATP6AP2/VhaPRR functions both as a novel planar cell polarity core protein and a regulator of endosomal trafficking. EMBO J. 2013;32:245-59 pubmed publisher
    ..Together, our results suggest two roles for VhaPRR, one for PCP and another in endosomal trafficking. This dual function establishes VhaPRR as a key factor in epithelial morphogenesis...
  9. Dow J, Davies S, Guo Y, Graham S, Finbow M, Kaiser K. Molecular genetic analysis of V-ATPase function in Drosophila melanogaster. J Exp Biol. 1997;200:237-45 pubmed
    ..These results, while providing the first gene knockouts of V-ATPases in animals, also illustrate the general utility of D. melanogaster as a model for the genetic analysis of ion transport and its control in epithelia. ..

More Information

Publications17

  1. Zhu J, Vereshchagina N, Sreekumar V, Burbulla L, Costa A, Daub K, et al. Knockdown of Hsc70-5/mortalin induces loss of synaptic mitochondria in a Drosophila Parkinson's disease model. PLoS ONE. 2013;8:e83714 pubmed publisher
  2. Adamson A, Chohan K, Swenson J, Lajeunesse D. A Drosophila model for genetic analysis of influenza viral/host interactions. Genetics. 2011;189:495-506 pubmed publisher
  3. Vaccari T, Duchi S, Cortese K, Tacchetti C, Bilder D. The vacuolar ATPase is required for physiological as well as pathological activation of the Notch receptor. Development. 2010;137:1825-32 pubmed publisher
    ..regulate Notch activation in endosomes, we isolated mutants in Drosophila genes that encode subunits of the vacuolar ATPase (V-ATPase) proton pump...
  4. Terhzaz S, Southall T, Lilley K, Kean L, Allan A, Davies S, et al. Differential gel electrophoresis and transgenic mitochondrial calcium reporters demonstrate spatiotemporal filtering in calcium control of mitochondria. J Biol Chem. 2006;281:18849-58 pubmed
    ..The results highlight the dynamic nature and both spatial and temporal heterogeneity of calcium signaling possible in differentiated, organotypic cells and provide a new model for neuroendocrine control of V-ATPase. ..
  5. Dow J. The multifunctional Drosophila melanogaster V-ATPase is encoded by a multigene family. J Bioenerg Biomembr. 1999;31:75-83 pubmed
    ..7.1, and vhaM9.7.2 are described. The Drosophila V-ATPase model is thus well-suited to both forward and reverse genetic analysis of this complex multifunctional enzyme. ..
  6. Day J, Wan S, Allan A, Kean L, Davies S, Gray J, et al. Identification of two partners from the bacterial Kef exchanger family for the apical plasma membrane V-ATPase of Metazoa. J Cell Sci. 2008;121:2612-9 pubmed publisher
    ..Thus, both CG10806 and CG31052 are functionally members of the CPA2 gene family, colocalise to the same apical membrane as the plasma membrane V-ATPase and show distinct ion specificities, as expected for the Wieczorek exchanger. ..
  7. Overend G, Luo Y, Henderson L, Douglas A, Davies S, Dow J. Molecular mechanism and functional significance of acid generation in the Drosophila midgut. Sci Rep. 2016;6:27242 pubmed publisher
    ..These results demonstrate that the acidic gut region protects the insect and gut microbiome from pathological disruption, and shed light on the mechanisms by which low pH can be maintained in the absence of H(+), K(+) ATPase. ..
  8. Mauvezin C, Nagy P, Juhász G, Neufeld T. Autophagosome-lysosome fusion is independent of V-ATPase-mediated acidification. Nat Commun. 2015;6:7007 pubmed publisher
    ..Collectively, our results indicate that lysosomal acidification is not a prerequisite for fusion, and that BafilomycinA1 inhibits fusion independent of its effect on lysosomal pH. ..