ush

Summary

Gene Symbol: ush
Description: u-shaped
Alias: CG2762, Dmel\CG2762, FOG, Ush, ZFPM2, dFOG, l(2)19, u-sh, ushaped, CG2762-PA, CG2762-PB, CG2762-PC, CG2762-PD, CG2762-PE, U-shaped, drosophila friend of GATA, friend of GATA, ush-PA, ush-PB, ush-PC, ush-PD, ush-PE, ushaped
Species: fruit fly

Top Publications

  1. ncbi The angle of the dorsoventral axis with respect to the anteroposterior axis in the Drosophila embryo is controlled by the distribution of gurken mRNA in the oocyte
    M Haenlin
    Laboratoire de Genetique Moleculaire des Eucaryotes du CNRS, Unite 184 de Biologie Moleculaire et de Genie Genetique de l INSERM, Faculte de Medecine, Strasbourg, France
    Mech Dev 49:97-106. 1995
  2. ncbi GETDB, a database compiling expression patterns and molecular locations of a collection of Gal4 enhancer traps
    Shigeo Hayashi
    National Institute of Genetics, Mishima, Shizuoka ken, Japan
    Genesis 34:58-61. 2002
  3. ncbi Differences in sensory projections between macro- and microchaetes in Drosophilid flies
    Akiko Usui-Ishihara
    Department of Zoology, University of Cambridge, Cambridge CB2 3EJ, United Kingdom
    Dev Biol 277:170-83. 2005
  4. doi CtBP is required for proper development of peripheral nervous system in Drosophila
    Mark D Stern
    Department of Cell and Developmental Biology, Weill Medical College of Cornell University, New York, NY 10065, USA
    Mech Dev 126:68-79. 2009
  5. pmc Zinc fingers as protein recognition motifs: structural basis for the GATA-1/friend of GATA interaction
    Chu Kong Liew
    School of Molecular and Microbial Biosciences, University of Sydney, Sydney, New South Wales 2006, Australia
    Proc Natl Acad Sci U S A 102:583-8. 2005
  6. ncbi The Drosophila lymph gland as a developmental model of hematopoiesis
    Seung Hye Jung
    Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA 90095, USA
    Development 132:2521-33. 2005
  7. pmc Two isoforms of Serpent containing either one or two GATA zinc fingers have different roles in Drosophila haematopoiesis
    Lucas Waltzer
    Centre de Biologie du Développement CNRS, 31062 Toulouse, France
    EMBO J 21:5477-86. 2002
  8. pmc The Friend of GATA proteins U-shaped, FOG-1, and FOG-2 function as negative regulators of blood, heart, and eye development in Drosophila
    N Fossett
    Department of Biochemistry and Molecular Biology, Graduate Program in Genes and Development, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 98:7342-7. 2001
  9. ncbi Dpp signaling thresholds in the dorsal ectoderm of the Drosophila embryo
    H L Ashe
    Department of Molecular and Cell Biology, Division of Genetics and Development, University of California, Berkeley, CA 94720, USA
    Development 127:3305-12. 2000
  10. ncbi The role of brinker in mediating the graded response to Dpp in early Drosophila embryos
    A Jazwinska
    Institut fuer Entwicklungsbiologie, Universitaet zu Koeln, Gyrhofstr 17, Germany
    Development 126:3323-34. 1999

Research Grants

Scientific Experts

  • Marc Haenlin
  • Richard Paul Sorrentino
  • Jennifer A Kennell
  • Eileen E M Furlong
  • Keith Brennan
  • Inna Biryukova
  • A Letsou
  • P Martin
  • Laurel Raftery
  • N Fossett
  • Marie Meister
  • Y M Chan
  • Pascal Heitzler
  • Arjumand Ghazi
  • J D Molkentin
  • Tsuyoshi Tokusumi
  • Robert A Schulz
  • Selen Muratoglu
  • Mark Russell
  • Lucas Waltzer
  • P Simpson
  • Per Henrik Holmqvist
  • Ken Ichi Hironaka
  • Cory J Evans
  • Shigeo Hayashi
  • Martin Stofanko
  • Yumiko Tokusumi
  • Catherine Fromental-Ramain
  • Seogang Hyun
  • Hongjuan Gao
  • Mark D Stern
  • Xiaomeng Wang
  • Joel L Frandsen
  • Kathleen M Gajewski
  • Joaquín de Navascués
  • Beatriz García Fernández
  • Atsushi Wada
  • Annalisa Letizia
  • Kathleen Gajewski
  • Claudia Mieko Mizutani
  • Julia Sellin
  • Akiko Usui-Ishihara
  • Chu Kong Liew
  • M Crossley
  • Viola Gesellchen
  • Seung Hye Jung
  • Anne Scuderi
  • K Usui
  • A H Fox
  • Utpal Banerjee
  • Pat Simpson
  • Amit Singh
  • Susan L Klinedinst
  • H D Lipshitz
  • Laetitia Bataillé
  • M L Lamka
  • Manuel Calleja
  • Ann Boija
  • Yoh Iwasa
  • Per Stenberg
  • J Turner
  • S D Podos
  • H Herranz
  • Mattias Mannervik
  • B E Stronach
  • Philge Philip
  • Yoshihiro Morishita
  • J Torres-Vazquez
  • Filip Crona
  • So Yeon Kwon
  • C Maurel-Zaffran
  • H L Ashe
  • Nathalie Taquet
  • Y Tomoyasu
  • Paul Badenhorst
  • Philippe Ramain
  • M Sato
  • D Brentrup
  • J M Matthews
  • R Wilk
  • Jessica Stoller-Conrad
  • Shubha Govind
  • Bumjin Namkoong
  • Hitoshi Aihara
  • Dereje Negeri
  • Hua Jin
  • Lila Cheung
  • Yutaka Nibu
  • Jung Hyun Lee
  • V Narry Kim

Detail Information

Publications77

  1. ncbi The angle of the dorsoventral axis with respect to the anteroposterior axis in the Drosophila embryo is controlled by the distribution of gurken mRNA in the oocyte
    M Haenlin
    Laboratoire de Genetique Moleculaire des Eucaryotes du CNRS, Unite 184 de Biologie Moleculaire et de Genie Genetique de l INSERM, Faculte de Medecine, Strasbourg, France
    Mech Dev 49:97-106. 1995
    ..The alteration of the embryonic fate map could be traced back to oogenesis where it was shown to correlate with the mislocalization of the grk transcripts...
  2. ncbi GETDB, a database compiling expression patterns and molecular locations of a collection of Gal4 enhancer traps
    Shigeo Hayashi
    National Institute of Genetics, Mishima, Shizuoka ken, Japan
    Genesis 34:58-61. 2002
  3. ncbi Differences in sensory projections between macro- and microchaetes in Drosophilid flies
    Akiko Usui-Ishihara
    Department of Zoology, University of Cambridge, Cambridge CB2 3EJ, United Kingdom
    Dev Biol 277:170-83. 2005
    ..We discuss the possibility that macro- and microchaetes may have different functions and that these have implications for evolutionary constraints on bristle patterns...
  4. doi CtBP is required for proper development of peripheral nervous system in Drosophila
    Mark D Stern
    Department of Cell and Developmental Biology, Weill Medical College of Cornell University, New York, NY 10065, USA
    Mech Dev 126:68-79. 2009
    ..We therefore propose that dCtBP is part of a gene circuitry that controls the patterning and differentiation of the fly PNS via multiple mechanisms...
  5. pmc Zinc fingers as protein recognition motifs: structural basis for the GATA-1/friend of GATA interaction
    Chu Kong Liew
    School of Molecular and Microbial Biosciences, University of Sydney, Sydney, New South Wales 2006, Australia
    Proc Natl Acad Sci U S A 102:583-8. 2005
    GATA-1 and friend of GATA (FOG) are zinc-finger transcription factors that physically interact to play essential roles in erythroid and megakaryocytic development...
  6. ncbi The Drosophila lymph gland as a developmental model of hematopoiesis
    Seung Hye Jung
    Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA 90095, USA
    Development 132:2521-33. 2005
    ..The cellular events identified in this analysis further establish Drosophila as a model system for hematopoiesis...
  7. pmc Two isoforms of Serpent containing either one or two GATA zinc fingers have different roles in Drosophila haematopoiesis
    Lucas Waltzer
    Centre de Biologie du Développement CNRS, 31062 Toulouse, France
    EMBO J 21:5477-86. 2002
    ..of the N-finger stabilizes the interaction of Srp with palindromic GATA sites and allows interaction with the Friend of GATA factor U-shaped (Ush)...
  8. pmc The Friend of GATA proteins U-shaped, FOG-1, and FOG-2 function as negative regulators of blood, heart, and eye development in Drosophila
    N Fossett
    Department of Biochemistry and Molecular Biology, Graduate Program in Genes and Development, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 98:7342-7. 2001
    b>Friend of GATA (FOG) proteins regulate GATA factor-activated gene transcription. During vertebrate hematopoiesis, FOG and GATA proteins cooperate to promote erythrocyte and megakaryocyte differentiation...
  9. ncbi Dpp signaling thresholds in the dorsal ectoderm of the Drosophila embryo
    H L Ashe
    Department of Molecular and Cell Biology, Division of Genetics and Development, University of California, Berkeley, CA 94720, USA
    Development 127:3305-12. 2000
    ..We also present evidence that the activation of Dpp/Scw target genes depends on the Drosophila homolog of the CBP histone acetyltransferase...
  10. ncbi The role of brinker in mediating the graded response to Dpp in early Drosophila embryos
    A Jazwinska
    Institut fuer Entwicklungsbiologie, Universitaet zu Koeln, Gyrhofstr 17, Germany
    Development 126:3323-34. 1999
    ..Here, both brk and sog antagonize the antineurogenic activity of Dpp so that only in brk sog double mutants is the neuroectoderm completely deleted...
  11. ncbi The Friend of GATA protein U-shaped functions as a hematopoietic tumor suppressor in Drosophila
    Richard Paul Sorrentino
    Department of Biochemistry and Molecular Biology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Dev Biol 311:311-23. 2007
    ..Here we show that the Friend of GATA (FOG) protein U-shaped (Ush) is expressed in circulating and lymph gland hemocytes, where it plays a critical ..
  12. ncbi Identification of a crystal cell-specific enhancer of the black cells prophenoloxidase gene in Drosophila
    Kathleen M Gajewski
    Department of Biochemistry and Molecular Biology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Genesis 45:200-7. 2007
    ..Thus, Srp and Lz do not just specify the crystal cell lineage, but also regulate the later differentiation of these cells. Additionally, we now have a sensitive tool for marking crystal cells in live animals...
  13. pmc Salmonella pathogenesis reveals that BMP signaling regulates blood cell homeostasis and immune responses in Drosophila
    Joel L Frandsen
    School of Life Sciences, Arizona State University, Tempe, AZ 85287 4501, USA
    Proc Natl Acad Sci U S A 105:14952-7. 2008
    ..continues with Zfh1 activation of Serpent (Srp; a GATA factor), and terminates with Srp activation of U-shaped (Ush) in hematopoietic cells. Hyperactivation of Zfh1, Srp, and Ush in dpp mutants leads to hyperplasia of plasmatocytes...
  14. pmc Preferential genome targeting of the CBP co-activator by Rel and Smad proteins in early Drosophila melanogaster embryos
    Per Henrik Holmqvist
    The Wenner Gren Institute, Developmental Biology, Stockholm University, Stockholm, Sweden
    PLoS Genet 8:e1002769. 2012
    ..We conclude that CBP occupancy in Drosophila embryos preferentially overlaps factors controlling dorso-ventral patterning and that CBP binds silent genes without causing histone hyperacetylation...
  15. pmc Lineage tracing of lamellocytes demonstrates Drosophila macrophage plasticity
    Martin Stofanko
    Institute of Biomedical Research, University of Birmingham, Edgbaston, England
    PLoS ONE 5:e14051. 2010
    ..Taken together, our data suggest that lamellocytes arise from plasmatocytes and that plasmatocytes may be inherently plastic, possessing the ability to differentiate further into lamellocytes upon appropriate challenge...
  16. doi Multiple feedback loops achieve robust localization of wingless expression in Drosophila notum development
    Ken Ichi Hironaka
    Department of Biology, Faculty of Sciences, Kyushu University, Higashi ku, Fukuoka, Japan
    J Theor Biol 292:18-29. 2012
    ..We demonstrate how the regulatory network for wingless expression realizes the conditions (i)-(iii) for its robust localization...
  17. pmc The microRNA miR-8 is a positive regulator of pigmentation and eclosion in Drosophila
    Jennifer A Kennell
    Department of Biology, Vassar College, Poughkeepsie, New York 12604, USA
    Dev Dyn 241:161-8. 2012
    ..In this study we demonstrate that miR-8 is also required for proper spatial patterning of pigment on the adult abdominal cuticle in females but not males...
  18. ncbi Amnioserosa is required for dorsal closure in Drosophila
    Anne Scuderi
    Department of Human Genetics, Eccles Institute of Human Genetics, University of Utah, Salt Lake City, Utah 84112, USA
    Dev Dyn 232:791-800. 2005
    ....
  19. ncbi Integrating transcriptional and signalling networks during muscle development
    Eileen E Furlong
    Developmental Biology and Gene Expression Programmes, EMBL, Heidelberg, Germany
    Curr Opin Genet Dev 14:343-50. 2004
    ..The integration of additional signalling inputs with localised repression within these competence domains results in diverse transcriptional responses within neighbouring cells, which in turn generates muscle diversity...
  20. pmc Cooperation between the GATA and RUNX factors Serpent and Lozenge during Drosophila hematopoiesis
    Lucas Waltzer
    Centre de Biologie du Developpement, CNRS UMR 5547, 118 route de Narbonne, 31062 Toulouse, France
    EMBO J 22:6516-25. 2003
    ..We propose that interaction and cooperation between GATA and RUNX factors may play an important role in regulating blood cell formation from Drosophila to mammals...
  21. ncbi Gradients and thresholds: BMP response gradients unveiled in Drosophila embryos
    Laurel A Raftery
    Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    Trends Genet 19:701-8. 2003
    ..The transition between two gradients of different shape yields new insights into the progression of Drosophila dorsal-ventral patterning and raises new issues about the mechanisms of gradient formation...
  22. ncbi Initial state of the Drosophila eye before dorsoventral specification is equivalent to ventral
    Amit Singh
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Development 130:6351-60. 2003
    ..Therefore, we propose that early state of the eye prior to DV lineage restriction is equivalent to ventral and requires L and Ser gene function...
  23. pmc Combinatorial interactions of serpent, lozenge, and U-shaped regulate crystal cell lineage commitment during Drosophila hematopoiesis
    Nancy Fossett
    Department of Biochemistry and Molecular Biology, Graduate Program in Genes and Development, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 100:11451-6. 2003
    ..In contrast U-shaped, a Friend of GATA class factor, antagonizes crystal cell formation...
  24. ncbi Prepattern genes and signaling molecules regulate stripe expression to specify Drosophila flight muscle attachment sites
    Arjumand Ghazi
    National Centre for Biological Sciences, Tata Institute of Fundamental Research, GKVK PO, Bangalore 560 065, India
    Mech Dev 120:519-28. 2003
    ..wg), decapentaplegic (dpp) and Notch (N) signaling pathways, and the prepattern genes pannier (pnr) and u-shaped (ush) establish domains of sr expression. N is required for initiation of sr expression...
  25. ncbi Gata factor Pannier is required to establish competence for heart progenitor formation
    Susan L Klinedinst
    Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA
    Development 130:3027-38. 2003
    ..In support, we find that manipulation of pannier activity in either germ layer affects cardiac specification, suggesting that its function is required in both the mesoderm and the ectoderm...
  26. pmc An RNA interference screen identifies Inhibitor of Apoptosis Protein 2 as a regulator of innate immune signalling in Drosophila
    Viola Gesellchen
    German Cancer Research Center DKFZ, Boveri Group Signaling and Functional Genomics, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    EMBO Rep 6:979-84. 2005
    ..Our results indicate that IAP gene family members may have acquired other functions, such as the regulation of the tumour necrosis factor-like IMD pathway during innate immune responses...
  27. ncbi Dynamics of heart differentiation, visualized utilizing heart enhancer elements of the Drosophila melanogaster bHLH transcription factor Hand
    Julia Sellin
    Universitat Osnabruck, Fachbereich Biologie Chemie Zoologie, Barbarastrasse 11, 49069 Osnabruck, Germany
    Gene Expr Patterns 6:360-75. 2006
    ....
  28. doi Type IV collagens regulate BMP signalling in Drosophila
    Xiaomeng Wang
    Faculty of Life Sciences, The University of Manchester, Oxford Road, Manchester M13 9PT, UK
    Nature 455:72-7. 2008
    ..On the basis of our findings that human type IV collagen binds BMP4, we predict that this role of type IV collagens will be conserved...
  29. pmc Characterization of a lamellocyte transcriptional enhancer located within the misshapen gene of Drosophila melanogaster
    Tsuyoshi Tokusumi
    Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana, United States of America
    PLoS ONE 4:e6429. 2009
    ....
  30. ncbi Dpp signalling orchestrates dorsal closure by regulating cell shape changes both in the amnioserosa and in the epidermis
    Beatriz García Fernández
    Instituto Gulbenkian de Ciencia, Rua da Quinta Grande 6, 2780 156 Oeiras, Portugal
    Mech Dev 124:884-97. 2007
    ..In summary, we show that Dpp plays a crucial role in coordinating the activity of the AS and its interactions with the LE cells during dorsal closure...
  31. pmc Upregulation of the Drosophila Friend of GATA gene U-shaped by JAK/STAT signaling maintains lymph gland prohemocyte potency
    Hongjuan Gao
    Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine, Room 215, 800 W Baltimore Street, Baltimore, MD 21201, USA
    Mol Cell Biol 29:6086-96. 2009
    ..In this study, we provide evidence that the Friend of GATA protein U-shaped is an important regulator of lymph gland prohemocyte potency and differentiation...
  32. pmc The GATA factor Serpent cross-regulates lozenge and u-shaped expression during Drosophila blood cell development
    Selen Muratoglu
    Center for Vascular and Inflammatory Diseases, Department of Pathology, University of Maryland, School of Medicine, 800 W Baltimore Street, Room 215, Baltimore, MD 21201, USA
    Dev Biol 311:636-49. 2007
    ..interacts with the RUNX factor Lozenge to activate the crystal cell program, whereas SerpentNC binds the Friend of GATA protein U-shaped to limit crystal cell production...
  33. doi Conserved MicroRNA miR-8/miR-200 and its target USH/FOG2 control growth by regulating PI3K
    Seogang Hyun
    School of Biological Sciences and National Creative Research Center, Seoul National University, Seoul, 151 742, Korea
    Cell 139:1096-108. 2009
    ..Here, we find that a conserved microRNA miR-8 and its target, USH, regulate body size in Drosophila...
  34. ncbi tailup, a LIM-HD gene, and Iro-C cooperate in Drosophila dorsal mesothorax specification
    Joaquín de Navascués
    Centro de Biologia Molecular Severo Ochoa, CSIC and UAM, Cantoblanco, Madrid, Spain
    Development 134:1779-88. 2007
    ..Our data support a model in which the EGFR and Dpp signalling pathways, with their respective downstream Iro-C and tup genes, converge and cooperate to commit cells to the notum developmental fate...
  35. ncbi Antagonistic and cooperative actions of the EGFR and Dpp pathways on the iroquois genes regulate Drosophila mesothorax specification and patterning
    Annalisa Letizia
    Centro de Biologia Molecular Severo Ochoa, CSIC and UAM, Cantoblanco, 28049 Madrid, Spain
    Development 134:1337-46. 2007
    ..These results help define the molecular mechanisms of the interplay between the EGFR and Dpp pathways in the specification and patterning of the notum...
  36. doi Transcriptional interactions between the pannier isoforms and the cofactor U-shaped during neural development in Drosophila
    Catherine Fromental-Ramain
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, 67404 Illkirch Cedex, France
    Mech Dev 127:442-57. 2010
    ..The cofactor U-shaped (Ush), which is known to down-regulate the function of Pnr during thorax patterning postranscriptionally, in addition ..
  37. ncbi Specialized extraembryonic cells connect embryonic and extraembryonic epidermis in response to Dpp during dorsal closure in Drosophila
    Atsushi Wada
    Laboratory for Morphogenetic Signaling, RIKEN Center for Developmental Biology, 2 2 3 Minatojima minamimachi, Chuo Ku, Kobe 650 0047, Japan
    Dev Biol 301:340-9. 2007
    ....
  38. pmc Threshold-dependent BMP-mediated repression: a model for a conserved mechanism that patterns the neuroectoderm
    Claudia Mieko Mizutani
    Section of Cell and Developmental Biology, University of California San Diego, La Jolla, California, USA
    PLoS Biol 4:e313. 2006
    ..We propose that BMPs played an ancestral role in patterning the metazoan neuroectoderm by threshold-dependent repression of neural identity genes...
  39. pmc Serpent, suppressor of hairless and U-shaped are crucial regulators of hedgehog niche expression and prohemocyte maintenance during Drosophila larval hematopoiesis
    Yumiko Tokusumi
    Department of Biological Sciences, University of Notre Dame, 147 Galvin Life Sciences Hall, Notre Dame, IN 46556, USA
    Development 137:3561-8. 2010
    ..Srp) is essential for hh activation in niche cells, whereas the Suppressor of Hairless [Su(H)] and U-shaped (Ush) transcriptional regulators prevent hh expression in blood cell progenitors and differentiated hemocytes...
  40. ncbi U-shaped protein domains required for repression of cardiac gene expression in Drosophila
    Tsuyoshi Tokusumi
    Department of Biochemistry and Molecular Biology, Program in Genes and Development, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Differentiation 75:166-74. 2007
    ..Together, these findings provide molecular insights into the function of U-shaped as a negative regulator of heart development in Drosophila...
  41. ncbi Epithelial fusions in the embryo
    Paul Martin
    Department Anatomy and Developmental Biology, University College London, UK
    Curr Opin Cell Biol 14:569-74. 2002
    ..It is now clear that there are intriguing parallels with more complex morphogenetic tissue movements in vertebrates...
  42. ncbi The hindsight gene is required for epithelial maintenance and differentiation of the tracheal system in Drosophila
    R Wilk
    Program in Developmental Biology, Research Institute, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, M5G 1X8, Canada
    Dev Biol 219:183-96. 2000
    ..These data suggest that HNT is a tissue-specific factor that regulates maintenance of the tracheal epithelium as well as differentiation of taenidia...
  43. ncbi A class of zinc fingers involved in protein-protein interactions biophysical characterization of CCHC fingers from fog and U-shaped
    J M Matthews
    Department of Biochemistry, University of Sydney, NSW, Australia
    Eur J Biochem 267:1030-8. 2000
    ..and biophysical characterization of several CCHC-type zinc fingers from the erythroid transcription factor FOG and the related Drosophila protein U-shaped...
  44. ncbi The dorsal-open group gene raw is required for restricted DJNK signaling during closure
    C L Byars
    Department of Human Genetics, Eccles Institute of Human Genetics, University of Utah, Salt Lake City, Utah 84112, USA anthea
    Development 126:4913-23. 1999
    ..Taken together, our results demonstrate a role for Raw in restriction of epidermal signaling during closure and suggest that this effect may be mediated via the amnioserosa...
  45. ncbi Conservation of neurogenic genes and mechanisms
    Y M Chan
    Howard Hughes Medical Institute Departments of Physiology and Biochemistry University of California, San Francisco 94143 0725, USA
    Curr Opin Neurobiol 9:582-8. 1999
    ..These findings pave the way for future work that will help to establish the extent to which these similarities represent evolutionary conservation...
  46. ncbi Different contributions of pannier and wingless to the patterning of the dorsal mesothorax of Drosophila
    M J García-García
    Centro de Biologia Molecular Severo Ochoa, CSIC and UAM, Cantoblanco, Spain
    Development 126:3523-32. 1999
    ..Thus, Wingless has only a permissive role on dorsocentral achaete-scute expression. We also provide evidence indicating that Pannier and U-shaped are main effectors of the regulation of wingless expression in the presumptive notum...
  47. ncbi Requirement for croquemort in phagocytosis of apoptotic cells in Drosophila
    N C Franc
    Cutaneous Biology Research Center, Laboratory of Developmental Immunology, and Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School Charlestown, MA 02129, USA
    Science 284:1991-4. 1999
    ..The expression of CRQ was regulated by the amount of apoptosis. These data define distinct pathways for the phagocytosis of corpses and bacteria in Drosophila...
  48. pmc Transcriptional cofactors of the FOG family interact with GATA proteins by means of multiple zinc fingers
    A H Fox
    Department of Biochemistry, G08, University of Sydney, NSW, 2006, Australia
    EMBO J 18:2812-22. 1999
    b>Friend of GATA-1 (FOG-1) is a zinc finger protein that has been shown to interact physically with the erythroid DNA-binding protein GATA-1 and modulate its transcriptional activity...
  49. ncbi The development and evolution of bristle patterns in Diptera
    P Simpson
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, BP 163, C U de Strasbourg, France u strasbg fr
    Development 126:1349-64. 1999
    ....
  50. pmc Transcriptional activity of pannier is regulated negatively by heterodimerization of the GATA DNA-binding domain with a cofactor encoded by the u-shaped gene of Drosophila
    M Haenlin
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique Institut National de la Santé et de la Recherche Médicale Université Louis Pasteur, 67404 Illkirch Cedex, France
    Genes Dev 11:3096-108. 1997
    The genes pannier (pnr) and u-shaped (ush) are required for the regulation of achaete-scute during establishment of the bristle pattern in Drosophila...
  51. pmc u-shaped encodes a zinc finger protein that regulates the proneural genes achaete and scute during the formation of bristles in Drosophila
    Y Cubadda
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique Institut National de la Santé et de la Recherche Médicale Université Louis Pasteur, 67404 Illkirch Cedex, France
    Genes Dev 11:3083-95. 1997
    ..A study of the sites at which the dorsocentral bristles arise in mosaic u-shaped nota, suggests that the levels of the u-shaped protein are crucial for the precise positioning of the precursors of these bristles...
  52. ncbi Control of germ-band retraction in Drosophila by the zinc-finger protein HINDSIGHT
    M L Yip
    Division of Biology, California Institute of Technology, Pasadena, USA
    Development 124:2129-41. 1997
    ..Second, hindsight might function both to maintain the amnioserosa and to regulate chemical signaling from the amnioserosa to the epidermal ectoderm, thus coordinating the cell shape changes and movements that drive germ-band retraction...
  53. ncbi Cellular pathways acting along the germband and in the amnioserosa may participate in germband retraction of the Drosophila melanogaster embryo
    R Goldman-Levi
    Hubert H Humphrey Center for Experimental Medicine and Cancer Research, Hebrew University Hadassah Medical School, Jerusalem, Israel
    Int J Dev Biol 40:1043-51. 1996
    ..While the role of the amnioserosa during germband retraction appears to be permissive, the action of DER in the germband may be mediated by the cytoskeleton...
  54. pmc A genetic analysis of pannier, a gene necessary for viability of dorsal tissues and bristle positioning in Drosophila
    P Heitzler
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Illkirch, France
    Genetics 143:1271-86. 1996
    ..A large number of alleles have been studied and reveal that pannier may have opposing effects on the expression of achaete and scute leading to a loss or a gain of bristles...
  55. ncbi A role for the mesoderm in endodermal migration and morphogenesis in Drosophila
    R Reuter
    Max Planck Institut fur Entwicklungsbiologie, Tubingen, FR Germany
    Development 119:1135-45. 1993
    ..We conclude that the visceral mesoderm serves as a substratum for the migrating endodermal cells and that the contact between visceral mesoderm and endoderm is required for the latter to become an epithelium...
  56. ncbi Cellular interactions in the developing nervous system of Drosophila
    J A Campos-Ortega
    Institut fur Entwicklungsbiologie, Universitat zu Koln, Federal Republic of Germany
    Cell 77:969-75. 1994
  57. ncbi Involvement of pannier and u-shaped in regulation of decapentaplegic-dependent wingless expression in developing Drosophila notum
    M Sato
    Department of Biophysics and Biochemistry, Graduate School of Science, University of Tokyo, Japan
    Mech Dev 93:127-38. 2000
    ..In the more lateral region, wingless expression is up-regulated by U-shaped-unbound Pannier. wingless expression is also weakly regulated by its own signaling...
  58. pmc The multitype zinc-finger protein U-shaped functions in heart cell specification in the Drosophila embryo
    N Fossett
    Department of Biochemistry and Molecular Biology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 97:7348-53. 2000
    Multitype zinc-finger proteins of the Friend of GATA/U-shaped (Ush) class function as transcriptional regulators of gene expression through their modulation of GATA factor activity...
  59. ncbi The DSmurf ubiquitin-protein ligase restricts BMP signaling spatially and temporally during Drosophila embryogenesis
    S D Podos
    Department of Molecular Genetics and Cell Biology, University of Chicago, Illinois 60637, USA
    Dev Cell 1:567-78. 2001
    ..After gastrulation, DSmurf mutations cause a temporal delay in downregulation of earlier DPP signals, resulting in a lethal defect in hindgut organogenesis...
  60. ncbi Conserved cardiogenic functions of the multitype zinc-finger proteins: U-shaped and FOG-2
    N Fossett
    Department of Biochemistry and Molecular Biology, Graduate Program in Genes and Development, The University of Texas M D Anderson Cancer Center, Houston, 77030, USA
    Trends Cardiovasc Med 11:185-90. 2001
    Multitype zinc-finger proteins murine Friend of GATA-2 (FOG-2) and Drosophila U-shaped (Ush) are required for heart development. Both FOG proteins participate in signal transduction pathways that are essential for cardiogenesis...
  61. pmc Notching up another pathway
    Keith Brennan
    School of Biological Sciences, University of Manchester, UK
    Bioessays 24:405-10. 2002
    ..In addition, they show that Wnt signalling may regulate this Deltex-dependent signal...
  62. ncbi The CtBP family: enigmatic and enzymatic transcriptional co-repressors
    J Turner
    Dept of Biochemistry, University of Sydney, Australia
    Bioessays 23:683-90. 2001
    ..Supplementary material for this article can be found on the BioEssays homepage at http://www.interscience.wiley.com/jpages/0265-9247/suppmat/v23_8.684...
  63. ncbi The transcription factor Schnurri plays a dual role in mediating Dpp signaling during embryogenesis
    J Torres-Vazquez
    Department of Developmental and Cell Biology, University of California Irvine, Irvine, CA 92697, USA
    Development 128:1657-70. 2001
    ..We find that Shn-mediated relief of brk repression establishes broad domains of gene activation, while the brk-independent input from Shn is crucial for defining the precise limits and levels of Dpp target gene expression in the embryo...
  64. ncbi How to pattern an epithelium: lessons from achaete-scute regulation on the notum of Drosophila
    Manuel Calleja
    Centro de Biologia Molecular, Universidad Autonoma de Madrid, 28049 Madrid, Spain
    Gene 292:1-12. 2002
    ..Thus there may be a common prepattern for the entire structure...
  65. ncbi The zinc finger-containing transcription factors GATA-4, -5, and -6. Ubiquitously expressed regulators of tissue-specific gene expression
    J D Molkentin
    Department of Pediatrics, University of Cincinnati, Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    J Biol Chem 275:38949-52. 2000
  66. ncbi Regulation of Drosophila wing vein patterning: net encodes a bHLH protein repressing rhomboid and is repressed by rhomboid-dependent Egfr signalling
    D Brentrup
    Institut fur Molekularbiologie, Universitat Zurich, CH 8057 Zurich, Switzerland
    Development 127:4729-41. 2000
    ..Our results further suggest that net is required to maintain intervein development by restricting Egfr signalling, which promotes vein development, to the Net-free vein regions of the wing disc...
  67. ncbi Cellular basis of the dynamic behavior of the imaginal thoracic discs during Drosophila metamorphosis
    K Usui
    Institut de Genetique et de Biologie Moleculaire et Cellulaire IGBMC, CNRS INSERM ULP, Illkirch Cedex, C U de Strasbourg, 67404, France
    Dev Biol 225:13-25. 2000
    ..Later the pro- and metathoracic discs intercalate between head and mesothorax and between abdomen and mesothorax, respectively, to reestablish the normal order...
  68. ncbi The decapentaplegic morphogen gradient regulates the notal wingless expression through induction of pannier and u-shaped in Drosophila
    Y Tomoyasu
    Division of Morphogenesis, Department of Developmental Biology, National Institute for Basic Biology, Nishigonaka Myodaijicho, 444 8585, Okazaki, Japan
    Mech Dev 96:37-49. 2000
    ....
  69. ncbi The functions of pannier during Drosophila embryogenesis
    H Herranz
    Centro de Biologia Molecular, Universidad Autonoma de Madrid, 28049 Madrid, Spain
    Development 128:4837-46. 2001
    ..These results, together with prior work on its function in adults, suggest that pnr is a major factor in the genetic subdivision of the body of Drosophila...
  70. ncbi A group of genes required for maintenance of the amnioserosa tissue in Drosophila
    L H Frank
    Department of Biology, New York University, NY 10003, USA
    Development 122:1343-52. 1996
    ..Here we show that a group of genes, which we refer to as the U-shaped-group (ush-group), is required for maintenance of the amnioserosa tissue once it has differentiated...
  71. ncbi Transcriptional regulation of hematopoiesis in Drosophila
    Cory J Evans
    Department of Molecular, Cell and Developmental Biology, University of California Los Angeles, Los Angeles, CA 90095, USA
    Blood Cells Mol Dis 30:223-8. 2003
    ..Herein, we describe the Drosophila blood cell types, their physical origin, and the transcriptional regulators that govern this process...
  72. ncbi Functional conservation of hematopoietic factors in Drosophila and vertebrates
    N Fossett
    Department of Biochemistry and Molecular Biology, Graduate Program in Genes and Development, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Differentiation 69:83-90. 2001
    The GATA, Friend of GATA, and Runt homology domain protein families function during hematopoiesis to promote progenitor cell development and regulate lineage commitment and differentiation...
  73. ncbi Blood cells of Drosophila: cell lineages and role in host defence
    Marie Meister
    Institut de Biologie Moleculaire et Cellulaire, 15 rue Rene Descartes, 67084 Strasbourg, France
    Curr Opin Immunol 16:10-5. 2004
    ..Crystal cells and lamellocytes have no clear mammalian homologues. Research into the molecular mechanisms that underlie the various immune functions of Drosophila blood cells, such as non-self recognition, is now taking wing...
  74. ncbi Investigation of leading edge formation at the interface of amnioserosa and dorsal ectoderm in the Drosophila embryo
    B E Stronach
    Department of Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
    Development 128:2905-13. 2001
    ..We propose that subsequent inductive signaling between amnioserosa and dorsal ectoderm restricts the formation of LE to a single row of cells...
  75. ncbi Role of the amnioserosa in germ band retraction of the Drosophila melanogaster embryo
    M L Lamka
    Department of Biology, University of Virginia, Charlottesville, Virginia 22903, USA
    Dev Biol 214:102-12. 1999
    ..Rather, it is likely that the amnioserosa functions in production, activation, or presentation of a diffusible signal required for retraction...
  76. ncbi pannier acts upstream of wingless to direct dorsal eye disc development in Drosophila
    C Maurel-Zaffran
    Skirball Institute of Biomolecular Medicine and Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA
    Development 127:1007-16. 2000
    ..Pannier is thus the most upstream element yet described in dorsoventral patterning of the eye disc...
  77. ncbi Regulation of Drosophila friend of GATA gene, u-shaped, during hematopoiesis: a direct role for serpent and lozenge
    Selen Muratoglu
    Center for Vascular and Inflammatory Diseases and the Department of Pathology, University of Maryland School of Medicine, 800 W Baltimore Street, Baltimore, MD 21201, USA
    Dev Biol 296:561-79. 2006
    b>Friend of GATA proteins interact with GATA factors to regulate development in a variety of tissues...

Research Grants10

  1. TGF-BETA FAMILY REGULATION OF EPITHELIAL MORPHOGENESIS
    Laurel Raftery; Fiscal Year: 2009
    ..PUBLIC HEALTH RELEVANCE: Protein signals move between cells to coordinate decisions. We study how these signals make cells do the right thing at the right time. ..
  2. TGF-BETA FAMILY REGULATION OF EPITHELIAL MORPHOGENESIS
    Laurel Raftery; Fiscal Year: 2007
    ..abstract_text> ..
  3. TGF-BETA FAMILY REGULATION OF EPITHELIAL MORPHOGENESIS
    Laurel Raftery; Fiscal Year: 2004
    ....
  4. TGF-BETA FAMILY REGULATION OF EPITHELIAL MORPHOGENESIS
    Laurel Raftery; Fiscal Year: 2009
    ..PUBLIC HEALTH RELEVANCE: Protein signals move between cells to coordinate decisions. We study how these signals make cells do the right thing at the right time. ..