Gene Symbol: Vamp7
Description: Vesicle-associated membrane protein 7
Alias: CG1599, Dmel\CG1599, TI-VAMP, VAMP7, dVamp7, Vesicle-associated membrane protein 7, CG1599-PA, CG1599-PC, Vamp7-PA, Vamp7-PC
Species: fruit fly
TakÃ¡ts S, Nagy P, Varga Ã, Pircs K, KÃ¡rpÃ¡ti M, Varga K, et al
. Autophagosomal Syntaxin17-dependent lysosomal degradation maintains neuronal function in Drosophila. J Cell Biol. 2013;201:531-9 pubmed publisher
..to the outer membrane of autophagosomes to mediate fusion through its interactions with ubisnap (SNAP-29) and VAMP7 in Drosophila melanogaster...
Jean S, Cox S, Nassari S, Kiger A. Starvation-induced MTMR13 and RAB21 activity regulates VAMP8 to promote autophagosome-lysosome fusion. EMBO Rep. 2015;16:297-311 pubmed publisher
..Sbf/MTMR13 GEF and RAB21 activity, as well as their induced binding to VAMP8 (or closest Drosophila homolog, Vamp7)...
Gao H, He F, Lin X, Wu Y. Drosophila VAMP7 regulates Wingless intracellular trafficking. PLoS ONE. 2017;12:e0186938 pubmed publisher
..Here, we showed that loss of vamp7, a gene required for vesicle fusion, dramatically increased Wg levels and decreased Wg signaling...
Martinez Arca S, Rudge R, Vacca M, Raposo G, Camonis J, Proux Gillardeaux V, et al
. A dual mechanism controlling the localization and function of exocytic v-SNAREs. Proc Natl Acad Sci U S A. 2003;100:9011-6 pubmed
..Longin domain of the v-SNARE TI-VAMP (tetanus neurotoxin-insensitive vesicle-associated membrane protein)/VAMP7 plays an inhibitory role in neurite outgrowth...
Rossi V, Banfield D, Vacca M, Dietrich L, Ungermann C, D Esposito M, et al
. Longins and their longin domains: regulated SNAREs and multifunctional SNARE regulators. Trends Biochem Sci. 2004;29:682-8 pubmed
..In mammals, TI-VAMP and Ykt6 are crucial for neuronal function, and defects in longin structure or function might underlie some human neurological pathologies. ..
Wong C, Li R, Montell C, Venkatachalam K. Drosophila TRPML is required for TORC1 activation. Curr Biol. 2012;22:1616-21 pubmed publisher
..Our findings delineate the interrelationship between the TRPML and TORC1 pathways and raise the intriguing possibility that a high-protein diet might reduce the severity of MLIV. ..
TakÃ¡ts S, Pircs K, Nagy P, Varga Ã, KÃ¡rpÃ¡ti M, HegedÅ±s K, et al
. Interaction of the HOPS complex with Syntaxin 17 mediates autophagosome clearance in Drosophila. Mol Biol Cell. 2014;25:1338-54 pubmed publisher
..Our results establish the role of HOPS and its likely mechanism of action during autophagy in metazoans. ..
Morelli E, Ginefra P, Mastrodonato V, Beznoussenko G, Rusten T, Bilder D, et al
. Multiple functions of the SNARE protein Snap29 in autophagy, endocytic, and exocytic trafficking during epithelial formation in Drosophila. Autophagy. 2014;10:2251-68 pubmed publisher
Tian X, Gala U, Zhang Y, Shang W, Nagarkar Jaiswal S, di Ronza A, et al
. A voltage-gated calcium channel regulates lysosomal fusion with endosomes and autophagosomes and is required for neuronal homeostasis. PLoS Biol. 2015;13:e1002103 pubmed publisher
..In summary, we present a model in which the VGCC plays a role in autophagy by regulating the fusion of AVs with lysosomes through its calcium channel activity and hence functions in maintaining neuronal homeostasis. ..