Gene Symbol: Usp47
Description: Ubiquitin specific protease 47
Alias: BcDNA:LD12764, CG5486, D-UBP-64E, D-Ubp-64E, Dmel\CG5486, E(var)1, E(var)3-64E, E-var(3)64E, Q24574, UBP, UBP64E, Ubp64, Ubp64E, Upd64E, dUSP47, dUbp64, ubp64, ubp64E, usp47, ubiquitin specific protease 47, CG5486-PA, CG5486-PB, CG5486-PD, Ubiquitin-specific protease 64E, Usp47-PA, Usp47-PB, Usp47-PD
Species: fruit fly

Top Publications

  1. Bilen J, Bonini N. Genome-wide screen for modifiers of ataxin-3 neurodegeneration in Drosophila. PLoS Genet. 2007;3:1950-64 pubmed
    ..These findings provide new insight into molecular pathways of polyQ toxicity, defining novel targets for promoting neuronal survival in human neurodegenerative disease. ..
  2. Chen X, Fischer J. In vivo Structure/Function analysis of the Drosophila fat facets deubiquitinating enzyme gene. Genetics. 2000;156:1829-36 pubmed
    ..The results indicate functions for specific conserved amino acids in the catalytic region of Fat facets and also indicate that regions of the protein both N- and C-terminal to the catalytic region are required for Fat facets function. ..
  3. Bingol B, Tea J, Phu L, Reichelt M, Bakalarski C, Song Q, et al. The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy. Nature. 2014;510:370-5 pubmed publisher
    ..Thus USP30 inhibition is potentially beneficial for Parkinson's disease by promoting mitochondrial clearance and quality control...
  4. Gnerer J, Venken K, Dierick H. Gene-specific cell labeling using MiMIC transposons. Nucleic Acids Res. 2015;43:e56 pubmed publisher
    ..We show the efficacy and broad applicability of these new tools by dissecting the cellular expression patterns of the Drosophila serotonin receptor gene family. ..
  5. Kang L, Aggarwal D, Rashkovetsky E, Korol A, Michalak P. Rapid genomic changes in Drosophila melanogaster adapting to desiccation stress in an experimental evolution system. BMC Genomics. 2016;17:233 pubmed publisher
    ..Desiccation stress, a common challenge to many organisms inhabiting dry environments, proves to be a very potent selecting factor having a big impact on genome diversity. ..
  6. Rørth P, Szabo K, Texido G. The level of C/EBP protein is critical for cell migration during Drosophila oogenesis and is tightly controlled by regulated degradation. Mol Cell. 2000;6:23-30 pubmed
    ..Through genetic screening, we identify two genes that are involved in this regulation. The Ubp64 ubiquitin hydrolase acts as a stabilizer of Slbo protein...
  7. Bajpe P, van der Knaap J, Demmers J, Bezstarosti K, Bassett A, van Beusekom H, et al. Deubiquitylating enzyme UBP64 controls cell fate through stabilization of the transcriptional repressor tramtrack. Mol Cell Biol. 2008;28:1606-15 pubmed
    ..Here, we show that the Drosophila ubiquitin protease UBP64 controls cell fate in the developing eye...
  8. Yagi Y, Lim Y, Tsuda L, Nishida Y. fat facets induces polyubiquitination of Imd and inhibits the innate immune response in Drosophila. Genes Cells. 2013;18:934-45 pubmed publisher
    ..Given that faf-dependent Imd polyubiquitination did not seem to cause protein degradation of Imd, Faf might inhibit the IMD pathway by modulating the state of Imd ubiquitination and/or stability. ..
  9. Ristić G, Tsou W, Guzi E, Kanack A, SCAGLIONE K, Todi S. USP5 Is Dispensable for Monoubiquitin Maintenance in Drosophila. J Biol Chem. 2016;291:9161-72 pubmed publisher
    ..Our work indicates that a primary physiological role of USP5 is not to recycle monoubiquitin for reutilization, but that it may involve disassembly of conjugated ubiquitin to maintain proteasome function. ..

More Information


  1. Pirrotta V. PcG complexes and chromatin silencing. Curr Opin Genet Dev. 1997;7:249-58 pubmed
    ..How such a complex interferes with transcriptional activity is not entirely clear but current evidence suggests that they compete with the chromatin structure required for the binding of activators. ..
  2. Simões Correia J, Silva D, Melo S, Figueiredo J, Caldeira J, Pinto M, et al. DNAJB4 molecular chaperone distinguishes WT from mutant E-cadherin, determining their fate in vitro and in vivo. Hum Mol Genet. 2014;23:2094-105 pubmed publisher
    ..Additionally, the expression of DNAJB4 and Ecad is concomitantly decreased in human gastric carcinomas. Altogether, we demonstrate that DNAJB4 is a sensor of Ecad structural features that might contribute to gastric cancer progression. ..
  3. Shi J, Liu Y, Xu X, Zhang W, Yu T, Jia J, et al. Deubiquitinase USP47/UBP64E Regulates β-Catenin Ubiquitination and Degradation and Plays a Positive Role in Wnt Signaling. Mol Cell Biol. 2015;35:3301-11 pubmed publisher
    ..Finally, in vivo studies in the Drosophila wing suggest that UBP64E, the USP47 counterpart in Drosophila, is required for Armadillo stabilization and plays a positive role in ..
  4. Dorn R, Szidonya J, Korge G, Sehnert M, Taubert H, Archoukieh E, et al. P transposon-induced dominant enhancer mutations of position-effect variegation in Drosophila melanogaster. Genetics. 1993;133:279-90 pubmed
    ..First studies on the developmentally regulated gene expression of PEV enhancer genes were performed by beta-galactosidase staining in P[lArB] induced mutations. ..
  5. Henchoz S, De Rubertis F, Pauli D, Spierer P. The dose of a putative ubiquitin-specific protease affects position-effect variegation in Drosophila melanogaster. Mol Cell Biol. 1996;16:5717-25 pubmed
    ..Sequencing of the cDNA reveals a large open reading frame encoding a putative ubiquitin-specific protease (Ubp). Ubiquitin marks various proteins, frequently for proteasome-dependent degradation...
  6. Ashton Beaucage D, Lemieux C, Udell C, Sahmi M, Rochette S, Therrien M. The Deubiquitinase USP47 Stabilizes MAPK by Counteracting the Function of the N-end Rule ligase POE/UBR4 in Drosophila. PLoS Biol. 2016;14:e1002539 pubmed publisher
    ..Here, we describe the function of one of these, the deubiquitinase (DUB) USP47. We found that USP47 acts post-translationally to counteract a proteasome-mediated event that reduces MAPK half-..
  7. Vidal O, Stec W, Bausek N, Smythe E, Zeidler M. Negative regulation of Drosophila JAK-STAT signalling by endocytic trafficking. J Cell Sci. 2010;123:3457-66 pubmed publisher
    ..As such, disruption in endocytic trafficking represents a potent negative regulator of the disease relevant JAK-STAT signalling cascade. ..