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Genomes and Genes | ushSummaryGene Symbol: ush Description: u-shaped Alias: CG2762, Dmel\CG2762, FOG, Ush, ZFPM2, dFOG, l(2)19, u-sh, ushaped, CG2762-PA, CG2762-PB, CG2762-PC, CG2762-PD, CG2762-PE, U-shaped, drosophila friend of GATA, friend of GATA, ush-PA, ush-PB, ush-PC, ush-PD, ush-PE, ushaped Species: fruit fly Top Publications
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Publications
The angle of the dorsoventral axis with respect to the anteroposterior axis in the Drosophila embryo is controlled by the distribution of gurken mRNA in the oocyteM Haenlin
Laboratoire de Genetique Moleculaire des Eucaryotes du CNRS, Unite 184 de Biologie Moleculaire et de Genie Genetique de l INSERM, Faculte de Medecine, Strasbourg, France
Mech Dev 49:97-106. 1995..The alteration of the embryonic fate map could be traced back to oogenesis where it was shown to correlate with the mislocalization of the grk transcripts...- GETDB, a database compiling expression patterns and molecular locations of a collection of Gal4 enhancer trapsShigeo Hayashi
National Institute of Genetics, Mishima, Shizuoka-ken, Japan
Genesis 34:58-61. 2002 - Differences in sensory projections between macro- and microchaetes in Drosophilid fliesAkiko Usui-Ishihara
Department of Zoology, University of Cambridge, Cambridge CB2 3EJ, United Kingdom
Dev Biol 277:170-83. 2005..We discuss the possibility that macro- and microchaetes may have different functions and that these have implications for evolutionary constraints on bristle patterns... 
CtBP is required for proper development of peripheral nervous system in DrosophilaMark D Stern
Department of Cell and Developmental Biology, Weill Medical College of Cornell University, New York, NY 10065, USA
Mech Dev 126:68-79. 2009..We therefore propose that dCtBP is part of a gene circuitry that controls the patterning and differentiation of the fly PNS via multiple mechanisms...- The Friend of GATA protein U-shaped functions as a hematopoietic tumor suppressor in DrosophilaRichard Paul Sorrentino
Department of Biochemistry and Molecular Biology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
Dev Biol 311:311-23. 2007..Here we show that the Friend of GATA (FOG) protein U-shaped (Ush) is expressed in circulating and lymph gland hemocytes, where it plays a critical .. - Identification of a crystal cell-specific enhancer of the black cells prophenoloxidase gene in DrosophilaKathleen M Gajewski
Department of Biochemistry and Molecular Biology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Genesis 45:200-7. 2007..Thus, Srp and Lz do not just specify the crystal cell lineage, but also regulate the later differentiation of these cells. Additionally, we now have a sensitive tool for marking crystal cells in live animals... 
Salmonella pathogenesis reveals that BMP signaling regulates blood cell homeostasis and immune responses in DrosophilaJoel L Frandsen
School of Life Sciences, Arizona State University, Tempe, AZ 85287 4501, USA
Proc Natl Acad Sci U S A 105:14952-7. 2008..continues with Zfh1 activation of Serpent (Srp; a GATA factor), and terminates with Srp activation of U-shaped (Ush) in hematopoietic cells. Hyperactivation of Zfh1, Srp, and Ush in dpp mutants leads to hyperplasia of plasmatocytes...- The role of brinker in mediating the graded response to Dpp in early Drosophila embryosA Jazwinska
Institut fuer Entwicklungsbiologie, Universitaet zu Koeln, Gyrhofstr 17, Germany
Development 126:3323-34. 1999..Here, both brk and sog antagonize the antineurogenic activity of Dpp so that only in brk sog double mutants is the neuroectoderm completely deleted... - Cooperation between the GATA and RUNX factors Serpent and Lozenge during Drosophila hematopoiesisLucas Waltzer
Centre de Biologie du Developpement, CNRS UMR 5547, 118 route de Narbonne, 31062 Toulouse, France
EMBO J 22:6516-25. 2003..We propose that interaction and cooperation between GATA and RUNX factors may play an important role in regulating blood cell formation from Drosophila to mammals... - Integrating transcriptional and signalling networks during muscle developmentEileen E Furlong
Developmental Biology and Gene Expression Programmes, EMBL, Heidelberg, Germany
Curr Opin Genet Dev 14:343-50. 2004..The integration of additional signalling inputs with localised repression within these competence domains results in diverse transcriptional responses within neighbouring cells, which in turn generates muscle diversity... - Amnioserosa is required for dorsal closure in DrosophilaAnne Scuderi
Department of Human Genetics, Eccles Institute of Human Genetics, University of Utah, Salt Lake City, Utah 84112, USA
Dev Dyn 232:791-800. 2005.... - An RNA interference screen identifies Inhibitor of Apoptosis Protein 2 as a regulator of innate immune signalling in DrosophilaViola Gesellchen
German Cancer Research Center DKFZ, Boveri Group Signaling and Functional Genomics, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
EMBO Rep 6:979-84. 2005..Our results indicate that IAP gene family members may have acquired other functions, such as the regulation of the tumour necrosis factor-like IMD pathway during innate immune responses... - Gradients and thresholds: BMP response gradients unveiled in Drosophila embryosLaurel A Raftery
Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
Trends Genet 19:701-8. 2003..The transition between two gradients of different shape yields new insights into the progression of Drosophila dorsal-ventral patterning and raises new issues about the mechanisms of gradient formation... - Initial state of the Drosophila eye before dorsoventral specification is equivalent to ventralAmit Singh
Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Development 130:6351-60. 2003..Therefore, we propose that early state of the eye prior to DV lineage restriction is equivalent to ventral and requires L and Ser gene function... - Combinatorial interactions of serpent, lozenge, and U-shaped regulate crystal cell lineage commitment during Drosophila hematopoiesisNancy Fossett
Department of Biochemistry and Molecular Biology, Graduate Program in Genes and Development, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Proc Natl Acad Sci U S A 100:11451-6. 2003..In contrast U-shaped, a Friend of GATA class factor, antagonizes crystal cell formation... - Prepattern genes and signaling molecules regulate stripe expression to specify Drosophila flight muscle attachment sitesArjumand Ghazi
National Centre for Biological Sciences, Tata Institute of Fundamental Research, GKVK PO, Bangalore 560 065, India
Mech Dev 120:519-28. 2003..wg), decapentaplegic (dpp) and Notch (N) signaling pathways, and the prepattern genes pannier (pnr) and u-shaped (ush) establish domains of sr expression. N is required for initiation of sr expression... - Gata factor Pannier is required to establish competence for heart progenitor formationSusan L Klinedinst
Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA
Development 130:3027-38. 2003..In support, we find that manipulation of pannier activity in either germ layer affects cardiac specification, suggesting that its function is required in both the mesoderm and the ectoderm... - Two isoforms of Serpent containing either one or two GATA zinc fingers have different roles in Drosophila haematopoiesisLucas Waltzer
Centre de Biologie du Développement CNRS, 31062 Toulouse, France
EMBO J 21:5477-86. 2002..of the N-finger stabilizes the interaction of Srp with palindromic GATA sites and allows interaction with the Friend of GATA factor U-shaped (Ush)... - Epithelial fusions in the embryoPaul Martin
Department Anatomy and Developmental Biology, University College London, UK
Curr Opin Cell Biol 14:569-74. 2002..It is now clear that there are intriguing parallels with more complex morphogenetic tissue movements in vertebrates... - How to pattern an epithelium: lessons from achaete-scute regulation on the notum of DrosophilaManuel Calleja
Centro de Biologia Molecular, Universidad Autonoma de Madrid, 28049 Madrid, Spain
Gene 292:1-12. 2002..Thus there may be a common prepattern for the entire structure... - Serpent, suppressor of hairless and U-shaped are crucial regulators of hedgehog niche expression and prohemocyte maintenance during Drosophila larval hematopoiesisYumiko Tokusumi
Department of Biological Sciences, University of Notre Dame, 147 Galvin Life Sciences Hall, Notre Dame, IN 46556, USA
Development 137:3561-8. 2010..Srp) is essential for hh activation in niche cells, whereas the Suppressor of Hairless [Su(H)] and U-shaped (Ush) transcriptional regulators prevent hh expression in blood cell progenitors and differentiated hemocytes... - Threshold-dependent BMP-mediated repression: a model for a conserved mechanism that patterns the neuroectodermClaudia Mieko Mizutani
Section of Cell and Developmental Biology, University of California San Diego, La Jolla, California, USA
PLoS Biol 4:e313. 2006..We propose that BMPs played an ancestral role in patterning the metazoan neuroectoderm by threshold-dependent repression of neural identity genes... - Transcriptional interactions between the pannier isoforms and the cofactor U-shaped during neural development in DrosophilaCatherine Fromental-Ramain
Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, 67404 Illkirch Cedex, France
Mech Dev 127:442-57. 2010..The cofactor U-shaped (Ush), which is known to down-regulate the function of Pnr during thorax patterning postranscriptionally, in addition .. - Conserved MicroRNA miR-8/miR-200 and its target USH/FOG2 control growth by regulating PI3KSeogang Hyun
School of Biological Sciences and National Creative Research Center, Seoul National University, Seoul, 151 742, Korea
Cell 139:1096-108. 2009..Here, we find that a conserved microRNA miR-8 and its target, USH, regulate body size in Drosophila... - Upregulation of the Drosophila Friend of GATA gene U-shaped by JAK/STAT signaling maintains lymph gland prohemocyte potencyHongjuan Gao
Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine, Room 215, 800 W Baltimore Street, Baltimore, MD 21201, USA
Mol Cell Biol 29:6086-96. 2009..In this study, we provide evidence that the Friend of GATA protein U-shaped is an important regulator of lymph gland prohemocyte potency and differentiation... - Characterization of a lamellocyte transcriptional enhancer located within the misshapen gene of Drosophila melanogasterTsuyoshi Tokusumi
Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana, United States of America
PLoS ONE 4:e6429. 2009.... - Type IV collagens regulate BMP signalling in DrosophilaXiaomeng Wang
Faculty of Life Sciences, The University of Manchester, Oxford Road, Manchester M13 9PT, UK
Nature 455:72-7. 2008..On the basis of our findings that human type IV collagen binds BMP4, we predict that this role of type IV collagens will be conserved... - Dpp signalling orchestrates dorsal closure by regulating cell shape changes both in the amnioserosa and in the epidermisBeatriz García Fernández
Instituto Gulbenkian de Ciencia, Rua da Quinta Grande 6, 2780 156 Oeiras, Portugal
Mech Dev 124:884-97. 2007..In summary, we show that Dpp plays a crucial role in coordinating the activity of the AS and its interactions with the LE cells during dorsal closure... - Dynamics of heart differentiation, visualized utilizing heart enhancer elements of the Drosophila melanogaster bHLH transcription factor HandJulia Sellin
Universitat Osnabruck, Fachbereich Biologie Chemie Zoologie, Barbarastrasse 11, 49069 Osnabruck, Germany
Gene Expr Patterns 6:360-75. 2006.... - The GATA factor Serpent cross-regulates lozenge and u-shaped expression during Drosophila blood cell developmentSelen Muratoglu
Center for Vascular and Inflammatory Diseases, Department of Pathology, University of Maryland, School of Medicine, 800 W Baltimore Street, Room 215, Baltimore, MD 21201, USA
Dev Biol 311:636-49. 2007..interacts with the RUNX factor Lozenge to activate the crystal cell program, whereas SerpentNC binds the Friend of GATA protein U-shaped to limit crystal cell production... - tailup, a LIM-HD gene, and Iro-C cooperate in Drosophila dorsal mesothorax specificationJoaquín de Navascués
Centro de Biologia Molecular Severo Ochoa, CSIC and UAM, Cantoblanco, Madrid, Spain
Development 134:1779-88. 2007..Our data support a model in which the EGFR and Dpp signalling pathways, with their respective downstream Iro-C and tup genes, converge and cooperate to commit cells to the notum developmental fate... - Antagonistic and cooperative actions of the EGFR and Dpp pathways on the iroquois genes regulate Drosophila mesothorax specification and patterningAnnalisa Letizia
Centro de Biologia Molecular Severo Ochoa, CSIC and UAM, Cantoblanco, 28049 Madrid, Spain
Development 134:1337-46. 2007..These results help define the molecular mechanisms of the interplay between the EGFR and Dpp pathways in the specification and patterning of the notum... - U-shaped protein domains required for repression of cardiac gene expression in DrosophilaTsuyoshi Tokusumi
Department of Biochemistry and Molecular Biology, Program in Genes and Development, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
Differentiation 75:166-74. 2007..Together, these findings provide molecular insights into the function of U-shaped as a negative regulator of heart development in Drosophila... - Specialized extraembryonic cells connect embryonic and extraembryonic epidermis in response to Dpp during dorsal closure in DrosophilaAtsushi Wada
Laboratory for Morphogenetic Signaling, RIKEN Center for Developmental Biology, 2 2 3 Minatojima minamimachi, Chuo Ku, Kobe 650 0047, Japan
Dev Biol 301:340-9. 2007.... - Notching up another pathwayKeith Brennan
School of Biological Sciences, University of Manchester, UK
Bioessays 24:405-10. 2002..In addition, they show that Wnt signalling may regulate this Deltex-dependent signal... - A class of zinc fingers involved in protein-protein interactions biophysical characterization of CCHC fingers from fog and U-shapedJ M Matthews
Department of Biochemistry, University of Sydney, NSW, Australia
Eur J Biochem 267:1030-8. 2000..and biophysical characterization of several CCHC-type zinc fingers from the erythroid transcription factor FOG and the related Drosophila protein U-shaped... - The dorsal-open group gene raw is required for restricted DJNK signaling during closureC L Byars
Department of Human Genetics, Eccles Institute of Human Genetics, University of Utah, Salt Lake City, Utah 84112, USA anthea
Development 126:4913-23. 1999..Taken together, our results demonstrate a role for Raw in restriction of epidermal signaling during closure and suggest that this effect may be mediated via the amnioserosa... - Conservation of neurogenic genes and mechanismsY M Chan
Howard Hughes Medical Institute Departments of Physiology and Biochemistry University of California, San Francisco 94143 0725, USA
Curr Opin Neurobiol 9:582-8. 1999..These findings pave the way for future work that will help to establish the extent to which these similarities represent evolutionary conservation... - Different contributions of pannier and wingless to the patterning of the dorsal mesothorax of DrosophilaM J García-García
Centro de Biologia Molecular Severo Ochoa, CSIC and UAM, Cantoblanco, Spain
Development 126:3523-32. 1999..Thus, Wingless has only a permissive role on dorsocentral achaete-scute expression. We also provide evidence indicating that Pannier and U-shaped are main effectors of the regulation of wingless expression in the presumptive notum... - Requirement for croquemort in phagocytosis of apoptotic cells in DrosophilaN C Franc
Cutaneous Biology Research Center, Laboratory of Developmental Immunology, and Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School Charlestown, MA 02129, USA
Science 284:1991-4. 1999..The expression of CRQ was regulated by the amount of apoptosis. These data define distinct pathways for the phagocytosis of corpses and bacteria in Drosophila... - Transcriptional cofactors of the FOG family interact with GATA proteins by means of multiple zinc fingersA H Fox
Department of Biochemistry, G08, University of Sydney, NSW, 2006, Australia
EMBO J 18:2812-22. 1999b>Friend of GATA-1 (FOG-1) is a zinc finger protein that has been shown to interact physically with the erythroid DNA-binding protein GATA-1 and modulate its transcriptional activity... - The development and evolution of bristle patterns in DipteraP Simpson
Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, BP 163, C U de Strasbourg, France u strasbg fr
Development 126:1349-64. 1999.... - Transcriptional activity of pannier is regulated negatively by heterodimerization of the GATA DNA-binding domain with a cofactor encoded by the u-shaped gene of DrosophilaM Haenlin
Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique Institut National de la Santé et de la Recherche Médicale Université Louis Pasteur, 67404 Illkirch Cedex, France
Genes Dev 11:3096-108. 1997The genes pannier (pnr) and u-shaped (ush) are required for the regulation of achaete-scute during establishment of the bristle pattern in Drosophila... - u-shaped encodes a zinc finger protein that regulates the proneural genes achaete and scute during the formation of bristles in DrosophilaY Cubadda
Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique Institut National de la Santé et de la Recherche Médicale Université Louis Pasteur, 67404 Illkirch Cedex, France
Genes Dev 11:3083-95. 1997..A study of the sites at which the dorsocentral bristles arise in mosaic u-shaped nota, suggests that the levels of the u-shaped protein are crucial for the precise positioning of the precursors of these bristles... - Control of germ-band retraction in Drosophila by the zinc-finger protein HINDSIGHTM L Yip
Division of Biology, California Institute of Technology, Pasadena, USA
Development 124:2129-41. 1997..Second, hindsight might function both to maintain the amnioserosa and to regulate chemical signaling from the amnioserosa to the epidermal ectoderm, thus coordinating the cell shape changes and movements that drive germ-band retraction... - Cellular pathways acting along the germband and in the amnioserosa may participate in germband retraction of the Drosophila melanogaster embryoR Goldman-Levi
Hubert H Humphrey Center for Experimental Medicine and Cancer Research, Hebrew University Hadassah Medical School, Jerusalem, Israel
Int J Dev Biol 40:1043-51. 1996..While the role of the amnioserosa during germband retraction appears to be permissive, the action of DER in the germband may be mediated by the cytoskeleton... - A genetic analysis of pannier, a gene necessary for viability of dorsal tissues and bristle positioning in DrosophilaP Heitzler
Institut de Genetique et de Biologie Moleculaire et Cellulaire, Illkirch, France
Genetics 143:1271-86. 1996..A large number of alleles have been studied and reveal that pannier may have opposing effects on the expression of achaete and scute leading to a loss or a gain of bristles... - A role for the mesoderm in endodermal migration and morphogenesis in DrosophilaR Reuter
Max Planck Institut fur Entwicklungsbiologie, Tubingen, FR Germany
Development 119:1135-45. 1993..We conclude that the visceral mesoderm serves as a substratum for the migrating endodermal cells and that the contact between visceral mesoderm and endoderm is required for the latter to become an epithelium... - Cellular interactions in the developing nervous system of DrosophilaJ A Campos-Ortega
, , Federal Republic of Germany
Cell 77:969-75. 1994 - The hindsight gene is required for epithelial maintenance and differentiation of the tracheal system in DrosophilaR Wilk
Program in Developmental Biology, Research Institute, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, M5G 1X8, Canada
Dev Biol 219:183-96. 2000..These data suggest that HNT is a tissue-specific factor that regulates maintenance of the tracheal epithelium as well as differentiation of taenidia... - Involvement of pannier and u-shaped in regulation of decapentaplegic-dependent wingless expression in developing Drosophila notumM Sato
Department of Biophysics and Biochemistry, Graduate School of Science, University of Tokyo, Japan
Mech Dev 93:127-38. 2000..In the more lateral region, wingless expression is up-regulated by U-shaped-unbound Pannier. wingless expression is also weakly regulated by its own signaling... - The zinc finger-containing transcription factors GATA-4, -5, and -6. Ubiquitously expressed regulators of tissue-specific gene expressionJ D Molkentin
Department of Pediatrics, University of Cincinnati, Children's Hospital Medical Center, Cincinnati, Ohio 45229-3039, USA
J Biol Chem 275:38949-52. 2000 - The transcription factor Schnurri plays a dual role in mediating Dpp signaling during embryogenesisJ Torres-Vazquez
Department of Developmental and Cell Biology, University of California Irvine, Irvine, CA 92697, USA
Development 128:1657-70. 2001..We find that Shn-mediated relief of brk repression establishes broad domains of gene activation, while the brk-independent input from Shn is crucial for defining the precise limits and levels of Dpp target gene expression in the embryo... - The CtBP family: enigmatic and enzymatic transcriptional co-repressorsJ Turner
Dept of Biochemistry, University of Sydney, Australia
Bioessays 23:683-90. 2001..Supplementary material for this article can be found on the BioEssays homepage at http://www.interscience.wiley.com/jpages/0265-9247/suppmat/v23_8.684... - Regulation of Drosophila wing vein patterning: net encodes a bHLH protein repressing rhomboid and is repressed by rhomboid-dependent Egfr signallingD Brentrup
Institut fur Molekularbiologie, Universitat Zurich, CH 8057 Zurich, Switzerland
Development 127:4729-41. 2000..Our results further suggest that net is required to maintain intervein development by restricting Egfr signalling, which promotes vein development, to the Net-free vein regions of the wing disc... - Cellular basis of the dynamic behavior of the imaginal thoracic discs during Drosophila metamorphosisK Usui
Institut de Genetique et de Biologie Moleculaire et Cellulaire IGBMC, CNRS INSERM ULP, Illkirch Cedex, C U de Strasbourg, 67404, France
Dev Biol 225:13-25. 2000..Later the pro- and metathoracic discs intercalate between head and mesothorax and between abdomen and mesothorax, respectively, to reestablish the normal order... - The decapentaplegic morphogen gradient regulates the notal wingless expression through induction of pannier and u-shaped in DrosophilaY Tomoyasu
Division of Morphogenesis, Department of Developmental Biology, National Institute for Basic Biology, Nishigonaka Myodaijicho, 444 8585, Okazaki, Japan
Mech Dev 96:37-49. 2000.... - Conserved cardiogenic functions of the multitype zinc-finger proteins: U-shaped and FOG-2N Fossett
Department of Biochemistry and Molecular Biology, Graduate Program in Genes and Development, The University of Texas M D Anderson Cancer Center, Houston, 77030, USA
Trends Cardiovasc Med 11:185-90. 2001Multitype zinc-finger proteins murine Friend of GATA-2 (FOG-2) and Drosophila U-shaped (Ush) are required for heart development. Both FOG proteins participate in signal transduction pathways that are essential for cardiogenesis... - The DSmurf ubiquitin-protein ligase restricts BMP signaling spatially and temporally during Drosophila embryogenesisS D Podos
Department of Molecular Genetics and Cell Biology, University of Chicago, Illinois 60637, USA
Dev Cell 1:567-78. 2001..After gastrulation, DSmurf mutations cause a temporal delay in downregulation of earlier DPP signals, resulting in a lethal defect in hindgut organogenesis... - The functions of pannier during Drosophila embryogenesisH Herranz
Centro de Biologia Molecular, Universidad Autonoma de Madrid, 28049 Madrid, Spain
Development 128:4837-46. 2001..These results, together with prior work on its function in adults, suggest that pnr is a major factor in the genetic subdivision of the body of Drosophila... - The multitype zinc-finger protein U-shaped functions in heart cell specification in the Drosophila embryoN Fossett
Department of Biochemistry and Molecular Biology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
Proc Natl Acad Sci U S A 97:7348-53. 2000Multitype zinc-finger proteins of the Friend of GATA/U-shaped (Ush) class function as transcriptional regulators of gene expression through their modulation of GATA factor activity... - The Friend of GATA proteins U-shaped, FOG-1, and FOG-2 function as negative regulators of blood, heart, and eye development in DrosophilaN Fossett
Department of Biochemistry and Molecular Biology, Graduate Program in Genes and Development, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Proc Natl Acad Sci U S A 98:7342-7. 2001b>Friend of GATA (FOG) proteins regulate GATA factor-activated gene transcription. During vertebrate hematopoiesis, FOG and GATA proteins cooperate to promote erythrocyte and megakaryocyte differentiation... - Investigation of leading edge formation at the interface of amnioserosa and dorsal ectoderm in the Drosophila embryoB E Stronach
Department of Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
Development 128:2905-13. 2001..We propose that subsequent inductive signaling between amnioserosa and dorsal ectoderm restricts the formation of LE to a single row of cells... - A group of genes required for maintenance of the amnioserosa tissue in DrosophilaL H Frank
Department of Biology, New York University, NY 10003, USA
Development 122:1343-52. 1996..Here we show that a group of genes, which we refer to as the U-shaped-group (ush-group), is required for maintenance of the amnioserosa tissue once it has differentiated... - Transcriptional regulation of hematopoiesis in DrosophilaCory J Evans
Department of Molecular, Cell and Developmental Biology, University of California Los Angeles, Los Angeles, CA 90095, USA
Blood Cells Mol Dis 30:223-8. 2003..Herein, we describe the Drosophila blood cell types, their physical origin, and the transcriptional regulators that govern this process... - The Drosophila lymph gland as a developmental model of hematopoiesisSeung Hye Jung
Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA 90095, USA
Development 132:2521-33. 2005..The cellular events identified in this analysis further establish Drosophila as a model system for hematopoiesis... - Role of the amnioserosa in germ band retraction of the Drosophila melanogaster embryoM L Lamka
Department of Biology, University of Virginia, Charlottesville, Virginia 22903, USA
Dev Biol 214:102-12. 1999..Rather, it is likely that the amnioserosa functions in production, activation, or presentation of a diffusible signal required for retraction... - Blood cells of Drosophila: cell lineages and role in host defenceMarie Meister
Institut de Biologie Moleculaire et Cellulaire, 15 rue Rene Descartes, 67084 Strasbourg, France
Curr Opin Immunol 16:10-5. 2004..Crystal cells and lamellocytes have no clear mammalian homologues. Research into the molecular mechanisms that underlie the various immune functions of Drosophila blood cells, such as non-self recognition, is now taking wing... - pannier acts upstream of wingless to direct dorsal eye disc development in DrosophilaC Maurel-Zaffran
Skirball Institute of Biomolecular Medicine and Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA
Development 127:1007-16. 2000..Pannier is thus the most upstream element yet described in dorsoventral patterning of the eye disc... - Regulation of Drosophila friend of GATA gene, u-shaped, during hematopoiesis: a direct role for serpent and lozengeSelen Muratoglu
Center for Vascular and Inflammatory Diseases and the Department of Pathology, University of Maryland School of Medicine, 800 W Baltimore Street, Baltimore, MD 21201, USA
Dev Biol 296:561-79. 2006b>Friend of GATA proteins interact with GATA factors to regulate development in a variety of tissues... - Dpp signaling thresholds in the dorsal ectoderm of the Drosophila embryoH L Ashe
Department of Molecular and Cell Biology, Division of Genetics and Development, University of California, Berkeley, CA 94720, USA
Development 127:3305-12. 2000..We also present evidence that the activation of Dpp/Scw target genes depends on the Drosophila homolog of the CBP histone acetyltransferase... - Functional conservation of hematopoietic factors in Drosophila and vertebratesN Fossett
Department of Biochemistry and Molecular Biology, Graduate Program in Genes and Development, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
Differentiation 69:83-90. 2001The GATA, Friend of GATA, and Runt homology domain protein families function during hematopoiesis to promote progenitor cell development and regulate lineage commitment and differentiation...
Research Grants
- TGF-BETA FAMILY REGULATION OF EPITHELIAL MORPHOGENESISLaurel Raftery; Fiscal Year: 2009..PUBLIC HEALTH RELEVANCE: Protein signals move between cells to coordinate decisions. We study how these signals make cells do the right thing at the right time. ..
- TGF-BETA FAMILY REGULATION OF EPITHELIAL MORPHOGENESISLaurel Raftery; Fiscal Year: 2007..abstract_text> ..
- TGF-BETA FAMILY REGULATION OF EPITHELIAL MORPHOGENESISLaurel Raftery; Fiscal Year: 2004....
- TGF-BETA FAMILY REGULATION OF EPITHELIAL MORPHOGENESISLaurel Raftery; Fiscal Year: 2009..PUBLIC HEALTH RELEVANCE: Protein signals move between cells to coordinate decisions. We study how these signals make cells do the right thing at the right time. ..