Vha44

Summary

Gene Symbol: Vha44
Description: Vacuolar H[+] ATPase 44kD subunit
Alias: 6072, ATP6V1C, CG8048, Dmel\CG8048, l(2)6072, l(2)SH1339, l(2)SH2 1339, vha44, vacuolar H[+] ATPase 44kD subunit, C subunit, CG8048-PA, CG8048-PB, CG8048-PC, CG8048-PE, CG8048-PF, V-ATPase C subunit, Vha44-PA, Vha44-PB, Vha44-PC, Vha44-PE, Vha44-PF, lethal (2) SH1339, vacuolar ATPase C-subunit, vacuolar H+ ATPase 44kD C subunit, vacuolar H[+] ATPase 44 kDa subunit, vacuolar H[+] ATPase 44kD C subunit
Species: fruit fly

Top Publications

  1. Hermle T, Guida M, Beck S, Helmstädter S, Simons M. Drosophila ATP6AP2/VhaPRR functions both as a novel planar cell polarity core protein and a regulator of endosomal trafficking. EMBO J. 2013;32:245-59 pubmed publisher
    ..Together, our results suggest two roles for VhaPRR, one for PCP and another in endosomal trafficking. This dual function establishes VhaPRR as a key factor in epithelial morphogenesis...
  2. Dow J, Davies S, Guo Y, Graham S, Finbow M, Kaiser K. Molecular genetic analysis of V-ATPase function in Drosophila melanogaster. J Exp Biol. 1997;200:237-45 pubmed
    ..These results, while providing the first gene knockouts of V-ATPases in animals, also illustrate the general utility of D. melanogaster as a model for the genetic analysis of ion transport and its control in epithelia. ..
  3. Terhzaz S, Southall T, Lilley K, Kean L, Allan A, Davies S, et al. Differential gel electrophoresis and transgenic mitochondrial calcium reporters demonstrate spatiotemporal filtering in calcium control of mitochondria. J Biol Chem. 2006;281:18849-58 pubmed
    ..The results highlight the dynamic nature and both spatial and temporal heterogeneity of calcium signaling possible in differentiated, organotypic cells and provide a new model for neuroendocrine control of V-ATPase. ..
  4. Adamson A, Chohan K, Swenson J, Lajeunesse D. A Drosophila model for genetic analysis of influenza viral/host interactions. Genetics. 2011;189:495-506 pubmed publisher
  5. Petzoldt A, Gleixner E, Fumagalli A, Vaccari T, Simons M. Elevated expression of the V-ATPase C subunit triggers JNK-dependent cell invasion and overgrowth in a Drosophila epithelium. Dis Model Mech. 2013;6:689-700 pubmed publisher
    The C subunit of the vacuolar H(+)-ATPase or V-ATPase regulates the activity and assembly of the proton pump at cellular membranes...
  6. Chang Y, Tang H, Liang S, Pu T, Meng T, Khoo K, et al. Evaluation of Drosophila metabolic labeling strategies for in vivo quantitative proteomic analyses with applications to early pupa formation and amino acid starvation. J Proteome Res. 2013;12:2138-50 pubmed publisher
  7. Dow J. The multifunctional Drosophila melanogaster V-ATPase is encoded by a multigene family. J Bioenerg Biomembr. 1999;31:75-83 pubmed
    ..7.1, and vhaM9.7.2 are described. The Drosophila V-ATPase model is thus well-suited to both forward and reverse genetic analysis of this complex multifunctional enzyme. ..
  8. Stotz S, Clapham D. Anion-sensitive fluorophore identifies the Drosophila swell-activated chloride channel in a genome-wide RNA interference screen. PLoS ONE. 2012;7:e46865 pubmed publisher
    ..dBest1 is an anion channel clearly responsive to swell; this activation depends upon its N-terminus. ..
  9. Serysheva E, Berhane H, Grumolato L, Demir K, Balmer S, Bodak M, et al. Wnk kinases are positive regulators of canonical Wnt/?-catenin signalling. EMBO Rep. 2013;14:718-25 pubmed publisher
    ..Importantly, knockdown of human WNK1 and WNK2 also results in decreased Wnt signalling in mammalian cell culture, suggesting that Wnk kinases have a conserved function in ensuring peak levels of canonical Wnt signalling. ..

More Information

Publications12

  1. Gleixner E, Canaud G, Hermle T, Guida M, Kretz O, Helmstädter M, et al. V-ATPase/mTOR signaling regulates megalin-mediated apical endocytosis. Cell Rep. 2014;8:10-9 pubmed publisher
    ..Thus, our findings unravel a homeostatic mechanism that allows epithelial cells to promote protein uptake under normal conditions and to prevent uptake in lysosomal stress conditions. ..
  2. Wang J, Binks T, Warr C, Burke R. Vacuolar-type H(+)-ATPase subunits and the neurogenic protein big brain are required for optimal copper and zinc uptake. Metallomics. 2014;6:2100-8 pubmed publisher
    ..These results suggest that metal ion transport is particularly sensitive to disturbances in cellular protein localization processes. ..
  3. Mauvezin C, Nagy P, Juhász G, Neufeld T. Autophagosome-lysosome fusion is independent of V-ATPase-mediated acidification. Nat Commun. 2015;6:7007 pubmed publisher
    ..Collectively, our results indicate that lysosomal acidification is not a prerequisite for fusion, and that BafilomycinA1 inhibits fusion independent of its effect on lysosomal pH. ..