Gene Symbol: Vha44
Description: Vacuolar H[+] ATPase 44kD subunit
Alias: 6072, ATP6V1C, CG8048, Dmel\CG8048, l(2)6072, l(2)SH1339, l(2)SH2 1339, vha44, vacuolar H[+] ATPase 44kD subunit, C subunit, CG8048-PA, CG8048-PB, CG8048-PC, CG8048-PE, CG8048-PF, V-ATPase C subunit, Vha44-PA, Vha44-PB, Vha44-PC, Vha44-PE, Vha44-PF, lethal (2) SH1339, vacuolar ATPase C-subunit, vacuolar H+ ATPase 44kD C subunit, vacuolar H[+] ATPase 44 kDa subunit, vacuolar H[+] ATPase 44kD C subunit
Species: fruit fly
Hermle T, Guida M, Beck S, Helmstädter S, Simons M. Drosophila ATP6AP2/VhaPRR functions both as a novel planar cell polarity core protein and a regulator of endosomal trafficking. EMBO J. 2013;32:245-59 pubmed publisher
..Together, our results suggest two roles for VhaPRR, one for PCP and another in endosomal trafficking. This dual function establishes VhaPRR as a key factor in epithelial morphogenesis...
Dow J, Davies S, Guo Y, Graham S, Finbow M, Kaiser K. Molecular genetic analysis of V-ATPase function in Drosophila melanogaster. J Exp Biol. 1997;200:237-45 pubmed
..These results, while providing the first gene knockouts of V-ATPases in animals, also illustrate the general utility of D. melanogaster as a model for the genetic analysis of ion transport and its control in epithelia. ..
Terhzaz S, Southall T, Lilley K, Kean L, Allan A, Davies S, et al
. Differential gel electrophoresis and transgenic mitochondrial calcium reporters demonstrate spatiotemporal filtering in calcium control of mitochondria. J Biol Chem. 2006;281:18849-58 pubmed
..The results highlight the dynamic nature and both spatial and temporal heterogeneity of calcium signaling possible in differentiated, organotypic cells and provide a new model for neuroendocrine control of V-ATPase. ..
Adamson A, Chohan K, Swenson J, Lajeunesse D. A Drosophila model for genetic analysis of influenza viral/host interactions. Genetics. 2011;189:495-506 pubmed publisher
Petzoldt A, Gleixner E, Fumagalli A, Vaccari T, Simons M. Elevated expression of the V-ATPase C subunit triggers JNK-dependent cell invasion and overgrowth in a Drosophila epithelium. Dis Model Mech. 2013;6:689-700 pubmed publisher
The C subunit of the vacuolar H(+)-ATPase or V-ATPase regulates the activity and assembly of the proton pump at cellular membranes...
Chang Y, Tang H, Liang S, Pu T, Meng T, Khoo K, et al
. Evaluation of Drosophila metabolic labeling strategies for in vivo quantitative proteomic analyses with applications to early pupa formation and amino acid starvation. J Proteome Res. 2013;12:2138-50 pubmed publisher
Dow J. The multifunctional Drosophila melanogaster V-ATPase is encoded by a multigene family. J Bioenerg Biomembr. 1999;31:75-83 pubmed
..7.1, and vhaM9.7.2 are described. The Drosophila V-ATPase model is thus well-suited to both forward and reverse genetic analysis of this complex multifunctional enzyme. ..
Stotz S, Clapham D. Anion-sensitive fluorophore identifies the Drosophila swell-activated chloride channel in a genome-wide RNA interference screen. PLoS ONE. 2012;7:e46865 pubmed publisher
..dBest1 is an anion channel clearly responsive to swell; this activation depends upon its N-terminus. ..
Serysheva E, Berhane H, Grumolato L, Demir K, Balmer S, Bodak M, et al
. Wnk kinases are positive regulators of canonical Wnt/?-catenin signalling. EMBO Rep. 2013;14:718-25 pubmed publisher
..Importantly, knockdown of human WNK1 and WNK2 also results in decreased Wnt signalling in mammalian cell culture, suggesting that Wnk kinases have a conserved function in ensuring peak levels of canonical Wnt signalling. ..