UQCR-C1

Summary

Gene Symbol: UQCR-C1
Description: Ubiquinol-cytochrome c reductase core protein 1
Alias: CG 3731, CG3731, Dmel\CG3731, MPPB, Mpp, UCR1, Ubiquinol-cytochrome c reductase core protein 1, CG3731-PA, CG3731-PB, UQCR-C1-PA, UQCR-C1-PB, Ubiquinol-cytochrome C reductase complex core protein I, Ubiquinol-cytochrome c oxidoreductase core protein 1, mitochondrial processing peptidase beta subunit, mitochondrial-processing protease
Species: fruit fly

Top Publications

  1. Loncle N, Boube M, Joulia L, Boschiero C, Werner M, Cribbs D, et al. Distinct roles for Mediator Cdk8 module subunits in Drosophila development. EMBO J. 2007;26:1045-54 pubmed
    ..These data reveal functional attributes of the Cdk8 module, apart from its regulated kinase activity, that may contribute to the diversification of genetic programs. ..
  2. Zhang W, Zou S, Song J. Term-tissue specific models for prediction of gene ontology biological processes using transcriptional profiles of aging in drosophila melanogaster. BMC Bioinformatics. 2008;9:129 pubmed publisher
    ..p < 0.01). This finding may be important in biology because the genes of mitochondria play a critical role in the longevity of C. elegans and D. melanogaster. ..
  3. Fernandez Ayala D, Sanz A, Vartiainen S, Kemppainen K, Babusiak M, Mustalahti E, et al. Expression of the Ciona intestinalis alternative oxidase (AOX) in Drosophila complements defects in mitochondrial oxidative phosphorylation. Cell Metab. 2009;9:449-60 pubmed publisher
    ..AOX appears to offer promise as a wide-spectrum therapeutic tool in OXPHOS disorders. ..
  4. Teixeira F, Sanchez C, Hurd T, Seifert J, Czech B, Preall J, et al. ATP synthase promotes germ cell differentiation independent of oxidative phosphorylation. Nat Cell Biol. 2015;17:689-96 pubmed publisher
    ..Taken together, our results suggest that ATP synthase-dependent crista maturation is a key developmental process required for differentiation independent of oxidative phosphorylation. ..
  5. McGurk L, Bonini N. Protein interacting with C kinase (PICK1) is a suppressor of spinocerebellar ataxia 3-associated neurodegeneration in Drosophila. Hum Mol Genet. 2012;21:76-84 pubmed publisher
    ..These findings indicate that interaction proteins may define a rich source of modifier pathways to target in disease situations. ..
  6. Sing A, Tsatskis Y, Fabian L, Hester I, Rosenfeld R, Serricchio M, et al. The atypical cadherin fat directly regulates mitochondrial function and metabolic state. Cell. 2014;158:1293-1308 pubmed publisher
    ..Defects in mitochondrial activity in ft mutants are independent of Hippo and PCP signaling and are reminiscent of the Warburg effect. ..