upd1

Summary

Gene Symbol: upd1
Description: unpaired 1
Alias: CG5993, Dmel\CG5993, UPD, Upd, Upd1, l(1)YC43, l(1)YM55, odsy, sis-C, sis-c, sisC, unp, upa, upd, unpaired 1, CG5993-PA, CG5993-PB, CG5993-PC, Unpaired/Out-stretched, outstretched, outstretched small eye, outstretched-smalleye, sisterless c, small-eye, unpaired, upd homolog, upd1-PA, upd1-PB, upd1-PC
Species: fruit fly

Top Publications

  1. Bartscherer K, Pelte N, Ingelfinger D, Boutros M. Secretion of Wnt ligands requires Evi, a conserved transmembrane protein. Cell. 2006;125:523-33 pubmed
    ..Our results show that Wg is retained by evi mutant cells and suggest that evi is the founding member of a gene family specifically required for Wg/Wnt secretion. ..
  2. Li Z, Zhang Y, Han L, Shi L, Lin X. Trachea-derived dpp controls adult midgut homeostasis in Drosophila. Dev Cell. 2013;24:133-43 pubmed publisher
    ..This work will provide important insights into the mechanisms of tissue homeostasis control by interorgan communication...
  3. Boyle M, Wong C, Rocha M, Jones D. Decline in self-renewal factors contributes to aging of the stem cell niche in the Drosophila testis. Cell Stem Cell. 2007;1:470-8 pubmed publisher
    ..older males display reduced expression of the cell adhesion molecule DE-cadherin and a key self-renewal signal unpaired (upd). Loss of upd correlates with an overall decrease in stem cells residing within the niche...
  4. Agaisse H, Petersen U, Boutros M, Mathey Prevot B, Perrimon N. Signaling role of hemocytes in Drosophila JAK/STAT-dependent response to septic injury. Dev Cell. 2003;5:441-50 pubmed
    ..We show that septic injury triggers the hemocyte-specific expression of upd3, a gene encoding a novel Upd-like cytokine that is necessary for the JAK/STAT-dependent activation of totA in the Drosophila counterpart of the ..
  5. Wu M, Pastor Pareja J, Xu T. Interaction between Ras(V12) and scribbled clones induces tumour growth and invasion. Nature. 2010;463:545-8 pubmed publisher
    ..Given the conservation of the pathways examined here, similar cooperative mechanisms could have a role in the development of human cancers. ..
  6. Apidianakis Y, Rahme L. Drosophila melanogaster as a model for human intestinal infection and pathology. Dis Model Mech. 2011;4:21-30 pubmed publisher
    ..In this Perspective, we discuss recent advances in the study of Drosophila intestinal infection and pathology, and briefly review the parallels and differences between human and Drosophila intestinal regeneration and disease. ..
  7. Rodrigues A, Zoranovic T, Ayala Camargo A, Grewal S, Reyes Robles T, Krasny M, et al. Activated STAT regulates growth and induces competitive interactions independently of Myc, Yorkie, Wingless and ribosome biogenesis. Development. 2012;139:4051-61 pubmed publisher
    ..As hyper-activated STATs are causal to tumorigenesis and stem cell niche occupancy, our results have therapeutic implications for cancer and regenerative medicine. ..
  8. Lovegrove B, Simoes S, Rivas M, Sotillos S, Johnson K, Knust E, et al. Coordinated control of cell adhesion, polarity, and cytoskeleton underlies Hox-induced organogenesis in Drosophila. Curr Biol. 2006;16:2206-16 pubmed
    ..We propose that during animal development, Hox-controlled genetic cascades coordinate the local cell-specific behaviors that result in organogenesis of segment-specific structures. ..
  9. Herz H, Chen Z, Scherr H, Lackey M, Bolduc C, Bergmann A. vps25 mosaics display non-autonomous cell survival and overgrowth, and autonomous apoptosis. Development. 2006;133:1871-80 pubmed
    ..In summary, the phenotypic analysis of vps25 mutants highlights the importance of receptor downregulation by endosomal protein sorting for appropriate tissue homeostasis, and may serve as a model for human cancer. ..

More Information

Publications76

  1. Ohsawa S, Sato Y, Enomoto M, Nakamura M, Betsumiya A, Igaki T. Mitochondrial defect drives non-autonomous tumour progression through Hippo signalling in Drosophila. Nature. 2012;490:547-51 pubmed publisher
    ..JNK cooperates with oncogenic Ras to inactivate the Hippo pathway, leading to upregulation of its targets Unpaired (an interleukin-6 homologue) and Wingless (a Wnt homologue)...
  2. Eberl D, Perkins L, Engelstein M, Hilliker A, Perrimon N. Genetic and developmental analysis of polytene section 17 of the X chromosome of Drosophila melanogaster. Genetics. 1992;130:569-83 pubmed
    ..In this interval of 37 to 43 polytene chromosome bands we have defined 17 genes, 12 (71%) of which are of significance to oogenesis or embryogenesis. ..
  3. Lin H. The stem-cell niche theory: lessons from flies. Nat Rev Genet. 2002;3:931-40 pubmed
    ..These findings are illuminating our understanding of the self-renewing mechanisms of tissue stem cells in general. ..
  4. Zeidler M, Bach E, Perrimon N. The roles of the Drosophila JAK/STAT pathway. Oncogene. 2000;19:2598-606 pubmed publisher
    ..Oncogene (2000)...
  5. Iwaki D, Johansen K, Singer J, Lengyel J. drumstick, bowl, and lines are required for patterning and cell rearrangement in the Drosophila embryonic hindgut. Dev Biol. 2001;240:611-26 pubmed
    ..the prospective small intestine, large intestine, and rectum of genes encoding cell signals (wingless, hedgehog, unpaired, Serrate, dpp) and transcription factors (engrailed, dead ringer)...
  6. Hombria J, Brown S. The fertile field of Drosophila Jak/STAT signalling. Curr Biol. 2002;12:R569-75 pubmed
    ..Drosophila's streamlined pathway offers a simple model to find new elements and analyse the function of existing ones. ..
  7. Silver D, Montell D. Paracrine signaling through the JAK/STAT pathway activates invasive behavior of ovarian epithelial cells in Drosophila. Cell. 2001;107:831-41 pubmed
    ..The ligand for this pathway, Unpaired (UPD), is expressed by two central cells within the migratory cell cluster...
  8. Avila F, Erickson J. Drosophila JAK/STAT pathway reveals distinct initiation and reinforcement steps in early transcription of Sxl. Curr Biol. 2007;17:643-8 pubmed
    ..Most XSEs encode transcription factors that bind SxlPe, but the XSE unpaired (upd) encodes a secreted ligand for the JAK/STAT pathway [5-7]...
  9. Xi R, McGregor J, Harrison D. A gradient of JAK pathway activity patterns the anterior-posterior axis of the follicular epithelium. Dev Cell. 2003;4:167-77 pubmed
    ..Here we demonstrate that the graded activity of the Janus kinase (JAK) pathway, stimulated by the Unpaired ligand, patterns the anterior-posterior axis of the follicular epithelium...
  10. Issigonis M, Matunis E. The Drosophila BCL6 homolog Ken and Barbie promotes somatic stem cell self-renewal in the testis niche. Dev Biol. 2012;368:181-92 pubmed publisher
    ..Studies of ken may inform our understanding of its vertebrate orthologue B-Cell Lymphoma 6 (BCL6) and how misregulation of this oncogene leads to human lymphomas. ..
  11. Johansen K, Green R, Iwaki D, Hernandez J, Lengyel J. The Drm-Bowl-Lin relief-of-repression hierarchy controls fore- and hindgut patterning and morphogenesis. Mech Dev. 2003;120:1139-51 pubmed
    ..then acts to promote spatially localized expression of genes (particularly the JAK/STAT pathway ligand encoded by upd) that control fore- and hindgut morphogenesis...
  12. Woodfield S, Graves H, Hernandez J, Bergmann A. De-regulation of JNK and JAK/STAT signaling in ESCRT-II mutant tissues cooperatively contributes to neoplastic tumorigenesis. PLoS ONE. 2013;8:e56021 pubmed publisher
    ..This is the first rigorous study of tissues predominantly mutant for endocytic nTSGs and provides clear evidence for cooperation among de-regulated signaling pathways leading to tumorigenesis. ..
  13. Zeidler M, Perrimon N, Strutt D. Polarity determination in the Drosophila eye: a novel role for unpaired and JAK/STAT signaling. Genes Dev. 1999;13:1342-53 pubmed
    ..We show that a localized source of the pathway ligand, Unpaired, is present at the midline of the developing eye, which is capable of activating the JAK/STAT pathway over long ..
  14. Harrison D, McCoon P, Binari R, Gilman M, Perrimon N. Drosophila unpaired encodes a secreted protein that activates the JAK signaling pathway. Genes Dev. 1998;12:3252-63 pubmed
    ..We have characterized the unpaired (upd) gene, which displays the same distinctive embryonic mutant defects as mutations in the Drosophila JAK (..
  15. Singh S, Zheng Z, Wang H, Oh S, Chen X, Hou S. Competitiveness for the niche and mutual dependence of the germline and somatic stem cells in the Drosophila testis are regulated by the JAK/STAT signaling. J Cell Physiol. 2010;223:500-10 pubmed publisher
    ..The hub expresses a growth factor unpaired (Upd) that activates the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway in GSCs ..
  16. Ekas L, Baeg G, Flaherty M, Ayala Camargo A, Bach E. JAK/STAT signaling promotes regional specification by negatively regulating wingless expression in Drosophila. Development. 2006;133:4721-9 pubmed
    ..Overexpression of the JAK/STAT activating ligand Unpaired in the eye leads to loss of wg expression and ectopic morphogenetic furrow initiation from the lateral margins...
  17. Moberg K, Schelble S, Burdick S, Hariharan I. Mutations in erupted, the Drosophila ortholog of mammalian tumor susceptibility gene 101, elicit non-cell-autonomous overgrowth. Dev Cell. 2005;9:699-710 pubmed
    ..This causes increased Notch-mediated signaling and ectopic expression of the Notch target gene unpaired (upd), which encodes the secreted ligand of the JAK-STAT pathway...
  18. Tsai Y, Sun Y. Long-range effect of upd, a ligand for Jak/STAT pathway, on cell cycle in Drosophila eye development. Genesis. 2004;39:141-53 pubmed
    b>unpaired (upd) encodes a ligand for the Jak/STAT signaling pathway in Drosophila. In the second instar and early third larval eye disc, upd is expressed in the center of the posterior margin...
  19. Sotillos S, Díaz Meco M, Moscat J, Castelli Gair Hombría J. Polarized subcellular localization of Jak/STAT components is required for efficient signaling. Curr Biol. 2008;18:624-9 pubmed publisher
    ..Our results also suggest that receptor polarization in the ectoderm cell membrane restricts the cell's response to ligands provided by neighboring cells. ..
  20. Beebe K, Lee W, Micchelli C. JAK/STAT signaling coordinates stem cell proliferation and multilineage differentiation in the Drosophila intestinal stem cell lineage. Dev Biol. 2010;338:28-37 pubmed publisher
  21. Wright V, Vogt K, Smythe E, Zeidler M. Differential activities of the Drosophila JAK/STAT pathway ligands Upd, Upd2 and Upd3. Cell Signal. 2011;23:920-7 pubmed publisher
    ..By contrast, the Drosophila genome encodes for only three related JAK/STAT ligands, Upd, Upd2 and Upd3...
  22. Arbouzova N, Bach E, Zeidler M. Ken & barbie selectively regulates the expression of a subset of Jak/STAT pathway target genes. Curr Biol. 2006;16:80-8 pubmed
    ..Ken therefore represents a novel regulator of JAK/STAT signaling whose dynamic spatial and temporal expression is capable of selectively modulating the transcriptional repertoire elicited by activated STAT92E in vivo. ..
  23. Tran V, Lim C, Xie J, Chen X. Asymmetric division of Drosophila male germline stem cell shows asymmetric histone distribution. Science. 2012;338:679-82 pubmed publisher
    ..This work suggests that stem cells retain preexisting canonical histones during asymmetric cell divisions, probably as a mechanism to maintain their unique molecular properties. ..
  24. Ren F, Wang B, Yue T, Yun E, Ip Y, Jiang J. Hippo signaling regulates Drosophila intestine stem cell proliferation through multiple pathways. Proc Natl Acad Sci U S A. 2010;107:21064-9 pubmed publisher
    ..We provide evidence that loss of Hpo signaling in epithelial cells increases the production of cytokines of the Upd family and multiple EGFR ligands that activate JAK-STAT and EGFR signaling pathways in ISCs to stimulate their ..
  25. Wang L, McLeod C, Jones D. Regulation of adult stem cell behavior by nutrient signaling. Cell Cycle. 2011;10:2628-34 pubmed
    ..Here we discuss our data regarding the effects and mechanisms by which changes in systemic nutritional conditions may influence the maintenance and activity of adult stem cells via insulin signaling. ..
  26. Leatherman J, Dinardo S. Zfh-1 controls somatic stem cell self-renewal in the Drosophila testis and nonautonomously influences germline stem cell self-renewal. Cell Stem Cell. 2008;3:44-54 pubmed publisher
    ..In contrast, germline-intrinsic STAT activation was insufficient for GSC renewal. These data reveal unexpected complexity in cell interactions in the niche, implicating CPCs in GSC self-renewal. ..
  27. Grammont M, Irvine K. Organizer activity of the polar cells during Drosophila oogenesis. Development. 2002;129:5131-40 pubmed
    ..The origin of asymmetry during Drosophila development can thus be traced back to the specification of the polar cells during early oogenesis. ..
  28. Fuller M, Spradling A. Male and female Drosophila germline stem cells: two versions of immortality. Science. 2007;316:402-4 pubmed
    ..Comparing these two stem cells and their niches in detail is likely to reveal how a common heritage has been adapted to the differing requirements of male and female gamete production. ..
  29. Krzemien J, Dubois L, Makki R, Meister M, Vincent A, Crozatier M. Control of blood cell homeostasis in Drosophila larvae by the posterior signalling centre. Nature. 2007;446:325-8 pubmed
  30. Singh S, Zhen W, Zheng Z, Wang H, Oh S, Liu W, et al. The Drosophila homolog of the human tumor suppressor gene BHD interacts with the JAK-STAT and Dpp signaling pathways in regulating male germline stem cell maintenance. Oncogene. 2006;25:5933-41 pubmed
    ..of DBHD gene activity suppresses the GSC overproliferation phenotype associated with overexpression of either unpaired (upd) or decapentaplegic (dpp)...
  31. Chen H, Chen X, Oh S, Marinissen M, Gutkind J, Hou S. mom identifies a receptor for the Drosophila JAK/STAT signal transduction pathway and encodes a protein distantly related to the mammalian cytokine receptor family. Genes Dev. 2002;16:388-98 pubmed
    ..We named this gene master of marelle (mom). Genetic analyses place mom's function between upd (the ligand) and hop...
  32. Ghiglione C, Devergne O, Georgenthum E, Carballès F, Medioni C, Cerezo D, et al. The Drosophila cytokine receptor Domeless controls border cell migration and epithelial polarization during oogenesis. Development. 2002;129:5437-47 pubmed
    ..During embryogenesis, transduction of the Unpaired [Upd; also known as Outstretched (Os)] ligand through the JAK/STAT pathway requires Domeless, a putative membrane protein with distant homology ..
  33. Agaisse H, Perrimon N. The roles of JAK/STAT signaling in Drosophila immune responses. Immunol Rev. 2004;198:72-82 pubmed
  34. Vaccari T, Bilder D. The Drosophila tumor suppressor vps25 prevents nonautonomous overproliferation by regulating notch trafficking. Dev Cell. 2005;9:687-98 pubmed
    ..Increased Notch activity leads to ectopic production of the mitogenic JAK-STAT pathway ligand Unpaired, which is secreted from mutant cells to induce overproliferation of the surrounding epithelium...
  35. Pastor Pareja J, Wu M, Xu T. An innate immune response of blood cells to tumors and tissue damage in Drosophila. Dis Model Mech. 2008;1:144-54; discussion 153 pubmed publisher
    ..Our findings reveal common mechanisms in the response to tumors and wounds in flies. A similar innate reaction may underlie the response to tumors and tissue damage in vertebrates and humans. ..
  36. Luo H, Dearolf C. The JAK/STAT pathway and Drosophila development. Bioessays. 2001;23:1138-47 pubmed
    ..Hence, the JAK/STAT pathway in Drosophila serves as an attractive model for in vivo functional analyses of JAK/STAT signaling. ..
  37. Kiger A, Jones D, Schulz C, Rogers M, Fuller M. Stem cell self-renewal specified by JAK-STAT activation in response to a support cell cue. Science. 2001;294:2542-5 pubmed
    ..Hub cells express the ligand Unpaired (Upd), which activates the Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway in ..
  38. Brown S, Hu N, Hombria J. Novel level of signalling control in the JAK/STAT pathway revealed by in situ visualisation of protein-protein interaction during Drosophila development. Development. 2003;130:3077-84 pubmed
    ..These results reveal a novel level of JAK/STAT signalling regulation that could also apply to vertebrates. ..
  39. Johansen K, Iwaki D, Lengyel J. Localized JAK/STAT signaling is required for oriented cell rearrangement in a tubular epithelium. Development. 2003;130:135-45 pubmed
    ..The difference in effect between localized expression of ligand (Unpaired) and dominant active JAK (Hopscotch) demonstrates that the ligand plays a cell non-autonomous role in hindgut ..
  40. Betz A, Lampen N, Martinek S, Young M, Darnell J. A Drosophila PIAS homologue negatively regulates stat92E. Proc Natl Acad Sci U S A. 2001;98:9563-8 pubmed
    ..To this end we use a LOF allele and conditionally overexpressed dpias in JAK-STAT pathway mutant backgrounds. We conclude that the correct dpias/stat92E ratio is crucial for blood cell and eye development. ..
  41. Mukherjee T, Hombria J, Zeidler M. Opposing roles for Drosophila JAK/STAT signalling during cellular proliferation. Oncogene. 2005;24:2503-11 pubmed
    ..Pro- and antiproliferative roles therefore represent ancestral activities conserved through evolution and subsequently assigned to distinct molecules. ..
  42. Rivas M, Cobreros L, Zeidler M, Hombria J. Plasticity of Drosophila Stat DNA binding shows an evolutionary basis for Stat transcription factor preferences. EMBO Rep. 2008;9:1114-20 pubmed publisher
    ..Our results indicate that the ancestral STAT protein had the capacity to bind to 3n and 4n sites and that specific STAT binding preferences evolved with the radiation of the vertebrate STAT family. ..
  43. Osman D, Buchon N, Chakrabarti S, Huang Y, Su W, Poidevin M, et al. Autocrine and paracrine unpaired signaling regulate intestinal stem cell maintenance and division. J Cell Sci. 2012;125:5944-9 pubmed publisher
    ..Three ligands, Unpaired 1, Unpaired 2 and Unpaired 3 (Upd1, Upd2 and Upd3, respectively) are known to activate the JAK/STAT pathway in ..
  44. Karpowicz P, Perez J, Perrimon N. The Hippo tumor suppressor pathway regulates intestinal stem cell regeneration. Development. 2010;137:4135-45 pubmed publisher
    ..This leads to the production of Upd cytokines from ECs, which in turn activate the Janus kinase (JAK)/Signal transducer and activator of transcription (..
  45. Devergne O, Ghiglione C, Noselli S. The endocytic control of JAK/STAT signalling in Drosophila. J Cell Sci. 2007;120:3457-64 pubmed
    ..Using both in vivo genetic analysis and cell culture assays, we show that ligand binding of Unpaired 1 (Upd1) induces clathrin-dependent endocytosis of receptor-ligand complexes and their subsequent trafficking ..
  46. Brown S, Hu N, Hombría J. Identification of the first invertebrate interleukin JAK/STAT receptor, the Drosophila gene domeless. Curr Biol. 2001;11:1700-5 pubmed
    ..This suggests that the vertebrate families evolved from a single ancestral receptor that also gave rise to dome. ..
  47. Gilbert M, Weaver B, Gergen J, Reich N. A novel functional activator of the Drosophila JAK/STAT pathway, unpaired2, is revealed by an in vivo reporter of pathway activation. Mech Dev. 2005;122:939-48 pubmed
    ..sites can be detected throughout embryogenesis, and is responsive to the Janus Kinase hopscotch and the ligand upd. The system has enabled us to identify the effect of a predicted gene related to upd, designated upd2, whose ..
  48. Starz Gaiano M, Melani M, Meinhardt H, Montell D. Interpretation of the UPD/JAK/STAT morphogen gradient in Drosophila follicle cells. Cell Cycle. 2009;8:2917-25 pubmed
    ..Under the influence of a graded signal, Unpaired (UPD), JAK/STAT becomes activated first in a graded fashion...
  49. Lin G, Xu N, Xi R. Paracrine unpaired signaling through the JAK/STAT pathway controls self-renewal and lineage differentiation of drosophila intestinal stem cells. J Mol Cell Biol. 2010;2:37-49 pubmed publisher
    ..Here we report the identification of Unpaired as another paracrine signal from the muscular niche, which activates a canonical JAK/STAT signaling cascade in ..
  50. Hombr a J, Brown S, H der S, Zeidler M. Characterisation of Upd2, a Drosophila JAK/STAT pathway ligand. Dev Biol. 2005;288:420-33 pubmed publisher
    ..we describe our analysis of the only invertebrate JAK/STAT pathway ligands identified to date, the Drosophila unpaired-like family...
  51. Thompson B, Mathieu J, Sung H, Loeser E, Rørth P, Cohen S. Tumor suppressor properties of the ESCRT-II complex component Vps25 in Drosophila. Dev Cell. 2005;9:711-20 pubmed
    ..These results highlight the importance of endocytic trafficking in regulating signaling and epithelial organization and suggest a possible role for ESCRT components in human cancer. ..
  52. Chao J, Tsai Y, Chiu S, Sun Y. Localized Notch signal acts through eyg and upd to promote global growth in Drosophila eye. Development. 2004;131:3839-47 pubmed
    ..In addition, we showed that N and eyg could induce expression of upd, which encodes the ligand for the Jak/STAT pathway and acts over long distance to promote cell proliferation...
  53. Guo Z, Driver I, Ohlstein B. Injury-induced BMP signaling negatively regulates Drosophila midgut homeostasis. J Cell Biol. 2013;201:945-61 pubmed publisher
    ..Our data establish a new link between injury and hyperplasia and may provide insight into how BMP signaling mutations drive formation of human intestinal cancers...
  54. Beccari S, Teixeira L, Rørth P. The JAK/STAT pathway is required for border cell migration during Drosophila oogenesis. Mech Dev. 2002;111:115-23 pubmed
    ..The activating ligand for the pathway, Unpaired, is expressed in polar cells...
  55. Shaw R, Kohlmaier A, Polesello C, Veelken C, Edgar B, Tapon N. The Hippo pathway regulates intestinal stem cell proliferation during Drosophila adult midgut regeneration. Development. 2010;137:4147-58 pubmed publisher
    ..Intestinal stress induces the activation of Upd/Jak/Stat signalling, which promotes intestinal regeneration by inducing rapid stem cell proliferation...
  56. Karsten P, Häder S, Zeidler M. Cloning and expression of Drosophila SOCS36E and its potential regulation by the JAK/STAT pathway. Mech Dev. 2002;117:343-6 pubmed
    ..SOCS36E is expressed in an essentially identical pattern to the Drosophila JAK/STAT pathway ligand unpaired (Upd)...
  57. Gutierrez Aviño F, Ferres Marco D, Dominguez M. The position and function of the Notch-mediated eye growth organizer: the roles of JAK/STAT and four-jointed. EMBO Rep. 2009;10:1051-8 pubmed publisher
    ..selector Iroquois complex defines the position of the organizer at the mid-first instar, and through its ligand, unpaired, the Janus kinase (JAK)/signal transducers and activator of transcription (STAT) pathway is thought to mediate ..
  58. Wang W, Li Y, Zhou L, Yue H, Luo H. Role of JAK/STAT signaling in neuroepithelial stem cell maintenance and proliferation in the Drosophila optic lobe. Biochem Biophys Res Commun. 2011;410:714-20 pubmed publisher
    ..Thus, in addition to its role in suppression of neuroblast formation, the JAK/STAT pathway is necessary and sufficient for optic lobe neuroepithelial growth. ..
  59. Sheng X, Brawley C, MATUNIS E. Dedifferentiating spermatogonia outcompete somatic stem cells for niche occupancy in the Drosophila testis. Cell Stem Cell. 2009;5:191-203 pubmed publisher
  60. Almudi I, Stocker H, Hafen E, Corominas M, Serras F. SOCS36E specifically interferes with Sevenless signaling during Drosophila eye development. Dev Biol. 2009;326:212-23 pubmed publisher
    ..The SOCS family of adaptor proteins may have evolved as modulators of specific signaling pathways that contribute to the robustness and precision of cell fate specification. ..
  61. Decotto E, Spradling A. The Drosophila ovarian and testis stem cell niches: similar somatic stem cells and signals. Dev Cell. 2005;9:501-10 pubmed
    ..These observations reveal striking similarities in the stem cell niches of male and female gonads, and suggest that they are largely governed by common mechanisms. ..
  62. Liu W, Singh S, Hou S. JAK-STAT is restrained by Notch to control cell proliferation of the Drosophila intestinal stem cells. J Cell Biochem. 2010;109:992-9 pubmed publisher
    ..is negatively regulated by Notch at least through a transcriptional control of the JAK-STAT signaling ligand, unpaired (upd)...
  63. Tsai Y, Yao J, Chen P, Posakony J, Barolo S, Kim J, et al. Upd/Jak/STAT signaling represses wg transcription to allow initiation of morphogenetic furrow in Drosophila eye development. Dev Biol. 2007;306:760-71 pubmed
    ..What determines MF initiates from the specific PC site is still unclear. The unpaired (upd) gene is expressed at PC at early third instar, just before the time of MF initiation...
  64. Bach E, Ekas L, Ayala Camargo A, Flaherty M, Lee H, Perrimon N, et al. GFP reporters detect the activation of the Drosophila JAK/STAT pathway in vivo. Gene Expr Patterns. 2007;7:323-31 pubmed
    ..JAK/STAT pathway activity at larval stages, as their expression pattern overlaps that of the activating ligand unpaired in imaginal discs. Moreover, the STAT92E-GFP reporters are activated by ectopic JAK/STAT signaling...
  65. Vaccari T, Rusten T, Menut L, Nezis I, Brech A, Stenmark H, et al. Comparative analysis of ESCRT-I, ESCRT-II and ESCRT-III function in Drosophila by efficient isolation of ESCRT mutants. J Cell Sci. 2009;122:2413-23 pubmed publisher
  66. Jiang H, Patel P, Kohlmaier A, Grenley M, McEwen D, Edgar B. Cytokine/Jak/Stat signaling mediates regeneration and homeostasis in the Drosophila midgut. Cell. 2009;137:1343-55 pubmed publisher
    ..midgut are subjected to apoptosis, enteric infection, or JNK-mediated stress signaling, they produce cytokines (Upd, Upd2, and Upd3) that activate Jak/Stat signaling in ISCs, promoting their rapid division...
  67. Spradling A, Drummond Barbosa D, Kai T. Stem cells find their niche. Nature. 2001;414:98-104 pubmed
    ..These studies are beginning to unify our understanding of stem cell regulation at the cellular and molecular levels, and promise to advance efforts to use stem cells therapeutically. ..