Gene Symbol: unk
Description: unkempt
Alias: CG4620, Dmel\CG4620, unkempt, CG4620-PA, CG4620-PB, CG4620-PC, CG4620-PD, CG4620-PE, CG4620-PF, CG4620-PG, unk-PA, unk-PB, unk-PC, unk-PD, unk-PE, unk-PF, unk-PG
Species: fruit fly

Top Publications

  1. Mohler J, Weiss N, Murli S, Mohammadi S, Vani K, Vasilakis G, et al. The embryonically active gene, unkempt, of Drosophila encodes a Cys3His finger protein. Genetics. 1992;131:377-88 pubmed
    The unkempt gene of Drosophila encodes a set of embryonic RNAs, which are abundant during early stages of embryogenesis and are present ubiquitously in most somatic tissues from the syncytial embryo through stage 15 of embryogenesis...
  2. Glatter T, Schittenhelm R, Rinner O, Roguska K, Wepf A, J√ľnger M, et al. Modularity and hormone sensitivity of the Drosophila melanogaster insulin receptor/target of rapamycin interaction proteome. Mol Syst Biol. 2011;7:547 pubmed publisher
    ..Subsequent genetic studies in flies suggest a role for dTTT in controlling cell growth via a dTORC1- and dTORC2-dependent mechanism. ..
  3. Raker V, Mironov A, Gelfand M, Pervouchine D. Modulation of alternative splicing by long-range RNA structures in Drosophila. Nucleic Acids Res. 2009;37:4533-44 pubmed publisher
    ..Thus, base-pairing interactions within introns, even those occurring over long distances, are more frequent modulators of alternative splicing than is currently assumed. ..
  4. Tiebe M, Lutz M, De La Garza A, Buechling T, Boutros M, Teleman A. REPTOR and REPTOR-BP Regulate Organismal Metabolism and Transcription Downstream of TORC1. Dev Cell. 2015;33:272-84 pubmed publisher
    ..In vivo functional analysis using knockout flies reveals that REPTOR and REPTOR-BP play critical roles in maintaining energy homeostasis and promoting animal survival upon nutrient restriction. ..
  5. Tabata T, Eaton S, Kornberg T. The Drosophila hedgehog gene is expressed specifically in posterior compartment cells and is a target of engrailed regulation. Genes Dev. 1992;6:2635-45 pubmed
    ..The ectopic expression of hh that is normally induced in patched (ptc) mutant embryos does not appear in ptc en double mutants. We discuss these findings in terms of the relationship between en and hh, and the role of the hh function. ..
  6. Mohler J, Vani K, Leung S, Epstein A. Segmentally restricted, cephalic expression of a leucine zipper gene during Drosophila embryogenesis. Mech Dev. 1991;34:3-9 pubmed
    ..Based on its protein sequence, we propose that CNC is a subunit of a heterodimeric regulatory protein involved in the control of head morphogenesis. ..
  7. Mohler J, Mahaffey J, Deutsch E, Vani K. Control of Drosophila head segment identity by the bZIP homeotic gene cnc. Development. 1995;121:237-47 pubmed
    ..This role of homeotic selector genes for the segment-specific maintenance of segment polarity gene expression is a unique feature of segmentation in the preoral head region of Drosophila. ..
  8. Mastushita Sakai T, White Grindley E, Samuelson J, Seidel C, Si K. Drosophila Orb2 targets genes involved in neuronal growth, synapse formation, and protein turnover. Proc Natl Acad Sci U S A. 2010;107:11987-92 pubmed publisher
    ..These targets suggest that the persistent form of the memory trace might be comprised of molecules that maintain a sustained, permissive environment for synaptic growth in an activated synapse. ..
  9. Avet Rochex A, Carvajal N, Christoforou C, Yeung K, Maierbrugger K, Hobbs C, et al. Unkempt is negatively regulated by mTOR and uncouples neuronal differentiation from growth control. PLoS Genet. 2014;10:e1004624 pubmed publisher
    ..We identified the conserved gene unkempt (unk), which encodes a zinc finger/RING domain containing protein, as a negative regulator of the timing of ..